JP2014533949A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014533949A5 JP2014533949A5 JP2014541330A JP2014541330A JP2014533949A5 JP 2014533949 A5 JP2014533949 A5 JP 2014533949A5 JP 2014541330 A JP2014541330 A JP 2014541330A JP 2014541330 A JP2014541330 A JP 2014541330A JP 2014533949 A5 JP2014533949 A5 JP 2014533949A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- subject
- seq
- acid sequence
- unc5c
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 33
- 230000002068 genetic Effects 0.000 claims 18
- 238000006467 substitution reaction Methods 0.000 claims 18
- 206010001897 Alzheimer's disease Diseases 0.000 claims 16
- 239000003153 chemical reaction reagent Substances 0.000 claims 12
- 102100015940 UNC5C Human genes 0.000 claims 11
- 101700048854 UNC5C Proteins 0.000 claims 11
- 239000000523 sample Substances 0.000 claims 11
- 101710022769 IL6R Proteins 0.000 claims 10
- 102100008185 IL6R Human genes 0.000 claims 10
- 102100016138 NTF4 Human genes 0.000 claims 10
- 101700079360 NTF4 Proteins 0.000 claims 10
- 238000001514 detection method Methods 0.000 claims 8
- 229920000272 Oligonucleotide Polymers 0.000 claims 6
- 239000003550 marker Substances 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000004166 bioassay Methods 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 102100007877 APOE Human genes 0.000 claims 1
- 101700025839 APOE Proteins 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims 1
- 239000003298 DNA probe Substances 0.000 claims 1
- 101700080605 NUC1 Proteins 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 108020004518 RNA Probes Proteins 0.000 claims 1
- 239000003391 RNA probe Substances 0.000 claims 1
- 210000003296 Saliva Anatomy 0.000 claims 1
- 210000000582 Semen Anatomy 0.000 claims 1
- 210000002966 Serum Anatomy 0.000 claims 1
- 210000003802 Sputum Anatomy 0.000 claims 1
- 210000004243 Sweat Anatomy 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- -1 cerebrospinal fluid Substances 0.000 claims 1
- 230000004059 degradation Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000003340 mental Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 101700006494 nucA Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920002033 ribozyme Polymers 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161558197P | 2011-11-10 | 2011-11-10 | |
| US61/558,197 | 2011-11-10 | ||
| US201261671531P | 2012-07-13 | 2012-07-13 | |
| US61/671,531 | 2012-07-13 | ||
| PCT/US2012/064466 WO2013071119A2 (en) | 2011-11-10 | 2012-11-09 | Methods for treating, diagnosing and monitoring alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090050A Division JP2018166507A (ja) | 2011-11-10 | 2018-05-08 | アルツハイマー病を治療、診断、および監視するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533949A JP2014533949A (ja) | 2014-12-18 |
| JP2014533949A5 true JP2014533949A5 (de) | 2016-01-07 |
| JP6338530B2 JP6338530B2 (ja) | 2018-06-06 |
Family
ID=47222323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541330A Expired - Fee Related JP6338530B2 (ja) | 2011-11-10 | 2012-11-09 | アルツハイマー病を治療、診断、および監視するための方法 |
| JP2018090050A Pending JP2018166507A (ja) | 2011-11-10 | 2018-05-08 | アルツハイマー病を治療、診断、および監視するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090050A Pending JP2018166507A (ja) | 2011-11-10 | 2018-05-08 | アルツハイマー病を治療、診断、および監視するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20140371094A1 (de) |
| EP (1) | EP2776582A2 (de) |
| JP (2) | JP6338530B2 (de) |
| KR (1) | KR20140089384A (de) |
| CN (3) | CN105063186A (de) |
| AR (1) | AR088827A1 (de) |
| BR (1) | BR112014011127A2 (de) |
| CA (1) | CA2854779A1 (de) |
| HK (1) | HK1214631A1 (de) |
| MX (1) | MX2014005683A (de) |
