PT1307457E - Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos - Google Patents

Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos

Info

Publication number
PT1307457E
PT1307457E PT01958173T PT01958173T PT1307457E PT 1307457 E PT1307457 E PT 1307457E PT 01958173 T PT01958173 T PT 01958173T PT 01958173 T PT01958173 T PT 01958173T PT 1307457 E PT1307457 E PT 1307457E
Authority
PT
Portugal
Prior art keywords
noemadamente
antibacterianos
medicines
preparation
heterocyclic compounds
Prior art date
Application number
PT01958173T
Other languages
English (en)
Inventor
Jozsef Aszodi
Claude Fromentin
Maxime Lampilas
David Alan Rowlands
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8853181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1307457(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of PT1307457E publication Critical patent/PT1307457E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT01958173T 2000-08-01 2001-07-24 Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos PT1307457E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010121A FR2812635B1 (fr) 2000-08-01 2000-08-01 Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens

Publications (1)

Publication Number Publication Date
PT1307457E true PT1307457E (pt) 2004-08-31

Family

ID=8853181

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01958173T PT1307457E (pt) 2000-08-01 2001-07-24 Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos

Country Status (42)

Country Link
US (5) US7112592B2 (pt)
EP (1) EP1307457B1 (pt)
JP (2) JP4515704B2 (pt)
KR (1) KR100632906B1 (pt)
CN (1) CN1289500C (pt)
AP (1) AP1614A (pt)
AR (1) AR031716A1 (pt)
AT (1) ATE263768T1 (pt)
AU (2) AU2001279905B2 (pt)
BG (1) BG66094B1 (pt)
BR (1) BRPI0112986B8 (pt)
CA (1) CA2417475C (pt)
CR (1) CR6895A (pt)
CZ (1) CZ294956B6 (pt)
DE (1) DE60102702T2 (pt)
DK (1) DK1307457T3 (pt)
DZ (1) DZ3397A1 (pt)
EA (1) EA004920B1 (pt)
EC (1) ECSP034460A (pt)
EE (1) EE05183B1 (pt)
ES (1) ES2220793T3 (pt)
FR (1) FR2812635B1 (pt)
HK (1) HK1060356A1 (pt)
HR (1) HRP20030034B1 (pt)
HU (1) HU226889B1 (pt)
IL (2) IL154187A0 (pt)
MA (1) MA26938A1 (pt)
ME (2) ME00060B (pt)
MX (1) MXPA03000881A (pt)
NO (1) NO324940B1 (pt)
NZ (1) NZ523707A (pt)
OA (1) OA12347A (pt)
PL (2) PL234468B1 (pt)
PT (1) PT1307457E (pt)
RS (1) RS50214B (pt)
SI (1) SI1307457T1 (pt)
SK (1) SK287597B6 (pt)
TR (1) TR200400859T4 (pt)
TW (1) TWI292401B (pt)
UA (1) UA73791C2 (pt)
WO (1) WO2002010172A1 (pt)
ZA (1) ZA200300676B (pt)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) * 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2848210B1 (fr) 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
CA2783572C (en) 2005-12-07 2016-08-09 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
BRPI0714343A2 (pt) 2006-07-13 2013-03-19 Achillion Pharmaceuticals Inc peptÍdeos de 4-amino-4-oxobutanoil como inibidores de replicaÇço viral
WO2008008398A2 (en) * 2006-07-14 2008-01-17 Shionogi & Co., Ltd. Oxime compounds and the use thereof
AU2007300531A1 (en) * 2006-09-27 2008-04-03 Merck Sharp & Dohme Corp. Novel inhibitors of beta-lactamase
AU2007309195A1 (en) * 2006-10-23 2008-05-02 Irm Llc Cathepsin proteases inhibitors
WO2008093737A1 (ja) 2007-01-31 2008-08-07 Dainippon Sumitomo Pharma Co., Ltd. アミド誘導体
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
JP5323063B2 (ja) 2007-05-31 2013-10-23 塩野義製薬株式会社 オキシイミノ化合物およびその使用
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
ES2533826T3 (es) * 2008-01-18 2015-04-15 Merck Sharp & Dohme Corp. Inhibidores de beta-lactamasa
ES2408159T3 (es) 2008-06-11 2013-06-18 Shionogi & Co., Ltd. Compuestos de oxicarbamoilo y su utilización
EP3260551A1 (en) 2008-06-19 2017-12-27 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1] octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
WO2010150840A1 (ja) 2009-06-24 2010-12-29 大日本住友製薬株式会社 N-置換-環状アミノ誘導体
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
