CY1113391T1 - Χρηση ενος συστατικου ενισχυσης διαλυτοτητας σε υδατικη συνθεση που περιλαμβανει τρυγικη βριμονιδινη - Google Patents

Χρηση ενος συστατικου ενισχυσης διαλυτοτητας σε υδατικη συνθεση που περιλαμβανει τρυγικη βριμονιδινη

Info

Publication number
CY1113391T1
CY1113391T1 CY20121101120T CY121101120T CY1113391T1 CY 1113391 T1 CY1113391 T1 CY 1113391T1 CY 20121101120 T CY20121101120 T CY 20121101120T CY 121101120 T CY121101120 T CY 121101120T CY 1113391 T1 CY1113391 T1 CY 1113391T1
Authority
CY
Cyprus
Prior art keywords
brimonidin
tragic
composition containing
oxychloro
component soluble
Prior art date
Application number
CY20121101120T
Other languages
English (en)
Inventor
Orest Olejnik
Edward D S Kerslake
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22814167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113391(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Publication of CY1113391T1 publication Critical patent/CY1113391T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Συνθέσεις οι οποίες περιλαμβάνουν θεραπευτικώς δραστικά συστατικά, ενισχυτικά της διαλυτότητας συστατικά διαφορετικά από κυκλοδεξτρίνες και οξυ-χλώρο συστατικά, όπου τα οξυ-χλώρο συστατικά ουσιαστικώς είναι αποτελεσματικά ως συντηρητικά. Σε μια πραγματοποίηση, τα οξυ-χλώρο συστατικά είναι χρήσιμα για συντήρηση των θεραπευτικώς δραστικών συστατικών. Σε μια πραγματοποίηση, τα οξυ-χλώρο συστατικά περιλαμβάνουν συστατικά χλωριώδους. Σε μια χρήσιμη πραγματοποίηση, τα ενισχυτικά διαλυτότητας συστατικά περιλαμβάνουν καρβοξυμεθυλοκυτταρίνη.
CY20121101120T 2000-07-14 2012-11-21 Χρηση ενος συστατικου ενισχυσης διαλυτοτητας σε υδατικη συνθεση που περιλαμβανει τρυγικη βριμονιδινη CY1113391T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21820600P 2000-07-14 2000-07-14
EP09176049A EP2153819B1 (en) 2000-07-14 2001-07-09 Use of a solubility enhancing component in an aqueous composition comprising brimonidine tartrate

Publications (1)

Publication Number Publication Date
CY1113391T1 true CY1113391T1 (el) 2016-06-22

Family

ID=22814167

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101120T CY1113391T1 (el) 2000-07-14 2012-11-21 Χρηση ενος συστατικου ενισχυσης διαλυτοτητας σε υδατικη συνθεση που περιλαμβανει τρυγικη βριμονιδινη

Country Status (23)

