DE60140868D1 - Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür - Google Patents

Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür

Info

Publication number
DE60140868D1
DE60140868D1 DE60140868T DE60140868T DE60140868D1 DE 60140868 D1 DE60140868 D1 DE 60140868D1 DE 60140868 T DE60140868 T DE 60140868T DE 60140868 T DE60140868 T DE 60140868T DE 60140868 D1 DE60140868 D1 DE 60140868D1
Authority
DE
Germany
Prior art keywords
glycoprotein
resistance
chromosome
human
homanese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60140868T
Other languages
English (en)
Inventor
Markus H Frank
Mohamed H Sayegh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Application granted granted Critical
Publication of DE60140868D1 publication Critical patent/DE60140868D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
DE60140868T 2000-06-05 2001-06-05 Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür Expired - Lifetime DE60140868D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20891300P 2000-06-05 2000-06-05
PCT/US2001/018032 WO2001094400A2 (en) 2000-06-05 2001-06-05 A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF

Publications (1)

Publication Number Publication Date
DE60140868D1 true DE60140868D1 (de) 2010-02-04

Family

ID=22776565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60140868T Expired - Lifetime DE60140868D1 (de) 2000-06-05 2001-06-05 Für ein homologes des humanen, für mehrfachresistenz verantwortlichen, p-glykoproteins auf chromosom 7p15-21 kodierendes gen sowie verwendungen dafür

Country Status (11)

Country Link
US (6) US6846883B2 (de)
EP (5) EP2298799B1 (de)
AT (1) ATE452909T1 (de)
CA (1) CA2411101C (de)
CY (2) CY1109941T1 (de)
DE (1) DE60140868D1 (de)
DK (4) DK1290028T3 (de)
ES (4) ES2434721T3 (de)
HK (2) HK1143823A1 (de)
PT (4) PT1290028E (de)
WO (1) WO2001094400A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1290028T3 (da) * 2000-06-05 2010-04-26 Brigham & Womens Hospital Gen, der koder for en multidrug-resistens-human P-glycoprotein-homolog på kromosom 7p15-21, og anvendelser deraf
WO2003025174A2 (en) * 2001-09-06 2003-03-27 Bayer Healthcare Ag Regulation of human mrp1-like protein
SI2772535T1 (sl) 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
WO2008127656A1 (en) 2007-04-12 2008-10-23 The Brigham And Women's Hospital, Inc. Targeting abcb5 for cancer therapy
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
EP2356446A4 (de) 2008-11-14 2014-03-19 Brigham & Womens Hospital Therapeutische und diagnostische verfahren im zusammenhang mit krebsstammzellen
CA2901931C (en) 2013-02-19 2023-03-07 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
WO2014182994A1 (en) 2013-05-10 2014-11-13 Children's Medical Center Corporation Wound healing and tissue engineering
EP3484496B1 (de) * 2016-07-14 2023-12-27 University of Southern California Verfahren und zusammensetzung zur herstellung und verwendung von immunzellen und stammzellen für zellbasierte therapien
WO2021222861A1 (en) * 2020-04-30 2021-11-04 Children's Medical Center Corporation Antibodies specific to abcb5 and uses thereof