CA2822758C (en) * 2010-12-22 2018-03-20 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivative and process for preparing the same
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
BR112013032415B1 (pt) * 2011-06-17 2021-07-27 Pfizer Anti-Infectives Ab Processos para preparar compostos e compostos
AU2012303691B2 (en) * 2011-08-27 2014-06-19 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
AU2012303693B2 (en) * 2011-08-30 2014-07-03 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan- 7 - one derivatives and their use in the treatment of bacterial infections
BR112014003476A2 (pt) * 2011-09-13 2017-03-01 Wockhardt Ltd compostos contendo nitrogênio e seu uso
US8969567B2 (en) 2011-09-13 2015-03-03 Wockhardt Ltd. Nitrogen containing compounds and their use
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
WO2013149136A1 (en) 2012-03-30 2013-10-03 Cubist Pharmaceuticals, Inc. ISOXAZOLE β-LACTAMASE INHIBITORS
US8933232B2 (en) 2012-03-30 2015-01-13 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
PL2857401T3 (pl) 2012-05-30 2020-02-28 Meiji Seika Pharma Co., Ltd. NOWY INHIBITOR ß–LAKTAMAZY I SPOSÓB JEGO WYTWARZANIA
AU2013308127B2 (en) * 2012-08-25 2015-08-13 Wockhardt Limited 1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections
EP2915805A4 (en) 2012-11-01 2016-03-23 Kaneka Corp METHOD FOR PRODUCING AN OPTICALLY ACTIVE BICYCLIC UREA COMPOUND
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
EP2889378B1 (en) 2013-02-19 2018-01-10 API Corporation Method for producing hydroxy-l-lysine employing an l-lysine hydroxylase and method for producing hydroxy-l-pipecolic acid
US9862718B2 (en) * 2013-03-08 2018-01-09 Wockhardt Limited Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation
WO2014135930A1 (en) 2013-03-08 2014-09-12 Wockhardt Limited A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
WO2014152996A1 (en) 2013-03-14 2014-09-25 Cubist Pharmaceuticals, Inc. Crystalline form of a beta-lactamase inhibitor
MX362348B (es) * 2013-06-10 2019-01-11 Merck Sharp & Dohme Preparacion de 4-((1r,2s,5r)-6-(benciloxi)-7-oxo-1,6-diazabiciclo[ 3.2.1]octano-2-carboxamido)piperidin-1-carboxilato de ter-butilo.
JP6453222B2 (ja) 2013-09-24 2019-01-16 Meiji Seikaファルマ株式会社 ジアザビシクロオクタン誘導体の製造法とその中間体
WO2015051101A1 (en) 2013-10-02 2015-04-09 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
HUE051925T2 (hu) 2013-10-08 2021-04-28 Meiji Seika Pharma Co Ltd Dizabiciklooktán származék kristályai és diazabiciklooktán származék kristályainak elõállítási eljárása
MX2016004509A (es) 2013-10-11 2016-10-28 Wockhardt Ltd Compuestos que contienen nitrogeno y su uso.
US9708336B2 (en) 2014-01-22 2017-07-18 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2015171474A1 (en) 2014-05-09 2015-11-12 Merck Sharp & Dohme Corp. Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
EA033829B1 (ru) 2014-11-17 2019-11-29 Entasis Therapeutics Ltd Комбинированная терапия для лечения устойчивых бактериальных инфекций
EP3227306B1 (en) 2014-12-02 2020-07-15 Merck Sharp & Dohme Corp. Process for the preparation of tert-butyl 4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
ES2821826T3 (es) 2014-12-05 2021-04-27 Meiji Seika Pharma Co Ltd Método para producir cristales de derivado de diazabiciclooctano y preparación liofilizada estable
US10667737B2 (en) 2015-03-23 2020-06-02 International Business Machines Corporation Monitoring a person for indications of a brain injury
AU2016257338B2 (en) * 2015-05-07 2020-03-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
EP3091018A1 (en) * 2015-05-07 2016-11-09 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2017002083A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002086A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002089A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002087A1 (en) 2015-07-02 2017-01-05 Wockhardtlimited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
