DE60009155D1 - Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung - Google Patents

Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung

Info

Publication number
DE60009155D1
DE60009155D1 DE60009155T DE60009155T DE60009155D1 DE 60009155 D1 DE60009155 D1 DE 60009155D1 DE 60009155 T DE60009155 T DE 60009155T DE 60009155 T DE60009155 T DE 60009155T DE 60009155 D1 DE60009155 D1 DE 60009155D1
Authority
DE
Germany
Prior art keywords
production
substituted phenyl
piperazine derivatives
piperazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60009155T
Other languages
English (en)
Other versions
DE60009155T2 (de
Inventor
Thomas Ruhland
Christian Krog-Jensen
Mario Rottlaender
Gitte Mikkelsen
Kim Andersen
Knud Moltzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of DE60009155D1 publication Critical patent/DE60009155D1/de
Publication of DE60009155T2 publication Critical patent/DE60009155T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60009155T 1999-12-30 2000-12-20 Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung Expired - Fee Related DE60009155T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK188599 1999-12-30
DKPA199901885 1999-12-30
PCT/DK2000/000721 WO2001049678A1 (en) 1999-12-30 2000-12-20 Substituted phenyl-piperazine derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
DE60009155D1 true DE60009155D1 (de) 2004-04-22
DE60009155T2 DE60009155T2 (de) 2005-01-05

Family

ID=8108803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009155T Expired - Fee Related DE60009155T2 (de) 1999-12-30 2000-12-20 Substituierte phenyl-piperazin-derivate, deren herstellung und verwendung

Country Status (28)

Country Link
US (1) US6699864B2 (de)
EP (1) EP1246816B1 (de)
JP (1) JP2003519224A (de)
KR (1) KR100790916B1 (de)
CN (1) CN1230432C (de)
AR (1) AR029428A1 (de)
AT (1) ATE261959T1 (de)
AU (1) AU2152101A (de)
BG (1) BG65262B1 (de)
BR (1) BR0016952A (de)
CA (1) CA2395705C (de)
CZ (1) CZ20022319A3 (de)
DE (1) DE60009155T2 (de)
EA (1) EA006071B1 (de)
ES (1) ES2213634T3 (de)
HU (1) HUP0203722A3 (de)
IL (2) IL150241A0 (de)
IS (1) IS2174B (de)
MX (1) MXPA02006223A (de)
NO (1) NO322666B1 (de)
NZ (1) NZ519647A (de)
PL (1) PL199351B1 (de)
PT (1) PT1246816E (de)
SK (1) SK9442002A3 (de)
TR (2) TR200400645T4 (de)
UA (1) UA72948C2 (de)
WO (1) WO2001049678A1 (de)
ZA (1) ZA200204814B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
SI1626720T1 (sl) 2003-04-04 2008-12-31 Lundbeck & Co As H Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
BRPI0417858B1 (pt) 2003-12-23 2017-10-10 H. Lundbeck A/S Derivative compounds of aniline and pharmaceutical composition that understand it
SE0400441D0 (sv) 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
MX2008016141A (es) 2006-06-16 2009-02-04 Lundbeck & Co As H 1-[2-(2,4-dimetilfenilsulfanil)-fenil] piperazina como un compuesto con actividad combinada de recaptación de serotonina, 5-ht3 y 5-ht1a.para el tratamiento de daño cognitivo.
US20090093513A1 (en) * 2007-10-09 2009-04-09 Hamann Mark T Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter
CN101970436A (zh) * 2008-03-14 2011-02-09 默克专利股份有限公司 用于治疗中枢神经系统功能障碍的氮杂吲哚化合物
PL2981520T3 (pl) 2013-04-04 2019-09-30 Lek Pharmaceuticals D.D. Nowy sposób syntezy 1-(2-((2,4-dimetylofenylo)tio)fenylo)piperazyny
WO2015169180A1 (en) * 2014-05-04 2015-11-12 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods and use thereof
CN105085491B (zh) * 2014-05-05 2019-06-25 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
CN106795160B (zh) * 2015-07-23 2019-04-19 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CA3077383A1 (en) 2017-09-29 2019-04-04 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN111518012A (zh) * 2020-05-27 2020-08-11 中国药科大学 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
FR2712591B1 (fr) 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
AU7564296A (en) 1995-11-17 1997-06-11 Ciba-Geigy Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
EP1200824B1 (de) 1999-06-15 2007-04-25 Aventis Pharmaceuticals, Inc. Festphasensynthese von n,n-disubstituierten diazacycloalkylcarboxy-derivaten
WO2001049681A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S A method for the preparation of substituted benzene derivatives

Also Published As

Publication number Publication date
WO2001049678A1 (en) 2001-07-12
CN1437597A (zh) 2003-08-20
KR100790916B1 (ko) 2008-01-03
KR20020063287A (ko) 2002-08-01
DE60009155T2 (de) 2005-01-05
WO2001049678A9 (en) 2002-10-10
IS6420A (is) 2002-06-13
CN1230432C (zh) 2005-12-07
PT1246816E (pt) 2004-08-31
BR0016952A (pt) 2002-10-08
NZ519647A (en) 2004-02-27
AU2152101A (en) 2001-07-16
NO20023146D0 (no) 2002-06-28
US6699864B2 (en) 2004-03-02
EA200200732A1 (ru) 2003-02-27
IS2174B (is) 2006-11-15
TR200400645T4 (tr) 2004-06-21
IL150241A0 (en) 2002-12-01
UA72948C2 (uk) 2005-05-16
ATE261959T1 (de) 2004-04-15
HUP0203722A3 (en) 2005-03-29
TR200201683T2 (tr) 2002-12-23
EA006071B1 (ru) 2005-08-25
ES2213634T3 (es) 2004-09-01
HUP0203722A2 (hu) 2003-03-28
BG65262B1 (bg) 2007-10-31
AR029428A1 (es) 2003-06-25
SK9442002A3 (en) 2002-11-06
NO20023146L (no) 2002-06-28
CA2395705A1 (en) 2001-07-12
PL199351B1 (pl) 2008-09-30
EP1246816B1 (de) 2004-03-17
PL355539A1 (en) 2004-05-04
JP2003519224A (ja) 2003-06-17
BG106930A (en) 2003-04-30
CA2395705C (en) 2006-10-17
MXPA02006223A (es) 2002-12-05
EP1246816A1 (de) 2002-10-09
ZA200204814B (en) 2003-08-27
US20030125320A1 (en) 2003-07-03
IL150241A (en) 2008-12-29
CZ20022319A3 (cs) 2002-10-16
NO322666B1 (no) 2006-11-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee