YU101202A - Rana dijagnoza konformacionih bolesti - Google Patents
Rana dijagnoza konformacionih bolestiInfo
- Publication number
- YU101202A YU101202A YU101202A YUP101202A YU101202A YU 101202 A YU101202 A YU 101202A YU 101202 A YU101202 A YU 101202A YU P101202 A YUP101202 A YU P101202A YU 101202 A YU101202 A YU 101202A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- diseases
- conformational diseases
- early diagnosis
- conformational
- pathogenic conformer
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Opisana je metoda za dijagnostiku ili otkrivanje konformacionih bolesti testiranjem markera (patogenog konformera) tih bolesti u uzorku, naznačen time da ova metoda obuhvata ciklus amplifikacionog sistema da se poveća nivo patogenog konformera koji izaziva te bolesti. Pre svega, ove prenosive konformacione bolesti mogu biti prionski encefalitisi. Otkrivaju se dijagnostički kompleti i aparat na bazi ovih metoda.[A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00114650 | 2000-07-07 | ||
EP00127892 | 2000-12-20 | ||
EP01102732 | 2001-02-07 | ||
PCT/GB2001/002584 WO2002004954A2 (en) | 2000-07-07 | 2001-06-13 | Early diagnosis of conformational diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
YU101202A true YU101202A (sh) | 2006-01-16 |
RS51523B RS51523B (sr) | 2011-06-30 |
Family
ID=27223071
Country Status (31)
Country | Link |
---|---|
US (1) | US7351526B2 (sh) |
EP (2) | EP1712920B1 (sh) |
JP (1) | JP4790966B2 (sh) |
KR (1) | KR100764981B1 (sh) |
CN (1) | CN1221807C (sh) |
AR (1) | AR029583A1 (sh) |
AT (2) | ATE426816T1 (sh) |
AU (2) | AU2001264089B2 (sh) |
BG (1) | BG66272B1 (sh) |
BR (1) | BRPI0112262B8 (sh) |
CA (1) | CA2413078C (sh) |
CY (1) | CY1109106T1 (sh) |
CZ (1) | CZ304365B6 (sh) |
DE (2) | DE60138146D1 (sh) |
DK (2) | DK1712920T3 (sh) |
EA (1) | EA007391B1 (sh) |
EE (1) | EE05675B1 (sh) |
ES (2) | ES2322660T3 (sh) |
HK (1) | HK1058065A1 (sh) |
HR (1) | HRP20030033B1 (sh) |
HU (1) | HU228813B1 (sh) |
IL (2) | IL153824A0 (sh) |
MX (1) | MXPA03000226A (sh) |
NO (1) | NO331624B1 (sh) |
NZ (1) | NZ523213A (sh) |
PL (1) | PL211154B1 (sh) |
PT (2) | PT1712920E (sh) |
RS (1) | RS51523B (sh) |
SI (2) | SI1299729T1 (sh) |
SK (1) | SK287768B6 (sh) |
WO (1) | WO2002004954A2 (sh) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002073210A1 (de) * | 2001-03-13 | 2002-09-19 | Manfred Eigen | Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten |
JP4235544B2 (ja) | 2001-05-31 | 2009-03-11 | アドライフ インコーポレーティッド | 欠陥折畳み蛋白質センサー方法 |
US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
CA2525517C (en) | 2003-06-19 | 2016-05-31 | Applied Research Systems Ars Holding N.V. | Use of prion conversion modulating agents |
DE10328125A1 (de) * | 2003-06-23 | 2005-01-13 | Roche Diagnostics Gmbh | Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion |
DE10328830A1 (de) * | 2003-06-26 | 2005-01-20 | Roche Diagnostics Gmbh | Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion |
US20070054322A1 (en) * | 2003-07-31 | 2007-03-08 | Hadasit Medical Research Services & Development Lt | Methods and kits for the detection of prion diseases |
EP1653844B1 (en) | 2003-08-13 | 2012-12-12 | Novartis Vaccines and Diagnostics, Inc. | Prion-specific peptide reagents |
US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
JP4568840B2 (ja) * | 2004-12-28 | 2010-10-27 | 国立大学法人金沢大学 | アルツハイマー病の検査方法 |
WO2006088823A2 (en) * | 2005-02-15 | 2006-08-24 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
WO2006113915A2 (en) * | 2005-04-20 | 2006-10-26 | Board Of Regents, The University Of Texas System | Ultrasensitive detection of prions by automated protein misfolding cyclic amplification |
EP1731911A1 (fr) | 2005-06-07 | 2006-12-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Procédé utile pour la détection d'encéphalopathies |
DE102005031429A1 (de) * | 2005-07-04 | 2007-01-11 | Heinrich-Heine-Universität Düsseldorf | Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen |
CA2621767A1 (en) | 2005-09-09 | 2007-03-15 | Novartis Ag | Prion-specific peptoid reagents |
US20070281367A1 (en) | 2006-05-03 | 2007-12-06 | Applera Corporation | Methods, Compositions, and Kits for Quantitating Antibodies |
WO2008013859A2 (en) * | 2006-07-28 | 2008-01-31 | Adlyfe, Inc. | Peptide probes for diagnostics and therapeutics |
EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS |
EP2554996B1 (en) * | 2007-07-20 | 2016-04-06 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Detection of infectious prion protein by seeded conversion of recombinant prion protein |
FR2929290B1 (fr) * | 2008-03-27 | 2010-05-07 | Lfb Biotechnologies | Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel |
US20110124843A1 (en) | 2008-05-28 | 2011-05-26 | Incorporated Administrative Agency National Agriculture And Food Research Organization | Method for efficiently amplifying abnormal prion protein derived from bse |
JP5209711B2 (ja) | 2008-05-28 | 2013-06-12 | 独立行政法人農業・食品産業技術総合研究機構 | 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法 |
ITMI20081052A1 (it) * | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
FR2935711A1 (fr) * | 2008-09-05 | 2010-03-12 | Lfb Biotechnologies | Clone cellulaire stable exprimant un prion |
JP2013510297A (ja) * | 2009-11-04 | 2013-03-21 | ノバルティス アーゲー | モノマーからのタンパク質凝集体の分離における結合試薬としての正に荷電した種 |
US10989718B2 (en) | 2014-09-11 | 2021-04-27 | Amprion, Inc. | Detection of misfolded alpha synuclein protein |
US10215763B2 (en) * | 2010-05-18 | 2019-02-26 | Board Of Regents Of The University Of Texas System | Methods for estimating prion concentration in fluids and tissue by quantitative PMCA |
IT1405762B1 (it) | 2010-11-25 | 2014-01-24 | Icgeb | Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio |
CA2824863A1 (en) * | 2011-01-18 | 2012-07-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for amplification and detection of prions |
FR2973114A1 (fr) | 2011-03-21 | 2012-09-28 | Ets Francais Du Sang | Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc |
WO2013056841A1 (en) | 2011-10-19 | 2013-04-25 | Inra (Institut National De La Recherche Agronomique) | A method for diagnosing tse |
KR101483438B1 (ko) * | 2014-04-17 | 2015-01-16 | 한림대학교 산학협력단 | 극미량 병원성 프리온 단백질 검출방법 및 장치 |
WO2016040903A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded amyloid beta protein |
MX2017003269A (es) | 2014-09-11 | 2017-12-04 | Univ Texas | Detección de las proteínas mal plegadas. |
US10359434B2 (en) | 2014-10-22 | 2019-07-23 | Colorado State University Research Foundation | In vitro detection of prions in blood |
WO2016149537A1 (en) | 2015-03-17 | 2016-09-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains |
EP3635393A4 (en) | 2017-05-16 | 2021-03-10 | Claudio Soto-Jara | DETECTION OF MISFOLDED TAU PROTEIN |
US20190353669A1 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of Brain Injury or Neurological Disease using Tau Protein |
US11598783B1 (en) | 2019-10-23 | 2023-03-07 | Colorado State University Research Foundation | In vitro detection of prions |
WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5262332A (en) * | 1989-04-05 | 1993-11-16 | Brigham And Women's Hospital | Diagnostic method for Alzheimer's disease: examination of non-neural tissue |
