NO20030494D0 - Nye heterosykliske forbindelser, deres fremstilling og deres anvendelse sommedikamenter, s¶rlig som antibakterielle midler - Google Patents

Nye heterosykliske forbindelser, deres fremstilling og deres anvendelse sommedikamenter, s¶rlig som antibakterielle midler

Info

Publication number
NO20030494D0
NO20030494D0 NO20030494A NO20030494A NO20030494D0 NO 20030494 D0 NO20030494 D0 NO 20030494D0 NO 20030494 A NO20030494 A NO 20030494A NO 20030494 A NO20030494 A NO 20030494A NO 20030494 D0 NO20030494 D0 NO 20030494D0
Authority
NO
Norway
Prior art keywords
drugs
preparation
antibacterial agents
heterocyclic compounds
new heterocyclic
Prior art date
Application number
NO20030494A
Other languages
English (en)
Other versions
NO324940B1 (no
NO20030494L (no
Inventor
Maxime Lampilas
Jozsef Aszodi
David Alan Rowlands
Claude Fromentin
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8853181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20030494(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20030494D0 publication Critical patent/NO20030494D0/no
Publication of NO20030494L publication Critical patent/NO20030494L/no
Publication of NO324940B1 publication Critical patent/NO324940B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20030494A 2000-08-01 2003-01-31 Nye heterosykliske forbindelser, deres fremstilling og deres anvendelse som medikamenter, saerlig som antibakterielle midler NO324940B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0010121A FR2812635B1 (fr) 2000-08-01 2000-08-01 Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
PCT/FR2001/002418 WO2002010172A1 (fr) 2000-08-01 2001-07-24 Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens

Publications (3)

Publication Number Publication Date
NO20030494D0 true NO20030494D0 (no) 2003-01-31
NO20030494L NO20030494L (no) 2003-03-28
NO324940B1 NO324940B1 (no) 2008-01-07

Family

ID=8853181

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030494A NO324940B1 (no) 2000-08-01 2003-01-31 Nye heterosykliske forbindelser, deres fremstilling og deres anvendelse som medikamenter, saerlig som antibakterielle midler

Country Status (42)

Country Link
US (5) US7112592B2 (no)
EP (1) EP1307457B1 (no)
JP (2) JP4515704B2 (no)
KR (1) KR100632906B1 (no)
CN (1) CN1289500C (no)
AP (1) AP1614A (no)
AR (1) AR031716A1 (no)
AT (1) ATE263768T1 (no)
AU (2) AU2001279905B2 (no)
BG (1) BG66094B1 (no)
BR (1) BRPI0112986B8 (no)
CA (1) CA2417475C (no)
CR (1) CR6895A (no)
CZ (1) CZ294956B6 (no)
DE (1) DE60102702T2 (no)
DK (1) DK1307457T3 (no)
DZ (1) DZ3397A1 (no)
EA (1) EA004920B1 (no)
EC (1) ECSP034460A (no)
EE (1) EE05183B1 (no)
ES (1) ES2220793T3 (no)
FR (1) FR2812635B1 (no)
HK (1) HK1060356A1 (no)
HR (1) HRP20030034B1 (no)
HU (1) HU226889B1 (no)
IL (2) IL154187A0 (no)
MA (1) MA26938A1 (no)
ME (2) ME00060B (no)
MX (1) MXPA03000881A (no)
NO (1) NO324940B1 (no)
NZ (1) NZ523707A (no)
OA (1) OA12347A (no)
PL (2) PL216028B1 (no)
PT (1) PT1307457E (no)
RS (1) RS50214B (no)
SI (1) SI1307457T1 (no)
SK (1) SK287597B6 (no)
TR (1) TR200400859T4 (no)
TW (1) TWI292401B (no)
UA (1) UA73791C2 (no)
WO (1) WO2002010172A1 (no)
ZA (1) ZA200300676B (no)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
FR2848210B1 (fr) 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
PT2308874E (pt) 2005-12-07 2013-04-26 Basilea Pharmaceutica Ag Monobactamas ligadas por pontes, úteis como inibidores de beta-lactamase
EA017448B1 (ru) 2006-07-13 2012-12-28 Ачиллион Фармасьютикалз, Инк. 4-амино-4-оксобутаноиловые пептиды как ингибиторы вирусной репликации
EP2040698A4 (en) * 2006-07-14 2011-08-10 Shionogi & Co OXIM CONNECTIONS AND ITS USE
WO2008039420A2 (en) * 2006-09-27 2008-04-03 Merck & Co., Inc. Novel inhibitors of beta-lactamase
WO2008051763A1 (en) * 2006-10-23 2008-05-02 Irm Llc Cathepsin proteases inhibitors
WO2008093737A1 (ja) 2007-01-31 2008-08-07 Dainippon Sumitomo Pharma Co., Ltd. アミド誘導体
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
WO2008150470A1 (en) 2007-05-31 2008-12-11 Shionogi & Co., Ltd. Oxyimino compounds and the use thereof
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
RU2445314C9 (ru) * 2008-01-18 2013-04-10 Мерк Шарп Энд Домэ Корп. Ингибиторы бета-лактамаз
US8518934B2 (en) 2008-06-11 2013-08-27 Shonogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
EP2921559A1 (en) 2008-06-19 2015-09-23 Astra Zeneca Holding France Use of (1r,2s,5r) 1,6-diazabicyclo [3.2.1]octane-2-carboxamide, 7-oxo-6-(sulfooxy)-, monosodium salt as a diagnostic reagent for detecting serine beta-lactamases
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
FR2951171A1 (fr) * 2009-10-09 2011-04-15 Novexel Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation
CA2822758C (en) * 2010-12-22 2018-03-20 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivative and process for preparing the same
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
US8829191B2 (en) * 2011-06-17 2014-09-09 Melanie Simone Ronsheim Processes for preparing heterocyclic compounds including trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof
DK2748165T3 (en) * 2011-08-27 2016-12-19 Wockhardt Ltd 1,6-diazabicyclo [3,2,1] octane-7-ON DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
CN103649088B (zh) * 2011-08-30 2016-05-11 沃克哈特有限公司 1, 6- 二氮杂双环[3, 2, 1]辛- 7- 酮衍生物及其在治疗细菌感染中的用途
WO2013038330A1 (en) * 2011-09-13 2013-03-21 Wockhardt Limited Nitrogen containing compounds and their use
US8969567B2 (en) 2011-09-13 2015-03-03 Wockhardt Ltd. Nitrogen containing compounds and their use
US9505761B2 (en) 2011-12-02 2016-11-29 Fedora Pharmaceuticals Inc. Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors
US8796257B2 (en) 2011-12-02 2014-08-05 Naeja Pharmaceutical Inc. Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
US8969570B2 (en) 2012-03-30 2015-03-03 Cubist Pharmaceuticals, Inc. Beta-lactamase inhibitors
SG11201406120SA (en) 2012-03-30 2014-10-30 Cubist Pharm Inc ISOXAZOLE β-LACTAMASE INHIBITORS
US8916709B2 (en) 2012-03-30 2014-12-23 Cubist Pharmaceuticals, Inc. 1,2,4-oxadiazole and 1,2,4-thiadiazole β-lactamase inhibitors
US8933232B2 (en) 2012-03-30 2015-01-13 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
AU2013268415B2 (en) * 2012-05-30 2017-05-25 Meiji Seika Pharma Co., Ltd. Novel beta-lactamase inhibitor and method for producing same
BR112015003592B1 (pt) * 2012-08-25 2020-04-14 Wockhardt Ltd derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas
US20150315145A1 (en) 2012-11-01 2015-11-05 Kaneka Corporation Process for producing optically active bicyclic urea compound
UA111925C2 (uk) 2012-12-11 2016-06-24 Федора Фармасьютікалз Інк. БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ
JP6476110B2 (ja) 2013-02-19 2019-02-27 株式会社エーピーアイ コーポレーション Ｌ−リジン水酸化酵素およびそれを利用したヒドロキシ−ｌ−リジンの製造法およびヒドロキシ−ｌ−ピペコリン酸の製造法
EP3013829A1 (en) * 2013-03-08 2016-05-04 Wockhardt Limited A process for sodium salt of (2s, 5r)-2-carboxamido-7-oxo-6-sulfooxy -1,6-diaza-bicyclo[3.2.1]octane
NZ711343A (en) * 2013-03-08 2016-07-29 Wockhardt Ltd Sodium salt of (2s, 5r)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1 ] octane-2-carboxylic acid and its preparation
WO2014152996A1 (en) 2013-03-14 2014-09-25 Cubist Pharmaceuticals, Inc. Crystalline form of a beta-lactamase inhibitor
MX362348B (es) * 2013-06-10 2019-01-11 Merck Sharp & Dohme Preparacion de 4-((1r,2s,5r)-6-(benciloxi)-7-oxo-1,6-diazabiciclo[ 3.2.1]octano-2-carboxamido)piperidin-1-carboxilato de ter-butilo.
CN105555787B (zh) 2013-09-24 2017-08-08 明治制果药业株式会社 二氮杂二环辛烷衍生物的制备方法及其中间体
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
CA2926071C (en) 2013-10-08 2021-11-09 Meiji Seika Pharma Co., Ltd. Crystalline forms of diazabicyclooctane derivative and production process thereof
CN106414444B (zh) 2013-10-11 2018-02-02 沃克哈特有限公司 含氮化合物以及它们的用途
EP3096754B1 (en) 2014-01-22 2018-08-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
US9839642B2 (en) 2014-05-09 2017-12-12 Merck Sharp & Dohme Corp. Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
MX2017006383A (es) 2014-11-17 2017-08-21 Entasis Therapeutics Ltd Terapia de combinacion para el tratamiento de infecciones bacterianas resistentes.
CN107428784B (zh) 2014-12-02 2020-08-21 默沙东公司 用于制备4-((2s,5r)-6-(苄基氧基)-7-氧代-1,6-二氮杂双环[3.2.1]辛烷-2-甲酰胺基)哌啶-1-甲酸叔丁酯及其类似物的方法
AU2015355970B2 (en) 2014-12-05 2020-05-21 Meiji Seika Pharma Co., Ltd. Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
US10667737B2 (en) 2015-03-23 2020-06-02 International Business Machines Corporation Monitoring a person for indications of a brain injury
EP3091018A1 (en) * 2015-05-07 2016-11-09 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
MX2017014080A (es) * 2015-05-07 2018-07-06 Mutabilis Compuestos heterociclicos y su uso en la prevencion o tratamiento de las infecciones bacterianas.
WO2016206101A1 (en) 2015-06-26 2016-12-29 Merck Sharp & Dohme Corp. Metallo-beta-lactamase inhibitors
WO2017002087A1 (en) 2015-07-02 2017-01-05 Wockhardtlimited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002083A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002089A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
WO2017002086A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
JP7075884B2 (ja) * 2015-08-10 2022-05-26 サンド・アクチエンゲゼルシヤフト アビバクタムナトリウムのｃ形
WO2017037607A1 (en) 2015-09-01 2017-03-09 Wockhardt Limited (aminomethylidene)amino-substituted (2s,5r)-6-(sulfonyl)-7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide derivatives with antibacterial activity
WO2017045510A1 (zh) 2015-09-16 2017-03-23 山东轩竹医药科技有限公司 β-内酰胺酶抑制剂及其用途
CN116396991A (zh) 2015-10-02 2023-07-07 株式会社Api 羟基-l-哌可酸的制造方法
EP3356357A4 (en) 2015-10-02 2019-02-20 LegoChem Biosciences, Inc. COMPOSITIONS AND METHODS OF INHIBITING BETA LACTAMASE
WO2017081615A1 (en) 2015-11-09 2017-05-18 Wockhardt Limited 7-oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections
CN106749242B (zh) * 2015-11-23 2021-04-02 上海医药工业研究院 阿维巴坦中间体的制备方法
EP3411359B1 (en) 2016-02-04 2021-10-13 Merck Sharp & Dohme Corp. Methods of preparing hydroxylamine derivatives useful in the preparation of anti-infective agents
CN105753867B (zh) * 2016-03-24 2018-03-27 齐鲁制药有限公司 一种改进的阿维巴坦钠中间体化合物的制备方法
EP3156400B1 (en) 2016-05-27 2019-05-15 Valoralia I Más D, SL Dihydrooxadiazine compounds for treating infections and cancer
CN106279163A (zh) * 2016-08-12 2017-01-04 上海龙翔生物医药开发有限公司 一种合成阿维巴坦及其中间体光学异构体的方法
WO2018037124A1 (en) * 2016-08-26 2018-03-01 Sandoz Ag Avibactam free acid
LT3512851T (lt) 2016-09-16 2022-10-25 Entasis Therapeutics Limited Beta-laktamazės inhibitorių junginiai
JOP20190061A1 (ar) 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
CN106699756B (zh) * 2016-12-30 2019-10-29 淄博鑫泉医药技术服务有限公司 β内酰胺酶抑制剂阿维巴坦的合成方法
US20200017496A1 (en) * 2017-02-06 2020-01-16 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
DK3630111T3 (en) 2017-05-08 2022-03-14 Entasis Therapeutics Inc Compounds and methods for treating bacterial infections
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
WO2018234962A1 (en) 2017-06-20 2018-12-27 Wockhardt Limited PROCESS FOR O-SULFONATION OF 1,6-DIAZABICYCLO [3.2.1] OCTANE COMPOUNDS
EP3654968B1 (en) 2017-07-17 2023-08-16 Merck Sharp & Dohme LLC Metallo-beta-lactamase inhibitors and methods of use thereof
AU2018345321B2 (en) 2017-10-02 2021-05-20 Arixa Pharmaceuticals, Inc. Aztreonam derivatives and uses thereof
CN109678856B (zh) * 2017-10-18 2020-09-25 新发药业有限公司 一种阿维巴坦中间体的制备方法
EP3714046A1 (en) 2017-11-23 2020-09-30 H. Hoffnabb-La Roche Ag Proline hydroxylases as well as uses, methods and products involving the same
CN109956941B (zh) * 2017-12-25 2020-08-04 新发药业有限公司 一种阿维巴坦的简便制备方法
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
US11180500B2 (en) 2018-10-01 2021-11-23 Arixa Pharmaceuticals, Inc. Derivatives of relebactam and uses thereof
CN111072660B (zh) * 2018-10-22 2021-05-18 新发药业有限公司 一种瑞来巴坦的简便制备方法
JP2022524118A (ja) 2019-03-12 2022-04-27 アリクサ ファーマシューティカルズ、インコーポレイテッド アビバクタム誘導体の結晶形
US11565999B2 (en) 2019-04-25 2023-01-31 Arixa Pharmaceuticals, Inc. Methods of synthesizing aztreonam derivatives
CN110078728B (zh) * 2019-05-23 2020-10-23 江西富祥药业股份有限公司 一种阿维巴坦中间体、制备方法及其应用
WO2021106864A1 (en) * 2019-11-25 2021-06-03 Eisai R&D Management Co., Ltd. Process for the preparation of producing pyrazolo[1,5-a] pyrimidine derivatives
US11814385B2 (en) 2021-06-25 2023-11-14 University Of South Florida Small molecule inhibitors targeting Clostridioides difficile sporulation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4939678B1 (no) * 1968-05-06 1974-10-28
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US4049821A (en) * 1976-05-12 1977-09-20 A. H. Robins Company, Inc. Method of treating allergy
JPS63119471A (ja) * 1986-09-02 1988-05-24 ザ・ユニバーシテイ・オブ・メルボルン ２−オキソ−４−カルボキシ−ピリミジン
EP0260057A3 (en) * 1986-09-02 1989-02-01 The University Of Melbourne 2-oxo-4-carboxy-pyrimidines
EP0737194B1 (en) * 1993-12-29 1999-03-03 Pfizer Inc. Diazabicyclic neurokinin antagonists
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
HUP0001741A3 (en) * 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
BR9811093A (pt) * 1997-02-10 2000-07-18 Pfizer Prod Inc Piridinas substituìdas com 2-amino-6-(4-fenóxi 2-substituìdo)
US6060585A (en) * 1997-03-04 2000-05-09 Wisconsin Alumni Research Foundation β-polypeptide foldamers of well-defined secondary structure
KR100207096B1 (ko) * 1997-07-08 1999-07-15 이명환 시사프라이드의 제조 방법
CA2328413A1 (en) * 1998-04-20 1999-10-28 Fujisawa Pharmaceutical Co., Ltd. Anthranilic acid derivatives as inhibitors of the cgmp-phosphodiesterase
GB9817029D0 (en) * 1998-08-05 1998-09-30 Smithkline Beecham Plc Novel compounds
FR2784682B1 (fr) * 1998-10-15 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives 2-halogene de 5-0-desosaminylerythronolide a, leur procede de preparation et leur application comme medicaments
WO2000039118A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Aromatic amides
EP1140878A1 (en) * 1999-01-02 2001-10-10 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them ( inhibitio of factor xa activity )
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases

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UA73791C2 (uk) 2005-09-15
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US8178554B2 (en) 2012-05-15
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BR0112986A (pt) 2003-07-08
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HRP20030034A2 (en) 2004-02-29
NO20030494L (no) 2003-03-28
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