BR112017004899A2 - detecção de proteínas mal dobradas - Google Patents
detecção de proteínas mal dobradasInfo
- Publication number
- BR112017004899A2 BR112017004899A2 BR112017004899A BR112017004899A BR112017004899A2 BR 112017004899 A2 BR112017004899 A2 BR 112017004899A2 BR 112017004899 A BR112017004899 A BR 112017004899A BR 112017004899 A BR112017004899 A BR 112017004899A BR 112017004899 A2 BR112017004899 A2 BR 112017004899A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- misfolded
- sample
- soluble protein
- incubation mixture
- Prior art date
Links
- 238000002331 protein detection Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 10
- 108090000623 proteins and genes Proteins 0.000 abstract 10
- 238000011534 incubation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 102000029797 Prion Human genes 0.000 abstract 1
- 108091000054 Prion Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
Abstract
são fornecidos métodos e kits para amplificação e detecção de proteínas mal dobradas a partir de amostras, por exemplo, de pacientes com mal de alzheimer, mal de parkinson e similares. por exemplo, um método para a determinação da presença de uma proteína solúvel mal dobrada em uma amostra pode incluir o contato da amostra com uma proteína monomérica dobrada para formar uma mistura para incubação; realização de um ciclo de incubação duas ou mais vezes eficaz para formar uma porção amplificada da proteína mal dobrada; incubação da mistura para incubação eficaz para causar o dobramento incorreto e/ou agregação de pelo menos uma porção da proteína monomérica dobrada; rompimento físico da mistura para incubação eficaz para romper pelo menos uma porção de qualquer agregado de proteína presente; e determinação da presença da proteína solúvel mal dobrada na amostra através da detecção de pelo menos uma porção da proteína solúvel mal dobrada. a proteína monomérica dobrada e a proteína solúvel mal dobrada podem excluir a proteína príon (prp) e suas isoformas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462049306P | 2014-09-11 | 2014-09-11 | |
PCT/US2015/049844 WO2016040907A1 (en) | 2014-09-11 | 2015-09-11 | Detection of misfolded proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017004899A2 true BR112017004899A2 (pt) | 2017-12-12 |
Family
ID=55454515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017004899A BR112017004899A2 (pt) | 2014-09-11 | 2015-09-11 | detecção de proteínas mal dobradas |
Country Status (15)
Country | Link |
---|---|
US (1) | US20160077112A1 (pt) |
EP (2) | EP3191599B1 (pt) |
JP (2) | JP6980953B2 (pt) |
KR (1) | KR102448128B1 (pt) |
CN (1) | CN107208125A (pt) |
AU (1) | AU2015314783B2 (pt) |
BR (1) | BR112017004899A2 (pt) |
CA (1) | CA2960830C (pt) |
ES (1) | ES2953855T3 (pt) |
HR (1) | HRP20231232T1 (pt) |
IL (2) | IL251052B (pt) |
MX (1) | MX2017003269A (pt) |
PL (1) | PL3191599T3 (pt) |
SG (2) | SG11201701953RA (pt) |
WO (1) | WO2016040907A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11249092B2 (en) | 2017-05-16 | 2022-02-15 | Amprion, Inc. | Detection of misfolded tau protein |
WO2016040905A1 (en) | 2014-09-11 | 2016-03-17 | Board Of Regents Of The University Of Texas System | Detection of misfolded alpha synuclein protein |
GB201611840D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Court Of The Univ Of Edinburgh The | Alpha-synuclein detection assay |
KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
WO2019070480A1 (en) * | 2017-10-02 | 2019-04-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | ASSAY FOR DETECTION OF ALPHA-SYNUCLEIN SELF-ACTIVATION ACTIVITY ASSOCIATED WITH SYNUCLEINOPATHIES |
GB201720970D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
GB201720975D0 (en) | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
WO2019121952A1 (en) * | 2017-12-21 | 2019-06-27 | H. Lundbeck A/S | Assay, method and treatment of alpha-synucleinopathies |
CN108088816A (zh) * | 2018-01-23 | 2018-05-29 | 深圳市国赛生物技术有限公司 | 小型特定蛋白分析仪 |
GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
WO2019222554A2 (en) * | 2018-05-16 | 2019-11-21 | Amprion, Inc. | Detection of brain injury or neurological disease using tau protein |
EP3821434B1 (en) * | 2018-09-21 | 2024-07-24 | DeepMind Technologies Limited | Machine learning for determining protein structures |
JP7376040B2 (ja) * | 2019-09-03 | 2023-11-08 | 国立大学法人京都工芸繊維大学 | 神経変性疾患におけるバイオマーカー分子の検出方法 |
WO2021046174A1 (en) * | 2019-09-04 | 2021-03-11 | Amprion, Inc. | Alpha-synuclein detection using beads |
KR102277871B1 (ko) * | 2019-12-17 | 2021-07-15 | 원광대학교산학협력단 | 소변의 알파-씨누클레인 중합체 측정에 의한 파킨슨병 진단 정보의 수집방법 및 그 키트 |
WO2021198098A1 (en) | 2020-04-03 | 2021-10-07 | Universität Zürich | Improved method of detecting biomarkers in a biological sample |
KR20230113574A (ko) * | 2020-11-21 | 2023-07-31 | 슈원 바이오테크 컴퍼니 리미티드 | 생물학적 시료 중의 미스폴딩된 단백질을 검출하기 위한 장치 및 방법 |
US20240192230A1 (en) * | 2021-04-15 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Digital Protein Misfolding Assays |
CN114199875B (zh) * | 2022-02-18 | 2022-05-20 | 之江实验室 | 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7351526B2 (en) | 2000-07-07 | 2008-04-01 | Laboratories Serono Sa | Early diagnosis of conformational diseases |
WO2002054083A2 (en) | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
EP1820806A1 (en) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinity regions |
US8372593B2 (en) * | 2005-02-15 | 2013-02-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
US7812150B2 (en) * | 2006-05-19 | 2010-10-12 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of Aha and therapeutic uses thereof |
EP2074222A4 (en) * | 2006-09-06 | 2010-03-03 | Univ Texas | METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS |
JP2010043865A (ja) * | 2006-12-12 | 2010-02-25 | Olympus Corp | 異常型プリオンの検出方法 |
WO2011064225A1 (en) * | 2009-11-24 | 2011-06-03 | Probiodrug Ag | Novel diagnostic method for the diagnosis of alzheimer's disease or mild cgnitive impairment |
US9133343B2 (en) * | 2009-11-30 | 2015-09-15 | Enzo Biochem, Inc. | Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications |
US9910049B2 (en) * | 2014-09-11 | 2018-03-06 | Amprion, Inc. | Detection of misfolded amyloid beta protein |
JP6109077B2 (ja) * | 2011-01-18 | 2017-04-05 | アメリカ合衆国 | プリオンの増幅および検出のための方法 |
US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
-
2015
- 2015-09-11 SG SG11201701953RA patent/SG11201701953RA/en unknown
- 2015-09-11 KR KR1020177009707A patent/KR102448128B1/ko active IP Right Grant
- 2015-09-11 PL PL15839278.7T patent/PL3191599T3/pl unknown
- 2015-09-11 WO PCT/US2015/049844 patent/WO2016040907A1/en active Application Filing
- 2015-09-11 JP JP2017533721A patent/JP6980953B2/ja active Active
- 2015-09-11 US US14/852,478 patent/US20160077112A1/en not_active Abandoned
- 2015-09-11 CA CA2960830A patent/CA2960830C/en active Active
- 2015-09-11 BR BR112017004899A patent/BR112017004899A2/pt active Search and Examination
- 2015-09-11 CN CN201580058606.3A patent/CN107208125A/zh active Pending
- 2015-09-11 ES ES15839278T patent/ES2953855T3/es active Active
- 2015-09-11 MX MX2017003269A patent/MX2017003269A/es unknown
- 2015-09-11 AU AU2015314783A patent/AU2015314783B2/en active Active
- 2015-09-11 EP EP15839278.7A patent/EP3191599B1/en active Active
- 2015-09-11 SG SG10202008464UA patent/SG10202008464UA/en unknown
- 2015-09-11 EP EP23189057.5A patent/EP4292654A3/en active Pending
- 2015-09-11 HR HRP20231232TT patent/HRP20231232T1/hr unknown
