CY1109941T1 - ΕΝΑ ΓΟΝΙΔΙΟ ΠΟΥ ΚΩΔΙΚΟΠΟΙΕΙ ΕΝΑ ΟΜΟΛΟΓΟ ΑΝΘΡΩΠΙΝΗΣ Ρ-ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΜΕ ΑΝΘΕΚΤΙΚΟΤΗΤΑ ΑΠΕΝΑΝΤΙ ΣΕ ΠΟΛΛΑ ΦΑΡΜΑΚΑ ΠΑΝΩ ΣΤΟ ΧΡΩΜΟΣΩΜΑ 7p15-21 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ - Google Patents
ΕΝΑ ΓΟΝΙΔΙΟ ΠΟΥ ΚΩΔΙΚΟΠΟΙΕΙ ΕΝΑ ΟΜΟΛΟΓΟ ΑΝΘΡΩΠΙΝΗΣ Ρ-ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΜΕ ΑΝΘΕΚΤΙΚΟΤΗΤΑ ΑΠΕΝΑΝΤΙ ΣΕ ΠΟΛΛΑ ΦΑΡΜΑΚΑ ΠΑΝΩ ΣΤΟ ΧΡΩΜΟΣΩΜΑ 7p15-21 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥInfo
- Publication number
- CY1109941T1 CY1109941T1 CY20101100281T CY101100281T CY1109941T1 CY 1109941 T1 CY1109941 T1 CY 1109941T1 CY 20101100281 T CY20101100281 T CY 20101100281T CY 101100281 T CY101100281 T CY 101100281T CY 1109941 T1 CY1109941 T1 CY 1109941T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hours
- glycoprotein
- many drugs
- over
- human
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 4
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 title abstract 3
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000003917 human chromosome Anatomy 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Η εφεύρεση αναφέρεται σε μία Ρ-γλυκοπρωτεΐνη της οικογένειας MDR που βρίσκεται πάνω στο ανθρώπινο χρωμόσωμα 7p 15-21, πολυνουκλεοτιδικές αλληλουχίες που κωδικοποιούν αυτή την Ρ-γλυκοπρωτείνη και θραύσματα αυτών. Αυτό το γονίδιο χρησιμοποιείται σε μεθόδους για τον προσδιορισμό της ευπάθειας των καρκινοκυττάρων σε θεραπείες κατευθυνόμενες ενάντια στην αντίσταση σε πολλά φάρμακα, και για το σχεδιασμό διαγνωστικών και θεραπευτικών μεθόδων που σχετίζονται με την αντίσταση σε πολλά φάρμακα για τον καρκίνο. Η εφεύρεση αναφέρεται επίσης σε μεθόδους για τον προσδιορισμό του κατά πόσον μία δοκιμαστική ένωση μπορεί ν' αναστείλει την ανθεκτικότητα απέναντι σε πολλά φάρμακα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20891300P | 2000-06-05 | 2000-06-05 | |
EP01941884A EP1290028B1 (en) | 2000-06-05 | 2001-06-05 | A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109941T1 true CY1109941T1 (el) | 2014-09-10 |
Family
ID=22776565
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100281T CY1109941T1 (el) | 2000-06-05 | 2010-03-23 | ΕΝΑ ΓΟΝΙΔΙΟ ΠΟΥ ΚΩΔΙΚΟΠΟΙΕΙ ΕΝΑ ΟΜΟΛΟΓΟ ΑΝΘΡΩΠΙΝΗΣ Ρ-ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΜΕ ΑΝΘΕΚΤΙΚΟΤΗΤΑ ΑΠΕΝΑΝΤΙ ΣΕ ΠΟΛΛΑ ΦΑΡΜΑΚΑ ΠΑΝΩ ΣΤΟ ΧΡΩΜΟΣΩΜΑ 7p15-21 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ |
CY181100185T CY1121053T1 (el) | 2000-06-05 | 2018-02-14 | Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181100185T CY1121053T1 (el) | 2000-06-05 | 2018-02-14 | Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου |
Country Status (11)
Country | Link |
---|---|
US (6) | US6846883B2 (el) |
EP (5) | EP3333182A1 (el) |
AT (1) | ATE452909T1 (el) |
CA (1) | CA2411101C (el) |
CY (2) | CY1109941T1 (el) |
DE (1) | DE60140868D1 (el) |
DK (4) | DK2298799T3 (el) |
ES (4) | ES2338756T3 (el) |
HK (2) | HK1143823A1 (el) |
PT (4) | PT1290028E (el) |
WO (1) | WO2001094400A2 (el) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2338756T3 (es) | 2000-06-05 | 2010-05-12 | The Brigham And Women's Hospital, Inc. | Un gen que codifica un homologo de glicoproteina p humana multifarmaco-resistente en el cromosoma 7p15-21 y usos del mismo. |
WO2003025174A2 (en) * | 2001-09-06 | 2003-03-27 | Bayer Healthcare Ag | Regulation of human mrp1-like protein |
PL2772535T3 (pl) | 2006-05-31 | 2022-09-05 | Children's Medical Center Corporation | Mezenchymalne komórki macierzyste ABC5 dodatnie jako immunomodulatory |
PT2155248E (pt) | 2007-04-12 | 2015-10-23 | Brigham & Womens Hospital | Direcionamento a abcb5 para tratameto do cancro |
US11542328B2 (en) | 2008-11-14 | 2023-01-03 | The Brigham And Women's Hospital, Inc. | Therapeutic and diagnostic methods relating to cancer stem cells |
