MX9706429A - HUMAN DNase I VARIANTS. - Google Patents

HUMAN DNase I VARIANTS.

Info

Publication number
MX9706429A
MX9706429A MX9706429A MX9706429A MX9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A MX 9706429 A MX9706429 A MX 9706429A
Authority
MX
Mexico
Prior art keywords
variants
human dnase
actin
relates
resistant
Prior art date
Application number
MX9706429A
Other languages
Spanish (es)
Inventor
Robert A Lazarus
Steven Shak
Jana S Ulmer
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/002366 external-priority patent/WO1996026278A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority claimed from PCT/US1996/002421 external-priority patent/WO1996026279A1/en
Publication of MX9706429A publication Critical patent/MX9706429A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to amino acid sequence variants of human DNase I that have reduced binding affinity for actin. The invention provides nucleic acid sequences encoding such actin-resistant variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic uses of actin-resistant variants of human DNase I.
MX9706429A 1995-02-24 1996-02-21 HUMAN DNase I VARIANTS. MX9706429A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1995/002366 WO1996026278A1 (en) 1995-02-24 1995-02-24 HUMAN DNase I VARIANTS
US54052795A 1995-10-10 1995-10-10
PCT/US1996/002421 WO1996026279A1 (en) 1995-02-24 1996-02-21 Human dnase i variants

Publications (1)

Publication Number Publication Date
MX9706429A true MX9706429A (en) 1997-11-29

Family

ID=24155835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9706429A MX9706429A (en) 1995-02-24 1996-02-21 HUMAN DNase I VARIANTS.

Country Status (5)

Country Link
JP (3) JP4624380B2 (en)
BG (1) BG64423B1 (en)
CZ (1) CZ297463B6 (en)
MX (1) MX9706429A (en)
PT (1) PT854927E (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0853121B1 (en) * 1988-12-23 2007-03-28 Genentech, Inc. Human DNase
US5464817A (en) * 1990-04-11 1995-11-07 Brigham And Women's Hospital Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I

Also Published As

Publication number Publication date
JP4624380B2 (en) 2011-02-02
BG101847A (en) 1998-07-31
BG64423B1 (en) 2005-01-31
JP2010057516A (en) 2010-03-18
CZ267897A3 (en) 1998-01-14
CZ297463B6 (en) 2006-12-13
JP2010088452A (en) 2010-04-22
PT854927E (en) 2008-09-08
JP2007312781A (en) 2007-12-06

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees