US3625214A
(en)
|
1970-05-18 |
1971-12-07 |
Alza Corp |
Drug-delivery device
|
US4906474A
(en)
|
1983-03-22 |
1990-03-06 |
Massachusetts Institute Of Technology |
Bioerodible polyanhydrides for controlled drug delivery
|
US4557508A
(en)
|
1984-04-12 |
1985-12-10 |
Cameron Iron Works, Inc. |
Tubular connector
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
US4789734A
(en)
|
1985-08-06 |
1988-12-06 |
La Jolla Cancer Research Foundation |
Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
|
US5023252A
(en)
|
1985-12-04 |
1991-06-11 |
Conrex Pharmaceutical Corporation |
Transdermal and trans-membrane delivery of drugs
|
CH671155A5
(da)
|
1986-08-18 |
1989-08-15 |
Clinical Technologies Ass |
|
US5811128A
(en)
|
1986-10-24 |
1998-09-22 |
Southern Research Institute |
Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
US5001139A
(en)
|
1987-06-12 |
1991-03-19 |
American Cyanamid Company |
Enchancers for the transdermal flux of nivadipine
|
US4992445A
(en)
|
1987-06-12 |
1991-02-12 |
American Cyanamid Co. |
Transdermal delivery of pharmaceuticals
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
GB8810400D0
(en)
|
1988-05-03 |
1988-06-08 |
Southern E |
Analysing polynucleotide sequences
|
US6054270A
(en)
|
1988-05-03 |
2000-04-25 |
Oxford Gene Technology Limited |
Analying polynucleotide sequences
|
US5700637A
(en)
|
1988-05-03 |
1997-12-23 |
Isis Innovation Limited |
Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
ATE151110T1
(de)
|
1988-09-02 |
1997-04-15 |
Protein Eng Corp |
Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
|
US5750373A
(en)
|
1990-12-03 |
1998-05-12 |
Genentech, Inc. |
Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants
|
US5776434A
(en)
|
1988-12-06 |
1998-07-07 |
Riker Laboratories, Inc. |
Medicinal aerosol formulations
|
US5744101A
(en)
|
1989-06-07 |
1998-04-28 |
Affymax Technologies N.V. |
Photolabile nucleoside protecting groups
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
US5527681A
(en)
|
1989-06-07 |
1996-06-18 |
Affymax Technologies N.V. |
Immobilized molecular synthesis of systematically substituted compounds
|
US5424186A
(en)
|
1989-06-07 |
1995-06-13 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis
|
US6040138A
(en)
|
1995-09-15 |
2000-03-21 |
Affymetrix, Inc. |
Expression monitoring by hybridization to high density oligonucleotide arrays
|
CA2045175C
(en)
|
1989-11-06 |
2003-03-18 |
Arthur I. Skoultchi |
Production of proteins using homologous recombination
|
US5252743A
(en)
|
1989-11-13 |
1993-10-12 |
Affymax Technologies N.V. |
Spatially-addressable immobilization of anti-ligands on surfaces
|
US5272071A
(en)
|
1989-12-22 |
1993-12-21 |
Applied Research Systems Ars Holding N.V. |
Method for the modification of the expression characteristics of an endogenous gene of a given cell line
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
ES2139598T3
(es)
|
1990-07-10 |
2000-02-16 |
Medical Res Council |
Procedimientos para la produccion de miembros de parejas de union especifica.
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
EP1046421B8
(en)
|
1990-12-06 |
2006-01-11 |
Affymetrix, Inc. (a Delaware Corporation) |
Methods and reagents for very large scale immobilized polymer synthesis
|
US5190029A
(en)
|
1991-02-14 |
1993-03-02 |
Virginia Commonwealth University |
Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
|
JP4146512B2
(ja)
|
1991-03-01 |
2008-09-10 |
ダイアックス コープ. |
小型タンパク質
|
DK1471142T3
(da)
|
1991-04-10 |
2009-03-09 |
Scripps Research Inst |
Heterodimere receptor-biblioteker under anvendelse af fagemider
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
US5384261A
(en)
|
1991-11-22 |
1995-01-24 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis using mechanically directed flow paths
|
US7534567B2
(en)
|
1992-03-04 |
2009-05-19 |
The Regents Of The University Of California |
Detection of nucleic acid sequence differences by comparative genomic hybridization
|
WO1993018186A1
(en)
|
1992-03-04 |
1993-09-16 |
The Regents Of The University Of California |
Comparative genomic hybridization (cgh)
|
US5541061A
(en)
|
1992-04-29 |
1996-07-30 |
Affymax Technologies N.V. |
Methods for screening factorial chemical libraries
|
US5376359A
(en)
|
1992-07-07 |
1994-12-27 |
Glaxo, Inc. |
Method of stabilizing aerosol formulations
|
US5288514A
(en)
|
1992-09-14 |
1994-02-22 |
The Regents Of The University Of California |
Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
|
US20040197774A1
(en)
|
1992-11-12 |
2004-10-07 |
Michael Wigler |
Representational approach to DNA analysis
|
CA2153391C
(en)
|
1993-01-11 |
2000-08-15 |
Kenneth Rock |
Inducing cytotoxic t lymphocyte responses
|
US5858659A
(en)
|
1995-11-29 |
1999-01-12 |
Affymetrix, Inc. |
Polymorphism detection
|
US5837832A
(en)
|
1993-06-25 |
1998-11-17 |
Affymetrix, Inc. |
Arrays of nucleic acid probes on biological chips
|
DE69433180T2
(de)
|
1993-10-26 |
2004-06-24 |
Affymetrix, Inc., Santa Clara |
Felder von nukleinsaeuresonden auf biologischen chips
|
EP0695941B1
(en)
|
1994-06-08 |
2002-07-31 |
Affymetrix, Inc. |
Method and apparatus for packaging a chip
|
US6287850B1
(en)
|
1995-06-07 |
2001-09-11 |
Affymetrix, Inc. |
Bioarray chip reaction apparatus and its manufacture
|
US6300063B1
(en)
|
1995-11-29 |
2001-10-09 |
Affymetrix, Inc. |
Polymorphism detection
|
AU730633B2
(en)
|
1996-05-29 |
2001-03-08 |
Phillip Belgrader |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
|
WO1998020019A1
(en)
|
1996-11-06 |
1998-05-14 |
Sequenom, Inc. |
Compositions and methods for immobilizing nucleic acids to solid supports
|
EP0878552A1
(en)
|
1997-05-13 |
1998-11-18 |
Erasmus Universiteit Rotterdam |
Molecular detection of chromosome aberrations
|
US6210878B1
(en)
|
1997-08-08 |
2001-04-03 |
The Regents Of The University Of California |
Array-based detection of genetic alterations associated with disease
|
DK1032705T3
(da)
|
1997-10-30 |
2012-03-26 |
Cold Spring Harbor Lab |
Probearrays og fremgangsmåder til at benytte probearrays til at skelne mellem DNA
|
US6207392B1
(en)
|
1997-11-25 |
2001-03-27 |
The Regents Of The University Of California |
Semiconductor nanocrystal probes for biological applications and process for making and using such probes
|
US20090304653A1
(en)
|
1998-01-30 |
2009-12-10 |
Evolutionary Genomics, Inc. |
Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
|
US6429027B1
(en)
|
1998-12-28 |
2002-08-06 |
Illumina, Inc. |
Composite arrays utilizing microspheres
|
US20030207295A1
(en)
|
1999-04-20 |
2003-11-06 |
Kevin Gunderson |
Detection of nucleic acid reactions on bead arrays
|
AU7335400A
(en)
|
1999-08-30 |
2001-03-26 |
Human Genome Sciences, Inc. |
Attractin-like polynucleotides, polypeptides, and antibodies
|
US6423499B1
(en)
|
1999-09-10 |
2002-07-23 |
The United States Of America, As Represented By The Secretary Of Agriculture |
