CY1113298T1 - Ανασυνδυασμενα αντισωματα υψηλης ισχυος και μεθοδος παραγωγης αυτων - Google Patents

Ανασυνδυασμενα αντισωματα υψηλης ισχυος και μεθοδος παραγωγης αυτων

Info

Publication number
CY1113298T1
CY1113298T1 CY20121100934T CY121100934T CY1113298T1 CY 1113298 T1 CY1113298 T1 CY 1113298T1 CY 20121100934 T CY20121100934 T CY 20121100934T CY 121100934 T CY121100934 T CY 121100934T CY 1113298 T1 CY1113298 T1 CY 1113298T1
Authority
CY
Cyprus
Prior art keywords
antibodies
neutralizing
producing
disclosed
methods
Prior art date
Application number
CY20121100934T
Other languages
English (en)
Inventor
James F Young
Scott Koenig
Leslie S Johnson
William D Huse
Herren Wu
Jeffry D Watkins
Original Assignee
Medimmune, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Inc. filed Critical Medimmune, Inc.
Publication of CY1113298T1 publication Critical patent/CY1113298T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

Abstract

Κοινοποιούνται αντισώματα υψηλής ισχύος συμπεριλαμβανομένων ανοσολογικά δραστικών κλασμάτων αυτών, που έχουν υψηλές σταθερές κινητικού προσεταιρισμού και προαιρετικά υψηλές χημικές συγγένειες, μαζί με μεθόδους για την παραγωγή τέτοιων αντισωμάτων. Τα αντισώματα υψηλής ισχύος που κοινοποιούνται στην παρούσα είναι είτε τύπου εξουδετέρωσης ή μη εξουδετέρωσης και έχουν ιδιαιτερότητα για τα αντιγόνα που εμφανίζονται από μικροοργανισμούς, ειδικότερα ιούς, καθώς και αντιγονικές περιοχές που εμφανίζονται πάνω σε καρκινικά κύτταρα και σε διάφορους τύπους τοξινών και τα προϊόντα τοξινών. Περιγράφονται επίσης διαδικασίες για την παραγωγή αντισωμάτων εξουδετέρωσης υψηλής ισχύος και αύξησης της ισχύος των ήδη υφισταμένων αντισωμάτων εξουδετέρωσης. Κοινοποιούνται μέθοδοι χρήσης των εν λόγω αντισωμάτων στην πρόληψη και/ ή την θεραπεία ασθενειών, ειδικότερα ασθενειών που επάγονται ή προκαλούνται από ιούς.
CY20121100934T 2000-03-01 2012-10-05 Ανασυνδυασμενα αντισωματα υψηλης ισχυος και μεθοδος παραγωγης αυτων CY1113298T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18625200P 2000-03-01 2000-03-01
EP01914657A EP1259547B1 (en) 2000-03-01 2001-03-01 High potency recombinant antibodies and method for producing them

Publications (1)

Publication Number Publication Date
CY1113298T1 true CY1113298T1 (el) 2016-04-13

Family

ID=22684221

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100934T CY1113298T1 (el) 2000-03-01 2012-10-05 Ανασυνδυασμενα αντισωματα υψηλης ισχυος και μεθοδος παραγωγης αυτων

Country Status (10)

Country Link
US (2) US7700735B2 (el)
EP (3) EP1259547B1 (el)
JP (2) JP2003525061A (el)
AU (4) AU2001240020B9 (el)
CA (1) CA2401652A1 (el)
CY (1) CY1113298T1 (el)
DK (1) DK1259547T3 (el)
ES (1) ES2390761T3 (el)
PT (1) PT1259547E (el)
WO (1) WO2001064751A2 (el)

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WO2001064751A3 (en) 2001-12-20
EP1259547A2 (en) 2002-11-27
US20020098189A1 (en) 2002-07-25
AU2001240020B2 (en) 2007-02-08
US8153133B2 (en) 2012-04-10
AU2007202040A1 (en) 2007-05-24
AU2001240020B9 (en) 2008-12-04
WO2001064751A2 (en) 2001-09-07
EP2341074A1 (en) 2011-07-06
PT1259547E (pt) 2012-10-15
AU2010219289B2 (en) 2012-05-10
US7700735B2 (en) 2010-04-20
DK1259547T3 (da) 2012-10-15
EP2341075A1 (en) 2011-07-06
AU2007202040B2 (en) 2010-06-10
JP2003525061A (ja) 2003-08-26
US20100239574A1 (en) 2010-09-23
EP1259547B1 (en) 2012-07-11
JP2010162025A (ja) 2010-07-29
AU4002001A (en) 2001-09-12
AU2010219289A1 (en) 2010-09-30
CA2401652A1 (en) 2001-09-07
ES2390761T3 (es) 2012-11-16

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