CY1111672T1 - Παραγωγα αντιγονου σχετιζομενα με ογκους απο την οικογενεια των mage, τα οποια χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης με τ βοηθητικα επιτοπα και συνθεσεων για εμβολιασμο - Google Patents

Παραγωγα αντιγονου σχετιζομενα με ογκους απο την οικογενεια των mage, τα οποια χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης με τ βοηθητικα επιτοπα και συνθεσεων για εμβολιασμο

Info

Publication number
CY1111672T1
CY1111672T1 CY20111100663T CY111100663T CY1111672T1 CY 1111672 T1 CY1111672 T1 CY 1111672T1 CY 20111100663 T CY20111100663 T CY 20111100663T CY 111100663 T CY111100663 T CY 111100663T CY 1111672 T1 CY1111672 T1 CY 1111672T1
Authority
CY
Cyprus
Prior art keywords
producers
antigen
preparation
volume used
mage family
Prior art date
Application number
CY20111100663T
Other languages
English (en)
Inventor
Silva Teresa Cabezon
Joseph Cohen
Moncef M Slaoui
Bassols Carlota Vinals
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9802543.0A external-priority patent/GB9802543D0/en
Priority claimed from GBGB9802650.3A external-priority patent/GB9802650D0/en
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1111672T1 publication Critical patent/CY1111672T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K39/001186—MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand

Abstract

Η παρούσα εφεύρεση αφορά νέες πρωτεΐνες και την παρασκευή τους, από την οικογένεια MAGE. Πιο συγκεκριμένα, μια πρωτεΐνη MAGE, συντηγμένη σε έναν ανοσολογικό εταίρο σύντηξης, όπως η Λιποπρωτεΐνη D. Τέτοια αντιγόνα μπορούν να διατυπωθούν ώστε να παράσχουν εμβόλια για την αντιμετώπιση ενός εύρος όγκων. Επίσης παρουσιάζονται νέες μέθοδοι για τον καθαρισμό των πρωτεϊνών MAGE.
CY20111100663T 1998-02-05 2011-07-08 Παραγωγα αντιγονου σχετιζομενα με ογκους απο την οικογενεια των mage, τα οποια χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης με τ βοηθητικα επιτοπα και συνθεσεων για εμβολιασμο CY1111672T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9802543.0A GB9802543D0 (en) 1998-02-05 1998-02-05 Vaccine
GBGB9802650.3A GB9802650D0 (en) 1998-02-06 1998-02-06 Vaccine
EP05076599A EP1584685B1 (en) 1998-02-05 1999-02-02 Tumor-associated antigen derivatives from the mage family, used for the preparation of fusion proteins with T-helper epitopes and of compositions for vaccination

Publications (1)

Publication Number Publication Date
CY1111672T1 true CY1111672T1 (el) 2015-10-07

Family

ID=26313069

Family Applications (4)

Application Number Title Priority Date Filing Date
CY20061100310T CY1105685T1 (el) 1998-02-05 2006-03-07 Συνδεομενα με ογκους αντιγονικα παραγωγα απο την οικογενεια mage, και ακολουθιες νουκλεϊκων οξεων που τα κωδικοποιουν, χρησιμοποιουμενα στην παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο
CY20101100509T CY1110180T1 (el) 1998-02-05 2010-06-10 Μεθοδος για τον καθαρισμο ή την παραγωγη μιας mage πρωτεϊνης
CY20111100663T CY1111672T1 (el) 1998-02-05 2011-07-08 Παραγωγα αντιγονου σχετιζομενα με ογκους απο την οικογενεια των mage, τα οποια χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης με τ βοηθητικα επιτοπα και συνθεσεων για εμβολιασμο
CY20111100885T CY1111831T1 (el) 1998-02-05 2011-09-14 Παραγωγα ογκο-συναφους αντιγονου απο την οικογενεια mage και αλληλουχιες νουκλεϊνικου οξεος που κωδικοποιουν αυτα, που χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CY20061100310T CY1105685T1 (el) 1998-02-05 2006-03-07 Συνδεομενα με ογκους αντιγονικα παραγωγα απο την οικογενεια mage, και ακολουθιες νουκλεϊκων οξεων που τα κωδικοποιουν, χρησιμοποιουμενα στην παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο
CY20101100509T CY1110180T1 (el) 1998-02-05 2010-06-10 Μεθοδος για τον καθαρισμο ή την παραγωγη μιας mage πρωτεϊνης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20111100885T CY1111831T1 (el) 1998-02-05 2011-09-14 Παραγωγα ογκο-συναφους αντιγονου απο την οικογενεια mage και αλληλουχιες νουκλεϊνικου οξεος που κωδικοποιουν αυτα, που χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο

Country Status (26)

Country Link
US (3) US8097257B2 (el)
EP (4) EP1659179B1 (el)
JP (2) JP4768121B2 (el)
KR (2) KR100824105B1 (el)
CN (1) CN1227360C (el)
AR (1) AR018064A1 (el)
AT (4) ATE505542T1 (el)
AU (1) AU737337B2 (el)
BR (1) BR9907691B1 (el)
CA (2) CA2584482C (el)
CY (4) CY1105685T1 (el)
CZ (2) CZ298347B6 (el)
DE (3) DE69929310T2 (el)
DK (4) DK1659179T3 (el)
ES (2) ES2255248T3 (el)
HK (4) HK1033838A1 (el)
HU (1) HU228467B1 (el)
IL (4) IL137442A0 (el)
NO (2) NO328507B1 (el)
NZ (1) NZ506086A (el)
PT (4) PT1584685E (el)
SA (1) SA99200126B1 (el)
SI (4) SI1659179T1 (el)
TR (1) TR200002284T2 (el)
TW (1) TWI238853B (el)
WO (1) WO1999040188A2 (el)

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