ATE545430T1 - Hsa-freie interferon-beta formulierungen - Google Patents
Hsa-freie interferon-beta formulierungenInfo
- Publication number
- ATE545430T1 ATE545430T1 AT01988466T AT01988466T ATE545430T1 AT E545430 T1 ATE545430 T1 AT E545430T1 AT 01988466 T AT01988466 T AT 01988466T AT 01988466 T AT01988466 T AT 01988466T AT E545430 T1 ATE545430 T1 AT E545430T1
- Authority
- AT
- Austria
- Prior art keywords
- hsa
- interferon beta
- ifn
- free interferon
- beta formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28261401P | 2001-04-09 | 2001-04-09 | |
US33040401P | 2001-10-18 | 2001-10-18 | |
US10/035,397 US6887462B2 (en) | 2001-04-09 | 2001-10-25 | HSA-free formulations of interferon-beta |
PCT/US2001/051074 WO2002080976A2 (en) | 2001-04-09 | 2001-10-26 | Hsa-free formulations of interferon-beta |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE545430T1 true ATE545430T1 (de) | 2012-03-15 |
Family
ID=27364838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01988466T ATE545430T1 (de) | 2001-04-09 | 2001-10-26 | Hsa-freie interferon-beta formulierungen |
Country Status (19)
Country | Link |
---|---|
US (5) | US6887462B2 (de) |
EP (3) | EP1381432B9 (de) |
JP (5) | JP2004529917A (de) |
KR (1) | KR100900753B1 (de) |
CN (1) | CN1313148C (de) |
AT (1) | ATE545430T1 (de) |
BG (1) | BG66300B1 (de) |
CA (2) | CA2442854C (de) |
CY (2) | CY1113609T1 (de) |
CZ (1) | CZ305994B6 (de) |
DK (1) | DK1381432T3 (de) |
ES (3) | ES2524322T3 (de) |
HU (1) | HU228581B1 (de) |
IL (2) | IL157963A0 (de) |
LU (1) | LU92060I2 (de) |
NO (1) | NO330259B1 (de) |
PL (1) | PL213297B1 (de) |
PT (2) | PT2283896E (de) |
WO (1) | WO2002080976A2 (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3473999A (en) * | 1998-04-03 | 1999-10-25 | Chiron Corporation | Injectable igf-formulations containing succinate as buffering agent |
US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
PL209928B1 (pl) * | 2000-11-07 | 2011-11-30 | Novartis Vaccines & Diagnostic | Kompozycja farmaceutyczna zawierająca biologicznie aktywny IFN-β i mannitol, wstępnie napełniona strzykawka zawierająca tę kompozycję oraz sposób wytwarzania preparatu IFN-β |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
UY27373A1 (es) * | 2001-07-09 | 2003-02-28 | Schering Ag | Formulaciones de interferón beta-humano |
CA2477577A1 (en) * | 2002-03-12 | 2003-09-18 | Maxygen Aps | Interferon beta-like molecules for treatment of stroke |
US20040037809A1 (en) * | 2002-06-28 | 2004-02-26 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of interferon beta |
DE10240894A1 (de) * | 2002-09-04 | 2004-03-11 | Procom Biotechnologische Produktions Gmbh | Verstärkung der Resorption von Subtanzen über die Haut und Schleimhaut |
US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
RS20050502A (en) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polymer conjugates of interferon- beta with enhanced biological potency |
PL396711A1 (pl) * | 2002-12-26 | 2011-12-19 | Mountain View Pharmaceuticals, Inc. | Koniugaty polimerów z cytokinami, chemokinami, czynnikami wzrostu, hormonami polipeptydowymi i ich antagonistami, kompozycja farmaceutyczna i sposób zapobiegania, diagnozowania lub leczenia |
TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
WO2005042002A2 (en) * | 2003-10-30 | 2005-05-12 | Entelos, Inc. | Treatment of rhematoid arthritis with flip antagonists |
EP1685160A1 (de) * | 2003-11-10 | 2006-08-02 | Arriva-Prometic Inc. | Trockene rekombinante humane alpha 1-antitrypsin-zusammensetzung |
