RS51523B - Rana dijagnoza konformacionih bolesti - Google Patents

Rana dijagnoza konformacionih bolesti

Info

Publication number
RS51523B
RS51523B YUP-1012/02A YUP101202A RS51523B RS 51523 B RS51523 B RS 51523B YU P101202 A YUP101202 A YU P101202A RS 51523 B RS51523 B RS 51523B
Authority
RS
Serbia
Prior art keywords
pathogenic conformer
conformer
sample
conformational
disease
Prior art date
Application number
YUP-1012/02A
Other languages
English (en)
Inventor
Claudio Soto
Gabriella Saborio
Original Assignee
Laboratoires Serono Sa.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa. filed Critical Laboratoires Serono Sa.
Publication of YU101202A publication Critical patent/YU101202A/sh
Publication of RS51523B publication Critical patent/RS51523B/sr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Postupak za dijagnozu ili detekciju konformacijske bolesti koja se odlikuje konformacijskim prelaskom osnovnog proteina između nepatogenog i patogenog konformera da konformacijski prelaz može da se propagira iz patogenog konformera do nepatogenog konformera testiranjem markera pomenute bolesti u uzorku, gde taj postupak obuhvata:(i) kontakt navedenog uzorka sa određenom količinom nepatogenog konformera(ii) razlaganje svih eventualnih agregata koji su se mogli stvoriti tokom koraka (i); i(iii) određivanje prisustva i/ili količine navedenog patogenog konformera u uzorku, gde je taj patogeni konformer marker prisustva pomenute bolesti,naznačen time, da korak (i) obuhvata korak (ia) inkubacije navedenog uzorka/nepatogenog konformera, a koraci (ia) i (ii) čine ciklus koji se ponavlja najmanje dva puta pre nego što se obavi korak (iii).Prijava sadrži još 5 nezavisnih i 8 zavisnih patentnih zahteva.
YUP-1012/02A 2000-07-07 2001-06-13 Rana dijagnoza konformacionih bolesti RS51523B (sr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (2)

Publication Number Publication Date
YU101202A YU101202A (sh) 2006-01-16
RS51523B true RS51523B (sr) 2011-06-30

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-1012/02A RS51523B (sr) 2000-07-07 2001-06-13 Rana dijagnoza konformacionih bolesti

Country Status (31)

