CY1113609T1 - ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ - Google Patents
ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥInfo
- Publication number
- CY1113609T1 CY1113609T1 CY20121100156T CY121100156T CY1113609T1 CY 1113609 T1 CY1113609 T1 CY 1113609T1 CY 20121100156 T CY20121100156 T CY 20121100156T CY 121100156 T CY121100156 T CY 121100156T CY 1113609 T1 CY1113609 T1 CY 1113609T1
- Authority
- CY
- Cyprus
- Prior art keywords
- ifn
- beta
- solubility
- chlorine solutions
- sodium chlorine
- Prior art date
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 title 1
- 108090000467 Interferon-beta Proteins 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 102100026720 Interferon beta Human genes 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000003996 Interferon-beta Human genes 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229960001388 interferon-beta Drugs 0.000 abstract 1
Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Παρέχονται σταθεροποιημένες φαρμακευτικές συνθέσεις που περιλαμβάνουν ουσιαστικώς μονομερική ιντερφερόνη-βήτα (ΙFΝ-β) και μέθοδοι χρήσιμοι στην παρασκευή αυτών. Οι συνθέσεις περιλαμβάνουν την ΙFΝ-β διαλυτοποιημένη σε φαρμακοτεχνική μορφή χαμηλής-ιονικής-ισχύος που διατηρεί την σύνθεση σε pΗ περίπου 5,0. Παρέχονται μέθοδοι για παρασκευή αυτών των συνθέσεων και για αύξηση διαλυτότητας ΙFΝ-β σε φαρμακευτικές συνθέσεις.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28261401P | 2001-04-09 | 2001-04-09 | |
US33040401P | 2001-10-18 | 2001-10-18 | |
US10/035,397 US6887462B2 (en) | 2001-04-09 | 2001-10-25 | HSA-free formulations of interferon-beta |
EP01988466A EP1381432B9 (en) | 2001-04-09 | 2001-10-26 | HSA-free formulations of interferon-beta |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113609T1 true CY1113609T1 (el) | 2015-08-05 |
Family
ID=27364838
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100156T CY1113609T1 (el) | 2001-04-09 | 2012-02-16 | ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ |
CY2012023C CY2012023I1 (el) | 2001-04-09 | 2012-08-13 | ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY2012023C CY2012023I1 (el) | 2001-04-09 | 2012-08-13 | ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ |
Country Status (19)
Country | Link |
---|---|
US (5) | US6887462B2 (el) |
EP (3) | EP1381432B9 (el) |
JP (5) | JP2004529917A (el) |
KR (1) | KR100900753B1 (el) |
CN (1) | CN1313148C (el) |
AT (1) | ATE545430T1 (el) |
BG (1) | BG66300B1 (el) |
CA (2) | CA2762966A1 (el) |
CY (2) | CY1113609T1 (el) |
CZ (1) | CZ305994B6 (el) |
DK (1) | DK1381432T3 (el) |
ES (3) | ES2367761T3 (el) |
HU (1) | HU228581B1 (el) |
IL (2) | IL157963A0 (el) |
LU (1) | LU92060I2 (el) |
NO (1) | NO330259B1 (el) |
PL (1) | PL213297B1 (el) |
PT (2) | PT2283896E (el) |
WO (1) | WO2002080976A2 (el) |
Families Citing this family (76)
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AU3473999A (en) * | 1998-04-03 | 1999-10-25 | Chiron Corporation | Injectable igf-formulations containing succinate as buffering agent |
US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
CZ20031259A3 (cs) * | 2000-11-07 | 2004-01-14 | Chiron Corporation | Stabilizované interferonové prostředky |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
AR034749A1 (es) * | 2001-07-09 | 2004-03-17 | Schering Ag | Formulaciones de interferon beta humano |
EP1487478A2 (en) * | 2002-03-12 | 2004-12-22 | Maxygen Aps | Interferon beta-like molecules for treatment of stroke |
US20040037809A1 (en) * | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
DE10240894A1 (de) * | 2002-09-04 | 2004-03-11 | Procom Biotechnologische Produktions Gmbh | Verstärkung der Resorption von Subtanzen über die Haut und Schleimhaut |
US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