EP1532983A1 (de) * | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulinpräparationen mit erhöhter Stabilität |
DK1691825T3 (da) * | 2003-12-11 | 2011-12-05 | Ares Trading Sa | Stabiliserede flydende interferon-formuleringer |
CN1557479A (zh) * | 2004-01-16 | 2004-12-29 | 深圳市海王英特龙生物技术股份有限公 | 干扰素脂质体乳膏 |
DE102004008168B4 (de) * | 2004-02-19 | 2015-12-10 | Voxeljet Ag | Verfahren und Vorrichtung zum Auftragen von Fluiden und Verwendung der Vorrichtung |
WO2005084303A2 (en) * | 2004-03-01 | 2005-09-15 | Enzon Pharmaceuticals, Inc. | Interferon-beta polymer conjugates |
US20050220764A1 (en) * | 2004-04-01 | 2005-10-06 | Schering Aktiengesellschaft | Higher-doses of interferon-beta for treatment of multiple sclerosis |
AU2005244448B2 (en) * | 2004-05-17 | 2011-03-17 | Ares Trading S.A. | Hydrogel interferon formulations |
ES2381674T3 (es) * | 2004-06-01 | 2012-05-30 | Ares Trading S.A. | Método de estabilizar proteínas |
BRPI0510526A (pt) * | 2004-06-01 | 2007-10-30 | Ares Trading Sa | formulações lìquidas estabilizadas de interferon |
KR101191536B1 (ko) * | 2004-06-01 | 2012-10-15 | 아레스 트레이딩 에스.에이. | 안정화된 인터페론 액상 제제 |
US20050276785A1 (en) * | 2004-06-09 | 2005-12-15 | Schering Aktiengesellschaft | Treatment of cardiomyopathy and of endothelial dysfunction |
JP2008507297A (ja) * | 2004-07-26 | 2008-03-13 | エンゾン ファーマシューティカルズ,インコーポレーテッド | 最適化されたインターフェロンβ遺伝子 |
EP2412816B1 (de) | 2004-07-26 | 2014-12-03 | Pfenex Inc. | Verfahren zur verbesserten Proteinexpression durch Strain-Engineering |
CA2576549C (en) * | 2004-08-12 | 2011-01-18 | Schering Corporation | Stable pegylated interferon formulation |
US20080076729A1 (en) * | 2005-05-19 | 2008-03-27 | Schering Aktiengesellachaft | Interferon-beta gene therapy using an improved, regulated expression system |
US20070179113A1 (en) * | 2005-05-19 | 2007-08-02 | Schering Aktiengesellachaft | GM-CSF gene therapy for Crohn's disease using an improved regulated expression system |
AR053284A1 (es) * | 2005-05-19 | 2007-04-25 | Schering Ag | Terapia genica de interferon -beta usando un sistema mejorado de expresion regulada |
TW200724679A (en) * | 2005-05-19 | 2007-07-01 | Schering Ag | Treatment of disease using an improved regulated expression system |
CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US8759292B2 (en) | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
US7553940B2 (en) * | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting EPO polypeptides and derivatives thereof and methods thereof |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
US8048848B2 (en) * | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
US8304386B2 (en) * | 2006-02-03 | 2012-11-06 | Prolor Biotech, Inc. | Long-acting growth hormone and methods of producing same |
US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
MX2009011523A (es) | 2007-04-27 | 2009-11-09 | Dow Global Technologies Inc | Metodo para clasificar rapidamente huespedes microbianos para identificar ciertas cepas con rendimiento y/o calidad mejorados en la expresion de proteinas heterologas. |
BRPI0810622A2 (pt) | 2007-05-02 | 2020-10-13 | Ambrx, Inc. | polipeptídeos de interferon beta modificados e seus usos |
ATE548382T1 (de) * | 2007-09-04 | 2012-03-15 | Biosteed Gene Expression Tech Co Ltd | Polyethylenglykolmodifiziertes interferon alpha 2b und herstellungsverfahren und anwendungen davon |