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EP0174810B1 (de) * 1984-09-10 1993-07-21 HSC Research Development Corporation Vielfache Drogen-Resistenz in Säugetierzellinien und Isolierung der determinanten Glykoprotein-DNS
US4837306A (en) 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
US5693622A (en) 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5399483A (en) 1989-03-30 1995-03-21 Suntory Limited Expression of MDR-related gene in yeast cell
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5434075A (en) * 1992-03-20 1995-07-18 Board Of Trustees Of The University Of Illinois Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
IT1257893B (it) * 1992-06-17 1996-02-16 Ist Superiore Sanita Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana.
WO1994009363A1 (en) * 1992-10-14 1994-04-28 Board Of Regents, The University Of Texas System Cancer diagnosis and therapy
CA2239227C (en) 1996-10-01 2007-10-30 Kenji Matsuno Nitrogen-containing heterocyclic compounds
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US6008002A (en) * 1997-09-29 1999-12-28 Bodey; Bela Immunomagnetic detection and isolation of cancer cells
JP4768121B2 (ja) * 1998-02-05 2011-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｍａｇｅファミリーからの腫瘍関連抗原及びそれらをコードする核酸配列、融合タンパク質の及びワクチン接種のための組成物の調製のための使用
AU749675B2 (en) 1998-03-13 2002-07-04 Mesoblast International Sarl Uses for human non-autologous mesenchymal stem cells
AU785363B2 (en) * 1999-09-28 2007-02-01 Gentest Corporation P-glycoproteins and uses thereof
AU3087801A (en) * 2000-02-04 2001-08-14 Molecular Dynamics Inc Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
DK1290028T3 (da) * 2000-06-05 2010-04-26 Brigham & Womens Hospital Gen, der koder for en multidrug-resistens-human P-glycoprotein-homolog på kromosom 7p15-21, og anvendelser deraf
ATE446366T1 (de) 2000-06-22 2009-11-15 Genentech Inc Agonistische monoklonale antikörper gegen trkc
AU2002241569A1 (en) * 2000-10-27 2002-05-27 Incyte Genomics, Inc. Transporters and ion channels
US7829336B2 (en) * 2003-11-24 2010-11-09 The Rockefeller University Method for isolating a self-renewing, multipotent, slow-cycling cell
US20050186672A1 (en) 2004-01-27 2005-08-25 Reliance Life Sciences Pvt. Ltd. Tissue system with undifferentiated stem cells derived from corneal limbus
CA2629330C (en) 2004-11-12 2018-05-22 Cambridge University Technical Services Ltd. Methods and means related to cancer stem cells
WO2006103685A2 (en) 2005-03-28 2006-10-05 Vision Research Foundation A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue
AU2006259583A1 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
SI2772535T1 (sl) * 2006-05-31 2022-08-31 Children's Medical Center Corporation ABC5 pozitivne mezenhimske matične celice kot imunomodulatorji
US20080118432A1 (en) * 2006-09-07 2008-05-22 Ivan Bergstein Monitoring cancer stem cells
WO2008127656A1 (en) 2007-04-12 2008-10-23 The Brigham And Women's Hospital, Inc. Targeting abcb5 for cancer therapy
EP2356446A4 (de) 2008-11-14 2014-03-19 Brigham & Womens Hospital Therapeutische und diagnostische verfahren im zusammenhang mit krebsstammzellen
CA2901931C (en) 2013-02-19 2023-03-07 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
WO2014182994A1 (en) 2013-05-10 2014-11-13 Children's Medical Center Corporation Wound healing and tissue engineering

Also Published As

Publication number Publication date
EP3333182A1 (de) 2018-06-13
EP2182005A1 (de) 2010-05-05
US20050049185A1 (en) 2005-03-03
US20020037522A1 (en) 2002-03-28
US6846883B2 (en) 2005-01-25
US7465554B2 (en) 2008-12-16
US8507273B2 (en) 2013-08-13
CY1121053T1 (el) 2019-12-11
US20090162873A1 (en) 2009-06-25
DK2230253T3 (da) 2013-11-18
CY1109941T1 (el) 2014-09-10
PT1290028E (pt) 2010-03-12
EP2298799A1 (de) 2011-03-23
US20120034196A1 (en) 2012-02-09
EP2230253A1 (de) 2010-09-22
ATE452909T1 (de) 2010-01-15
US8425876B2 (en) 2013-04-23
ES2338756T3 (es) 2010-05-12
DK2298799T3 (en) 2018-02-19
DK1290028T3 (da) 2010-04-26
US8076091B2 (en) 2011-12-13
CA2411101C (en) 2018-01-16
ES2540102T3 (es) 2015-07-08
ES2659877T3 (es) 2018-03-19
PT2298799T (pt) 2018-02-16
EP2230253B1 (de) 2013-08-07
ES2434721T3 (es) 2013-12-17
EP1290028A2 (de) 2003-03-12
HK1257165A1 (zh) 2019-10-18
WO2001094400A3 (en) 2002-07-04
US20100145030A1 (en) 2010-06-10
EP1290028B1 (de) 2009-12-23
WO2001094400A2 (en) 2001-12-13
US20130287785A1 (en) 2013-10-31
US9561264B2 (en) 2017-02-07
PT2230253E (pt) 2013-11-11
HK1143823A1 (en) 2011-01-14
PT2182005E (pt) 2015-07-20
CA2411101A1 (en) 2001-12-13
EP2298799B1 (de) 2017-11-15
EP2182005B1 (de) 2015-03-25
DK2182005T3 (en) 2015-06-29

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