| RU (1) | RU2014123511A (de) |
| WO (1) | WO2013071119A2 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10522240B2 (en) | 2006-05-03 | 2019-12-31 | Population Bio, Inc. | Evaluating genetic disorders |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| US8862410B2 (en) | 2010-08-02 | 2014-10-14 | Population Diagnostics, Inc. | Compositions and methods for discovery of causative mutations in genetic disorders |
| DK2766483T3 (da) | 2011-10-10 | 2022-04-19 | Hospital For Sick Children | Fremgangsmåder og sammensætninger til screening for og behandling af udviklingsforstyrrelser |
| EP2773779B1 (de) * | 2011-11-04 | 2020-10-14 | Population Bio, Inc. | Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen |
| DK2812452T3 (da) | 2012-02-09 | 2020-06-29 | Population Bio Inc | Fremgangsmåder og sammensætninger til screening og behandling af udviklingsforstyrrelser |
| EP2895621B1 (de) | 2012-09-14 | 2020-10-21 | Population Bio, Inc. | Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen |
| EP2900835A4 (de) | 2012-09-27 | 2016-05-11 | Population Diagnotics Inc | Verfahren und zusammensetzungen zum screening und zur behandlung von entwicklungsstörungen |
| US9782075B2 (en) | 2013-03-15 | 2017-10-10 | I2Dx, Inc. | Electronic delivery of information in personalized medicine |
| EP3077533B1 (de) * | 2013-12-06 | 2019-04-24 | Life & Brain GmbH | Verfahren zur erstellung einer klinischen prognose von erkrankungen in zusammenhang mit der bildung von aggregaten von abeta1-42 |
| CA2996445A1 (en) | 2014-09-05 | 2016-03-10 | Eli Hatchwell | Methods and compositions for inhibiting and treating neurological conditions |
| JP6485843B2 (ja) * | 2014-09-30 | 2019-03-20 | ビージーアイ シェンチェン | 関節リウマチのバイオマーカー及びその使用 |
| WO2017062867A1 (en) * | 2015-10-09 | 2017-04-13 | Helmy Eltoukhy | Population based treatment recommender using cell free dna |
| JP2017189121A (ja) * | 2016-04-11 | 2017-10-19 | 国立大学法人旭川医科大学 | 抗ＴＮＦα抗体適応疾患の治療における抗ＴＮＦα抗体投与時反応の発症リスクを判定する方法、並びに該判定用オリゴヌクレオチドキット |
| KR102024862B1 (ko) * | 2016-10-19 | 2019-09-25 | 삼성디스플레이 주식회사 | 표시 장치 |
| US11725232B2 (en) | 2016-10-31 | 2023-08-15 | The Hong Kong University Of Science And Technology | Compositions, methods and kits for detection of genetic variants for alzheimer's disease |
| US10240205B2 (en) | 2017-02-03 | 2019-03-26 | Population Bio, Inc. | Methods for assessing risk of developing a viral disease using a genetic test |
| US20200370101A1 (en) * | 2017-05-15 | 2020-11-26 | Ifomeditech Co., Ltd. | Apoe promotor snp associated with risk of alzheimer's disease and the use thereof |
| JP7112660B2 (ja) * | 2018-03-13 | 2022-08-04 | アイ２ディーエックス インコーポレイテッド | 個別化医療における情報の電子配信 |
| CN108753954B (zh) * | 2018-06-26 | 2022-11-18 | 中南大学湘雅医院 | 痴呆相关基因的捕获探针组、试剂盒、文库构建方法和用途 |
| EP3625368B8 (de) | 2018-08-08 | 2022-12-14 | PML Screening, LLC | Verfahren zur beurteilung des risikos der entwicklung von durch john-cunningham-virus verursachter progressiver multifokaler leukenzephalopathie durch genetisches testen |
| WO2020143044A1 (zh) * | 2019-01-11 | 2020-07-16 | 深圳市双科生物科技有限公司 | 一种双质控检测方法 |
| WO2020231081A1 (ko) * | 2019-05-10 | 2020-11-19 | 주식회사 엠제이브레인바이오 | Top3b 유전자 변이 기반 치매 진단방법 |
| US20220325347A1 (en) * | 2019-08-29 | 2022-10-13 | The Hong Kong University Of Science And Technology | Genetic variants for diagnosis of alzheimer's disease |
| GB202004832D0 (en) * | 2020-04-01 | 2020-05-13 | Instituto De Medicina Molecular Faculdade De Medicina Univ De Lisboa | Therapeutic agaents, pharmaceutical compositions, and associated biomarkers |
| CN112980954B (zh) * | 2021-03-03 | 2022-02-25 | 首都医科大学宣武医院 | 一种预测神经退行性疾病风险的试剂盒及其用途 |
| CN117230184B (zh) * | 2023-11-13 | 2024-03-19 | 深圳康美生物科技股份有限公司 | 基于飞行时间核酸质谱技术检测阿尔兹海默病基因的核酸组合及应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
| US4683203A (en) | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| ATE191853T1 (de) | 1992-07-27 | 2000-05-15 | Us Health | Zielgerichte liposome zur blut-hirne schranke |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| CA2255774C (en) | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| JP2004507226A (ja) | 2000-05-30 | 2004-03-11 | ピーイー コーポレイション （エヌワイ） | ライゲーションおよび増幅の組み合わせを用いて標的核酸を検出するための方法 |
| US6514221B2 (en) | 2000-07-27 | 2003-02-04 | Brigham And Women's Hospital, Inc. | Blood-brain barrier opening |
| US20030083299A1 (en) | 2000-11-04 | 2003-05-01 | Ferguson Ian A. | Non-invasive delivery of polypeptides through the blood-brain barrier |
| DE10121982B4 (de) | 2001-05-05 | 2008-01-24 | Lts Lohmann Therapie-Systeme Ag | Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| KR101111477B1 (ko) | 2002-12-03 | 2012-02-23 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 치료제와 연결된 콜레스테롤을 포함하는 접합체 |
| NZ589309A (en) * | 2008-04-29 | 2012-03-30 | Pharnext | New therapeutic approaches for treating alzheimer disease and related disorders through a modulation of cell stress response |
| CN101812525A (zh) * | 2010-04-09 | 2010-08-25 | 南通大学 | 与ad发病相关的基因网络通路分析模型的建立方法 |
-
2012
- 2012-11-09 WO PCT/US2012/064466 patent/WO2013071119A2/en active Application Filing
- 2012-11-09 EP EP12791045.3A patent/EP2776582A2/de not_active Withdrawn
- 2012-11-09 CN CN201510445488.3A patent/CN105063186A/zh active Pending
- 2012-11-09 KR KR1020147014033A patent/KR20140089384A/ko not_active Application Discontinuation
- 2012-11-09 AR ARP120104237A patent/AR088827A1/es unknown
- 2012-11-09 JP JP2014541330A patent/JP6338530B2/ja not_active Expired - Fee Related
- 2012-11-09 CN CN201280055180.2A patent/CN103930568A/zh active Pending
- 2012-11-09 MX MX2014005683A patent/MX2014005683A/es unknown
- 2012-11-09 RU RU2014123511/10A patent/RU2014123511A/ru unknown
- 2012-11-09 CA CA2854779A patent/CA2854779A1/en not_active Abandoned
- 2012-11-09 BR BR112014011127A patent/BR112014011127A2/pt not_active IP Right Cessation
- 2012-11-09 CN CN201610369743.5A patent/CN106011243A/zh active Pending
- 2012-11-09 US US14/357,192 patent/US20140371094A1/en not_active Abandoned
-
2014
- 2014-08-06 HK HK16102579.7A patent/HK1214631A1/zh unknown
-
2018
- 2018-05-08 JP JP2018090050A patent/JP2018166507A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014533949A5 (de) | ||
| RU2014123511A (ru) | Способы лечения, диагностики и мониторинга болезни альцгеймера | |
| CN105143467B (zh) | 用于预测间质性肺炎的风险的方法 | |
| CN107475371B (zh) | 发现药物基因组生物标志物的方法 | |
| JP2008526249A5 (de) | ||
| JP2012503985A5 (de) | ||
| JP2010520745A5 (de) | ||
| JP2011528903A5 (de) | ||
| JP2010533477A5 (de) | ||
| JP2010528590A5 (de) | ||
| JP2009523411A5 (de) | ||
| JP5663491B2 (ja) | 標的核酸の検出方法 | |
| KR20110094041A (ko) | 정상 안압 녹내장 질환 감수성 유전자 및 그 이용 | |
| JP2013074888A (ja) | ＩＬ２８Ｂ（ｒｓ８０９９９１７）とＩＴＰＡ（ｒｓ１１２７３５４）の変異を検出する方法 | |
| JP2012507291A5 (de) | ||
| KR101761801B1 (ko) | 코 표현형 판단용 조성물 | |
| EP3315613B1 (de) | Verfahren und kits zur diagnose oder beurteilung des risikos von gebärmutterhalskrebs | |
| JP5322471B2 (ja) | メチル化ｄｎａの解析方法及びプライマーセット | |
| TWI579722B (zh) | 藥物不良反應風險評估方法及其裝置 | |
| WO2005038427A2 (en) | Rapid identification of viruses of the upper respiratory tract infection including sars causing coronus viruses | |
| JP6494356B2 (ja) | 非アルコール性脂肪性肝疾患及び／又は非アルコール性脂肪肝炎の発症リスク及び／又は重症化リスクの判定方法、並びに該判定用オリゴヌクレオチドキット | |
| JP5243829B2 (ja) | メチル化ｄｎａの解析方法 | |
| KR102268059B1 (ko) | 운동 민감도 예측용 조성물, 키트, 및 이를 이용한 방법 | |
| CN112662754A (zh) | 用于预测小耳畸形发生概率的组合物的应用方法 | |
| WO2012056694A1 (ja) | 乳がん発症感受性の判定方法 |