EP2196475B1 (de) * | 2007-09-04 | 2012-06-06 | Biosteed Gene Expression Tech. CO., LTD. | Polyethylenglykolmodifiziertes interferon alpha 2a, verfahren für dessen synthese und anwendung |
US8273561B2 (en) * | 2007-10-05 | 2012-09-25 | Nuron Biotech, Inc. | High pressure treatment of aggregated interferons |
EA201070773A1 (ru) * | 2007-12-20 | 2010-12-30 | Мерк Сероно С. А. | Составы пэг-интерферона-бета |
US20100196272A1 (en) * | 2009-01-30 | 2010-08-05 | Neoprobe Corporation | Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran |
US20100203014A1 (en) * | 2009-02-04 | 2010-08-12 | Aegis Therapeutics Llc | Zwitterionic buffered acidic peptide and protein formulations |
EP2440251A4 (de) | 2009-06-09 | 2013-01-16 | Defyrus Inc | Verabreichung von interferon zur prophylaxe gegen oder zur behandlung von krankheitserregenden infektionen |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
DK2531218T3 (en) | 2010-02-04 | 2019-04-01 | Csl Behring Ag | immunoglobulin |
EP2361636A1 (de) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunglobulinpräparat und Aufbewahrungssystem für ein Immunglobulinpräparat |
US20120269770A1 (en) * | 2010-11-22 | 2012-10-25 | Mark Brader | Stable Preserved Compositions of Interferon-Beta |
BR112013023062B1 (pt) * | 2011-03-10 | 2022-01-18 | Xeris Pharmaceuticals, Inc | Solução estável para a injeção parenteral e método de fabricação da mesma |
PE20142405A1 (es) | 2012-04-19 | 2015-01-25 | Opko Biolog Ltd | Variantes de oxintomodulina de accion prolongada y metodos de produccion de las mismas |
ES2882890T3 (es) | 2012-11-20 | 2021-12-03 | Opko Biologics Ltd | Método para aumentar el volumen hidrodinámico de polipéptidos mediante la unión a péptidos carboxi terminales de la gonadotrofina |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
JPWO2016052584A1 (ja) * | 2014-09-30 | 2017-07-13 | 東レ株式会社 | ポリエチレングリコール修飾インターフェロン−βの検出及び定量に使用する試料液の前処理方法、ポリエチレングリコール修飾インターフェロン−βの検出方法及び定量方法 |
CN104766952B (zh) * | 2015-04-21 | 2017-01-25 | 武汉凯迪工程技术研究总院有限公司 | 利用生物质气化炉滤渣制备锂离子电池负极材料的方法 |
WO2016203482A2 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
FI126979B (en) * | 2016-02-29 | 2017-09-15 | Faron Pharmaceuticals Oy | Lyophilized pharmaceutical formulation and use thereof |
BR112019000610A2 (pt) | 2016-07-11 | 2019-07-02 | Opko Biologics Ltd | fator vii de coagulação de longa ação e métodos de produção do mesmo |
JP7386080B2 (ja) * | 2016-08-02 | 2023-11-24 | アンバー アイピー リミテッド | 安定なイブプロフェン注射製剤用組成物 |
KR101943160B1 (ko) | 2016-10-06 | 2019-01-30 | 에이비온 주식회사 | 인터페론 베타 변이체의 안정화 제제 |
US11690799B2 (en) | 2018-04-19 | 2023-07-04 | Lts Lohmann Therapie-Systeme Ag | Microneedle system for applying interferon |
MX2020011004A (es) * | 2018-04-19 | 2020-11-09 | Lts Lohmann Therapie Systeme Ag | Sistema de microagujas para la aplicacion de interferon. |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU538665B2 (en) | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
DE3165463D1 (en) | 1980-01-08 | 1984-09-20 | Biogen Nv | Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides |
DE3005897A1 (de) | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
US4439181A (en) | 1981-01-26 | 1984-03-27 | Regents Of The University Of Minnesota | Polyol-hormone mixture for use in chronic parenteral hormone administration |
JPS5821691A (ja) | 1981-07-29 | 1983-02-08 | Mochida Pharmaceut Co Ltd | α−及びβ−インタ−フェロンの精製方法 |
DE3273597D1 (en) | 1981-11-28 | 1986-11-06 | Sunstar Kk | Pharmaceutical composition containing interferon in stable state |