EP3334734B1 (en) * 2015-08-10 2020-01-01 Sandoz AG Form c of avibactam sodium
WO2017037607A1 (en) 2015-09-01 2017-03-09 Wockhardt Limited (aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity
KR20170131661A (ko) 2015-09-16 2017-11-29 수안주 파마 코포레이션 리미티드 β-락타메이즈 억제제 및 이의 용도
CA3000087A1 (en) 2015-10-02 2017-04-06 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
EP3358016A4 (en) 2015-10-02 2018-11-14 API Corporation Method for producing hydroxy-l-pipecolic acid
WO2017081615A1 (en) 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CN106749242B (zh) * 2015-11-23 2021-04-02 上海医药工业研究院 阿维巴坦中间体的制备方法
WO2017136254A1 (en) 2016-02-04 2017-08-10 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
CN105753867B (zh) * 2016-03-24 2018-03-27 齐鲁制药有限公司 一种改进的阿维巴坦钠中间体化合物的制备方法
EP3156400B1 (en) 2016-05-27 2019-05-15 Valoralia I Más D, SL Dihydrooxadiazine compounds for treating infections and cancer
CN106279163A (zh) * 2016-08-12 2017-01-04 上海龙翔生物医药开发有限公司 一种合成阿维巴坦及其中间体光学异构体的方法
KR102482826B1 (ko) * 2016-08-26 2022-12-28 산도즈 아게 아비박탐 유리 산
WO2018053215A1 (en) 2016-09-16 2018-03-22 Entasis Therapeutics Limited Beta-lactamase inhibitor compounds
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法
AU2018216243A1 (en) * 2017-02-06 2019-08-22 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
HRP20220231T1 (hr) 2017-05-08 2022-04-29 Entasis Therapeutics, Inc. Spojevi i postupci za liječenje bakterijskih infekcija
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
WO2018234962A1 (en) 2017-06-20 2018-12-27 Wockhardt Limited PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
US11207312B2 (en) 2017-07-17 2021-12-28 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors and methods of use thereof
CA3077474A1 (en) 2017-10-02 2019-04-11 Arixa Pharmaceuticals, Inc. Aztreonam derivatives and uses thereof
CN109678856B (zh) * 2017-10-18 2020-09-25 新发药业有限公司 一种阿维巴坦中间体的制备方法
JP7289836B2 (ja) 2017-11-23 2023-06-12 エフ. ホフマン-ラ ロシュ アーゲー プロリンヒドロキシラーゼ、ならびにそれに伴う使用、方法および生成物
CN109956941B (zh) * 2017-12-25 2020-08-04 新发药业有限公司 一种阿维巴坦的简便制备方法
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
JP7437847B2 (ja) 2018-10-01 2024-02-26 アリクサ ファーマシューティカルズ、インコーポレイテッド レレバクタムの誘導体およびその使用
CN111072660B (zh) * 2018-10-22 2021-05-18 新发药业有限公司 一种瑞来巴坦的简便制备方法
JP2022524118A (ja) 2019-03-12 2022-04-27 アリクサ ファーマシューティカルズ、インコーポレイテッド アビバクタム誘導体の結晶形
US11565999B2 (en) 2019-04-25 2023-01-31 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
CN110078728B (zh) * 2019-05-23 2020-10-23 江西富祥药业股份有限公司 一种阿维巴坦中间体、制备方法及其应用
WO2021106864A1 (en) * 2019-11-25 2021-06-03 Eisai R&D Management Co., Ltd. Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4939678B1 (pt) * 1968-05-06 1974-10-28
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US4049821A (en) * 1976-05-12 1977-09-20 A. H. Robins Company, Inc. Method of treating allergy
JPS63119471A (ja) * 1986-09-02 1988-05-24 ザ・ユニバーシテイ・オブ・メルボルン 2−オキソ−4−カルボキシ−ピリミジン
EP0260057A3 (en) * 1986-09-02 1989-02-01 The University Of Melbourne 2-oxo-4-carboxy-pyrimidines
RU2124014C1 (ru) * 1993-12-29 1998-12-27 Пфайзер Инк. Диазабициклические соединения и содержащая их фармацевтическая композиция
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
AU744313B2 (en) * 1997-02-10 2002-02-21 Pfizer Products Inc. 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines
US6060585A (en) * 1997-03-04 2000-05-09 Wisconsin Alumni Research Foundation β-polypeptide foldamers of well-defined secondary structure
KR100207096B1 (ko) * 1997-07-08 1999-07-15 이명환 시사프라이드의 제조 방법
US6384080B1 (en) * 1998-04-20 2002-05-07 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
US6635657B1 (en) * 1998-12-23 2003-10-21 Eli Lilly And Company Aromatic amides
CA2358578A1 (en) * 1999-01-02 2000-07-13 Aventis Pharma Deutschland Gmbh Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor xa activity)
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

Also Published As

Publication number Publication date
HUP0302943A2 (hu) 2003-12-29
YU6303A (sh) 2006-03-03
US7112592B2 (en) 2006-09-26
BR0112986B1 (pt) 2014-04-01
TR200400859T4 (tr) 2004-06-21
ATE263768T1 (de) 2004-04-15
CN1468242A (zh) 2004-01-14
PL401469A1 (pl) 2013-02-04
ECSP034460A (es) 2003-03-10
AP1614A (en) 2006-05-21
HUP0302943A3 (en) 2007-08-28
MEP17108A (en) 2010-06-10
DK1307457T3 (da) 2004-08-09
IL154187A (en) 2009-02-11
EA200300211A1 (ru) 2003-06-26
US7638529B2 (en) 2009-12-29
HK1060356A1 (en) 2004-08-06
UA73791C2 (uk) 2005-09-15
BR0112986A (pt) 2003-07-08
CN1289500C (zh) 2006-12-13
JP2004505088A (ja) 2004-02-19
MA26938A1 (fr) 2004-12-20
EP1307457B1 (fr) 2004-04-07
DE60102702T2 (de) 2005-04-07
WO2002010172A1 (fr) 2002-02-07
KR100632906B1 (ko) 2006-10-13
EE05183B1 (et) 2009-06-15
PL234468B1 (pl) 2020-02-28
BG66094B1 (bg) 2011-04-29
HU226889B1 (en) 2010-01-28
RS50214B (sr) 2009-07-15
JP4515704B2 (ja) 2010-08-04
AU7990501A (en) 2002-02-13
AU2001279905B2 (en) 2005-12-08
DE60102702D1 (de) 2004-05-13
JP2010138206A (ja) 2010-06-24
OA12347A (fr) 2006-05-15
EP1307457A1 (fr) 2003-05-07
NO324940B1 (no) 2008-01-07
EE200300046A (et) 2004-10-15
CA2417475A1 (fr) 2002-02-07
US20030199541A1 (en) 2003-10-23
SK1052003A3 (en) 2003-11-04
EA004920B1 (ru) 2004-10-28
HRP20030034A2 (en) 2004-02-29
US20110213147A1 (en) 2011-09-01
BG107497A (bg) 2003-09-30
KR20030019642A (ko) 2003-03-06
CA2417475C (en) 2010-04-20
AP2003002726A0 (en) 2003-06-30
US7732610B2 (en) 2010-06-08
DZ3397A1 (fr) 2002-02-07
ME00060B (me) 2010-06-10
CR6895A (es) 2007-07-12
FR2812635B1 (fr) 2002-10-11
HRP20030034B1 (en) 2011-03-31
NZ523707A (en) 2005-02-25
IL154187A0 (en) 2003-07-31
PL365162A1 (en) 2004-12-27
US20060189652A1 (en) 2006-08-24
SK287597B6 (sk) 2011-03-04
CZ2003223A3 (cs) 2003-08-13
FR2812635A1 (fr) 2002-02-08
AR031716A1 (es) 2003-10-01
CZ294956B6 (cs) 2005-04-13
ES2220793T3 (es) 2004-12-16
NO20030494L (no) 2003-03-28
ZA200300676B (en) 2004-05-10
BRPI0112986B8 (pt) 2021-05-25
TWI292401B (en) 2008-01-11
US20110021772A1 (en) 2011-01-27
MXPA03000881A (es) 2003-06-06
US8178554B2 (en) 2012-05-15
US20060046995A1 (en) 2006-03-02
PL216028B1 (pl) 2014-02-28
NO20030494D0 (no) 2003-01-31
SI1307457T1 (en) 2004-08-31

Similar Documents

Publication Publication Date Title
PT1307457E (pt) Compostos heterociclicos sua preparacao e utilizacao como medicamentos noemadamente como antibacterianos
ITTO20010008A0 (it) Formulazione farmaceutica
NO20030627D0 (no) Hydrogel-drevet medikament doseringsform
NO20071303L (no) Farmasoytiske preparater
ATE392890T1 (de) Hydrogel-gesteuerte dosierungsform
DK1524266T3 (da) Farmaceutisk sammensætning
NO20025450L (no) Ny farmasöytisk sammensetning
ATE540013T1 (de) Naphthalinderivate
PT1083171E (pt) Derivados de pirazolina sua preparacao e aplicacao como medicamentos
DE60144010D1 (de) Wegwerfwindel
EE200200626A (et) Antraniilamiidid ja nende kasutamine ravimitena
DE60109968D1 (de) Wegwerfwindel
EE05020B1 (et) Glburiidi ravimkoostis
DE60029737D1 (de) Wegwerfwindel
DE60120890D1 (de) Wegwerfwindel
DE60125492D1 (de) Wegwerfwindel
PT1246816E (pt) Derivados de fenilpiperazina substituidos sua preparacao e utilizacao
DE50102752D1 (de) Fungizide wirkstoffkombinationen
DE60105927D1 (de) Wegwerfwindel
NO20014926L (no) Farmasöytiske forbindelser
DE60105232D1 (de) Wegwerfwindel
ATE366128T1 (de) Pharmazeutische zusammensetzung
DE60106165D1 (de) Wegwerfwindel
DE10196460T1 (de) Selbstzerstör-Spritze
PT1200444E (pt) Novos compostos xantona, sua preparacao e sua utilizacao como medicamento