BR0112262A - Diagnóstico precoce de doenças conformacionais - Google Patents

Diagnóstico precoce de doenças conformacionais

Info

Publication number
BR0112262A
BR0112262A BR0112262-2A BR0112262A BR0112262A BR 0112262 A BR0112262 A BR 0112262A BR 0112262 A BR0112262 A BR 0112262A BR 0112262 A BR0112262 A BR 0112262A
Authority
BR
Brazil
Prior art keywords
diseases
early diagnosis
conformational diseases
conformational
agent
Prior art date
Application number
BR0112262-2A
Other languages
English (en)
Other versions
BRPI0112262B8 (pt
BRPI0112262B1 (pt
Inventor
Claudio Soto Jara
Gabriella Saborio
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BR0112262A publication Critical patent/BR0112262A/pt
Publication of BRPI0112262B1 publication Critical patent/BRPI0112262B1/pt
Publication of BRPI0112262B8 publication Critical patent/BRPI0112262B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DIAGNóSTICO PRECOCE DE DOENçAS CONFORMACIONAIS". A invenção descreve um processo para diagnóstico ou detecção de doenças conformacionais, realizando um teste para encontrar um marcador (o agente conformador patogênico) dessas doenças em uma amostra, processo esse que compreende um sistema de amplificação cíclica, para aumentar os níveis do agente conformador patogênico, que causa essas doenças. Particularmente, essas doenças conformacionais transmissíveis podem ser encefalopatias de príon. A invenção também descreve os testes, kits de diagnóstico e aparelhos baseados nesses métodos.
BRPI0112262A 2000-07-07 2001-06-13 processo para detecção e teste para um marcador de uma doença conformacional, kit, processo para identificar um composto, processo para detectar a presença de uma forma patogênica prp sc de proteína de príon, e aparelho BRPI0112262B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (3)

Publication Number Publication Date
BR0112262A true BR0112262A (pt) 2003-05-20
BRPI0112262B1 BRPI0112262B1 (pt) 2016-08-09
BRPI0112262B8 BRPI0112262B8 (pt) 2021-07-27

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112262A BRPI0112262B8 (pt) 2000-07-07 2001-06-13 processo para detecção e teste para um marcador de uma doença conformacional, kit, processo para identificar um composto, processo para detectar a presença de uma forma patogênica prp sc de proteína de príon, e aparelho

Country Status (31)

Country Link
US (1) US7351526B2 (pt)
EP (2) EP1712920B1 (pt)
JP (1) JP4790966B2 (pt)
KR (1) KR100764981B1 (pt)
CN (1) CN1221807C (pt)
AR (1) AR029583A1 (pt)
AT (2) ATE335204T1 (pt)
AU (2) AU6408901A (pt)
BG (1) BG66272B1 (pt)
BR (1) BRPI0112262B8 (pt)
CA (1) CA2413078C (pt)
CY (1) CY1109106T1 (pt)
CZ (1) CZ304365B6 (pt)
DE (2) DE60138146D1 (pt)
DK (2) DK1299729T3 (pt)
EA (1) EA007391B1 (pt)
EE (1) EE05675B1 (pt)
ES (2) ES2264691T3 (pt)
HK (1) HK1058065A1 (pt)
HR (1) HRP20030033B1 (pt)
HU (1) HU228813B1 (pt)
IL (2) IL153824A0 (pt)
MX (1) MXPA03000226A (pt)
NO (1) NO331624B1 (pt)
NZ (1) NZ523213A (pt)
PL (1) PL211154B1 (pt)
PT (2) PT1712920E (pt)
RS (1) RS51523B (pt)
SI (2) SI1712920T1 (pt)
SK (1) SK287768B6 (pt)
WO (1) WO2002004954A2 (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
AU2002320045B2 (en) * 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2525517C (en) * 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
EP1651964A2 (en) * 2003-07-31 2006-05-03 Hadasit Medical Research Services & Development Ltd. Methods and kits for the detection of prion diseases
WO2005016127A2 (en) 2003-08-13 2005-02-24 Chiron Corporation Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification
EP1731911A1 (fr) * 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
EP1931695B1 (en) 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
BRPI0714930A2 (pt) * 2006-07-28 2013-05-21 Adlyfe Inc sondas peptÍdicas para fins diagnàsticos e terapÊuticos
CA2662863A1 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
EP2179293B1 (en) * 2007-07-20 2014-09-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
US20110124843A1 (en) 2008-05-28 2011-05-26 Incorporated Administrative Agency National Agriculture And Food Research Organization Method for efficiently amplifying abnormal prion protein derived from bse
EP2280028B1 (en) 2008-05-28 2013-03-27 Incorporated Administrative Agency National Agriculture and Food Research Organization Method for efficiently amplifying abnormal prion protein derived from sheep scrapie
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
AU2010315133B2 (en) * 2009-11-04 2015-09-10 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
US9910049B2 (en) 2014-09-11 2018-03-06 Amprion, Inc. Detection of misfolded amyloid beta protein
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
AU2012207454B2 (en) * 2011-01-18 2016-11-17 Prionics Ag Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
BR112017004899A2 (pt) 2014-09-11 2017-12-12 Amprion Inc detecção de proteínas mal dobradas
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
EP3635393A4 (en) 2017-05-16 2021-03-10 Claudio Soto-Jara DETECTION OF MISFOLDED TAU PROTEIN
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) * 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
NZ335290A (en) * 1996-10-15 2001-08-31 D Gen Ltd Diagnosis an typing of spongiform encephalopathy (or bovine spongiform encephalopathy (BSE))
CA2376914A1 (en) * 1999-06-29 2001-01-04 Mcgill University Prion protein binding proteins and uses thereof
CA2393607A1 (en) * 1999-12-10 2001-06-28 Ronald R. Manna Ultrasonic horn assembly
US20060263767A1 (en) * 2005-04-20 2006-11-23 The Board Of Regents Of The University Of Texas System Ultrasensitive detection of prions by automated protein misfolding cyclic amplification

