ES8102136A1 - Procedimiento para la obtencion de derivados de vinil-3 ce- falosporina - Google Patents

Procedimiento para la obtencion de derivados de vinil-3 ce- falosporina

Info

Publication number
ES8102136A1
ES8102136A1 ES491687A ES491687A ES8102136A1 ES 8102136 A1 ES8102136 A1 ES 8102136A1 ES 491687 A ES491687 A ES 491687A ES 491687 A ES491687 A ES 491687A ES 8102136 A1 ES8102136 A1 ES 8102136A1
Authority
ES
Spain
Prior art keywords
radical
vinyl
protective
protective radical
bicyclooct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491687A
Other languages
English (en)
Other versions
ES491687A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Publication of ES491687A0 publication Critical patent/ES491687A0/es
Publication of ES8102136A1 publication Critical patent/ES8102136A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE VINIL-3 CEFALOSPORINA, QUE RESPONDEN A LAS FORMULAS (I) Y (II), Y SUS SALES, DONDE R1, R3, R4, R, R1 ELEVADO A O Y R2 ELEVADO A O SON DIVERSOS TIPOS DE RADICALES, Y R2 ES FACILMENTE ELIMINABLE POR VIA ENZIMATICA. SEGUN LOS VALORES RELATIVOS DE LOS RADICALES INDICADOS, LOS PRODUCTOS CON FORMULA GENERAL (I) SE OBTIENEN POR DIFERENTES PROCEDIMIENTOS. UNO DE ELLOS CONSISTE EN LA REACCION DE UN PRODUCTO DE FORMULA (III) SOBRE UN DERIVADO DE CEFALOSPORINA, DE FORMULA GENERAL (IV), QUE SE PRESENTA EN FORMA DE METIL-3 BICICLOOCTERNO-2 O -3 METILENO-3 BICICLOOCTENO, SIENDO R''11 Y R11 DIFERENTES RADICALES. UN PROCEDIMIENTO PARA OBTENER UN DERIVADO (V) DE TIPO (II) CONSISTE EN PREPARAR UN COMPUESTO POR HIDROLISIS EN MEDIO ACIDO A PARTIR DE LA ENAMINA O DE MEZCLA DE SUS ISOMEROS. ESTOS COMPUESTOS PRESENTAN PROPIEDADES ANTIBACTERIANAS. *FORMULA*
ES491687A 1979-05-23 1980-05-21 Procedimiento para la obtencion de derivados de vinil-3 ce- falosporina Expired ES8102136A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7913096A FR2457296A1 (fr) 1979-05-23 1979-05-23 Nouveaux derives de vinyl-3 cephalosporines et leur preparation

Publications (2)

Publication Number Publication Date
ES491687A0 ES491687A0 (es) 1980-12-16
ES8102136A1 true ES8102136A1 (es) 1980-12-16

Family

ID=9225762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES491687A Expired ES8102136A1 (es) 1979-05-23 1980-05-21 Procedimiento para la obtencion de derivados de vinil-3 ce- falosporina

Country Status (31)

