NO963018L - CTLA4-mutantmolekyler og anvendelser derav - Google Patents

CTLA4-mutantmolekyler og anvendelser derav

Info

Publication number
NO963018L
NO963018L NO963018A NO963018A NO963018L NO 963018 L NO963018 L NO 963018L NO 963018 A NO963018 A NO 963018A NO 963018 A NO963018 A NO 963018A NO 963018 L NO963018 L NO 963018L
Authority
NO
Norway
Prior art keywords
ctla4 mutant
molecules
mutant molecules
soluble
interactions
Prior art date
Application number
NO963018A
Other languages
English (en)
Other versions
NO317836B1 (no
NO963018D0 (no
Inventor
Peter S Linsley
Jeffrey A Ledbetter
Robert Peach
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO963018D0 publication Critical patent/NO963018D0/no
Publication of NO963018L publication Critical patent/NO963018L/no
Publication of NO317836B1 publication Critical patent/NO317836B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19963018A 1995-07-21 1996-07-19 CTLA4-mutantmolekyl, fremgangsmate for fremstilling og anvendelser derav, inkludert nukleinsyremolekyl som koder for CTLA4-mutantmolekylet, plasmid og vertsvektor-system omfattende nukleinsyremolekylet og farmasoytisk blanding omfattende CTLA-mutantmolekylet. NO317836B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/505,058 US5773253A (en) 1993-01-22 1995-07-21 MYPPPY variants of CTL A4 and uses thereof

Publications (3)

Publication Number Publication Date
NO963018D0 NO963018D0 (no) 1996-07-19
NO963018L true NO963018L (no) 1997-01-22
NO317836B1 NO317836B1 (no) 2004-12-20

Family

ID=24008824

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19963018A NO317836B1 (no) 1995-07-21 1996-07-19 CTLA4-mutantmolekyl, fremgangsmate for fremstilling og anvendelser derav, inkludert nukleinsyremolekyl som koder for CTLA4-mutantmolekylet, plasmid og vertsvektor-system omfattende nukleinsyremolekylet og farmasoytisk blanding omfattende CTLA-mutantmolekylet.

Country Status (11)

Country Link
US (1) US5773253A (no)
EP (1) EP0757099B1 (no)
JP (1) JP3808553B2 (no)
AT (1) ATE268818T1 (no)
AU (1) AU696664B2 (no)
CA (1) CA2181394C (no)
DE (1) DE69632667T2 (no)
ES (1) ES2223061T3 (no)
IL (1) IL118890A (no)
MX (1) MX9602879A (no)
NO (1) NO317836B1 (no)

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US6051227A (en) * 1995-07-25 2000-04-18 The Regents Of The University Of California, Office Of Technology Transfer Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
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US20060034844A1 (en) * 1996-12-04 2006-02-16 The Regents Of The University Of California Stimulation of T cells against self antigens using CTLA-4 blocking agents
AU735459B2 (en) 1997-01-30 2001-07-12 University Of Virginia Patent Foundation Cysteine-depleted peptides recognized by A3-restricted cytotoxic lymphocytes, and uses therefor
US20030219863A1 (en) * 1997-01-31 2003-11-27 Bristol-Myers Squibb Company Soluble CTLA4 mutant molecules and uses thereof
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WO1999015552A1 (fr) * 1997-09-19 1999-04-01 Yoshitomi Pharmaceutical Industries, Ltd. Composes oligopeptidiques
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US6521419B1 (en) 1998-09-22 2003-02-18 Kanakaraju Koduri Expression vectors containing hot spot for increased recombinant protein expression in transfected cells
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US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
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US20040058445A1 (en) * 2001-04-26 2004-03-25 Ledbetter Jeffrey Alan Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
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CA2646329C (en) 2006-03-20 2018-07-03 The Regents Of The University Of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
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Also Published As

Publication number Publication date
JP3808553B2 (ja) 2006-08-16
AU6059096A (en) 1997-01-30
DE69632667T2 (de) 2005-06-16
JPH09202800A (ja) 1997-08-05
CA2181394A1 (en) 1997-01-22
US5773253A (en) 1998-06-30
ATE268818T1 (de) 2004-06-15
MX9602879A (es) 1997-06-28
DE69632667D1 (de) 2004-07-15
EP0757099A3 (en) 1999-05-26
CA2181394C (en) 2010-11-02
NO317836B1 (no) 2004-12-20
ES2223061T3 (es) 2005-02-16
IL118890A (en) 2005-08-31
EP0757099A2 (en) 1997-02-05
EP0757099B1 (en) 2004-06-09
AU696664B2 (en) 1998-09-17
NO963018D0 (no) 1996-07-19
IL118890A0 (en) 1996-10-31

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