PCR primers for detection and identification of plant pathogenic species, subspecies, and strains of acidovorax
|
US6146834A
(en)
|
1999-09-10 |
2000-11-14 |
The United States Of America As Represented By The Secretary Of Agriculture |
PCR primers for detection of plant pathogenic species and subspecies of acidovorax
|
US7244559B2
(en)
|
1999-09-16 |
2007-07-17 |
454 Life Sciences Corporation |
Method of sequencing a nucleic acid
|
US7211390B2
(en)
|
1999-09-16 |
2007-05-01 |
454 Life Sciences Corporation |
Method of sequencing a nucleic acid
|
US7030231B1
(en)
|
1999-09-30 |
2006-04-18 |
Catalyst Biosciences, Inc. |
Membrane type serine protease 1 (MT-SP1) and uses thereof
|
US6251607B1
(en)
|
1999-12-09 |
2001-06-26 |
National Science Council Of Republic Of China |
PCR primers for the rapid and specific detection of Salmonella typhimurium
|
US6892141B1
(en)
|
2000-03-17 |
2005-05-10 |
Hitachi, Ltd. |
Primer design system
|
US20020012921A1
(en)
|
2000-01-21 |
2002-01-31 |
Stanton Vincent P. |
Identification of genetic components of drug response
|
US6828097B1
(en)
|
2000-05-16 |
2004-12-07 |
The Childrens Mercy Hospital |
Single copy genomic hybridization probes and method of generating same
|
DE60131903T2
(de)
|
2000-10-24 |
2008-11-27 |
The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto |
Direkte multiplex charakterisierung von genomischer dna
|
US20040018491A1
(en)
|
2000-10-26 |
2004-01-29 |
Kevin Gunderson |
Detection of nucleic acid reactions on bead arrays
|
AU785425B2
(en)
|
2001-03-30 |
2007-05-17 |
Genetic Technologies Limited |
Methods of genomic analysis
|
GB0113908D0
(en)
|
2001-06-07 |
2001-08-01 |
Univ London |
Designing degenerate PCR primers
|
US20030049663A1
(en)
|
2001-06-27 |
2003-03-13 |
Michael Wigler |
Use of reflections of DNA for genetic analysis
|
US6951761B2
(en)
|
2001-08-31 |
2005-10-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Measurements of multiple molecules using a CryoArray
|
US20030082606A1
(en)
|
2001-09-04 |
2003-05-01 |
Lebo Roger V. |
Optimizing genome-wide mutation analysis of chromosomes and genes
|
US6977148B2
(en)
|
2001-10-15 |
2005-12-20 |
Qiagen Gmbh |
Multiple displacement amplification
|
US6902921B2
(en)
|
2001-10-30 |
2005-06-07 |
454 Corporation |
Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
|
US20050124022A1
(en)
|
2001-10-30 |
2005-06-09 |
Maithreyan Srinivasan |
Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
|
US7107155B2
(en)
|
2001-12-03 |
2006-09-12 |
Dnaprint Genomics, Inc. |
Methods for the identification of genetic features for complex genetics classifiers
|
US6916621B2
(en)
|
2002-03-27 |
2005-07-12 |
Spectral Genomics, Inc. |
Methods for array-based comparitive binding assays
|
US7282330B2
(en)
|
2002-05-28 |
2007-10-16 |
U.S. Genomics, Inc. |
Methods and apparati using single polymer analysis
|
WO2004018633A2
(en)
|
2002-08-20 |
2004-03-04 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Healthand Human Services |
Abca13 nucleic acids and proteins, and uses thereof
|
US7011949B2
(en)
|
2002-09-30 |
2006-03-14 |
Agilent Technologies, Inc. |
Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications
|
WO2004044225A2
(en)
|
2002-11-11 |
2004-05-27 |
Affymetrix, Inc. |
Methods for identifying dna copy number changes
|
US7822555B2
(en)
|
2002-11-11 |
2010-10-26 |
Affymetrix, Inc. |
Methods for identifying DNA copy number changes
|
US10229244B2
(en)
|
2002-11-11 |
2019-03-12 |
Affymetrix, Inc. |
Methods for identifying DNA copy number changes using hidden markov model based estimations
|
CA2728746C
(en)
|
2003-01-29 |
2018-01-16 |
454 Corporation |
Methods of amplifying and sequencing nucleic acids
|
US20050021236A1
(en)
|
2003-02-14 |
2005-01-27 |
Oklahoma Medical Research Foundation And Intergenetics, Inc. |
Statistically identifying an increased risk for disease
|
NZ544235A
(en)
|
2003-05-23 |
2009-12-24 |
Cold Spring Harbor Lab |
