CA2242562A1 - Human dnase resistant to actin inhibition - Google Patents

Human dnase resistant to actin inhibition

Info

Publication number
CA2242562A1
CA2242562A1 CA002242562A CA2242562A CA2242562A1 CA 2242562 A1 CA2242562 A1 CA 2242562A1 CA 002242562 A CA002242562 A CA 002242562A CA 2242562 A CA2242562 A CA 2242562A CA 2242562 A1 CA2242562 A1 CA 2242562A1
Authority
CA
Canada
Prior art keywords
dnase
human dnase
actin
inhibition
dnase resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002242562A
Other languages
French (fr)
Other versions
CA2242562C (en
Inventor
Kevin P. Baker
Will F. Baron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1997/001506 external-priority patent/WO1997028266A1/en
Publication of CA2242562A1 publication Critical patent/CA2242562A1/en
Application granted granted Critical
Publication of CA2242562C publication Critical patent/CA2242562C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to a novel human deoxyribonuclease, referred to as LS-DNase, that is relatively resistant to inhibition by actin, as compared to human DNase I. The invention provides nucleic acid sequences encoding LS-DNase, thereby enabling the production of LS-DNase by recombinant DNA methods in quantities sufficient for clinical use.
The invention also relates to pharmaceutical compositions and therapeutic uses of LS-DNase.
CA002242562A 1996-02-05 1997-02-03 Human dnase resistant to actin inhibition Expired - Lifetime CA2242562C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59707896A 1996-02-05 1996-02-05
US08/597078 1996-02-05
PCT/US1997/001506 WO1997028266A1 (en) 1996-02-05 1997-02-03 Human dnase resistant to actin inhibition

Publications (2)

Publication Number Publication Date
CA2242562A1 true CA2242562A1 (en) 1997-08-07
CA2242562C CA2242562C (en) 2007-05-22

Family

ID=38156721

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002242562A Expired - Lifetime CA2242562C (en) 1996-02-05 1997-02-03 Human dnase resistant to actin inhibition

Country Status (1)

Country Link
CA (1) CA2242562C (en)

Also Published As

Publication number Publication date
CA2242562C (en) 2007-05-22

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Effective date: 20170203