IT1167610B (it) | 1982-01-19 | 1987-05-13 | Cetus Corp | Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione |
AU1234383A (en) | 1982-03-17 | 1983-09-22 | Inter-Yeda Ltd. | Interferon stabilised with polyvinyl-pyrrolidone |
US5702699A (en) | 1982-09-23 | 1997-12-30 | Cetus Corporation | Process for the recovery of lipophilic proteins |
US5643566A (en) | 1982-09-23 | 1997-07-01 | Cetus Corporation | Formulation processes for lipophilic proteins |
US4992271A (en) | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
US4462940A (en) | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
US5166331A (en) | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
FI82266C (fi) | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
US4588585A (en) | 1982-10-19 | 1986-05-13 | Cetus Corporation | Human recombinant cysteine depleted interferon-β muteins |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US4816400A (en) | 1983-05-19 | 1989-03-28 | Karl Tryggvason | Basement membrane collagen degrading enzyme and method of purifying same |
US4588584A (en) | 1983-06-01 | 1986-05-13 | The United States Of America As Represented By The Secretary Of Agriculture | Medium for the isolation of Pseudomonas cepacia biotype from soil and the isolated biotype |
GB8317880D0 (en) | 1983-07-01 | 1983-08-03 | Searle & Co | Structure and synthesis of interferons |
DE3484374D1 (de) | 1983-08-04 | 1991-05-08 | Green Cross Corp | Gamma-interferonzusammensetzung. |
JPS6069037A (ja) | 1983-09-26 | 1985-04-19 | Sunstar Inc | エリテマト−デス治療用外用剤 |
DE3482657D1 (de) | 1983-11-21 | 1990-08-09 | Univ Minnesota | Gepuffertes polyol-hormones gemisch zur verwendung bei chronischer parenteraler hormonverabreichung. |
US4530787A (en) | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
JPS60243028A (ja) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | インタ−フエロンの可溶化方法 |
GB8412564D0 (en) | 1984-05-17 | 1984-06-20 | Searle & Co | Structure and properties |
US4605555A (en) | 1984-09-20 | 1986-08-12 | Sun Star Kabushiki Kaisha | Composition and method for treating keratosic disorder of skin and mucosa |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
US4572798A (en) | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US4816440A (en) | 1985-09-26 | 1989-03-28 | Cetus Corporation | Stable formulation of biologically active proteins for parenteral injection |
US5183746A (en) | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
US4894330A (en) | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
EP0284249A1 (de) | 1987-03-13 | 1988-09-28 | Interferon Sciences, Inc. | Gefriergetrocknete Lymphokin-Zusammensetzung |
US5151265A (en) | 1987-11-03 | 1992-09-29 | Genentech, Inc. | Gamma interferon formulation |
US5004605A (en) | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
DK0410207T3 (da) | 1989-07-24 | 1997-07-14 | Bayer Ag | Stabilisering af højrensede proteiner. |
JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
US5763566A (en) * | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: tissue SELEX |
WO1994016759A1 (en) | 1991-03-05 | 1994-08-04 | Miris Medical Corporation | An automatic aerosol medication delivery system and methods |
AU662919B2 (en) | 1991-07-02 | 1995-09-21 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
US5497763A (en) | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
TW249202B (de) | 1993-08-13 | 1995-06-11 | Ciba Gerigy Corp | |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
US5545723A (en) | 1994-03-15 | 1996-08-13 | Biogen Inc. | Muteins of IFN-β |
FR2719479B1 (fr) | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
US5453433A (en) | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
IT1272252B (it) * | 1994-05-16 | 1997-06-16 | Applied Research Systems | Formulazioni liquide di interferone beta |
CA2190502A1 (en) | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
ES2302332T3 (es) | 1994-09-21 | 2008-07-01 | Nektar Therapeutics | Aparato y metodos para dispersar medicamentos en polvo seco. |
JP2758154B2 (ja) | 1995-04-06 | 1998-05-28 | エフ・ホフマン−ラ ロシユ アーゲー | インターフェロンを含む液体製剤 |
US5780014A (en) | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
US5814485A (en) | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
KR20000069664A (ko) * | 1996-12-24 | 2000-11-25 | 아스트루 마이클 제이 | 안정한 액체 인터페론 제제 |
JP2001507702A (ja) | 1996-12-31 | 2001-06-12 | インヘイル・セラピューティックス・システムズ・インコーポレテッド | 親水性賦形剤を有する疎水性薬剤の水性懸濁液を噴霧乾燥させる方法およびその方法によって作製された組成物 |
PT1017413E (pt) | 1997-09-23 | 2003-02-28 | Rentschler Biotech Gmbh | Formulacoes liquidas de interferao (beta) |
AU3473999A (en) | 1998-04-03 | 1999-10-25 | Chiron Corporation | Injectable igf-formulations containing succinate as buffering agent |
EP1121156B1 (de) * | 1998-10-16 | 2006-02-22 | Biogen Idec MA Inc. | Polymerkonjugate von interferon-beta-1a und deren verwendungen |
CA2477857C (en) * | 1999-10-04 | 2012-04-10 | Chiron Corporation | Stabilized liquid polypeptide-containing pharmaceutical compositions |
US6465425B1 (en) * | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
US7544354B2 (en) | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
UY27373A1 (es) * | 2001-07-09 | 2003-02-28 | Schering Ag | Formulaciones de interferón beta-humano |
-
2001
- 2001-10-25 US US10/035,397 patent/US6887462B2/en not_active Expired - Lifetime
- 2001-10-26 ES ES10180630.5T patent/ES2524322T3/es not_active Expired - Lifetime
- 2001-10-26 WO PCT/US2001/051074 patent/WO2002080976A2/en active Search and Examination
- 2001-10-26 DK DK01988466.7T patent/DK1381432T3/da active
- 2001-10-26 KR KR1020037013202A patent/KR100900753B1/ko active IP Right Grant
- 2001-10-26 CA CA2442854A patent/CA2442854C/en not_active Expired - Lifetime
- 2001-10-26 AT AT01988466T patent/ATE545430T1/de active
- 2001-10-26 PT PT101806305T patent/PT2283896E/pt unknown
- 2001-10-26 EP EP01988466A patent/EP1381432B9/de not_active Expired - Lifetime
- 2001-10-26 ES ES01988466T patent/ES2367761T3/es not_active Expired - Lifetime
- 2001-10-26 EP EP10180630.5A patent/EP2283896B1/de not_active Expired - Lifetime
- 2001-10-26 CZ CZ2003-2735A patent/CZ305994B6/cs unknown
- 2001-10-26 JP JP2002579014A patent/JP2004529917A/ja not_active Withdrawn
- 2001-10-26 EP EP10180658.6A patent/EP2283897B1/de not_active Expired - Lifetime
- 2001-10-26 HU HU0303732A patent/HU228581B1/hu active Protection Beyond IP Right Term
- 2001-10-26 PT PT01988466T patent/PT1381432E/pt unknown
- 2001-10-26 CN CNB018231225A patent/CN1313148C/zh not_active Expired - Lifetime
- 2001-10-26 CA CA2762966A patent/CA2762966A1/en not_active Abandoned
- 2001-10-26 PL PL366790A patent/PL213297B1/pl unknown
- 2001-10-26 ES ES10180658.6T patent/ES2453623T3/es not_active Expired - Lifetime
- 2001-10-26 IL IL15796301A patent/IL157963A0/xx unknown
-
2003
- 2003-09-17 IL IL157963A patent/IL157963A/en active IP Right Grant