Also Published As

Publication number Publication date
RS51523B (sr) 2011-06-30
PL360397A1 (en) 2004-09-06
ES2264691T3 (es) 2007-01-16
DK1712920T3 (da) 2009-05-11
YU101202A (sh) 2006-01-16
SI1299729T1 (sl) 2006-10-31
KR100764981B1 (ko) 2007-10-09
NO20030059L (no) 2003-03-07
AU2001264089B2 (en) 2006-03-30
ES2322660T3 (es) 2009-06-24
EE200300005A (et) 2004-08-16
JP4790966B2 (ja) 2011-10-12
EP1299729A2 (en) 2003-04-09
WO2002004954A2 (en) 2002-01-17
BG66272B1 (bg) 2012-11-30
DE60138146D1 (de) 2009-05-07
IL153824A (en) 2010-02-17
BG107498A (bg) 2003-11-28
JP2004503748A (ja) 2004-02-05
BRPI0112262B8 (pt) 2021-07-27
DK1299729T3 (da) 2006-12-04
CN1449497A (zh) 2003-10-15
CZ200336A3 (cs) 2003-06-18
CZ304365B6 (cs) 2014-04-02
PL211154B1 (pl) 2012-04-30
NO20030059D0 (no) 2003-01-06
ATE335204T1 (de) 2006-08-15
WO2002004954A3 (en) 2002-10-24
CY1109106T1 (el) 2014-07-02
AR029583A1 (es) 2003-07-02
SK287768B6 (sk) 2011-09-05
SI1712920T1 (sl) 2009-10-31
HU228813B1 (en) 2013-05-28
CA2413078C (en) 2010-08-03
NO331624B1 (no) 2012-02-06
DE60121958D1 (de) 2006-09-14
HUP0301020A3 (en) 2010-03-29
AU6408901A (en) 2002-01-21
DE60121958T2 (de) 2007-02-01
US20050064505A1 (en) 2005-03-24
US7351526B2 (en) 2008-04-01
NZ523213A (en) 2005-01-28
HRP20030033B1 (en) 2008-04-30
ATE426816T1 (de) 2009-04-15
SK18582002A3 (sk) 2003-05-02
EA007391B1 (ru) 2006-10-27
CA2413078A1 (en) 2002-01-17
EP1712920A1 (en) 2006-10-18
CN1221807C (zh) 2005-10-05
EA200300126A1 (ru) 2003-06-26
EP1299729B1 (en) 2006-08-02
KR20030036257A (ko) 2003-05-09
EE05675B1 (et) 2013-08-15
IL153824A0 (en) 2003-07-31
HUP0301020A2 (hu) 2003-07-28
HK1058065A1 (en) 2004-04-30
HRP20030033A2 (en) 2004-02-29
BRPI0112262B1 (pt) 2016-08-09
PT1299729E (pt) 2006-10-31
MXPA03000226A (es) 2004-05-21
EP1712920B1 (en) 2009-03-25
PT1712920E (pt) 2009-04-09

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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