PL219741B1 (pl) * | 2002-12-26 | 2015-07-31 | Mountain View Pharmaceuticals | Sposób zwiększania antyproliferacyjnego potencjału nieglikozylowanego interferonu-beta-1b in vitro, koniugat wytworzony tym sposobem i jego zastosowanie oraz kompozycja farmaceutyczna zawierająca koniugat i jej zastosowanie |
PL380269A1 (pl) * | 2002-12-26 | 2007-01-08 | Mountain View Pharmaceuticals, Inc. | Koniugaty polimerowe cytokin, czynników wzrostu, hormonów polipeptydowych i ich antagonistów o zachowanej zdolności do wiązania receptora |
TWI272948B (en) * | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
US20050208151A1 (en) * | 2003-10-30 | 2005-09-22 | Entelos, Inc. | Treatment of rheumatoid arthritis with FLIP antagonists |
JP2007534633A (ja) * | 2003-11-10 | 2007-11-29 | アライバ−プロメティック インコーポレイティド | ヒト・アルファ1−抗トリプシン製剤 |
EP1532983A1 (en) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
ATE526032T1 (de) * | 2003-12-11 | 2011-10-15 | Ares Trading Sa | Stabilisierte flüssige interferon-formulierungen |
CN1557479A (zh) * | 2004-01-16 | 2004-12-29 | 深圳市海王英特龙生物技术股份有限公 | 干扰素脂质体乳膏 |
DE102004008168B4 (de) * | 2004-02-19 | 2015-12-10 | Voxeljet Ag | Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung |
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US20050220764A1 (en) * | 2004-04-01 | 2005-10-06 | Schering Aktiengesellschaft | Higher-doses of interferon-beta for treatment of multiple sclerosis |
CA2566364A1 (en) * | 2004-05-17 | 2005-11-24 | Ares Trading S.A. | Hydrogel interferon formulations |
KR101191536B1 (ko) * | 2004-06-01 | 2012-10-15 | 아레스 트레이딩 에스.에이. | 안정화된 인터페론 액상 제제 |
US7858082B2 (en) * | 2004-06-01 | 2010-12-28 | Ares Trading S.A. | Method of stabilizing proteins |
US7731948B2 (en) * | 2004-06-01 | 2010-06-08 | Ares Trading S.A. | Stabilized interferon liquid formulations |
WO2005120540A2 (en) * | 2004-06-09 | 2005-12-22 | Schering Aktiengesellschaft | Interferon alpha or beta for treatment of cardiomyopathy and endothelial dysfunction |
US7642072B2 (en) | 2004-07-26 | 2010-01-05 | Enzon Pharmaceuticals, Inc. | Optimized interferon-beta gene |
CA2574953A1 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technolgies Inc. | Process for improved protein expression by strain engineering |
KR20070045244A (ko) * | 2004-08-12 | 2007-05-02 | 쉐링 코포레이션 | 안정한 페길화된 인터페론 제형 |
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CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
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2001
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- 2001-10-26 CZ CZ2003-2735A patent/CZ305994B6/cs unknown
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- 2001-10-26 KR KR1020037013202A patent/KR100900753B1/ko active IP Right Grant
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- 2001-10-26 JP JP2002579014A patent/JP2004529917A/ja not_active Withdrawn
- 2001-10-26 PL PL366790A patent/PL213297B1/pl unknown
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- 2001-10-26 HU HU0303732A patent/HU228581B1/hu active Protection Beyond IP Right Term
- 2001-10-26 DK DK01988466.7T patent/DK1381432T3/da active
- 2001-10-26 WO PCT/US2001/051074 patent/WO2002080976A2/en active Search and Examination
- 2001-10-26 EP EP10180630.5A patent/EP2283896B1/en not_active Expired - Lifetime
- 2001-10-26 IL IL15796301A patent/IL157963A0/xx unknown
- 2001-10-26 ES ES10180658.6T patent/ES2453623T3/es not_active Expired - Lifetime
- 2001-10-26 PT PT01988466T patent/PT1381432E/pt unknown
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- 2001-10-26 AT AT01988466T patent/ATE545430T1/de active
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- 2009-10-26 JP JP2009245975A patent/JP2010018633A/ja not_active Withdrawn
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