ES2796111T3 (es) | 2008-11-14 | 2020-11-25 | Brigham & Womens Hospital Inc | Métodos terapéuticos relacionados con células madre cancerosas |
JP7027026B2 (ja) | 2013-02-19 | 2022-03-01 | ザ チルドレンズ メディカル センター コーポレーション | 眼疾患を処置するためのabcb5(+)幹細胞 |
KR102319899B1 (ko) | 2013-05-10 | 2021-11-01 | 칠드런'즈 메디컬 센터 코포레이션 | 상처 치유 및 조직 공학 |
CA3030603A1 (en) * | 2016-07-14 | 2018-01-18 | University Of Southern California | Methods and composition for producing and using immune cells and stem cells for cell-based therapies |
CA3181591A1 (en) * | 2020-04-30 | 2021-11-04 | Children's Medical Center Corporation | Antibodies specific to abcb5 and uses thereof |
Family Cites Families (29)
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DE3587465T2 (de) * | 1984-09-10 | 1994-01-20 | Hsc Res Dev Corp | Vielfache Drogen-Resistenz in Säugetierzellinien und Isolierung der determinanten Glykoprotein-DNS. |
US4837306A (en) * | 1985-02-25 | 1989-06-06 | The Ontario Cancer Institute | Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen |
US5693622A (en) | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
US5399483A (en) * | 1989-03-30 | 1995-03-21 | Suntory Limited | Expression of MDR-related gene in yeast cell |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5434075A (en) * | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
IT1257893B (it) * | 1992-06-17 | 1996-02-16 | Ist Superiore Sanita | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
WO1994009363A1 (en) * | 1992-10-14 | 1994-04-28 | Board Of Regents, The University Of Texas System | Cancer diagnosis and therapy |
JP4073961B2 (ja) | 1996-10-01 | 2008-04-09 | 協和醗酵工業株式会社 | 含窒素複素環化合物 |
US6020191A (en) | 1997-04-14 | 2000-02-01 | Genzyme Corporation | Adenoviral vectors capable of facilitating increased persistence of transgene expression |
US6008002A (en) * | 1997-09-29 | 1999-12-28 | Bodey; Bela | Immunomagnetic detection and isolation of cancer cells |
ATE315088T1 (de) * | 1998-02-05 | 2006-02-15 | Glaxosmithkline Biolog Sa | Tumorassoziierte antigenderivate der mage-familie,nukleinsäuresequenzen die dafür kodieren, zur herstellung von fusionsproteinen und zusammensetzungen zur impfung |
WO1999046366A1 (en) | 1998-03-13 | 1999-09-16 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
JP2003510071A (ja) * | 1999-09-28 | 2003-03-18 | ジェンテスト・コーポレーション | P−糖タンパク質およびその使用 |
AU3087801A (en) * | 2000-02-04 | 2001-08-14 | Molecular Dynamics Inc | Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells |
ES2338756T3 (es) | 2000-06-05 | 2010-05-12 | The Brigham And Women's Hospital, Inc. | Un gen que codifica un homologo de glicoproteina p humana multifarmaco-resistente en el cromosoma 7p15-21 y usos del mismo. |
PL208113B1 (pl) | 2000-06-22 | 2011-03-31 | Genentech Inc | Agonistyczne przeciwciało monoklonalne anty-trkC, mysie agonistyczne przeciwciało monoklonalne, ludzkie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca mysie agonistyczne przeciwciało monoklonalne, wyizolowana cząsteczka kwasu nukleinowego kodująca ludzkie przeciwciało anty-trkC, cząsteczka kwasu nukleinowego, linia komórek gospodarza, linia komórek hybrydomy, przeciwciało wytwarzane przez tę linię komórek hybrydomy, wyizolowana cząsteczka kwasu nukleinowego i wektor zawierający tę cząsteczkę kwasu nukleinowego, przeciwciało, polipeptyd, kompozycja |
CA2427010A1 (en) * | 2000-10-27 | 2002-05-23 | Incyte Genomics, Inc. | Transporters and ion channels |
AU2004295680A1 (en) * | 2003-11-24 | 2005-06-16 | The Rockefeller University | A method for isolating a self-renewing, multipotent slow-cycling cell |
US20050186672A1 (en) | 2004-01-27 | 2005-08-25 | Reliance Life Sciences Pvt. Ltd. | Tissue system with undifferentiated stem cells derived from corneal limbus |