Country Link
US (2) US6562873B2 (el)
EP (2) EP2153819B1 (el)
JP (1) JP2004503593A (el)
KR (1) KR20030023700A (el)
CN (1) CN1441679A (el)
AR (1) AR035039A1 (el)
AU (2) AU7326801A (el)
BR (1) BR0112461A (el)
CA (1) CA2416169C (el)
CY (1) CY1113391T1 (el)
DK (1) DK2153819T3 (el)
ES (1) ES2392636T3 (el)
HU (1) HU230383B1 (el)
IL (2) IL153322A0 (el)
MX (1) MXPA02012206A (el)
NO (1) NO331816B1 (el)
NZ (1) NZ522610A (el)
PL (1) PL361027A1 (el)
PT (1) PT2153819E (el)
RU (1) RU2291685C2 (el)
TW (1) TWI287992B (el)
WO (1) WO2002005822A2 (el)
ZA (1) ZA200209877B (el)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026924A1 (en) * 2000-07-14 2005-02-03 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US8858961B2 (en) 2000-07-14 2014-10-14 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
BR0109317A (pt) * 2000-07-14 2003-06-17 Allergan Inc Composições contendo componentes agonistas alfa-2-adrenérgicos
BR0112461A (pt) * 2000-07-14 2003-07-22 Allergan Inc Composições que contém componentes terapeuticamente ativos tendo uma solubilidade aumentada
US20040214829A1 (en) * 2000-07-14 2004-10-28 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
US20050282774A1 (en) * 2000-10-31 2005-12-22 Eek Bjorn C Method and pharmaceutical to treat spinal discs
US20030114460A1 (en) * 2001-12-14 2003-06-19 Allergan Sales, Inc. Pharmaceutical conjugates with enhanced pharmacokinetic characteristics
US7642258B2 (en) * 2002-04-19 2010-01-05 Allergan, Inc. Combination of brimonidine and timolol for topical ophthalmic use
US7030149B2 (en) 2002-04-19 2006-04-18 Allergan, Inc. Combination of brimonidine timolol for topical ophthalmic use
US6982079B2 (en) 2002-04-26 2006-01-03 Allergan, Inc. Compositions for treating hyperemia
WO2004010894A2 (en) * 2002-07-30 2004-02-05 Omeros Corporation Ophthalmologic irrigation solutions and method
US20040137079A1 (en) * 2003-01-08 2004-07-15 Cook James N. Contact lens and eye drop rewetter compositions and methods
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
US9808471B2 (en) * 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7811606B2 (en) * 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US6933289B2 (en) * 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7022740B2 (en) * 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions
CA2505836C (en) * 2004-05-06 2013-08-27 Alcon Inc. Topical brimonidine tartrate formulations that lack chlorine dioxide
US8569367B2 (en) * 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
US20070238732A1 (en) * 2006-04-10 2007-10-11 Allergan, Inc. Brimonidine and timolol compositions
US9561178B2 (en) * 2006-07-25 2017-02-07 Allergan, Inc. Cyclosporin compositions
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP2279005A1 (en) * 2008-05-19 2011-02-02 Alcon Research, Ltd. Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
US20110003823A1 (en) * 2008-08-01 2011-01-06 Alpha Synergy Development, Inc. Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage
US8080550B2 (en) * 2008-08-01 2011-12-20 Alpha Synergy Development, Inc. Anesthetic compositions and methods of use
US20110244058A1 (en) * 2008-08-01 2011-10-06 Gerald Horn Compositions and methods for treatment of pulmonary diseases and conditions
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
US20100203165A1 (en) 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
US20100197694A1 (en) * 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
US20100202979A1 (en) * 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of pulmonary diseases and conditions
EP2396070A4 (en) 2009-02-12 2012-09-19 Incept Llc ACTIVE COMPOSITION WITH HYDROGEL PLUGS
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
US20110152271A1 (en) * 2009-12-17 2011-06-23 Gerald Horn Compositions and methods for ophthalmic delivery of nasal decongestants
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
ES2634551T3 (es) 2010-04-03 2017-09-28 Praful Doshi Métodos para revestir una lente de contacto
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
EP2555750A2 (en) * 2010-04-07 2013-02-13 Allergan, Inc. Combinations of preservative compositions for ophthalmic formulations
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP2621281A1 (de) 2010-10-01 2013-08-07 Elektra Management s.r.o. Lösung von guanidinium-verbindungen, verfahren unter einsatz dieser lösung sowie deren verwendung
US8445526B2 (en) 2011-02-03 2013-05-21 Glaucoma & Nasal Therapies Llc Compositions and methods for treatment of glaucoma
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
US9314528B2 (en) 2011-12-07 2016-04-19 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US9107943B2 (en) 2012-01-20 2015-08-18 Aratana Therapeutics Nv Eye drop composition
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
US8999938B2 (en) 2013-06-21 2015-04-07 Gnt Llc Ophthalmic lipophilic drug delivery vehicle formulations
EA030615B1 (ru) 2013-12-24 2018-08-31 Сентисс Фарма Прайвет Лимитед Офтальмологический раствор бримонидина для местного применения
MX2017006474A (es) 2014-11-25 2017-09-12 Allergan Inc Composiciones oftalmicas estabilizadas de omega 3.
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
KR20170129823A (ko) * 2015-03-19 2017-11-27 알러간, 인코포레이티드 브리모니딘 및 티몰롤의 고정된 용량 조합
US11242367B2 (en) 2016-08-12 2022-02-08 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
PT3548000T (pt) * 2017-05-11 2021-12-10 Vyluma Inc Composiões farmacológicas com atropina
GR1009419B (el) 2017-11-07 2018-12-14 Φαρματεν Αβεε Οφθαλμικο φαρμακευτικο σκευασμα που περιεχει εναν συνδυασμο βρινζολαμιδης και βριμονιδινης και μεθοδος για την παρασκευη αυτου
US20230218611A1 (en) 2020-04-29 2023-07-13 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of brinzolamide and brimonidine
GR1010024B (el) * 2020-05-06 2021-06-01 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση που περιλαμβανει βριμονιδινη
JP2021183606A (ja) * 2020-05-20 2021-12-02 千寿製薬株式会社 ブリモニジンを含有する液体製剤

