HUP9702147A2 - Humán DNáz I variánsok - Google Patents

Humán DNáz I variánsok

Info

Publication number
HUP9702147A2
HUP9702147A2 HU9702147A HUP9702147A HUP9702147A2 HU P9702147 A2 HUP9702147 A2 HU P9702147A2 HU 9702147 A HU9702147 A HU 9702147A HU P9702147 A HUP9702147 A HU P9702147A HU P9702147 A2 HUP9702147 A2 HU P9702147A2
Authority
HU
Hungary
Prior art keywords
variants
actin
dnase
well
human dnase
Prior art date
Application number
HU9702147A
Other languages
English (en)
Inventor
Robert A. Lazarus
Steven Shak
Jana S. Ulmer
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HUP9702147A2 publication Critical patent/HUP9702147A2/hu
Publication of HUP9702147A3 publication Critical patent/HUP9702147A3/hu
Publication of HU222665B1 publication Critical patent/HU222665B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány a hűmán dexőxiribőnűkleáz (I) (DNáz I) aktinnal szembencsökkentett kötési affinitású aminősavszekvencia-variánsairavőnatkőzik. A találmány magában főglalja az aktinrezisztensvariánsőkat kódőló nűkleinsav-szekvenciákat, valamint a variánsőkklinikai felhasználásra alkalmas mennyiségeinek előállítási eljárásaitis. A találmány tárgyát képezik a hűmán DNáz (I) aktinrezisztensvariánsait tartalmazó gyógyszerkészítmény, valamint a variánsők ésgyógyszerkészítményeik gyógyászati alkalmazásai is. ŕ
HU9702147A 1995-02-24 1996-02-21 Humán DNáz I variánsok HU222665B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10
PCT/US1996/002421 WO1996026279A1 (en) 1995-02-24 1996-02-21 Human dnase i variants

Publications (3)

Publication Number Publication Date
HUP9702147A2 true HUP9702147A2 (hu) 1999-07-28
HUP9702147A3 HUP9702147A3 (en) 1999-09-28
HU222665B1 HU222665B1 (hu) 2003-09-29

Family

ID=26789529

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702147A HU222665B1 (hu) 1995-02-24 1996-02-21 Humán DNáz I variánsok

Country Status (20)

Country Link
EP (2) EP0854927B1 (hu)
JP (1) JP4549439B2 (hu)
AR (1) AR003926A1 (hu)
AT (1) ATE397073T1 (hu)
AU (1) AU695863B2 (hu)
BR (1) BR9607328A (hu)
CA (1) CA2211413C (hu)
DE (1) DE69637548D1 (hu)
DK (1) DK0854927T3 (hu)
ES (1) ES2308775T3 (hu)
HU (1) HU222665B1 (hu)
IL (1) IL117218A (hu)
NO (1) NO326616B1 (hu)
NZ (1) NZ334762A (hu)
PL (1) PL184951B1 (hu)
RO (1) RO118886B1 (hu)
SI (1) SI9620043A (hu)
SK (1) SK284191B6 (hu)
TR (1) TR199700842T1 (hu)
WO (1) WO1996026279A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391607B1 (en) 1996-06-14 2002-05-21 Genentech, Inc. Human DNase I hyperactive variants
US9603907B2 (en) * 2012-02-01 2017-03-28 Protalix Ltd. Dry powder formulations of dNase I
US10988745B2 (en) 2013-10-31 2021-04-27 Resolve Therapeutics, Llc Therapeutic nuclease-albumin fusions and methods
CN104131093B (zh) * 2014-07-23 2015-12-09 哈尔滨工程大学 DNA蛋白结合位点的DNase高通测序检测信号处理方法
US11225648B2 (en) * 2015-01-04 2022-01-18 Protalix Ltd. Modified DNase and uses thereof
IL301970A (en) 2020-10-07 2023-06-01 Protalix Ltd A long-acting DNase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP0272253A4 (en) 1986-03-07 1990-02-05 Massachusetts Inst Technology METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
WO1990007572A1 (en) * 1988-12-23 1990-07-12 Genentech, Inc. HUMAN DNase
US5464817A (en) 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I
US5279823A (en) 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE
ATE155581T1 (de) 1992-11-02 1997-08-15 Genentech Inc Verdichtungsprüfung zur bewertung einer therapie für eine atmungskrankheit
CZ288633B6 (cs) * 1995-02-24 2001-08-15 Genentech, Inc. Na aktin rezistentní varianta lidské DNázy I a izolovaná nukleová kyselina ji kódující

Also Published As

Publication number Publication date
NO973877D0 (no) 1997-08-22
NO326616B1 (no) 2009-01-19
ES2308775T3 (es) 2008-12-01
PL184951B1 (pl) 2003-01-31
JP4549439B2 (ja) 2010-09-22
JPH11503004A (ja) 1999-03-23
NZ334762A (en) 2000-10-27
HUP9702147A3 (en) 1999-09-28
AU695863B2 (en) 1998-08-27
DK0854927T3 (da) 2008-09-08
EP1980618A2 (en) 2008-10-15
SK114897A3 (en) 1998-03-04
ATE397073T1 (de) 2008-06-15
CA2211413A1 (en) 1996-08-29
IL117218A0 (en) 1996-06-18
SK284191B6 (sk) 2004-10-05
NO973877L (no) 1997-10-24
WO1996026279A1 (en) 1996-08-29
SI9620043A (sl) 1998-06-30
TR199700842T1 (xx) 1998-01-21
EP0854927B1 (en) 2008-05-28
RO118886B1 (ro) 2003-12-30
PL322002A1 (en) 1998-01-05
IL117218A (en) 2004-06-01
BR9607328A (pt) 1997-12-30
CA2211413C (en) 2010-06-22
EP0854927A1 (en) 1998-07-29
AR003926A1 (es) 1998-09-30
AU5026396A (en) 1996-09-11
DE69637548D1 (de) 2008-07-10
HU222665B1 (hu) 2003-09-29

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Legal Events

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HFG4 Patent granted, date of granting

Effective date: 20030724

MM4A Lapse of definitive patent protection due to non-payment of fees