CA2629330C (en) | 2004-11-12 | 2018-05-22 | Cambridge University Technical Services Ltd. | Methods and means related to cancer stem cells |
WO2006103685A2 (en) | 2005-03-28 | 2006-10-05 | Vision Research Foundation | A method for cultivating cells derived from corneal limbal tissue and cells deived from corneal limbal tissue |
WO2006138275A2 (en) | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
PL2772535T3 (pl) | 2006-05-31 | 2022-09-05 | Children's Medical Center Corporation | Mezenchymalne komórki macierzyste ABC5 dodatnie jako immunomodulatory |
EP2526969A1 (en) * | 2006-09-07 | 2012-11-28 | Stemline Therapeutics, Inc. | Monitoring cancer stem cells |
PT2155248E (pt) | 2007-04-12 | 2015-10-23 | Brigham & Womens Hospital | Direcionamento a abcb5 para tratameto do cancro |
ES2796111T3 (es) | 2008-11-14 | 2020-11-25 | Brigham & Womens Hospital Inc | Métodos terapéuticos relacionados con células madre cancerosas |
JP7027026B2 (ja) | 2013-02-19 | 2022-03-01 | ザ チルドレンズ メディカル センター コーポレーション | 眼疾患を処置するためのabcb5(+)幹細胞 |
KR102319899B1 (ko) | 2013-05-10 | 2021-11-01 | 칠드런'즈 메디컬 센터 코포레이션 | 상처 치유 및 조직 공학 |
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2001
- 2001-06-05 ES ES01941884T patent/ES2338756T3/es not_active Expired - Lifetime
- 2001-06-05 PT PT01941884T patent/PT1290028E/pt unknown
- 2001-06-05 DK DK10185365.3T patent/DK2298799T3/en active
- 2001-06-05 ES ES10185365.3T patent/ES2659877T3/es not_active Expired - Lifetime
- 2001-06-05 CA CA2411101A patent/CA2411101C/en not_active Expired - Lifetime
- 2001-06-05 WO PCT/US2001/018032 patent/WO2001094400A2/en active Application Filing
- 2001-06-05 EP EP17201739.4A patent/EP3333182A1/en not_active Withdrawn
- 2001-06-05 DE DE60140868T patent/DE60140868D1/de not_active Expired - Lifetime
- 2001-06-05 DK DK01941884.7T patent/DK1290028T3/da active
- 2001-06-05 ES ES09180026.8T patent/ES2540102T3/es not_active Expired - Lifetime
- 2001-06-05 EP EP01941884A patent/EP1290028B1/en not_active Expired - Lifetime
- 2001-06-05 AT AT01941884T patent/ATE452909T1/de active
- 2001-06-05 US US09/873,409 patent/US6846883B2/en not_active Expired - Lifetime
- 2001-06-05 EP EP10151972.6A patent/EP2230253B1/en not_active Expired - Lifetime
- 2001-06-05 DK DK09180026.8T patent/DK2182005T3/en active
- 2001-06-05 EP EP09180026.8A patent/EP2182005B1/en not_active Expired - Lifetime
- 2001-06-05 PT PT101519726T patent/PT2230253E/pt unknown
- 2001-06-05 DK DK10151972.6T patent/DK2230253T3/da active
- 2001-06-05 EP EP10185365.3A patent/EP2298799B1/en not_active Expired - Lifetime
- 2001-06-05 ES ES10151972T patent/ES2434721T3/es not_active Expired - Lifetime
- 2001-06-05 PT PT101853653T patent/PT2298799T/pt unknown
- 2001-06-05 PT PT91800268T patent/PT2182005E/pt unknown
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2004
- 2004-09-29 US US10/952,328 patent/US7465554B2/en not_active Expired - Lifetime
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2008
- 2008-11-19 US US12/273,849 patent/US8076091B2/en not_active Expired - Fee Related
-
2010
- 2010-02-09 US US12/702,570 patent/US8425876B2/en not_active Expired - Lifetime
- 2010-03-23 CY CY20101100281T patent/CY1109941T1/el unknown
- 2010-11-05 HK HK10110380.5A patent/HK1143823A1/xx not_active IP Right Cessation
-
2011
- 2011-10-24 US US13/279,549 patent/US8507273B2/en not_active Expired - Lifetime
-
2013
- 2013-07-10 US US13/938,938 patent/US9561264B2/en not_active Expired - Lifetime
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2018
- 2018-02-14 CY CY181100185T patent/CY1121053T1/el unknown
- 2018-12-13 HK HK18116046.0A patent/HK1257165A1/zh unknown
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