PT1246816E - Derivados de fenilpiperazina substituidos sua preparacao e utilizacao - Google Patents
Derivados de fenilpiperazina substituidos sua preparacao e utilizacaoInfo
- Publication number
- PT1246816E PT1246816E PT00984924T PT00984924T PT1246816E PT 1246816 E PT1246816 E PT 1246816E PT 00984924 T PT00984924 T PT 00984924T PT 00984924 T PT00984924 T PT 00984924T PT 1246816 E PT1246816 E PT 1246816E
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- phenylpiperazine derivatives
- substituted phenylpiperazine
- substituted
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199901885 | 1999-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1246816E true PT1246816E (pt) | 2004-08-31 |
Family
ID=8108803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00984924T PT1246816E (pt) | 1999-12-30 | 2000-12-20 | Derivados de fenilpiperazina substituidos sua preparacao e utilizacao |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6699864B2 (pt) |
| EP (1) | EP1246816B1 (pt) |
| JP (1) | JP2003519224A (pt) |
| KR (1) | KR100790916B1 (pt) |
| CN (1) | CN1230432C (pt) |
| AR (1) | AR029428A1 (pt) |
| AT (1) | ATE261959T1 (pt) |
| AU (1) | AU2152101A (pt) |
| BG (1) | BG65262B1 (pt) |
| BR (1) | BR0016952A (pt) |
| CA (1) | CA2395705C (pt) |
| CZ (1) | CZ20022319A3 (pt) |
| DE (1) | DE60009155T2 (pt) |
| EA (1) | EA006071B1 (pt) |
| ES (1) | ES2213634T3 (pt) |
| HU (1) | HUP0203722A3 (pt) |
| IL (2) | IL150241A0 (pt) |
| IS (1) | IS2174B (pt) |
| MX (1) | MXPA02006223A (pt) |
| NO (1) | NO322666B1 (pt) |
| NZ (1) | NZ519647A (pt) |
| PL (1) | PL199351B1 (pt) |
| PT (1) | PT1246816E (pt) |
| SK (1) | SK9442002A3 (pt) |
| TR (2) | TR200400645T4 (pt) |
| UA (1) | UA72948C2 (pt) |
| WO (1) | WO2001049678A1 (pt) |
| ZA (1) | ZA200204814B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| DE10259244A1 (de) * | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
| ATE406894T1 (de) | 2003-04-04 | 2008-09-15 | Lundbeck & Co As H | 4-(2-phenylsulfanyl-phenyl)-piperidin-derivate als serotonin-wiederaufnahme-hemmer |
| UA81300C2 (en) * | 2003-04-04 | 2007-12-25 | Lundbeck & Co As H | Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture |
| RS50589B (sr) | 2003-12-23 | 2010-05-07 | H. Lundbeck A/S. | 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri |
| SE0400441D0 (sv) | 2004-02-25 | 2004-02-25 | Active Biotech Ab | Novel Benzofurans and Indols |
| AR052308A1 (es) | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7629473B2 (en) | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| WO2007144005A1 (en) | 2006-06-16 | 2007-12-21 | H. Lundbeck A/S | 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
| US20090093513A1 (en) * | 2007-10-09 | 2009-04-09 | Hamann Mark T | Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter |
| CN101970436A (zh) * | 2008-03-14 | 2011-02-09 | 默克专利股份有限公司 | 用于治疗中枢神经系统功能障碍的氮杂吲哚化合物 |
| PL2981520T3 (pl) | 2013-04-04 | 2019-09-30 | Lek Pharmaceuticals D.D. | Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny |
| CN105085482B (zh) * | 2014-05-04 | 2018-08-10 | 广东东阳光药业有限公司 | 取代的哌嗪化合物及其使用方法和用途 |
| CN105085491B (zh) * | 2014-05-05 | 2019-06-25 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| CN106795160B (zh) * | 2015-07-23 | 2019-04-19 | 广东东阳光药业有限公司 | 取代的吲哚化合物及其使用方法和用途 |
| ES2974248T3 (es) * | 2017-09-29 | 2024-06-26 | Sunshine Lake Pharma Co Ltd | Compuesto de pirimidin-piperazina sustituido y uso del mismo |