Virtual representations of nucleotide sequences
|
US20050053980A1
(en)
|
2003-06-20 |
2005-03-10 |
Illumina, Inc. |
Methods and compositions for whole genome amplification and genotyping
|
KR100647277B1
(ko)
|
2003-08-14 |
2006-11-17 |
삼성전자주식회사 |
B형 간염 검사용 pcr 프라이머 세트 및 이를 포함하는 b형 간염 검사 키트
|
US20070141577A1
(en)
|
2003-09-11 |
2007-06-21 |
Moore Thomas F |
Method
|
US7563569B2
(en)
|
2003-10-28 |
2009-07-21 |
Michael Seul |
Optimization of gene expression analysis using immobilized capture probes
|
US7169560B2
(en)
|
2003-11-12 |
2007-01-30 |
Helicos Biosciences Corporation |
Short cycle methods for sequencing polynucleotides
|
JP2008504803A
(ja)
*
|
2004-01-09 |
2008-02-21 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
遺伝子発現の細胞型特異的パターン
|
US20050233339A1
(en)
|
2004-04-20 |
2005-10-20 |
Barrett Michael T |
Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number
|
CA2562310A1
(en)
|
2004-04-30 |
2005-11-17 |
Yale University |
Methods and compositions for cancer diagnosis
|
EP1747467A1
(en)
|
2004-05-11 |
2007-01-31 |
Bayer HealthCare AG |
Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 6 (dpp6)
|
US20060024711A1
(en)
|
2004-07-02 |
2006-02-02 |
Helicos Biosciences Corporation |
Methods for nucleic acid amplification and sequence determination
|
US20060012793A1
(en)
|
2004-07-19 |
2006-01-19 |
Helicos Biosciences Corporation |
Apparatus and methods for analyzing samples
|
US7276720B2
(en)
|
2004-07-19 |
2007-10-02 |
Helicos Biosciences Corporation |
Apparatus and methods for analyzing samples
|
US20060024678A1
(en)
|
2004-07-28 |
2006-02-02 |
Helicos Biosciences Corporation |
Use of single-stranded nucleic acid binding proteins in sequencing
|
US7595159B2
(en)
|
2004-11-03 |
2009-09-29 |
The Brigham And Women's Hospital, Inc. |
Prediction of Parkinson's disease using gene expression levels of peripheral blood samples
|
NO323175B1
(no)
|
2004-12-23 |
2007-01-15 |
Jan O Aasly |
Framgangsmate for a pavise en mutasjon som forarsaker arvelig parkinsonisme
|
CN100340674C
(zh)
|
2005-04-28 |
2007-10-03 |
中国人民解放军总医院 |
耳聋相关基因突变及其检测方法
|
DK3091462T3
(da)
|
2005-12-14 |
2020-08-31 |
Cold Spring Harbor Laboratory |
Fremgangsmåder til evaluering af probabilistiske målinger af klinisk resultat ved anvendelse af genomisk profilering
|
US20070207481A1
(en)
|
2005-12-14 |
2007-09-06 |
Michael Wigler |
Use of roma for characterizing genomic rearrangements
|
US20090191556A1
(en)
|
2006-04-12 |
2009-07-30 |
Medical Research Council |
Method
|
US7702468B2
(en)
|
2006-05-03 |
2010-04-20 |
Population Diagnostics, Inc. |
Evaluating genetic disorders
|
US10522240B2
(en)
|
2006-05-03 |
2019-12-31 |
Population Bio, Inc. |
Evaluating genetic disorders
|
CN101148684A
(zh)
|
2006-09-22 |
2008-03-26 |
上海交通大学医学院附属瑞金医院 |
多发性内分泌腺瘤ii型基因突变检测的新方法
|
EP2089011A1
(en)
|
2006-10-31 |
2009-08-19 |
Janssen Pharmaceutica N.V. |
Treatment of pervasive developmental disorders
|
US20080131887A1
(en)
|
2006-11-30 |
2008-06-05 |
Stephan Dietrich A |
Genetic Analysis Systems and Methods
|
EP2674751B1
(en)
|
2006-12-14 |
2017-02-01 |
Life Technologies Corporation |
Apparatus for measuring analytes using large scale FET arrays
|
US8262900B2
(en)
|
2006-12-14 |
2012-09-11 |
Life Technologies Corporation |
Methods and apparatus for measuring analytes using large scale FET arrays
|
US20110111014A1
(en)
|
2007-06-26 |
2011-05-12 |
Parkinson's Institute |
Methods and compositions for treatment of neurological disorders
|
JP5680964B2
(ja)
|
2007-10-04 |
2015-03-04 |
ザ ホスピタル フォー シック チルドレン |
自閉症スペクトラム障害のためのバイオマーカー
|
WO2009073764A1
(en)
|
2007-12-04 |
2009-06-11 |
University Of Miami |
Molecular targets for modulating intraocular pressure and differentiation of steroid responders versus non-responders
|
US8470594B2
(en)
|
2008-04-15 |
2013-06-25 |
President And Fellows Of Harvard College |
Methods for identifying agents that affect the survival of motor neurons
|
WO2010008486A2
(en)
|
2008-06-24 |
2010-01-21 |
Parkinsons Institute |
Pluripotent cell lines and methods of use thereof
|
US7998744B2
(en)
|
2008-07-28 |
2011-08-16 |
Greenwood Genetic Center, Inc. |
Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders
|
US20100035252A1
(en)
|
2008-08-08 |
2010-02-11 |
Ion Torrent Systems Incorporated |
Methods for sequencing individual nucleic acids under tension
|
WO2010036965A2
(en)
|
2008-09-25 |
2010-04-01 |
Suregene Llc |
Genetic markers of schizophrenia endophenotypes
|
US20100137143A1
(en)
|
2008-10-22 |
2010-06-03 |
Ion Torrent Systems Incorporated |
Methods and apparatus for measuring analytes
|
CN101403008B
(zh)
|
2008-11-07 |
2011-07-27 |
北京市神经外科研究所 |
一种检测成人早衰老综合症的基因诊断试剂盒
|
CA2743542A1
(en)
|
2008-11-12 |
2010-05-20 |
University Of Utah Research Foundation |
Autism associated genetic markers
|
AU2009313759B2
(en)
|
2008-11-14 |
2016-05-12 |
The Children's Hospital Of Philadelphia |
Genetic variants underlying human cognition and methods of use thereof as diagnostic and therapeutic targets
|
WO2010083044A1
(en)
|
2009-01-16 |
2010-07-22 |
Massachusetts Institute Of Technology |
Diagnosis and treatment of autism spectrum disorders
|
ES2581178T3
(es)
|
2009-07-29 |
2016-09-01 |
Pharnext |
Nuevas herramientas de diagnóstico para enfermedad de Alzheimer
|
US20120172251A1
(en)
|
2009-09-16 |
2012-07-05 |
The Regents Of The University Of Colorado, A Body Corporate |
Methods and compositions for diagnosing heart failure
|
US8187811B2
(en)
|
2009-11-30 |
2012-05-29 |
23Andme, Inc. |
Polymorphisms associated with Parkinson's disease
|
US20130123124A1
(en)
|
2010-03-12 |
2013-05-16 |
Children's Medical Center Corporation |
Methods and compositions for characterizing autism spectrum disorder based on gene expression patterns
|
US20120046877A1
(en)
|
2010-07-06 |
2012-02-23 |
Life Technologies Corporation |
Systems and methods to detect copy number variation
|
DK2601609T3
(da)
|
2010-08-02 |
2017-06-06 |
Population Bio Inc |
Sammensætninger og fremgangsmåder til opdagelse af mutationer, der forårsager genetiske forstyrrelser
|
EP2608274A1
(en)
|
2010-08-17 |
2013-06-26 |
Toppan Printing Co., Ltd. |
Ink for production of compound semiconductor thin film, compound semiconductor thin film produced using the ink, solar cell equipped with the compound semiconductor thin film, and process for production of the solar cell
|
CA2807505A1
(en)
|
2010-08-24 |
2012-03-01 |
The Children's Hospital Of Philadelphia |
Association of rare recurrent genetic variations to attention-deficit, hyperactivity disorder (adhd) and methods of use thereof for the diagnosis and treatment of the same
|
CA2744424A1
(en)
|
2010-09-14 |
2012-03-14 |
The Hospital For Sick Children |
Biomarkers for autism spectrum disorders
|
AU2010361988A1
(en)
|
2010-10-07 |
2013-05-02 |
Integragen Sa |
Compositions and methods for diagnosing autism
|
US10221454B2
(en)
|
2011-10-10 |
2019-03-05 |
The Hospital For Sick Children |
Methods and compositions for screening and treating developmental disorders
|
EP2773779B1
(en)
|
2011-11-04 |
2020-10-14 |
Population Bio, Inc. |
Methods and compositions for diagnosing, prognosing, and treating neurological conditions
|
MX2014005683A
(es)
|
2011-11-10 |
2015-01-22 |
Genentech Inc |
Metodos para tratar, diagnosticar y vigilar enfermedad de alzheimer.
|
EP2812452B1
(en)
|
2012-02-09 |
2020-05-27 |
Population Bio, Inc. |
Methods and compositions for screening and treating developmental disorders
|
DK2895621T3
(da)
|
2012-09-14 |
2020-11-30 |
Population Bio Inc |
Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
|
US10233495B2
(en)
|
2012-09-27 |
2019-03-19 |
The Hospital For Sick Children |
Methods and compositions for screening and treating developmental disorders
|
JP2016031772A
(ja)
|
2014-07-30 |
2016-03-07 |
株式会社日立ハイテクファインシステムズ |
熱アシスト磁気ヘッド素子の検査方法及びその装置
|