CY1109106T1 - Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων - Google Patents
Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνωνInfo
- Publication number
- CY1109106T1 CY1109106T1 CY20091100569T CY091100569T CY1109106T1 CY 1109106 T1 CY1109106 T1 CY 1109106T1 CY 20091100569 T CY20091100569 T CY 20091100569T CY 091100569 T CY091100569 T CY 091100569T CY 1109106 T1 CY1109106 T1 CY 1109106T1
- Authority
- CY
- Cyprus
- Prior art keywords
- diseases
- protein
- conference
- primary diagnosis
- pathogenic
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Περιγράφεται μια μέθοδος για τη διάγνωση ή την ανίχνευση των ασθενειών διαταραχής διαμόρφωσης πρωτεϊνών μέσω εξέτασης ενός δείκτη (του παθογόνου διαμορφωτή) τέτοιου είδους ασθενειών μέσα σε ένα δείγμα, η οποία μέθοδος περιλαμβάνει ένα σύστημα κυκλικής διεύρυνσης ώστε να αυξήσει τα επίπεδα του παθογόνου διαμορφωτή ο οποίος προκαλεί τέτοιου είδους ασθένειες. Συγκεκριμένα, τέτοιου είδους μεταδιδόμενες ασθένειες διαταραχής διαμόρφωσης πρωτεϊνών μπορεί να είναι εγκεφαλοπάθειες από πριόνες (prion encephalopathies). Επίσης περιέχονται δοκιμασίες, διαγνωστικά κιτία και συσκευές βασιζόμενες σε αυτού του είδους τις μεθόδους.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00114650 | 2000-07-07 | ||
EP00127892 | 2000-12-20 | ||
EP01102732 | 2001-02-07 | ||
EP06015975A EP1712920B1 (en) | 2000-07-07 | 2001-06-13 | Early diagnosis of conformational diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109106T1 true CY1109106T1 (el) | 2014-07-02 |
Family
ID=27223071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100569T CY1109106T1 (el) | 2000-07-07 | 2009-05-28 | Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων |
Country Status (31)
Country | Link |
---|---|
US (1) | US7351526B2 (el) |
EP (2) | EP1712920B1 (el) |
JP (1) | JP4790966B2 (el) |
KR (1) | KR100764981B1 (el) |
CN (1) | CN1221807C (el) |
AR (1) | AR029583A1 (el) |
AT (2) | ATE335204T1 (el) |
AU (2) | AU2001264089B2 (el) |
BG (1) | BG66272B1 (el) |
BR (1) | BRPI0112262B8 (el) |
CA (1) | CA2413078C (el) |
CY (1) | CY1109106T1 (el) |
CZ (1) | CZ304365B6 (el) |
DE (2) | DE60138146D1 (el) |
DK (2) | DK1712920T3 (el) |
EA (1) | EA007391B1 (el) |
EE (1) | EE05675B1 (el) |
ES (2) | ES2264691T3 (el) |
HK (1) | HK1058065A1 (el) |
HR (1) | HRP20030033B1 (el) |
HU (1) | HU228813B1 (el) |
IL (2) | IL153824A0 (el) |
MX (1) | MXPA03000226A (el) |
NO (1) | NO331624B1 (el) |
NZ (1) | NZ523213A (el) |
PL (1) | PL211154B1 (el) |
PT (2) | PT1299729E (el) |
RS (1) | RS51523B (el) |
SI (2) | SI1299729T1 (el) |
SK (1) | SK287768B6 (el) |
WO (1) | WO2002004954A2 (el) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002073210A1 (de) * | 2001-03-13 | 2002-09-19 | Manfred Eigen | Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten |
US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
US7166471B2 (en) | 2001-05-31 | 2007-01-23 | Arete Associates | Misfolded protein sensor method in body fluids |
WO2004111652A1 (en) | 2003-06-19 | 2004-12-23 | Applied Research Systems Ars Holding N.V. | Use of prion conversion modulating agents |
DE10328125A1 (de) * | 2003-06-23 | 2005-01-13 | Roche Diagnostics Gmbh | Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion |
DE10328830A1 (de) * | 2003-06-26 | 2005-01-20 | Roche Diagnostics Gmbh | Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion |
US20070054322A1 (en) * | 2003-07-31 | 2007-03-08 | Hadasit Medical Research Services & Development Lt | Methods and kits for the detection of prion diseases |
US7439041B2 (en) | 2003-08-13 | 2008-10-21 | Novartis Vaccines And Diagnostics, Inc. | Prion-specific peptide reagents |
US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
JP4568840B2 (ja) * | 2004-12-28 | 2010-10-27 | 国立大学法人金沢大学 | アルツハイマー病の検査方法 |
US8372593B2 (en) * | 2005-02-15 | 2013-02-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
CN101218510A (zh) * | 2005-04-20 | 2008-07-09 | 得克萨斯系统大学评议会 | 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒 |
EP1731911A1 (fr) * | 2005-06-07 | 2006-12-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Procédé utile pour la détection d'encéphalopathies |
DE102005031429A1 (de) * | 2005-07-04 | 2007-01-11 | Heinrich-Heine-Universität Düsseldorf | Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen |
WO2007030804A1 (en) | 2005-09-09 | 2007-03-15 | Novartis Ag | Prion-specific peptoid reagents |
US20070281367A1 (en) | 2006-05-03 | 2007-12-06 | Applera Corporation | Methods, Compositions, and Kits for Quantitating Antibodies |
JP5097206B2 (ja) * | 2006-07-28 | 2012-12-12 | エイディーライフ インコーポレイティッド | 診断および治療のためのペプチドプローブ |
EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS |
EP2179293B1 (en) * | 2007-07-20 | 2014-09-03 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Detection of infectious prion protein by seeded conversion of recombinant prion protein |
FR2929290B1 (fr) * | 2008-03-27 | 2010-05-07 | Lfb Biotechnologies | Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel |
EP2280029A4 (en) | 2008-05-28 | 2014-10-01 | Inc Admin Agency Naro | METHOD FOR EFFICIENT AMPLIFICATION OF ABNORMAL PRION PROTEIN DERIVED FROM BSE |
JP5209711B2 (ja) | 2008-05-28 | 2013-06-12 | 独立行政法人農業・食品産業技術総合研究機構 | 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法 |
ITMI20081052A1 (it) * | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
FR2935711A1 (fr) * | 2008-09-05 | 2010-03-12 | Lfb Biotechnologies | Clone cellulaire stable exprimant un prion |
EP2496947A1 (en) * | 2009-11-04 | 2012-09-12 | Novartis AG | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
US9910049B2 (en) | 2014-09-11 | 2018-03-06 | Amprion, Inc. | Detection of misfolded amyloid beta protein |
US10215763B2 (en) * | 2010-05-18 | 2019-02-26 | Board Of Regents Of The University Of Texas System | Methods for estimating prion concentration in fluids and tissue by quantitative PMCA |
US11249092B2 (en) | 2017-05-16 | 2022-02-15 | Amprion, Inc. | Detection of misfolded tau protein |
IT1405762B1 (it) | 2010-11-25 | 2014-01-24 | Icgeb | Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio |
JP6109077B2 (ja) * | 2011-01-18 | 2017-04-05 | アメリカ合衆国 | プリオンの増幅および検出のための方法 |
FR2973114A1 (fr) | 2011-03-21 | 2012-09-28 | Ets Francais Du Sang | Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc |
WO2013056841A1 (en) | 2011-10-19 | 2013-04-25 | Inra (Institut National De La Recherche Agronomique) | A method for diagnosing tse |
WO2015160007A1 (ko) * | 2014-04-17 | 2015-10-22 | 한림대학교 산학협력단 | 극미량 병원성 프리온 단백질 검출방법 및 장치 |
WO2016040905A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded alpha synuclein protein |
SG11201701953RA (en) | 2014-09-11 | 2017-04-27 | Univ Texas | Detection of misfolded proteins |
US10359434B2 (en) | 2014-10-22 | 2019-07-23 | Colorado State University Research Foundation | In vitro detection of prions in blood |
WO2016149537A1 (en) | 2015-03-17 | 2016-09-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains |
WO2019222554A2 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of brain injury or neurological disease using tau protein |
US11598783B1 (en) | 2019-10-23 | 2023-03-07 | Colorado State University Research Foundation | In vitro detection of prions |
WO2021198098A1 (en) * | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262332A (en) * | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
US5616871A (en) * | 1995-09-28 | 1997-04-01 | Drummond Scientific Company | Pipet gun assembly |
US5750361A (en) * | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
AU4711597A (en) * | 1996-10-15 | 1998-05-11 | D-Gen Limited | Diagnosis of spongiform encephalopathy |
JP2003531356A (ja) | 1999-06-29 | 2003-10-21 | マクギル ユニバーシティー | プリオンタンパク質結合タンパク質及びそれらの使用 |
JP2003517848A (ja) * | 1999-12-10 | 2003-06-03 | ミソニクス インコーポレイテッド | 超音波角アッセンブリ |
CN101218510A (zh) * | 2005-04-20 | 2008-07-09 | 得克萨斯系统大学评议会 | 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒 |
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2001
- 2001-06-13 US US10/332,370 patent/US7351526B2/en not_active Expired - Lifetime
- 2001-06-13 CA CA2413078A patent/CA2413078C/en not_active Expired - Lifetime
- 2001-06-13 SK SK1858-2002A patent/SK287768B6/sk not_active IP Right Cessation
- 2001-06-13 KR KR1020027018065A patent/KR100764981B1/ko active IP Right Grant
- 2001-06-13 BR BRPI0112262A patent/BRPI0112262B8/pt not_active IP Right Cessation
- 2001-06-13 PL PL360397A patent/PL211154B1/pl unknown
- 2001-06-13 WO PCT/GB2001/002584 patent/WO2002004954A2/en active IP Right Grant
- 2001-06-13 SI SI200130612T patent/SI1299729T1/sl unknown
- 2001-06-13 HU HU0301020A patent/HU228813B1/hu unknown
- 2001-06-13 AT AT01938411T patent/ATE335204T1/de active
- 2001-06-13 PT PT01938411T patent/PT1299729E/pt unknown
- 2001-06-13 DK DK06015975T patent/DK1712920T3/da active
- 2001-06-13 EE EEP200300005A patent/EE05675B1/xx unknown
- 2001-06-13 CN CNB018149200A patent/CN1221807C/zh not_active Expired - Lifetime
- 2001-06-13 SI SI200130918T patent/SI1712920T1/sl unknown
- 2001-06-13 MX MXPA03000226A patent/MXPA03000226A/es active IP Right Grant
- 2001-06-13 EP EP06015975A patent/EP1712920B1/en not_active Expired - Lifetime
- 2001-06-13 ES ES01938411T patent/ES2264691T3/es not_active Expired - Lifetime
- 2001-06-13 ES ES06015975T patent/ES2322660T3/es not_active Expired - Lifetime
- 2001-06-13 CZ CZ2003-36A patent/CZ304365B6/cs not_active IP Right Cessation
- 2001-06-13 DK DK01938411T patent/DK1299729T3/da active
- 2001-06-13 DE DE60138146T patent/DE60138146D1/de not_active Expired - Lifetime
- 2001-06-13 AT AT06015975T patent/ATE426816T1/de active
- 2001-06-13 IL IL15382401A patent/IL153824A0/xx unknown
- 2001-06-13 PT PT06015975T patent/PT1712920E/pt unknown
- 2001-06-13 EA EA200300126A patent/EA007391B1/ru not_active IP Right Cessation
- 2001-06-13 AU AU2001264089A patent/AU2001264089B2/en not_active Expired
- 2001-06-13 AU AU6408901A patent/AU6408901A/xx active Pending
- 2001-06-13 NZ NZ523213A patent/NZ523213A/en not_active IP Right Cessation
- 2001-06-13 JP JP2002509773A patent/JP4790966B2/ja not_active Expired - Lifetime
- 2001-06-13 DE DE60121958T patent/DE60121958T2/de not_active Expired - Lifetime
- 2001-06-13 EP EP01938411A patent/EP1299729B1/en not_active Expired - Lifetime
- 2001-06-13 RS YUP-1012/02A patent/RS51523B/sr unknown
- 2001-07-06 AR ARP010103239A patent/AR029583A1/es active IP Right Grant
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2003
- 2003-01-06 NO NO20030059A patent/NO331624B1/no not_active IP Right Cessation
- 2003-01-07 IL IL153824A patent/IL153824A/en active IP Right Grant
- 2003-01-20 HR HR20030033A patent/HRP20030033B1/xx not_active IP Right Cessation
- 2003-01-24 BG BG107498A patent/BG66272B1/bg unknown
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2004
- 2004-02-09 HK HK04100841A patent/HK1058065A1/xx not_active IP Right Cessation
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2009
- 2009-05-28 CY CY20091100569T patent/CY1109106T1/el unknown
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