| CN111518012A (zh) * | 2020-05-27 | 2020-08-11 | 中国药科大学 | 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2138865A1 (de) * | 1970-08-15 | 1973-02-22 | Sumitomo Chemical Co | 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| US5814644A (en) * | 1993-04-15 | 1998-09-29 | Merck Sharp & Dohme, Ltd. | Indole derivatives as dopamine D4 antagonists |
| FR2712591B1 (fr) | 1993-11-19 | 1996-02-09 | Pf Medicament | Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique. |
| WO1997019039A1 (en) | 1995-11-17 | 1997-05-29 | Novartis Ag | Solid phase synthesis of heterocyclic compounds and combinatorial compound library |
| USH2007H1 (en) * | 1996-01-19 | 2001-12-04 | Fmc Corporation | Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines |
| ES2128266B1 (es) * | 1997-07-08 | 2000-01-16 | Vita Invest Sa | Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes. |
| WO2000077519A1 (en) | 1999-06-15 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives |
| WO2001049681A1 (en) * | 1999-12-30 | 2001-07-12 | H. Lundbeck A/S | A method for the preparation of substituted benzene derivatives |
-
2000
- 2000-12-20 PT PT00984924T patent/PT1246816E/pt unknown
- 2000-12-20 JP JP2001550218A patent/JP2003519224A/ja active Pending
- 2000-12-20 KR KR1020027008608A patent/KR100790916B1/ko not_active IP Right Cessation
- 2000-12-20 AU AU21521/01A patent/AU2152101A/en not_active Abandoned
- 2000-12-20 WO PCT/DK2000/000721 patent/WO2001049678A1/en active IP Right Grant
- 2000-12-20 IL IL15024100A patent/IL150241A0/xx unknown
- 2000-12-20 AT AT00984924T patent/ATE261959T1/de not_active IP Right Cessation
- 2000-12-20 PL PL355539A patent/PL199351B1/pl not_active IP Right Cessation
- 2000-12-20 HU HU0203722A patent/HUP0203722A3/hu unknown
- 2000-12-20 EA EA200200732A patent/EA006071B1/ru not_active IP Right Cessation
- 2000-12-20 CA CA002395705A patent/CA2395705C/en not_active Expired - Fee Related
- 2000-12-20 SK SK944-2002A patent/SK9442002A3/sk unknown
- 2000-12-20 MX MXPA02006223A patent/MXPA02006223A/es active IP Right Grant
- 2000-12-20 EP EP00984924A patent/EP1246816B1/en not_active Expired - Lifetime
- 2000-12-20 TR TR2004/00645T patent/TR200400645T4/xx unknown
- 2000-12-20 UA UA2002065260A patent/UA72948C2/uk unknown
- 2000-12-20 CN CNB008192057A patent/CN1230432C/zh not_active Expired - Fee Related
- 2000-12-20 TR TR2002/01683T patent/TR200201683T2/xx unknown
- 2000-12-20 NZ NZ519647A patent/NZ519647A/en unknown
- 2000-12-20 BR BR0016952-8A patent/BR0016952A/pt not_active Application Discontinuation
- 2000-12-20 DE DE60009155T patent/DE60009155T2/de not_active Expired - Fee Related
- 2000-12-20 CZ CZ20022319A patent/CZ20022319A3/cs unknown
- 2000-12-20 ES ES00984924T patent/ES2213634T3/es not_active Expired - Lifetime
- 2000-12-28 AR ARP000106987A patent/AR029428A1/es unknown
-
2002
- 2002-06-13 IS IS6420A patent/IS2174B/is unknown
- 2002-06-14 ZA ZA200204814A patent/ZA200204814B/xx unknown
- 2002-06-16 IL IL150241A patent/IL150241A/en not_active IP Right Cessation
- 2002-06-20 US US10/177,261 patent/US6699864B2/en not_active Expired - Fee Related
- 2002-06-28 NO NO20023146A patent/NO322666B1/no not_active IP Right Cessation
- 2002-07-17 BG BG106930A patent/BG65262B1/bg unknown
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