CY1121053T1 - Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου - Google Patents

Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου

Info

Publication number
CY1121053T1
CY1121053T1 CY181100185T CY181100185T CY1121053T1 CY 1121053 T1 CY1121053 T1 CY 1121053T1 CY 181100185 T CY181100185 T CY 181100185T CY 181100185 T CY181100185 T CY 181100185T CY 1121053 T1 CY1121053 T1 CY 1121053T1
Authority
CY
Cyprus
Prior art keywords
glycoprotein
gene
multiple drugs
human
codes
Prior art date
Application number
CY181100185T
Other languages
English (en)
Inventor
Mohamed H Sayegh
Markus H Frank
Original Assignee
The Brigham And Women´S Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham And Women´S Hospital Inc filed Critical The Brigham And Women´S Hospital Inc
Publication of CY1121053T1 publication Critical patent/CY1121053T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Η εφεύρεση σχετίζεται με μία Ρ-γλυκοπρωτεΐνη της οικογένειας MDR που βρίσκεται πάνω στο ανθρώπινο χρωμόσωμα, με αλληλουχίες πολυνουκλεοτιδίου, που κωδικοποιούν αυτήν την Ρ-γλυκοπρωτεΐνη και θραύσματα αυτής. Αυτό το γονίδιο χρησιμοποιείται σε μεθόδους για τον προσδιορισμό της ευαισθησίας των καρκινικών κυττάρων σε θεραπείες που κατευθύνονται έναντι της ανθεκτικότητας σε πολλαπλά φάρμακα, και στον σχεδιασμό διαγνωστικών και θεραπευτικών μεθόδων, που σχετίζονται με την ανθεκτικότητα απέναντι σε πολλαπλά φάρμακα για τον καρκίνο. Αυτή η εφεύρεση σχετίζεται επίσης με μεθόδους για τον προσδιορισμό του κατά πόσον μία δοκιμαστική ένωση μπορεί να αναστείλει την ανθεκτικότητα σε πολλαπλά φάρμακα.
CY181100185T 2000-06-05 2018-02-14 Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου CY1121053T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20891300P 2000-06-05 2000-06-05
EP09180026.8A EP2182005B1 (en) 2000-06-05 2001-06-05 A gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
EP01941884A EP1290028B1 (en) 2000-06-05 2001-06-05 A GENE ENCODING A MULTIDRUG RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7p15-21 AND USES THEREOF

Publications (1)

Publication Number Publication Date
CY1121053T1 true CY1121053T1 (el) 2019-12-11

Family

ID=22776565

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20101100281T CY1109941T1 (el) 2000-06-05 2010-03-23 ΕΝΑ ΓΟΝΙΔΙΟ ΠΟΥ ΚΩΔΙΚΟΠΟΙΕΙ ΕΝΑ ΟΜΟΛΟΓΟ ΑΝΘΡΩΠΙΝΗΣ Ρ-ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΜΕ ΑΝΘΕΚΤΙΚΟΤΗΤΑ ΑΠΕΝΑΝΤΙ ΣΕ ΠΟΛΛΑ ΦΑΡΜΑΚΑ ΠΑΝΩ ΣΤΟ ΧΡΩΜΟΣΩΜΑ 7p15-21 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ
CY181100185T CY1121053T1 (el) 2000-06-05 2018-02-14 Ενα γονιδιο που κωδικοποιει ενα ομολογο ανθρωπινης ρ-γλυκοπρωτεϊνης με ανθεκτικοτητα απεναντι σε πολλαπλα φαρμακα πανω στο χρωμοσωμα 7p15-21 και χρησεις αυτου

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20101100281T CY1109941T1 (el) 2000-06-05 2010-03-23 ΕΝΑ ΓΟΝΙΔΙΟ ΠΟΥ ΚΩΔΙΚΟΠΟΙΕΙ ΕΝΑ ΟΜΟΛΟΓΟ ΑΝΘΡΩΠΙΝΗΣ Ρ-ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΜΕ ΑΝΘΕΚΤΙΚΟΤΗΤΑ ΑΠΕΝΑΝΤΙ ΣΕ ΠΟΛΛΑ ΦΑΡΜΑΚΑ ΠΑΝΩ ΣΤΟ ΧΡΩΜΟΣΩΜΑ 7p15-21 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΟΥ

Country Status (11)

Country Link
US (6) US6846883B2 (el)
EP (5) EP2298799B1 (el)
AT (1) ATE452909T1 (el)
CA (1) CA2411101C (el)
CY (2) CY1109941T1 (el)
DE (1) DE60140868D1 (el)
DK (4) DK2298799T3 (el)
ES (4) ES2338756T3 (el)
HK (2) HK1143823A1 (el)
PT (4) PT1290028E (el)
WO (1) WO2001094400A2 (el)

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EP2298799B1 (en) 2000-06-05 2017-11-15 The Brigham and Women's Hospital, Inc. A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof
WO2003025174A2 (en) * 2001-09-06 2003-03-27 Bayer Healthcare Ag Regulation of human mrp1-like protein
EP2772535B1 (en) * 2006-05-31 2022-04-06 Children's Medical Center Corporation ABC5 positive mesenchymal stem cells as immunomodulators
HUE027593T2 (en) 2007-04-12 2016-11-28 Brigham & Womens Hospital Inc ABCB5 targeting cancer therapy
US11542328B2 (en) 2008-11-14 2023-01-03 The Brigham And Women's Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
US20110287034A1 (en) 2008-11-14 2011-11-24 The Brigham And Womens Hospital, Inc. Therapeutic and diagnostic methods relating to cancer stem cells
CA2901931C (en) 2013-02-19 2023-03-07 Children's Medical Center Corporation Abcb5(+) stem cells for treating ocular disease
AU2014262590B2 (en) 2013-05-10 2018-05-10 Children's Medical Center Corporation Wound healing and tissue engineering
CA3030603A1 (en) * 2016-07-14 2018-01-18 University Of Southern California Methods and composition for producing and using immune cells and stem cells for cell-based therapies
CN116096753A (zh) * 2020-04-30 2023-05-09 儿童医学中心公司 对abcb5具有特异性的抗体及其用途

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Also Published As

Publication number Publication date
US20130287785A1 (en) 2013-10-31
US20120034196A1 (en) 2012-02-09
CA2411101C (en) 2018-01-16
DK2182005T3 (en) 2015-06-29
PT2230253E (pt) 2013-11-11
CY1109941T1 (el) 2014-09-10
EP1290028A2 (en) 2003-03-12
US8507273B2 (en) 2013-08-13
EP2298799B1 (en) 2017-11-15
DK1290028T3 (da) 2010-04-26
PT1290028E (pt) 2010-03-12
EP3333182A1 (en) 2018-06-13
ES2338756T3 (es) 2010-05-12
ES2540102T3 (es) 2015-07-08
ES2659877T3 (es) 2018-03-19
WO2001094400A2 (en) 2001-12-13
EP1290028B1 (en) 2009-12-23
US8425876B2 (en) 2013-04-23
US8076091B2 (en) 2011-12-13
EP2182005B1 (en) 2015-03-25
PT2298799T (pt) 2018-02-16
US20090162873A1 (en) 2009-06-25
EP2298799A1 (en) 2011-03-23
DK2298799T3 (en) 2018-02-19
ES2434721T3 (es) 2013-12-17
HK1143823A1 (en) 2011-01-14
EP2230253B1 (en) 2013-08-07
US9561264B2 (en) 2017-02-07
EP2182005A1 (en) 2010-05-05
US20050049185A1 (en) 2005-03-03
US7465554B2 (en) 2008-12-16
CA2411101A1 (en) 2001-12-13
US20100145030A1 (en) 2010-06-10
HK1257165A1 (zh) 2019-10-18
US6846883B2 (en) 2005-01-25
US20020037522A1 (en) 2002-03-28
WO2001094400A3 (en) 2002-07-04
DK2230253T3 (da) 2013-11-18
DE60140868D1 (de) 2010-02-04
PT2182005E (pt) 2015-07-20
ATE452909T1 (de) 2010-01-15
EP2230253A1 (en) 2010-09-22

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