Country Link
US (1) US7351526B2 (sr)
EP (2) EP1712920B1 (sr)
JP (1) JP4790966B2 (sr)
KR (1) KR100764981B1 (sr)
CN (1) CN1221807C (sr)
AR (1) AR029583A1 (sr)
AT (2) ATE426816T1 (sr)
AU (2) AU2001264089B2 (sr)
BG (1) BG66272B1 (sr)
BR (1) BRPI0112262B8 (sr)
CA (1) CA2413078C (sr)
CY (1) CY1109106T1 (sr)
CZ (1) CZ304365B6 (sr)
DE (2) DE60121958T2 (sr)
DK (2) DK1299729T3 (sr)
EA (1) EA007391B1 (sr)
EE (1) EE05675B1 (sr)
ES (2) ES2264691T3 (sr)
HK (1) HK1058065A1 (sr)
HR (1) HRP20030033B1 (sr)
HU (1) HU228813B1 (sr)
IL (2) IL153824A0 (sr)
MX (1) MXPA03000226A (sr)
NO (1) NO331624B1 (sr)
NZ (1) NZ523213A (sr)
PL (1) PL211154B1 (sr)
PT (2) PT1712920E (sr)
RS (1) RS51523B (sr)
SI (2) SI1299729T1 (sr)
SK (1) SK287768B6 (sr)
WO (1) WO2002004954A2 (sr)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
WO2004111652A1 (en) 2003-06-19 2004-12-23 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US7439041B2 (en) 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
US7834144B2 (en) 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
MX2009001079A (es) 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
EP2554996B1 (en) * 2007-07-20 2016-04-06 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
NZ589487A (en) 2008-05-28 2012-03-30 Inc Admin Agency Naro Protein misfolding cyclic amplification of prion protein performed in the presence of a polysaccharide sulfate
EP2280028B1 (en) 2008-05-28 2013-03-27 Incorporated Administrative Agency National Agriculture and Food Research Organization Method for efficiently amplifying abnormal prion protein derived from sheep scrapie
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
CA2779846A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CA2824863A1 (en) * 2011-01-18 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
WO2016040907A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded proteins
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
KR20200007945A (ko) 2017-05-16 2020-01-22 암프리온, 인코퍼레이티드 미스폴딩된 타우 단백질의 검출
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ES2134749T3 (es) * 1996-10-15 2005-03-16 D-Gen Limited Diagnostico de la encefalopatia espongiforme.
AU5778400A (en) 1999-06-29 2001-01-31 Caprion Pharmaceuticals, Inc. Prion protein binding proteins and uses thereof
CA2393607A1 (en) 1999-12-10 2001-06-28 Ronald R. Manna Ultrasonic horn assembly
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
EP1712920B1 (en) 2009-03-25
DE60138146D1 (de) 2009-05-07
ATE335204T1 (de) 2006-08-15
CN1221807C (zh) 2005-10-05
HUP0301020A3 (en) 2010-03-29
EE200300005A (et) 2004-08-16
DK1712920T3 (da) 2009-05-11
ATE426816T1 (de) 2009-04-15
NO20030059L (no) 2003-03-07
HK1058065A1 (en) 2004-04-30
NO20030059D0 (no) 2003-01-06
CZ200336A3 (cs) 2003-06-18
AU6408901A (en) 2002-01-21
EE05675B1 (et) 2013-08-15
SK287768B6 (sk) 2011-09-05
SI1712920T1 (sl) 2009-10-31
JP2004503748A (ja) 2004-02-05
HU228813B1 (en) 2013-05-28
US20050064505A1 (en) 2005-03-24
SK18582002A3 (sk) 2003-05-02
PL211154B1 (pl) 2012-04-30
ES2264691T3 (es) 2007-01-16
WO2002004954A3 (en) 2002-10-24
EA200300126A1 (ru) 2003-06-26
NZ523213A (en) 2005-01-28
CZ304365B6 (cs) 2014-04-02
BG66272B1 (bg) 2012-11-30
CN1449497A (zh) 2003-10-15
MXPA03000226A (es) 2004-05-21
DE60121958T2 (de) 2007-02-01
CY1109106T1 (el) 2014-07-02
BRPI0112262B1 (pt) 2016-08-09
AU2001264089B2 (en) 2006-03-30
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
PT1299729E (pt) 2006-10-31
JP4790966B2 (ja) 2011-10-12
BG107498A (bg) 2003-11-28
AR029583A1 (es) 2003-07-02
DK1299729T3 (da) 2006-12-04
BRPI0112262B8 (pt) 2021-07-27
EP1299729B1 (en) 2006-08-02
NO331624B1 (no) 2012-02-06
SI1299729T1 (sl) 2006-10-31
EP1712920A1 (en) 2006-10-18
DE60121958D1 (de) 2006-09-14
HRP20030033A2 (en) 2004-02-29
BR0112262A (pt) 2003-05-20
US7351526B2 (en) 2008-04-01
KR100764981B1 (ko) 2007-10-09
CA2413078C (en) 2010-08-03
EP1299729A2 (en) 2003-04-09
IL153824A (en) 2010-02-17
HRP20030033B1 (en) 2008-04-30
ES2322660T3 (es) 2009-06-24
KR20030036257A (ko) 2003-05-09
CA2413078A1 (en) 2002-01-17
YU101202A (sh) 2006-01-16
IL153824A0 (en) 2003-07-31
PL360397A1 (en) 2004-09-06
PT1712920E (pt) 2009-04-09
WO2002004954A2 (en) 2002-01-17

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