Country Link
US (1) US4307233A (es)
JP (1) JPS55154981A (es)
AT (1) AT369375B (es)
AU (1) AU534806B2 (es)
BE (1) BE883416A (es)
CA (1) CA1144919A (es)
CH (1) CH645379A5 (es)
CS (1) CS244405B2 (es)
DD (1) DD150899A5 (es)
DE (1) DE3019462A1 (es)
DK (1) DK222080A (es)
ES (1) ES8102136A1 (es)
FI (1) FI801641A (es)
FR (1) FR2457296A1 (es)
GB (1) GB2051062B (es)
GR (1) GR68426B (es)
HU (1) HU185890B (es)
IE (1) IE49814B1 (es)
IL (1) IL60139A (es)
IT (1) IT1140974B (es)
LU (1) LU82477A1 (es)
NL (1) NL8003023A (es)
NO (1) NO801502L (es)
NZ (1) NZ193799A (es)
PH (1) PH15946A (es)
PL (1) PL126481B1 (es)
PT (1) PT71276A (es)
SE (1) SE451072B (es)
SU (1) SU1031409A3 (es)
YU (1) YU136880A (es)
ZA (1) ZA803038B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7909401L (sv) * 1978-11-15 1980-05-16 Glaxo Group Ltd Cefalosporinantibiotika
FR2494275A2 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
FR2494280A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine et leur preparation
FR2494279A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouvelles oxacephalosporines, leur preparation et les medicaments qui les contiennent
FR2505334A1 (fr) * 1981-05-11 1982-11-12 Rhone Poulenc Sante Nouvelles oxacephalosporines et leur preparation
FR2511372A1 (fr) * 1981-08-17 1983-02-18 Rhone Poulenc Sante Nouveaux derives de la cephalosporine et leur preparation
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
US4560749A (en) * 1983-11-18 1985-12-24 Eli Lilly And Company Cephem-3-imidates and 3-amidines
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US5084453A (en) * 1986-04-14 1992-01-28 Banyu Pharmaceutical Co., Ltd. 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives
DE69737382T2 (de) 1996-11-06 2007-10-31 Basilea Pharmaceutica Ag Vinylpyrrolidinon-Cephalosporin-Derivate
US8883772B2 (en) 2007-10-09 2014-11-11 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
GB1463077A (en) * 1973-04-19 1977-02-02 Glaxo Lab Ltd 7-substituted-ethyl-cephalosporin derivatives
US4144393A (en) * 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
DE2460537A1 (de) * 1973-12-21 1975-07-03 Glaxo Lab Ltd Cephalosporin-antibiotika
JPS5129492A (en) * 1974-09-04 1976-03-12 Sankyo Co Sefuarosuhorinjudotai no seiho
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
JPS5253890A (en) * 1975-10-14 1977-04-30 Syntex Inc Production of cephalosporin type compound
PT71651B (en) * 1979-08-15 1982-01-21 Merck & Co Inc Process for preparing allysulfoxide enzyme inhibitors

Also Published As

Publication number Publication date
AU5859580A (en) 1980-11-27
PL224391A1 (es) 1981-02-13
ZA803038B (en) 1981-05-27
CS244405B2 (en) 1986-07-17
DE3019462A1 (de) 1980-12-04
NO801502L (no) 1980-11-24
HU185890B (en) 1985-04-28
US4307233A (en) 1981-12-22
FR2457296B1 (es) 1982-02-05
CS354380A2 (es) 1985-09-17
PL126481B1 (en) 1983-08-31
LU82477A1 (fr) 1980-12-16
NZ193799A (en) 1983-03-15
AT369375B (de) 1982-12-27
PH15946A (en) 1983-04-29
JPS55154981A (en) 1980-12-02
YU136880A (en) 1983-04-30
ES491687A0 (es) 1980-12-16
GR68426B (es) 1981-12-30
SE8003821L (sv) 1980-11-24
DD150899A5 (de) 1981-09-23
IL60139A (en) 1984-04-30
JPH0246595B2 (es) 1990-10-16
BE883416A (fr) 1980-11-21
AU534806B2 (en) 1984-02-16
IT8022243A0 (it) 1980-05-21
ATA270980A (de) 1982-05-15
IL60139A0 (en) 1980-07-31
IE49814B1 (en) 1985-12-25
PT71276A (fr) 1980-06-01
GB2051062B (en) 1983-10-12
CH645379A5 (fr) 1984-09-28
FI801641A (fi) 1980-11-24
IE801062L (en) 1980-11-23
FR2457296A1 (fr) 1980-12-19
CA1144919A (fr) 1983-04-19
SE451072B (sv) 1987-08-31
IT1140974B (it) 1986-10-10
SU1031409A3 (ru) 1983-07-23
DK222080A (da) 1980-11-24
GB2051062A (en) 1981-01-14
NL8003023A (nl) 1980-11-25

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