AR029581A1 - Metodos para la identificacion de combinaciones de entidades como agentes terapeuticos - Google Patents

Metodos para la identificacion de combinaciones de entidades como agentes terapeuticos

Info

Publication number
AR029581A1
AR029581A1 ARP010103237A ARP010103237A AR029581A1 AR 029581 A1 AR029581 A1 AR 029581A1 AR P010103237 A ARP010103237 A AR P010103237A AR P010103237 A ARP010103237 A AR P010103237A AR 029581 A1 AR029581 A1 AR 029581A1
Authority
AR
Argentina
Prior art keywords
entities
combinations
identification
methods
therapeutic agents
Prior art date
Application number
ARP010103237A
Other languages
English (en)
Original Assignee
Combinatorx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinatorx Inc filed Critical Combinatorx Inc
Publication of AR029581A1 publication Critical patent/AR029581A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La invencion caracteriza un método de rastreo de combinaciones de dos entidades o más, para determinar actividad biologica usando disposiciones de combinacion. El método incluye los pasos de: (a) proporcionar las entidades, (b) crear una disposicion de combinaciones de entidades, (c) proporcionar un elemento de evaluacion que incluye una o más porciones biologicas distintas, (d) poner en contacto la disposicion de combinaciones de entidades con el elemento de evaluacion, bajo condiciones que aseguren que cada entidad/elemento de evaluacion que se pone en contacto está separado de los otros, (e) detectar o medir una propiedad del elemento de evaluacion y (f) identificar combinaciones de entidades que causen un efecto sobre la propiedad el elemento de evaluacion, que es diferente del efecto de una entidad de la combinacion por si misma.
ARP010103237A 2000-07-07 2001-07-06 Metodos para la identificacion de combinaciones de entidades como agentes terapeuticos AR029581A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61183500A 2000-07-07 2000-07-07

Publications (1)

Publication Number Publication Date
AR029581A1 true AR029581A1 (es) 2003-07-02

Family

ID=24450586

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103237A AR029581A1 (es) 2000-07-07 2001-07-06 Metodos para la identificacion de combinaciones de entidades como agentes terapeuticos

Country Status (20)

Country Link
US (3) US20020019011A1 (es)
EP (2) EP1586900A3 (es)
JP (1) JP3790447B2 (es)
KR (1) KR100470825B1 (es)
CN (1) CN1452719A (es)
AR (1) AR029581A1 (es)
AT (1) ATE298424T1 (es)
AU (1) AU2001271841A1 (es)
BR (1) BR0102781A (es)
CA (1) CA2352515C (es)
DE (1) DE60111595T2 (es)
DK (1) DK1170591T3 (es)
ES (1) ES2243367T3 (es)
IL (1) IL144049A (es)
MX (1) MXPA01006914A (es)
NZ (2) NZ524186A (es)
PT (1) PT1170591E (es)
SG (1) SG148027A1 (es)
TW (1) TWI240074B (es)
WO (1) WO2002004946A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243327A1 (de) * 2001-03-19 2002-09-25 BioChip Technologies GmbH Oberfläche mit einem Muster aus Zellen und Verfahren zu deren Herstellung
TW573125B (en) * 2001-08-29 2004-01-21 Combinatorx Inc A screening system for identifying drug-drug interactions and methods of use thereof
WO2004080445A1 (en) * 2003-03-12 2004-09-23 Molecular Engines Laboratories Sa Methods and compositions for the treatment of cancer
ES2343411T3 (es) 2003-03-26 2010-07-30 Synergy Biosystems Ltd. Procedimientos para identificar agentes biologicamente activos y combinaciones sinergicas.
JP2007526438A (ja) * 2003-06-06 2007-09-13 コンビナトルックス インコーポレイテッド 組成物の組み合わせの多次元評価システムおよび方法
JP4632400B2 (ja) 2003-12-16 2011-02-16 キヤノン株式会社 細胞培養用基板、その製造方法、それを用いた細胞スクリーニング法
WO2005059086A1 (en) * 2003-12-16 2005-06-30 Canon Kabushiki Kaisha Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same
US20060040338A1 (en) * 2004-08-18 2006-02-23 Odyssey Thera, Inc. Pharmacological profiling of drugs with cell-based assays
WO2008105855A2 (en) * 2006-11-13 2008-09-04 University Of Wyoming Apparatus and method for measuring the fluorescence of large multi-cellular organisms
US20090269772A1 (en) * 2008-04-29 2009-10-29 Andrea Califano Systems and methods for identifying combinations of compounds of therapeutic interest
CN104090094A (zh) * 2013-05-28 2014-10-08 长兴化学工业股份有限公司 生物医学装置
EP3374751B1 (en) * 2015-11-13 2024-01-24 The United States of America, as represented by The Secretary, Department of Health and Human Services Fixatives and methods of use
EP3510175A4 (en) * 2016-09-08 2020-06-24 Curematch, Inc. OPTIMIZATION OF THERAPEUTIC OPTIONS IN PERSONALIZED MEDICINE
DE102020202529A1 (de) * 2020-02-27 2021-09-02 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zur Identifikation einer Wirkstoffkombination

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
CA2058252A1 (en) * 1991-03-18 1992-09-19 Linda R. Robertson Synergistic product selection test for biocides
US5885782A (en) * 1994-09-13 1999-03-23 Nce Pharmaceuticals, Inc. Synthetic antibiotics
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5756304A (en) * 1995-07-14 1998-05-26 Molecular Solutions Screening of microorganisms for bioremediation
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
US6030942A (en) * 1996-08-30 2000-02-29 The Trustees Of The University Of Pennsylvania Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
ATE322477T1 (de) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
US5992226A (en) * 1998-05-08 1999-11-30 The United States Of America As Represented By The Secretary Of The Navy Apparatus and method for measuring intermolecular interactions by atomic force microscopy
US6219674B1 (en) * 1999-11-24 2001-04-17 Classen Immunotherapies, Inc. System for creating and managing proprietary product data
US7266458B2 (en) * 2000-03-06 2007-09-04 Bioseek, Inc. BioMAP analysis

Also Published As

Publication number Publication date
NZ524186A (en) 2004-10-29
WO2002004946A2 (en) 2002-01-17
EP1170591B1 (en) 2005-06-22
PT1170591E (pt) 2005-11-30
EP1586900A2 (en) 2005-10-19
US20020019010A1 (en) 2002-02-14
DE60111595T2 (de) 2006-05-18
EP1170591A2 (en) 2002-01-09
DK1170591T3 (da) 2005-10-10
IL144049A0 (en) 2002-04-21
WO2002004946A3 (en) 2003-01-23
DE60111595D1 (de) 2005-07-28
US20020019011A1 (en) 2002-02-14
CA2352515C (en) 2007-06-19
BR0102781A (pt) 2002-03-12
IL144049A (en) 2006-12-10
MXPA01006914A (es) 2004-10-15
JP3790447B2 (ja) 2006-06-28
NZ512821A (en) 2003-05-30
SG148027A1 (en) 2008-12-31
KR20020065340A (ko) 2002-08-13
ATE298424T1 (de) 2005-07-15
EP1170591A3 (en) 2002-09-18
CA2352515A1 (en) 2002-01-07
AU2001271841A1 (en) 2002-01-21
ES2243367T3 (es) 2005-12-01
US20060177877A1 (en) 2006-08-10
TWI240074B (en) 2005-09-21
CN1452719A (zh) 2003-10-29
KR100470825B1 (ko) 2005-03-08
JP2002328124A (ja) 2002-11-15
EP1586900A3 (en) 2005-12-14

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