-
2017
- 2017-03-09 IL IL251052A patent/IL251052B/en unknown
-
2021
- 2021-05-12 JP JP2021081274A patent/JP7104943B2/ja active Active
-
2022
- 2022-03-30 IL IL291809A patent/IL291809B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2017003269A (es) | 2017-12-04 |
US20160077112A1 (en) | 2016-03-17 |
AU2015314783B2 (en) | 2021-10-21 |
JP2017530373A (ja) | 2017-10-12 |
PL3191599T3 (pl) | 2023-12-27 |
SG10202008464UA (en) | 2020-10-29 |
EP3191599C0 (en) | 2023-08-02 |
JP6980953B2 (ja) | 2021-12-15 |
KR20170103741A (ko) | 2017-09-13 |
EP3191599B1 (en) | 2023-08-02 |
AU2015314783A1 (en) | 2017-04-27 |
IL291809B2 (en) | 2023-06-01 |
EP3191599A1 (en) | 2017-07-19 |
WO2016040907A1 (en) | 2016-03-17 |
EP4292654A2 (en) | 2023-12-20 |
SG11201701953RA (en) | 2017-04-27 |
CA2960830A1 (en) | 2016-03-17 |
CN107208125A (zh) | 2017-09-26 |
EP3191599A4 (en) | 2018-03-14 |
IL251052A0 (en) | 2017-04-30 |
CA2960830C (en) | 2023-09-05 |
IL251052B (en) | 2022-05-01 |
JP2022000629A (ja) | 2022-01-04 |
HRP20231232T1 (hr) | 2024-01-19 |
EP4292654A3 (en) | 2024-01-03 |
JP7104943B2 (ja) | 2022-07-22 |
IL291809A (en) | 2022-06-01 |
KR102448128B1 (ko) | 2022-09-27 |
ES2953855T3 (es) | 2023-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112017004899A2 (pt) | detecção de proteínas mal dobradas | |
MX2020009021A (es) | Ensayos para detectar la presencia o la cantidad de un anticuerpo antifarmaco. | |
BR112016028944A2 (pt) | kit ou dispositivo para a detecção de câncer do trato biliar e método de detecção | |
MX2021006791A (es) | Metodos y composiciones para detectar proteinas mal plegadas. | |
BR112016019836A2 (pt) | método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito | |
BR112016029521A2 (pt) | ?kit, dispositivo e método para a detecção de câncer de estômago? | |
BR112017006598A2 (pt) | anticorpo de repetições antidipeptídeo derivado de ser humano (dprs) | |
BR112017020582A2 (pt) | composições e métodos para a detecção de um contaminante biológico | |
MY187050A (en) | Cancer cell-specific antibody, anticancer agent, and cancer testing method | |
BR112018006018A2 (pt) | detecção de beta-amiloide através de espectrometria de massa | |
BR112018006843A2 (pt) | sistema de fluxo e métodos para contagem digital | |
EA201892325A1 (ru) | Композиции и способы детектирования белков клетки-хозяина | |
BR112016024730A2 (pt) | dispositivo, método e conjunto de análise imunocromatográfica | |
BR112016009460A8 (pt) | método para detectar a presença de anticorpos neutralizantes, e, kit | |
BR112018010764A2 (pt) | método para detectar atividade bacteriana em uma amostra biológica e unidade de detecção correspondente | |
BR112019005172A2 (pt) | método e kit para analisar uma amostra | |
BR112019005167A2 (pt) | método e kit para analisar uma amostra | |
PH12019550236A1 (en) | Detection of misfolded tau protein | |
BR112016024624A2 (pt) | produto de combinação para detectar marcador alvo | |
BR112017004412A2 (pt) | método para medir reatividade de fviii | |
BR112017028627A2 (pt) | dispositivo para detectar proteínas deformadas e métodos de uso mesmo | |
BR112016017901A2 (pt) | ensaio inovador para detectar periostina humana | |
WO2011109112A3 (en) | Method of detecting tau protein and tau fragments in serum | |
WO2020037250A8 (en) | Stem-loop receptor-based field-effect transistor sensor devices for small-molecule target detection under physiological salt concentrations | |
BR112016021714A2 (pt) | imunoensaio e anticorpos para a detecção de cromogranina a |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07B | Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 7.4 NA RPI NO 2544 DE 08/10/2019 POR TER SIDO INDEVIDA. |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |