CY1109106T1 - Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων - Google Patents

Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων

Info

Publication number
CY1109106T1
CY1109106T1 CY20091100569T CY091100569T CY1109106T1 CY 1109106 T1 CY1109106 T1 CY 1109106T1 CY 20091100569 T CY20091100569 T CY 20091100569T CY 091100569 T CY091100569 T CY 091100569T CY 1109106 T1 CY1109106 T1 CY 1109106T1
Authority
CY
Cyprus
Prior art keywords
diseases
protein
conference
primary diagnosis
pathogenic
Prior art date
Application number
CY20091100569T
Other languages
English (en)
Inventor
Claudio Soto-Jaro
Gabriela Saborio
Original Assignee
Merck Serono S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono S.A. filed Critical Merck Serono S.A.
Publication of CY1109106T1 publication Critical patent/CY1109106T1/el

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφεται μια μέθοδος για τη διάγνωση ή την ανίχνευση των ασθενειών διαταραχής διαμόρφωσης πρωτεϊνών μέσω εξέτασης ενός δείκτη (του παθογόνου διαμορφωτή) τέτοιου είδους ασθενειών μέσα σε ένα δείγμα, η οποία μέθοδος περιλαμβάνει ένα σύστημα κυκλικής διεύρυνσης ώστε να αυξήσει τα επίπεδα του παθογόνου διαμορφωτή ο οποίος προκαλεί τέτοιου είδους ασθένειες. Συγκεκριμένα, τέτοιου είδους μεταδιδόμενες ασθένειες διαταραχής διαμόρφωσης πρωτεϊνών μπορεί να είναι εγκεφαλοπάθειες από πριόνες (prion encephalopathies). Επίσης περιέχονται δοκιμασίες, διαγνωστικά κιτία και συσκευές βασιζόμενες σε αυτού του είδους τις μεθόδους.
CY20091100569T 2000-07-07 2009-05-28 Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων CY1109106T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
EP06015975A EP1712920B1 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (1)

Publication Number Publication Date
CY1109106T1 true CY1109106T1 (el) 2014-07-02

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100569T CY1109106T1 (el) 2000-07-07 2009-05-28 Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων

Country Status (31)

Country Link
US (1) US7351526B2 (el)
EP (2) EP1712920B1 (el)
JP (1) JP4790966B2 (el)
KR (1) KR100764981B1 (el)
CN (1) CN1221807C (el)
AR (1) AR029583A1 (el)
AT (2) ATE335204T1 (el)
AU (2) AU2001264089B2 (el)
BG (1) BG66272B1 (el)
BR (1) BRPI0112262B8 (el)
CA (1) CA2413078C (el)
CY (1) CY1109106T1 (el)
CZ (1) CZ304365B6 (el)
DE (2) DE60138146D1 (el)
DK (2) DK1712920T3 (el)
EA (1) EA007391B1 (el)
EE (1) EE05675B1 (el)
ES (2) ES2264691T3 (el)
HK (1) HK1058065A1 (el)
HR (1) HRP20030033B1 (el)
HU (1) HU228813B1 (el)
IL (2) IL153824A0 (el)
MX (1) MXPA03000226A (el)
NO (1) NO331624B1 (el)
NZ (1) NZ523213A (el)
PL (1) PL211154B1 (el)
PT (2) PT1299729E (el)
RS (1) RS51523B (el)
SI (2) SI1299729T1 (el)
SK (1) SK287768B6 (el)
WO (1) WO2002004954A2 (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US7166471B2 (en) 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
WO2004111652A1 (en) 2003-06-19 2004-12-23 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US7439041B2 (en) 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
WO2007030804A1 (en) 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
EP2074222A4 (en) * 2006-09-06 2010-03-03 Univ Texas METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS
EP2179293B1 (en) * 2007-07-20 2014-09-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
EP2280029A4 (en) 2008-05-28 2014-10-01 Inc Admin Agency Naro METHOD FOR EFFICIENT AMPLIFICATION OF ABNORMAL PRION PROTEIN DERIVED FROM BSE
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
EP2496947A1 (en) * 2009-11-04 2012-09-12 Novartis AG Positively charged species as binding reagents in the separation of protein aggregates from monomers
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US11249092B2 (en) 2017-05-16 2022-02-15 Amprion, Inc. Detection of misfolded tau protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
JP6109077B2 (ja) * 2011-01-18 2017-04-05 アメリカ合衆国 プリオンの増幅および検出のための方法
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
SG11201701953RA (en) 2014-09-11 2017-04-27 Univ Texas Detection of misfolded proteins
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
AU4711597A (en) * 1996-10-15 1998-05-11 D-Gen Limited Diagnosis of spongiform encephalopathy
JP2003531356A (ja) 1999-06-29 2003-10-21 マクギル ユニバーシティー プリオンタンパク質結合タンパク質及びそれらの使用
JP2003517848A (ja) * 1999-12-10 2003-06-03 ミソニクス インコーポレイテッド 超音波角アッセンブリ
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒

Also Published As

Publication number Publication date
ES2322660T3 (es) 2009-06-24
CN1221807C (zh) 2005-10-05
AU6408901A (en) 2002-01-21
NO20030059L (no) 2003-03-07
HUP0301020A3 (en) 2010-03-29
IL153824A (en) 2010-02-17
MXPA03000226A (es) 2004-05-21
WO2002004954A3 (en) 2002-10-24
YU101202A (sh) 2006-01-16
JP4790966B2 (ja) 2011-10-12
AR029583A1 (es) 2003-07-02
US20050064505A1 (en) 2005-03-24
EP1299729B1 (en) 2006-08-02
SK287768B6 (sk) 2011-09-05
BRPI0112262B8 (pt) 2021-07-27
DK1299729T3 (da) 2006-12-04
EE200300005A (et) 2004-08-16
SK18582002A3 (sk) 2003-05-02
DE60121958D1 (de) 2006-09-14
HRP20030033B1 (en) 2008-04-30
DE60138146D1 (de) 2009-05-07
BRPI0112262B1 (pt) 2016-08-09
DE60121958T2 (de) 2007-02-01
KR20030036257A (ko) 2003-05-09
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
HU228813B1 (en) 2013-05-28
PT1299729E (pt) 2006-10-31
US7351526B2 (en) 2008-04-01
PL360397A1 (en) 2004-09-06
CZ200336A3 (cs) 2003-06-18
EE05675B1 (et) 2013-08-15
NZ523213A (en) 2005-01-28
HK1058065A1 (en) 2004-04-30
BG107498A (bg) 2003-11-28
EP1712920B1 (en) 2009-03-25
HRP20030033A2 (en) 2004-02-29
IL153824A0 (en) 2003-07-31
ES2264691T3 (es) 2007-01-16
SI1299729T1 (sl) 2006-10-31
JP2004503748A (ja) 2004-02-05
RS51523B (sr) 2011-06-30
NO331624B1 (no) 2012-02-06
WO2002004954A2 (en) 2002-01-17
PT1712920E (pt) 2009-04-09
CN1449497A (zh) 2003-10-15
EP1299729A2 (en) 2003-04-09
SI1712920T1 (sl) 2009-10-31
DK1712920T3 (da) 2009-05-11
EP1712920A1 (en) 2006-10-18
CA2413078C (en) 2010-08-03
PL211154B1 (pl) 2012-04-30
AU2001264089B2 (en) 2006-03-30
BG66272B1 (bg) 2012-11-30
ATE335204T1 (de) 2006-08-15
CA2413078A1 (en) 2002-01-17
KR100764981B1 (ko) 2007-10-09
EA200300126A1 (ru) 2003-06-26
NO20030059D0 (no) 2003-01-06
CZ304365B6 (cs) 2014-04-02
ATE426816T1 (de) 2009-04-15
BR0112262A (pt) 2003-05-20

Similar Documents

Publication Publication Date Title
CY1109106T1 (el) Εγκαιρη διαγνωση ασθενειων διαταραχης διαμορφωσης πρωτεϊνων
CY1117631T1 (el) Ανιχνευση της χρησης κανναβεως
TW200512457A (en) Method of diagnosing SARS corona virus infection
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
CY1107358T1 (el) Μεθοδος για τη διαγνωση της ιδιοπαθους σκολιωσης εφηβων και σχετικων συνδρομων
EA201400710A1 (ru) Способы детекции признаков заболеваний или состояний в жидкостях организма
ATE406578T1 (de) Candida-nachweis
CY1110948T1 (el) Μεθοδος διαγνωσης lawsonia intracellularis
BR112022011312A2 (pt) Análise de um analito disposto dentro de um meio
GB2384903A (en) Method and device for speech analysis
ES2570627T3 (es) Ensayo in vitro de Ezrina para el diagnóstico del cáncer colorrectal
EA202092087A1 (ru) Анализы для выявления нейродегенеративных заболеваний
BR0202561A (pt) Dispositivo e método de avaliação de desempenho de canto
WO2021207209A3 (en) Peptides for detection and differentiation of antibody responses to sars-cov-2 and other human corona viruses
ES2141249T3 (es) Procedimiento para la identificacion de celulas humanas y animales que presentan la capacidad para una proliferacion ilimitada o para una formacion de tumores.
Kurabi et al. Active transport of peptides across the intact human tympanic membrane
RU2008123384A (ru) БИОМАРКЕРЫ ДЛЯ ЛЕЧЕНИЯ АНТИТЕЛОМ к Nogo-A ПРИ ПОВРЕЖДЕНИЯХ СПИННОГО МОЗГА
ATE484765T1 (de) Vorrichtung und verfahren zur messung optischer eigenschaften eines objekts
Stefanidou et al. Fundamental Issues in Forensic Semen Detection.
DE69713146D1 (de) Helicobacter pylori diagnostika
DE60014064D1 (de) Einetenascin-c isoform als marker für neoplasmen
CY1106349T1 (el) Συστηματα ανιχνευσης ανοσοπροσδιορισμου ιικου αντιγονου ηπατιτιδας c
JP2007053926A (ja) 光毒性の高感度検出方法及び光毒性検出用キット
EA199901001A1 (ru) Бетаины, используемые в качестве адъювантов для проверки чувствительности и антимикробной терапии
BR0209172A (pt) Método de detecção de doenças induzidas por glúten em uma amostra sanguìnea de um indivìduo, e kit teste para uso no método