DE602005011008D1 - Verwendung der Gene Kir2.3 und DRD2 als molekulare Marker zur Diagnose von Schizophrenie - Google Patents
Verwendung der Gene Kir2.3 und DRD2 als molekulare Marker zur Diagnose von SchizophrenieInfo
- Publication number
- DE602005011008D1 DE602005011008D1 DE602005011008T DE602005011008T DE602005011008D1 DE 602005011008 D1 DE602005011008 D1 DE 602005011008D1 DE 602005011008 T DE602005011008 T DE 602005011008T DE 602005011008 T DE602005011008 T DE 602005011008T DE 602005011008 D1 DE602005011008 D1 DE 602005011008D1
- Authority
- DE
- Germany
- Prior art keywords
- drd2
- schizophrenia
- genes
- pcr
- qrt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102100020756 D(2) dopamine receptor Human genes 0.000 title abstract 4
- 101000931901 Homo sapiens D(2) dopamine receptor Proteins 0.000 title abstract 4
- 101000944267 Homo sapiens Inward rectifier potassium channel 4 Proteins 0.000 title abstract 4
- 201000000980 schizophrenia Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 102100033057 Inward rectifier potassium channel 4 Human genes 0.000 abstract 3
- 238000011529 RT qPCR Methods 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000000698 schizophrenic effect Effects 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 108010009983 Inwardly Rectifying Potassium Channels Proteins 0.000 abstract 1
- 102000009855 Inwardly Rectifying Potassium Channels Human genes 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000002493 microarray Methods 0.000 abstract 1
- 238000010208 microarray analysis Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400904A HU227246B1 (en) | 2004-04-30 | 2004-04-30 | Use of genes as molecular markers in diagnosis of schizophrenia and diagnostic kit |
| PCT/HU2005/000044 WO2005106026A1 (en) | 2004-04-30 | 2005-05-02 | Use of genes as molecular markers in diagnosis of schizophrenia and diagnostic kit for the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005011008D1 true DE602005011008D1 (de) | 2008-12-24 |
Family
ID=89982187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005011008T Active DE602005011008D1 (de) | 2004-04-30 | 2005-05-02 | Verwendung der Gene Kir2.3 und DRD2 als molekulare Marker zur Diagnose von Schizophrenie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080274455A1 (de) |
| EP (1) | EP1761642B1 (de) |
| AT (1) | ATE414180T1 (de) |
| DE (1) | DE602005011008D1 (de) |
| HU (1) | HU227246B1 (de) |
| WO (1) | WO2005106026A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2449819A (en) * | 2006-02-28 | 2008-12-03 | Univ California | Genes differentially expressed in bipolar disorder and/or schizophrenia |
| US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
| US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
| US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
| US12090480B2 (en) | 2008-09-23 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| CA3210271A1 (en) | 2008-09-23 | 2010-04-01 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US12162008B2 (en) | 2008-09-23 | 2024-12-10 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
| US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
| US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
| US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
| US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
| US8633015B2 (en) | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
| US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
| KR101062167B1 (ko) | 2008-10-23 | 2011-09-05 | 사회복지법인 삼성생명공익재단 | Ｋｉｒ2.2 억제제를 포함하는 암 치료용 조성물 |
| US8346485B2 (en) | 2008-11-25 | 2013-01-01 | Quest Diagnostics Investments Incorporated | Methods and apparatuses for estimating initial target nucleic acid concentration in a sample by modeling background signal and cycle-dependent amplification efficiency of a polymerase chain reaction |
| CA3021714C (en) | 2009-09-02 | 2021-03-09 | Bio-Rad Laboratories, Inc. | System for mixing fluids by coalescence of multiple emulsions |
| CA2767113A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Detection system for droplet-based assays |
| CA2767114A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Droplet transport system for detection |
| CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
| JP5922139B2 (ja) | 2010-11-01 | 2016-05-24 | バイオ−ラッド・ラボラトリーズ・インコーポレーテッド | エマルジョンを形成するためのシステム |
| US12097495B2 (en) | 2011-02-18 | 2024-09-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
| CN103534360A (zh) | 2011-03-18 | 2014-01-22 | 伯乐生命医学产品有限公司 | 借助对信号的组合使用进行的多重数字分析 |
| EP2702175B1 (de) | 2011-04-25 | 2018-08-08 | Bio-Rad Laboratories, Inc. | Verfahren und zusammensetzungen zur nukleinsäureanalyse |
| EP2737089B1 (de) | 2011-07-29 | 2017-09-06 | Bio-rad Laboratories, Inc. | Bibliothekscharakterisierung durch digitalen test |
| WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
| CN110396541A (zh) * | 2019-05-07 | 2019-11-01 | 中国人民解放军联勤保障部队第九0四医院 | 精神分裂症小鼠模型海马lncRNA测序分析及试剂盒 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931270A (en) * | 1988-07-07 | 1990-06-05 | Nelson Research & Development | Method for detecting dopaminergic diseases using fluorine-18 radiolabelled D2 dopamine receptor ligands |
| JP3507884B2 (ja) * | 2000-03-07 | 2004-03-15 | 新潟大学長 | 遺伝子発現を指標とする統合失調症の客観的診断法 |
| IL137865A0 (en) * | 2000-08-15 | 2001-10-31 | Yeda Res & Dev | Method for the diagnosis and follow-up of schizophrenia |
| WO2002040661A2 (en) * | 2000-11-15 | 2002-05-23 | Deltagen, Inc. | TRANSGENIC MICE CONTAINING Kir2.3 POTASSIUM K+ CHANNEL GENE DISRUPTIONS |
| EP1348963A1 (de) * | 2002-03-28 | 2003-10-01 | Mitsubishi Pharma Corporation | Mit Schizophrenie in Zusammenhang stehendes Gen |
-
2004
- 2004-04-30 HU HU0400904A patent/HU227246B1/hu not_active IP Right Cessation
-
2005
- 2005-05-02 AT AT05741102T patent/ATE414180T1/de not_active IP Right Cessation
- 2005-05-02 DE DE602005011008T patent/DE602005011008D1/de active Active
- 2005-05-02 EP EP05741102A patent/EP1761642B1/de not_active Not-in-force
- 2005-05-02 US US11/568,467 patent/US20080274455A1/en not_active Abandoned
- 2005-05-02 WO PCT/HU2005/000044 patent/WO2005106026A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0400904A2 (en) | 2006-02-28 |
| ATE414180T1 (de) | 2008-11-15 |
| US20080274455A1 (en) | 2008-11-06 |
| WO2005106026A1 (en) | 2005-11-10 |
| HU0400904D0 (en) | 2004-07-28 |
| WO2005106026B1 (en) | 2006-01-19 |
| HU227246B1 (en) | 2010-12-28 |
| EP1761642B1 (de) | 2008-11-12 |
| EP1761642A1 (de) | 2007-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |