DK1712920T3 - Tidlig diagnose af konformationelle sygdomme - Google Patents

Tidlig diagnose af konformationelle sygdomme

Info

Publication number
DK1712920T3
DK1712920T3 DK06015975T DK06015975T DK1712920T3 DK 1712920 T3 DK1712920 T3 DK 1712920T3 DK 06015975 T DK06015975 T DK 06015975T DK 06015975 T DK06015975 T DK 06015975T DK 1712920 T3 DK1712920 T3 DK 1712920T3
Authority
DK
Denmark
Prior art keywords
early diagnosis
conformational diseases
conformational
diseases
diagnosis
Prior art date
Application number
DK06015975T
Other languages
English (en)
Inventor
Claudio Soto-Jaro
Gabriela Saborio
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of DK1712920T3 publication Critical patent/DK1712920T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases
DK06015975T 2000-07-07 2001-06-13 Tidlig diagnose af konformationelle sygdomme DK1712920T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (1)

Publication Number Publication Date
DK1712920T3 true DK1712920T3 (da) 2009-05-11

Family

ID=27223071

Family Applications (2)

Application Number Title Priority Date Filing Date
DK06015975T DK1712920T3 (da) 2000-07-07 2001-06-13 Tidlig diagnose af konformationelle sygdomme
DK01938411T DK1299729T3 (da) 2000-07-07 2001-06-13 Tidlig diagnosticering af konformationelle sygdomme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01938411T DK1299729T3 (da) 2000-07-07 2001-06-13 Tidlig diagnosticering af konformationelle sygdomme

Country Status (31)

Country Link
US (1) US7351526B2 (da)
EP (2) EP1712920B1 (da)
JP (1) JP4790966B2 (da)
KR (1) KR100764981B1 (da)
CN (1) CN1221807C (da)
AR (1) AR029583A1 (da)
AT (2) ATE335204T1 (da)
AU (2) AU2001264089B2 (da)
BG (1) BG66272B1 (da)
BR (1) BRPI0112262B8 (da)
CA (1) CA2413078C (da)
CY (1) CY1109106T1 (da)
CZ (1) CZ304365B6 (da)
DE (2) DE60138146D1 (da)
DK (2) DK1712920T3 (da)
EA (1) EA007391B1 (da)
EE (1) EE05675B1 (da)
ES (2) ES2322660T3 (da)
HK (1) HK1058065A1 (da)
HR (1) HRP20030033B1 (da)
HU (1) HU228813B1 (da)
IL (2) IL153824A0 (da)
MX (1) MXPA03000226A (da)
NO (1) NO331624B1 (da)
NZ (1) NZ523213A (da)
PL (1) PL211154B1 (da)
PT (2) PT1299729E (da)
RS (1) RS51523B (da)
SI (2) SI1712920T1 (da)
SK (1) SK287768B6 (da)
WO (1) WO2002004954A2 (da)

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EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2448981C (en) 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
AU2004248302B2 (en) 2003-06-19 2009-07-30 Merck Serono Sa Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
JP4709149B2 (ja) 2003-08-13 2011-06-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
MX2007009819A (es) * 2005-02-15 2007-11-07 Adlyfe Inc Metodo para detectar proteinas y priones desplegados.
WO2006113915A2 (en) * 2005-04-20 2006-10-26 Board Of Regents, The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
JP5209477B2 (ja) 2005-09-09 2013-06-12 ノバルティス アーゲー プリオンに特異的なペプトイド試薬
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
CN101802609A (zh) 2006-07-28 2010-08-11 阿德利夫股份有限公司 用于诊断和治疗的肽探针
EP2074222A4 (en) * 2006-09-06 2010-03-03 Univ Texas METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS
US8216788B2 (en) * 2007-07-20 2012-07-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
CA2725100C (en) 2008-05-28 2014-02-18 Incorporated Administrative Agency National Agriculture And Food Research Organization Method for efficiently amplifying abnormal prion protein derived from bse
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
WO2011057029A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CN103460049B (zh) * 2011-01-18 2016-08-17 美国政府(由卫生和人类服务部的部长所代表) 扩增和检测朊病毒的方法
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
KR102448128B1 (ko) 2014-09-11 2022-09-27 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 미스폴딩된 단백질의 검출
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2018213440A1 (en) 2017-05-16 2018-11-22 Amprion, Inc. Detection of misfolded tau protein
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
NZ335290A (en) * 1996-10-15 2001-08-31 D Gen Ltd Diagnosis an typing of spongiform encephalopathy (or bovine spongiform encephalopathy (BSE))
EP1210110A4 (en) * 1999-06-29 2003-03-19 Univ Mcgill PROTEINS BINDING TO PRION PROTEIN AND THEIR USE
EP1238290A1 (en) * 1999-12-10 2002-09-11 Misonix Incorporated Ultrasonic horn assembly
WO2006113915A2 (en) * 2005-04-20 2006-10-26 Board Of Regents, The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
BRPI0112262B1 (pt) 2016-08-09
ATE335204T1 (de) 2006-08-15
YU101202A (sh) 2006-01-16
SI1299729T1 (sl) 2006-10-31
EE05675B1 (et) 2013-08-15
HUP0301020A3 (en) 2010-03-29
ATE426816T1 (de) 2009-04-15
CN1221807C (zh) 2005-10-05
JP4790966B2 (ja) 2011-10-12
US20050064505A1 (en) 2005-03-24
BR0112262A (pt) 2003-05-20
WO2002004954A2 (en) 2002-01-17
CN1449497A (zh) 2003-10-15
WO2002004954A3 (en) 2002-10-24
SK287768B6 (sk) 2011-09-05
CY1109106T1 (el) 2014-07-02
BRPI0112262B8 (pt) 2021-07-27
IL153824A (en) 2010-02-17
HU228813B1 (en) 2013-05-28
IL153824A0 (en) 2003-07-31
DE60121958T2 (de) 2007-02-01
US7351526B2 (en) 2008-04-01
HUP0301020A2 (hu) 2003-07-28
DE60138146D1 (de) 2009-05-07
JP2004503748A (ja) 2004-02-05
EP1712920B1 (en) 2009-03-25
CZ304365B6 (cs) 2014-04-02
DK1299729T3 (da) 2006-12-04
DE60121958D1 (de) 2006-09-14
EE200300005A (et) 2004-08-16
CA2413078A1 (en) 2002-01-17
CZ200336A3 (cs) 2003-06-18
EP1299729A2 (en) 2003-04-09
MXPA03000226A (es) 2004-05-21
AU6408901A (en) 2002-01-21
NO20030059D0 (no) 2003-01-06
AR029583A1 (es) 2003-07-02
NZ523213A (en) 2005-01-28
NO331624B1 (no) 2012-02-06
EA007391B1 (ru) 2006-10-27
AU2001264089B2 (en) 2006-03-30
BG107498A (bg) 2003-11-28
BG66272B1 (bg) 2012-11-30
ES2264691T3 (es) 2007-01-16
SI1712920T1 (sl) 2009-10-31
HK1058065A1 (en) 2004-04-30
EP1299729B1 (en) 2006-08-02
PT1712920E (pt) 2009-04-09
ES2322660T3 (es) 2009-06-24
PT1299729E (pt) 2006-10-31
CA2413078C (en) 2010-08-03
NO20030059L (no) 2003-03-07
HRP20030033A2 (en) 2004-02-29
EP1712920A1 (en) 2006-10-18
KR100764981B1 (ko) 2007-10-09
SK18582002A3 (sk) 2003-05-02
HRP20030033B1 (en) 2008-04-30
KR20030036257A (ko) 2003-05-09
EA200300126A1 (ru) 2003-06-26
PL360397A1 (en) 2004-09-06
RS51523B (sr) 2011-06-30
PL211154B1 (pl) 2012-04-30

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