US5616871A (en) * | 1995-09-28 | 1997-04-01 | Drummond Scientific Company | Pipet gun assembly |
US5750361A (en) * | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
CA2268904A1 (en) * | 1996-10-15 | 1998-04-23 | Imperial College Of Science, Technology And Medicine | Diagnosis of spongiform encephalopathy |
EP1210110A4 (en) * | 1999-06-29 | 2003-03-19 | Univ Mcgill | PROTEINS BINDING TO PRION PROTEIN AND THEIR USE |
CA2393607A1 (en) * | 1999-12-10 | 2001-06-28 | Ronald R. Manna | Ultrasonic horn assembly |
WO2006113915A2 (en) * | 2005-04-20 | 2006-10-26 | Board Of Regents, The University Of Texas System | Ultrasensitive detection of prions by automated protein misfolding cyclic amplification |
-
2001
- 2001-06-13 EA EA200300126A patent/EA007391B1/ru not_active IP Right Cessation
- 2001-06-13 RS YUP-1012/02A patent/RS51523B/sr unknown
- 2001-06-13 AT AT06015975T patent/ATE426816T1/de active
- 2001-06-13 CN CNB018149200A patent/CN1221807C/zh not_active Expired - Lifetime
- 2001-06-13 EE EEP200300005A patent/EE05675B1/xx unknown
- 2001-06-13 DK DK06015975T patent/DK1712920T3/da active
- 2001-06-13 MX MXPA03000226A patent/MXPA03000226A/es active IP Right Grant
- 2001-06-13 BR BRPI0112262A patent/BRPI0112262B8/pt not_active IP Right Cessation
- 2001-06-13 JP JP2002509773A patent/JP4790966B2/ja not_active Expired - Lifetime
- 2001-06-13 DK DK01938411T patent/DK1299729T3/da active
- 2001-06-13 EP EP06015975A patent/EP1712920B1/en not_active Expired - Lifetime
- 2001-06-13 US US10/332,370 patent/US7351526B2/en not_active Expired - Lifetime
- 2001-06-13 PT PT06015975T patent/PT1712920E/pt unknown
- 2001-06-13 SI SI200130612T patent/SI1299729T1/sl unknown
- 2001-06-13 ES ES06015975T patent/ES2322660T3/es not_active Expired - Lifetime
- 2001-06-13 HU HU0301020A patent/HU228813B1/hu unknown
- 2001-06-13 WO PCT/GB2001/002584 patent/WO2002004954A2/en active IP Right Grant
- 2001-06-13 IL IL15382401A patent/IL153824A0/xx unknown
- 2001-06-13 SI SI200130918T patent/SI1712920T1/sl unknown
- 2001-06-13 KR KR1020027018065A patent/KR100764981B1/ko active IP Right Grant
- 2001-06-13 NZ NZ523213A patent/NZ523213A/en not_active IP Right Cessation
- 2001-06-13 ES ES01938411T patent/ES2264691T3/es not_active Expired - Lifetime
- 2001-06-13 PL PL360397A patent/PL211154B1/pl unknown
- 2001-06-13 CA CA2413078A patent/CA2413078C/en not_active Expired - Lifetime
- 2001-06-13 SK SK1858-2002A patent/SK287768B6/sk not_active IP Right Cessation
- 2001-06-13 DE DE60138146T patent/DE60138146D1/de not_active Expired - Lifetime
- 2001-06-13 AT AT01938411T patent/ATE335204T1/de active
- 2001-06-13 PT PT01938411T patent/PT1299729E/pt unknown
- 2001-06-13 AU AU2001264089A patent/AU2001264089B2/en not_active Expired
- 2001-06-13 CZ CZ2003-36A patent/CZ304365B6/cs not_active IP Right Cessation
- 2001-06-13 EP EP01938411A patent/EP1299729B1/en not_active Expired - Lifetime
- 2001-06-13 DE DE60121958T patent/DE60121958T2/de not_active Expired - Lifetime
- 2001-06-13 AU AU6408901A patent/AU6408901A/xx active Pending
- 2001-07-06 AR ARP010103239A patent/AR029583A1/es active IP Right Grant
-
2003
- 2003-01-06 NO NO20030059A patent/NO331624B1/no not_active IP Right Cessation
- 2003-01-07 IL IL153824A patent/IL153824A/en active IP Right Grant
- 2003-01-20 HR HR20030033A patent/HRP20030033B1/xx not_active IP Right Cessation
- 2003-01-24 BG BG107498A patent/BG66272B1/bg unknown
-
2004
- 2004-02-09 HK HK04100841A patent/HK1058065A1/xx not_active IP Right Cessation
-
2009
- 2009-05-28 CY CY20091100569T patent/CY1109106T1/el unknown
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