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286080A (el) * 1961-11-30
US3278447A (en) * 1963-12-02 1966-10-11 Cloro Bac Products Inc Process for stabilizing chlorine dioxide solution
BE795970A (fr) 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4089969A (en) 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS542338A (en) * 1977-04-22 1979-01-09 Sandoz Ag Pharmaceutical composition
US4474787A (en) 1977-05-04 1984-10-02 Fisons Limited 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
US4530920A (en) 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4806556A (en) 1985-12-12 1989-02-21 Regents Of The University Of Minnesota Gut-selective opiates
US5089509A (en) 1988-09-15 1992-02-18 Allergan, Inc. Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5607698A (en) 1988-08-04 1997-03-04 Ciba-Geigy Corporation Method of preserving ophthalmic solution and compositions therefor
CA2007181C (en) 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
US5202128A (en) 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5352796A (en) 1989-10-30 1994-10-04 The Salk Institute For Biological Studies Amino acids useful in making GnRH analogs
US5021416A (en) 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
GB9017353D0 (en) 1990-08-08 1990-09-19 Merck Sharp & Dohme Chemical process
EP0643581B1 (en) 1992-04-21 1999-10-20 The Schepens Eye Research Institute, Inc. Ocular androgen therapy in sjögren's syndrome
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
US5688819A (en) 1992-09-21 1997-11-18 Allergan Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
AU6124494A (en) 1993-01-28 1994-08-15 University Of Iowa Research Foundation, The Ophthalmic uses of signa agonists
EP0723447B1 (en) 1993-10-13 2002-12-11 Allergan, Inc. Use of (2-imidazolin-2-ylamino) quinoxaline derivatives
US5994110A (en) 1995-02-10 1999-11-30 Mosbach; Klaus Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
ZA965837B (en) 1995-07-11 1997-01-31 Merck & Co Inc A triazolylmethyl-indole ethylamine bisulfate salt
US5952345A (en) 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5675024A (en) 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
EP0834308A1 (en) 1996-09-30 1998-04-08 LG Chemical Limited Ophthalmic formulation for treating myopia comprising dopamine agonist and cyclodextrin
JP2001522358A (ja) 1997-04-18 2001-11-13 アボツト・ラボラトリーズ 高純度６，７−ジクロロ−５−ニトロ−２，３−ジヒドロキノキサリン−２，３−ジオンの調製方法
AU2870899A (en) 1998-02-26 1999-09-15 Abbott Laboratories Oral formulation for hydrophilic drugs
CN1133466C (zh) 1998-04-07 2004-01-07 阿尔康实验室公司 含有黄原胶的胶凝性眼用组合物
JP2002523475A (ja) * 1998-09-02 2002-07-30 アラーガン・セイルズ・インコーポレイテッド 防腐したシクロデキストリン含有組成物
EP1119347B1 (en) * 1998-10-08 2005-03-02 Hampar L. Karagoezian Synergistic antimicrobial, dermatological and ophthalmic preparations containing chlorite and hydrogen peroxide
US6514504B1 (en) * 1999-08-18 2003-02-04 The Procter & Gamble Company Discontinuous films from skin care compositions
BR0109317A (pt) * 2000-07-14 2003-06-17 Allergan Inc Composições contendo componentes agonistas alfa-2-adrenérgicos
BR0112461A (pt) * 2000-07-14 2003-07-22 Allergan Inc Composições que contém componentes terapeuticamente ativos tendo uma solubilidade aumentada

Also Published As

Publication number Publication date
EP2153819B1 (en) 2012-09-05
RU2291685C2 (ru) 2007-01-20
US20030153530A1 (en) 2003-08-14
HUP0301405A3 (en) 2006-02-28
AU7326801A (en) 2002-01-30
CA2416169A1 (en) 2002-01-24
KR20030023700A (ko) 2003-03-19
IL153322A (en) 2011-01-31
US20020071874A1 (en) 2002-06-13
NZ522610A (en) 2004-11-26
NO331816B1 (no) 2012-04-10
EP2153819A3 (en) 2010-05-12
PL361027A1 (en) 2004-09-20
NO20030153L (no) 2003-01-13
CN1441679A (zh) 2003-09-10
ZA200209877B (en) 2003-09-29
EP1301210A2 (en) 2003-04-16
JP2004503593A (ja) 2004-02-05
ES2392636T3 (es) 2012-12-12
NO20030153D0 (no) 2003-01-13
PT2153819E (pt) 2012-11-14
CA2416169C (en) 2008-09-23
WO2002005822A3 (en) 2002-05-02
TWI287992B (en) 2007-10-11
MXPA02012206A (es) 2003-06-04
EP2153819A2 (en) 2010-02-17
DK2153819T3 (da) 2012-12-03
AR035039A1 (es) 2004-04-14
HU230383B1 (hu) 2016-03-29
IL153322A0 (en) 2003-07-06
AU2001273268B2 (en) 2005-08-25
HUP0301405A2 (hu) 2003-08-28
US6562873B2 (en) 2003-05-13
WO2002005822A2 (en) 2002-01-24
BR0112461A (pt) 2003-07-22

Similar Documents

Publication Publication Date Title
CY1113391T1 (el) Χρηση ενος συστατικου ενισχυσης διαλυτοτητας σε υδατικη συνθεση που περιλαμβανει τρυγικη βριμονιδινη
CY1113609T1 (el) ΔΙΑΛΥΤΟΤΗΤΑ ΙFΝ-ΒΗΤΑ-1b ΣΕ ΔΙΑΛΥΜΑΤΑ ΧΛΩΡΙΟΥΧΟΥ ΝΑΤΡΙΟΥ
TR200200068T2 (tr) Nematisital triflüorobütenler
CY1105065T1 (el) Φαρμακευτικα μεσα βασιζομενα σε γεσταγονα για δepματικη χρηση
DK1157037T3 (da) GCSF-konjugater
IL216579A0 (en) Aminocyclohexyl ether derivatives and pharmaceutical compositions containing the same
CY1114631T1 (el) Φαρμακοτεχνικες μορφες εχινοκανδινης που περιεχουν επιφανειοδραστικα που σχηματιζουν μικκυλιο
ATE527238T1 (de) Mittel mit wirkung gegen sichelzellenanämie
CY1106076T1 (el) Παραγωγα γλυκοπυρανοσυλοξυβενζυλο βενζολιου και ιατρικες συνθεσεις που πepιεχουν τα ιδια
EA200300050A1 (ru) Гликопептидфосфонатные производные
CY1112687T1 (el) Μεθοδος για χρηση δικετοπιπεραζινων και συνθεσεις που περιλαμβανουν αυτες
DK1086706T3 (da) Stabiliserede sammensætninger indeholdende nootropiske lægemidler
CY1111742T1 (el) Πολυδυναμες συνθεσεις υψηλου φορτιου συμπυκνωματος για τον ελεγχο εκτοπαρασιτων
AP1424A (en) 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens.
CY1111698T1 (el) Συνδυασμος που περιλαμβανει εναν ανταγωνιστη υποδοχεα ατ1 και εναν ενισχυτη εκκρισης ινσουλινης ή εναν ευαισθητοποιητη ινσουλινης
SE0102843D0 (sv) Stabilized oral pharmaceutical composition containing lodide and lodate and method
CY1107485T1 (el) 3-θειομεθυλπυραζoλες ως παρασιτοκτoνα
DE60105322D1 (de) Wässerige zusammensetzung enthaltend amphotericin b
YU87202A (sh) Derivati arilmetilamina koji se koriste kao inhibitori triptaze
ES2180319T3 (es) Utilizacion de derivados de metilenbisoxazolidina y composiciones de los mismos.
EP1136080A3 (en) Use of o-vanillin and o-vanillin/trolox combinations
ATE391489T1 (de) Haarbehandlungszusammensetzungen
ATE229532T1 (de) Fungizide
BR0114911A (pt) 4,5-diidro-1,2,4-triazin-3-onas substituìdas, 1,2,4-triazin-3-onas e o seu uso como fungicidas e inseticidas
HRP20020071B1 (en) Pharmaceutical composition and preparation thereof