- 2003-10-07 NO NO20034492A patent/NO330259B1/no not_active IP Right Cessation
- 2003-11-07 BG BG108322A patent/BG66300B1/bg unknown
-
2004
- 2004-04-09 US US10/821,333 patent/US7399463B2/en not_active Expired - Fee Related
-
2005
- 2005-02-18 US US11/062,146 patent/US7371373B2/en not_active Expired - Fee Related
-
2008
- 2008-04-09 US US12/082,177 patent/US7892531B2/en not_active Expired - Lifetime
- 2008-07-07 JP JP2008177303A patent/JP5580521B2/ja not_active Expired - Lifetime
-
2009
- 2009-10-26 JP JP2009245975A patent/JP2010018633A/ja not_active Withdrawn
-
2011
- 2011-01-11 US US13/004,658 patent/US8333958B2/en not_active Expired - Lifetime
-
2012
- 2012-02-16 CY CY20121100156T patent/CY1113609T1/el unknown
- 2012-08-13 CY CY2012023C patent/CY2012023I1/el unknown
- 2012-08-13 LU LU92060C patent/LU92060I2/fr unknown
-
2013
- 2013-01-15 JP JP2013004395A patent/JP5701323B2/ja not_active Expired - Fee Related
-
2014
- 2014-12-11 JP JP2014250577A patent/JP2015044882A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE545430T1 (de) | Hsa-freie interferon-beta formulierungen | |
ATE161836T1 (de) | 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate | |
DE60030263D1 (de) | Neue phosphor enthaltende medikamentenvorläuferverbindungen | |
IT1204826B (it) | Composizioni farmaceutiche per inalazione | |
BR9808933A (pt) | Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo | |
PL300194A1 (en) | Interferon conjugate, method of obtaining same and pharmaceutical composition containing it | |
MY125921A (en) | Compositions containing organic compounds | |
ATE148630T1 (de) | Stabilisierte derivate von vitamin d2 und d3 enthaltende pharmazeutische zusammensetzungen | |
HUP0401224A3 (en) | Process for preparing pharmaceutical compositions for use with soft gelatin formulations | |
SE0102036D0 (sv) | Pharmaceutical formulation for the efficient administration of apomorphine, 6aR- (-) -N- Propyl- norapomorphine and their derivatives and pro-drugs thereof | |
TR199801861T2 (xx) | Farmas�tik olarak yararl� bile�imler. | |
TW221378B (de) | ||
DE60216305D1 (de) | Zusammensetzungen zur verabreichung von arzneimittelkombinationen | |
DK0614362T3 (da) | Farmaceutiske præparater på basis af ebastin og dermed analoge forbindelser | |
IL155788A (en) | A highly purified ifn – β active and mannitol-containing preparation, a method to make an improved stability of ifn – β active, and a method to enhance the stability of ifn – β in biologically active formulation. | |
NO20073914L (no) | Biologisk aktive peptider | |
IT1284604B1 (it) | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva | |
SE9902742D0 (sv) | New pharmaceutical formultion | |
DE69900466D1 (de) | Orale zusammensetzungen mit niedrigdosierten zytotoxischen proteinen | |
IT1243358B (it) | Composizioni farmaceutiche per la somministrazione orale di irudina | |
ATE135917T1 (de) | Stabilisierte pharmaceutische zusammensetzung die nicht-glycozylierte, reduzierte rekombinante human il-2 umfasst und verfahren zu ihrer herstellung | |
IT1204778B (it) | Formulazioni farmaceutiche iniettabili di principi attivi ad attivita' anestetica generale | |
DK0418990T3 (da) | 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler | |
GB0011734D0 (en) | Pharmaceutical composition for anthelmintics (1) | |
ITMI912324A1 (it) | Derivati dall'acido beta-idrossibutirrico, procedimento per la loro preparazione e relative composizioni farmaceutiche. |