ATE426816T1 - Fruhdiagnose von konformationellen erkrankungen - Google Patents

Fruhdiagnose von konformationellen erkrankungen

Info

Publication number
ATE426816T1
ATE426816T1 AT06015975T AT06015975T ATE426816T1 AT E426816 T1 ATE426816 T1 AT E426816T1 AT 06015975 T AT06015975 T AT 06015975T AT 06015975 T AT06015975 T AT 06015975T AT E426816 T1 ATE426816 T1 AT E426816T1
Authority
AT
Austria
Prior art keywords
early diagnosis
conformational diseases
conformational
diseases
diagnosis
Prior art date
Application number
AT06015975T
Other languages
English (en)
Inventor
Claudio Soto-Jaro
Gabriela Saborio
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Application granted granted Critical
Publication of ATE426816T1 publication Critical patent/ATE426816T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06015975T 2000-07-07 2001-06-13 Fruhdiagnose von konformationellen erkrankungen ATE426816T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07

Publications (1)

Publication Number Publication Date
ATE426816T1 true ATE426816T1 (de) 2009-04-15

Family

ID=27223071

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06015975T ATE426816T1 (de) 2000-07-07 2001-06-13 Fruhdiagnose von konformationellen erkrankungen
AT01938411T ATE335204T1 (de) 2000-07-07 2001-06-13 Frühdiagnose von konformationellen erkrankungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01938411T ATE335204T1 (de) 2000-07-07 2001-06-13 Frühdiagnose von konformationellen erkrankungen

Country Status (31)

Country Link
US (1) US7351526B2 (de)
EP (2) EP1712920B1 (de)
JP (1) JP4790966B2 (de)
KR (1) KR100764981B1 (de)
CN (1) CN1221807C (de)
AR (1) AR029583A1 (de)
AT (2) ATE426816T1 (de)
AU (2) AU2001264089B2 (de)
BG (1) BG66272B1 (de)
BR (1) BRPI0112262B8 (de)
CA (1) CA2413078C (de)
CY (1) CY1109106T1 (de)
CZ (1) CZ304365B6 (de)
DE (2) DE60121958T2 (de)
DK (2) DK1299729T3 (de)
EA (1) EA007391B1 (de)
EE (1) EE05675B1 (de)
ES (2) ES2264691T3 (de)
HK (1) HK1058065A1 (de)
HR (1) HRP20030033B1 (de)
HU (1) HU228813B1 (de)
IL (2) IL153824A0 (de)
MX (1) MXPA03000226A (de)
NO (1) NO331624B1 (de)
NZ (1) NZ523213A (de)
PL (1) PL211154B1 (de)
PT (2) PT1712920E (de)
RS (1) RS51523B (de)
SI (2) SI1299729T1 (de)
SK (1) SK287768B6 (de)
WO (1) WO2002004954A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
WO2004111652A1 (en) 2003-06-19 2004-12-23 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US7439041B2 (en) 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (de) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Verfahren zum Nachweis von Enzephalopathien
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
US7834144B2 (en) 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
MX2009001079A (es) 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
EP2554996B1 (de) * 2007-07-20 2016-04-06 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Nachweis eines infektiösen Prionenproteins mittels beimpfter Umwandlung eines rekombinanten Prionenproteins
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
NZ589487A (en) 2008-05-28 2012-03-30 Inc Admin Agency Naro Protein misfolding cyclic amplification of prion protein performed in the presence of a polysaccharide sulfate
EP2280028B1 (de) 2008-05-28 2013-03-27 Incorporated Administrative Agency National Agriculture and Food Research Organization Verfahren zur effizienten amplifizierung von aus scrapie abgeleiteten abnormalen prionproteinen
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
CA2779846A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CA2824863A1 (en) * 2011-01-18 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
WO2016040907A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded proteins
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
KR20200007945A (ko) 2017-05-16 2020-01-22 암프리온, 인코퍼레이티드 미스폴딩된 타우 단백질의 검출
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
ES2134749T3 (es) * 1996-10-15 2005-03-16 D-Gen Limited Diagnostico de la encefalopatia espongiforme.
AU5778400A (en) 1999-06-29 2001-01-31 Caprion Pharmaceuticals, Inc. Prion protein binding proteins and uses thereof
CA2393607A1 (en) 1999-12-10 2001-06-28 Ronald R. Manna Ultrasonic horn assembly
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
EP1712920B1 (de) 2009-03-25
DE60138146D1 (de) 2009-05-07
ATE335204T1 (de) 2006-08-15
CN1221807C (zh) 2005-10-05
HUP0301020A3 (en) 2010-03-29
EE200300005A (et) 2004-08-16
DK1712920T3 (da) 2009-05-11
NO20030059L (no) 2003-03-07
HK1058065A1 (en) 2004-04-30
NO20030059D0 (no) 2003-01-06
RS51523B (sr) 2011-06-30
CZ200336A3 (cs) 2003-06-18
AU6408901A (en) 2002-01-21
EE05675B1 (et) 2013-08-15
SK287768B6 (sk) 2011-09-05
SI1712920T1 (sl) 2009-10-31
JP2004503748A (ja) 2004-02-05
HU228813B1 (en) 2013-05-28
US20050064505A1 (en) 2005-03-24
SK18582002A3 (sk) 2003-05-02
PL211154B1 (pl) 2012-04-30
ES2264691T3 (es) 2007-01-16
WO2002004954A3 (en) 2002-10-24
EA200300126A1 (ru) 2003-06-26
NZ523213A (en) 2005-01-28
CZ304365B6 (cs) 2014-04-02
BG66272B1 (bg) 2012-11-30
CN1449497A (zh) 2003-10-15
MXPA03000226A (es) 2004-05-21
DE60121958T2 (de) 2007-02-01
CY1109106T1 (el) 2014-07-02
BRPI0112262B1 (pt) 2016-08-09
AU2001264089B2 (en) 2006-03-30
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
PT1299729E (pt) 2006-10-31
JP4790966B2 (ja) 2011-10-12
BG107498A (bg) 2003-11-28
AR029583A1 (es) 2003-07-02
DK1299729T3 (da) 2006-12-04
BRPI0112262B8 (pt) 2021-07-27
EP1299729B1 (de) 2006-08-02
NO331624B1 (no) 2012-02-06
SI1299729T1 (sl) 2006-10-31
EP1712920A1 (de) 2006-10-18
DE60121958D1 (de) 2006-09-14
HRP20030033A2 (en) 2004-02-29
BR0112262A (pt) 2003-05-20
US7351526B2 (en) 2008-04-01
KR100764981B1 (ko) 2007-10-09
CA2413078C (en) 2010-08-03
EP1299729A2 (de) 2003-04-09
IL153824A (en) 2010-02-17
HRP20030033B1 (en) 2008-04-30
ES2322660T3 (es) 2009-06-24
KR20030036257A (ko) 2003-05-09
CA2413078A1 (en) 2002-01-17
YU101202A (sh) 2006-01-16
IL153824A0 (en) 2003-07-31
PL360397A1 (en) 2004-09-06
PT1712920E (pt) 2009-04-09
WO2002004954A2 (en) 2002-01-17

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