AR029583A1 - Diagnostico precoz de enfermedades de conformacion - Google Patents

Diagnostico precoz de enfermedades de conformacion

Info

Publication number
AR029583A1
AR029583A1 ARP010103239A ARP010103239A AR029583A1 AR 029583 A1 AR029583 A1 AR 029583A1 AR P010103239 A ARP010103239 A AR P010103239A AR P010103239 A ARP010103239 A AR P010103239A AR 029583 A1 AR029583 A1 AR 029583A1
Authority
AR
Argentina
Prior art keywords
diseases
conformation
early diagnosis
conformator
pathogenic
Prior art date
Application number
ARP010103239A
Other languages
English (en)
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of AR029583A1 publication Critical patent/AR029583A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un método para el diagnostico o deteccion de enfermedades de la conformacion mediante el análisis de un marcador (el conformador patogénico) de tales enfermedades en una muestra, cuyo método comprende un sistema de amplificacion cíclica para aumentar los niveles del conformador patogénico que causa tales enfermedades. En particular, tales enfermedades de la conformacion pueden ser encefalopatías de prion. También se revelan análisis, equipos de diagnostico y aparatos basados en tales métodos.
ARP010103239A 2000-07-07 2001-07-06 Diagnostico precoz de enfermedades de conformacion AR029583A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07

Publications (1)

Publication Number Publication Date
AR029583A1 true AR029583A1 (es) 2003-07-02

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103239A AR029583A1 (es) 2000-07-07 2001-07-06 Diagnostico precoz de enfermedades de conformacion

Country Status (31)

Country Link
US (1) US7351526B2 (es)
EP (2) EP1299729B1 (es)
JP (1) JP4790966B2 (es)
KR (1) KR100764981B1 (es)
CN (1) CN1221807C (es)
AR (1) AR029583A1 (es)
AT (2) ATE426816T1 (es)
AU (2) AU6408901A (es)
BG (1) BG66272B1 (es)
BR (1) BRPI0112262B8 (es)
CA (1) CA2413078C (es)
CY (1) CY1109106T1 (es)
CZ (1) CZ304365B6 (es)
DE (2) DE60138146D1 (es)
DK (2) DK1712920T3 (es)
EA (1) EA007391B1 (es)
EE (1) EE05675B1 (es)
ES (2) ES2264691T3 (es)
HK (1) HK1058065A1 (es)
HR (1) HRP20030033B1 (es)
HU (1) HU228813B1 (es)
IL (2) IL153824A0 (es)
MX (1) MXPA03000226A (es)
NO (1) NO331624B1 (es)
NZ (1) NZ523213A (es)
PL (1) PL211154B1 (es)
PT (2) PT1299729E (es)
RS (1) RS51523B (es)
SI (2) SI1299729T1 (es)
SK (1) SK287768B6 (es)
WO (1) WO2002004954A2 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
ES2401645T3 (es) * 2003-06-19 2013-04-23 Merck Serono Sa Uso de agentes moduladores de la conversión de priones
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
US20070054322A1 (en) * 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
JP4709149B2 (ja) 2003-08-13 2011-06-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
ATE528649T1 (de) * 2005-02-15 2011-10-15 Adlyfe Inc Verfahren zum nachweis falsch gefalteter proteine und prionen
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
NZ566020A (en) 2005-09-09 2012-08-31 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
WO2008013859A2 (en) 2006-07-28 2008-01-31 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
EP2179293B1 (en) * 2007-07-20 2014-09-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
CA2725100C (en) 2008-05-28 2014-02-18 Incorporated Administrative Agency National Agriculture And Food Research Organization Method for efficiently amplifying abnormal prion protein derived from bse
EP2280028B1 (en) 2008-05-28 2013-03-27 Incorporated Administrative Agency National Agriculture and Food Research Organization Method for efficiently amplifying abnormal prion protein derived from sheep scrapie
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
CA2779846A1 (en) * 2009-11-04 2011-05-12 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
US10989718B2 (en) 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CN103460049B (zh) * 2011-01-18 2016-08-17 美国政府(由卫生和人类服务部的部长所代表) 扩增和检测朊病毒的方法
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
EP3191599B1 (en) 2014-09-11 2023-08-02 Board Of Regents Of the University Of Texas System Detection of misfolded proteins
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
KR20200007945A (ko) 2017-05-16 2020-01-22 암프리온, 인코퍼레이티드 미스폴딩된 타우 단백질의 검출
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
WO1998016834A1 (en) 1996-10-15 1998-04-23 Imperial College Of Science, Technology And Medicine Diagnosis of spongiform encephalopathy
CA2376914A1 (en) 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
WO2001046714A1 (en) * 1999-12-10 2001-06-28 Misonix Incorporated Ultrasonic horn assembly
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒

Also Published As

Publication number Publication date
HK1058065A1 (en) 2004-04-30
EP1299729A2 (en) 2003-04-09
SI1712920T1 (sl) 2009-10-31
WO2002004954A3 (en) 2002-10-24
EP1712920B1 (en) 2009-03-25
CZ200336A3 (cs) 2003-06-18
SI1299729T1 (sl) 2006-10-31
DE60138146D1 (de) 2009-05-07
HU228813B1 (en) 2013-05-28
EP1712920A1 (en) 2006-10-18
PL360397A1 (en) 2004-09-06
HRP20030033A2 (en) 2004-02-29
US7351526B2 (en) 2008-04-01
ES2264691T3 (es) 2007-01-16
CY1109106T1 (el) 2014-07-02
AU6408901A (en) 2002-01-21
PL211154B1 (pl) 2012-04-30
EE05675B1 (et) 2013-08-15
EP1299729B1 (en) 2006-08-02
BRPI0112262B1 (pt) 2016-08-09
HRP20030033B1 (en) 2008-04-30
JP4790966B2 (ja) 2011-10-12
DK1299729T3 (da) 2006-12-04
EA200300126A1 (ru) 2003-06-26
CN1221807C (zh) 2005-10-05
IL153824A0 (en) 2003-07-31
SK287768B6 (sk) 2011-09-05
ATE426816T1 (de) 2009-04-15
BRPI0112262B8 (pt) 2021-07-27
ATE335204T1 (de) 2006-08-15
KR100764981B1 (ko) 2007-10-09
IL153824A (en) 2010-02-17
DE60121958T2 (de) 2007-02-01
RS51523B (sr) 2011-06-30
DE60121958D1 (de) 2006-09-14
EE200300005A (et) 2004-08-16
BR0112262A (pt) 2003-05-20
WO2002004954A2 (en) 2002-01-17
ES2322660T3 (es) 2009-06-24
SK18582002A3 (sk) 2003-05-02
NZ523213A (en) 2005-01-28
CZ304365B6 (cs) 2014-04-02
PT1299729E (pt) 2006-10-31
NO20030059L (no) 2003-03-07
JP2004503748A (ja) 2004-02-05
YU101202A (sh) 2006-01-16
NO331624B1 (no) 2012-02-06
AU2001264089B2 (en) 2006-03-30
CA2413078A1 (en) 2002-01-17
BG107498A (bg) 2003-11-28
DK1712920T3 (da) 2009-05-11
US20050064505A1 (en) 2005-03-24
MXPA03000226A (es) 2004-05-21
HUP0301020A3 (en) 2010-03-29
PT1712920E (pt) 2009-04-09
KR20030036257A (ko) 2003-05-09
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
NO20030059D0 (no) 2003-01-06
CA2413078C (en) 2010-08-03
BG66272B1 (bg) 2012-11-30
CN1449497A (zh) 2003-10-15

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