WO2000026362A3 - Proteins of the stomatin family and their use as target proteins for pain therapy - Google Patents

Proteins of the stomatin family and their use as target proteins for pain therapy Download PDF

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Publication number
WO2000026362A3
WO2000026362A3 PCT/DE1999/003434 DE9903434W WO0026362A3 WO 2000026362 A3 WO2000026362 A3 WO 2000026362A3 DE 9903434 W DE9903434 W DE 9903434W WO 0026362 A3 WO0026362 A3 WO 0026362A3
Authority
WO
WIPO (PCT)
Prior art keywords
stomatin
proteins
family
pain therapy
target proteins
Prior art date
Application number
PCT/DE1999/003434
Other languages
German (de)
French (fr)
Other versions
WO2000026362A2 (en
Inventor
Anne Gabriele Mannsfeldt
Gary Richard Lewin
Original Assignee
Max Delbrueck Centrum
Anne Gabriele Mannsfeldt
Gary Richard Lewin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum, Anne Gabriele Mannsfeldt, Gary Richard Lewin filed Critical Max Delbrueck Centrum
Publication of WO2000026362A2 publication Critical patent/WO2000026362A2/en
Publication of WO2000026362A3 publication Critical patent/WO2000026362A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to stomatin and novel proteins of the stomatin family, especially N-stomatin comprising 287 amino acids, its 1847 nucleotide coding cDNA, and their use as target proteins for pain therapy. The invention also relates to their use for developing therapeutic agents for treating pain, analgesics/anesthetics, for building genes, for developing pharmaceutically relevant substances and for diagnostic kits.
PCT/DE1999/003434 1998-10-30 1999-10-28 Proteins of the stomatin family and their use as target proteins for pain therapy WO2000026362A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1998150015 DE19850015A1 (en) 1998-10-30 1998-10-30 Proteins of the stomatin family and their use as target proteins for ore therapy
DE19850015.7 1998-10-30

Publications (2)

Publication Number Publication Date
WO2000026362A2 WO2000026362A2 (en) 2000-05-11
WO2000026362A3 true WO2000026362A3 (en) 2000-06-22

Family

ID=7886124

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/003434 WO2000026362A2 (en) 1998-10-30 1999-10-28 Proteins of the stomatin family and their use as target proteins for pain therapy

Country Status (2)

Country Link
DE (1) DE19850015A1 (en)
WO (1) WO2000026362A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2813499B1 (en) 2000-09-04 2004-11-26 Pasteur Institut MUTANT NON-HUMAN MAMMAL FOR THE EXPRESSION OF THE ALPHA6 SUBUNIT OF THE NICOTINIC ACETYLCHOLINE RECEPTOR AND USE FOR THE SCREENING OF SUBSTANCES LIKELY TO INTERACT WITH THIS RECEPTOR
IL151980A0 (en) * 2002-09-29 2003-04-10 Yeda Res & Dev Resistin binding proteins, their preparation and use
WO2004040299A2 (en) * 2002-10-30 2004-05-13 Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch Method for identifying compounds which inhibit mechanotransduction in neurons

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030690A1 (en) * 1997-01-09 1998-07-16 Incyte Pharmaceuticals, Inc. Novel human membrane protein
WO1999025825A2 (en) * 1997-11-13 1999-05-27 Genset EXTENDED cDNAs FOR SECRETED PROTEINS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030690A1 (en) * 1997-01-09 1998-07-16 Incyte Pharmaceuticals, Inc. Novel human membrane protein
WO1999025825A2 (en) * 1997-11-13 1999-05-27 Genset EXTENDED cDNAs FOR SECRETED PROTEINS

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARNES T M ET AL: "THE CAENORHABDITIS ELEGANS BEHAVIORAL GENE UNC-24 ENCODES A NOVEL BIPARTITE PROTEIN SIMILAR TO BOTH ERYTHROCYTE BAND 7.2 (STOMATIN) AND NONSPECIFIC LIPID TRANSFER PROTEIN", JOURNAL OF NEUROCHEMISTRY,US,NEW YORK, NY, vol. 67, 1 January 1996 (1996-01-01), pages 46 - 55, XP002063568, ISSN: 0022-3042 *
MANNSFELDT, A.G. ET AL.: "Stomatin, a MEC-2 Like Protein, Is Expressed by Mammalian Sensory Neurons", MOL. CELL. NEUROSCI., vol. 13, no. 6, June 1999 (1999-06-01), pages 391 - 404, XP000889811 *
RAJARAM, S. ET AL.: "unc-1: A stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans.", PROC, NATL. ACAD. SCI., vol. 95, July 1998 (1998-07-01), pages 8761 - 8766, XP002132341 *
SCHLEGEL W ET AL: "Cloning and analysis of a cDNA encoding the BALB/c murine erythrocyte band 7 integral membrane protein", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 178, no. 1, 31 October 1996 (1996-10-31), pages 115 - 118, XP004043348, ISSN: 0378-1119 *
SEIDEL G ET AL: "Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 225, no. 1-2, 28 December 1998 (1998-12-28), pages 23 - 29, XP004153617, ISSN: 0378-1119 *
STEWART G W ET AL: "ISOLATION OF CDNA CODING FOR AN UBIQUITOUS MEMBRANE PROTEIN DEFICIENT IN HIGH NA+, LOW K STOMATOCYTIC ERYTHROCYTES", BLOOD,US,PHILADELPHIA, PA, vol. 79, 1 January 1992 (1992-01-01), pages 1593 - 1601, XP002063567, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2000026362A2 (en) 2000-05-11
DE19850015A1 (en) 2000-05-04

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