NO20023146L - Substituerte fenyl-piperazinderivater, deres fremstilling og anvendelse - Google Patents

Substituerte fenyl-piperazinderivater, deres fremstilling og anvendelse

Info

Publication number
NO20023146L
NO20023146L NO20023146A NO20023146A NO20023146L NO 20023146 L NO20023146 L NO 20023146L NO 20023146 A NO20023146 A NO 20023146A NO 20023146 A NO20023146 A NO 20023146A NO 20023146 L NO20023146 L NO 20023146L
Authority
NO
Norway
Prior art keywords
preparation
substituted phenyl
piperazine derivatives
piperazine
derivatives
Prior art date
Application number
NO20023146A
Other languages
English (en)
Other versions
NO20023146D0 (no
NO322666B1 (no
Inventor
Thomas Ruhland
Christian Krog-Jensen
Mario Rottlaender
Gitte Mikkelsen
Ejner Knud Moltzen
Kim Andersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20023146D0 publication Critical patent/NO20023146D0/no
Publication of NO20023146L publication Critical patent/NO20023146L/no
Publication of NO322666B1 publication Critical patent/NO322666B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20023146A 1999-12-30 2002-06-28 Substituerte fenyl-piperazinderivater, farmasoytiske sammensetninger inneholdende disse og deres anvendelse NO322666B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901885 1999-12-30
PCT/DK2000/000721 WO2001049678A1 (en) 1999-12-30 2000-12-20 Substituted phenyl-piperazine derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
NO20023146D0 NO20023146D0 (no) 2002-06-28
NO20023146L true NO20023146L (no) 2002-06-28
NO322666B1 NO322666B1 (no) 2006-11-13

Family

ID=8108803

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023146A NO322666B1 (no) 1999-12-30 2002-06-28 Substituerte fenyl-piperazinderivater, farmasoytiske sammensetninger inneholdende disse og deres anvendelse

Country Status (28)

Country Link
US (1) US6699864B2 (no)
EP (1) EP1246816B1 (no)
JP (1) JP2003519224A (no)
KR (1) KR100790916B1 (no)
CN (1) CN1230432C (no)
AR (1) AR029428A1 (no)
AT (1) ATE261959T1 (no)
AU (1) AU2152101A (no)
BG (1) BG65262B1 (no)
BR (1) BR0016952A (no)
CA (1) CA2395705C (no)
CZ (1) CZ20022319A3 (no)
DE (1) DE60009155T2 (no)
EA (1) EA006071B1 (no)
ES (1) ES2213634T3 (no)
HU (1) HUP0203722A3 (no)
IL (2) IL150241A0 (no)
IS (1) IS2174B (no)
MX (1) MXPA02006223A (no)
NO (1) NO322666B1 (no)
NZ (1) NZ519647A (no)
PL (1) PL199351B1 (no)
PT (1) PT1246816E (no)
SK (1) SK9442002A3 (no)
TR (2) TR200201683T2 (no)
UA (1) UA72948C2 (no)
WO (1) WO2001049678A1 (no)
ZA (1) ZA200204814B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
CA2521258C (en) 2003-04-04 2009-12-01 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
DK1701940T3 (da) 2003-12-23 2008-09-08 Lundbeck & Co As H 2-(1H-indolylsulfanyl)-bensylaminderivater som SSRI
SE0400441D0 (sv) 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
FI2044043T5 (fi) 2006-06-16 2023-11-21 H Lundbeck A/S 1-[2-(2,4-dimetyylifenyylisulfanyyli)fenyyli]piperatsiini yhdisteenä, jolla on yhdistetty serotonin takaisinotto-, 5-HT3- ja 5-HT1A -aktiivisuus käytettäväksi kognitiivisten häiriöiden hoitoon
US20090093513A1 (en) * 2007-10-09 2009-04-09 Hamann Mark T Method to Use Compositions Having Antidepressant Anxiolytic and Other Neurological Activity and Compositions of Matter
US20110059982A1 (en) * 2008-03-14 2011-03-10 Merck Patent Gesellschaft Mit Beschrankter Haftung Azaindole compounds for treatment of central nervous system disorders
EP2981520B1 (en) 2013-04-04 2019-03-06 LEK Pharmaceuticals d.d. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
WO2015169180A1 (en) * 2014-05-04 2015-11-12 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods and use thereof
CN105085491B (zh) * 2014-05-05 2019-06-25 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
WO2017012579A1 (zh) * 2015-07-23 2017-01-26 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
AU2018340376B2 (en) * 2017-09-29 2022-09-01 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN111518012A (zh) * 2020-05-27 2020-08-11 中国药科大学 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5814644A (en) * 1993-04-15 1998-09-29 Merck Sharp & Dohme, Ltd. Indole derivatives as dopamine D4 antagonists
FR2712591B1 (fr) 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
AU7564296A (en) 1995-11-17 1997-06-11 Ciba-Geigy Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
US7138526B1 (en) 1999-06-15 2006-11-21 Aventis Pharmaceuticals Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
JP2003519227A (ja) * 1999-12-30 2003-06-17 ハー・ルンドベック・アクチエゼルスカベット 置換されたベンゼン誘導体の製造方法

Also Published As

Publication number Publication date
SK9442002A3 (en) 2002-11-06
NZ519647A (en) 2004-02-27
DE60009155T2 (de) 2005-01-05
EP1246816A1 (en) 2002-10-09
IS2174B (is) 2006-11-15
EA006071B1 (ru) 2005-08-25
BG106930A (en) 2003-04-30
CN1230432C (zh) 2005-12-07
ATE261959T1 (de) 2004-04-15
AR029428A1 (es) 2003-06-25
EA200200732A1 (ru) 2003-02-27
CZ20022319A3 (cs) 2002-10-16
EP1246816B1 (en) 2004-03-17
ZA200204814B (en) 2003-08-27
US6699864B2 (en) 2004-03-02
JP2003519224A (ja) 2003-06-17
MXPA02006223A (es) 2002-12-05
CA2395705A1 (en) 2001-07-12
PL199351B1 (pl) 2008-09-30
AU2152101A (en) 2001-07-16
HUP0203722A2 (hu) 2003-03-28
WO2001049678A9 (en) 2002-10-10
CA2395705C (en) 2006-10-17
IS6420A (is) 2002-06-13
TR200400645T4 (tr) 2004-06-21
DE60009155D1 (de) 2004-04-22
US20030125320A1 (en) 2003-07-03
CN1437597A (zh) 2003-08-20
NO20023146D0 (no) 2002-06-28
KR100790916B1 (ko) 2008-01-03
BG65262B1 (bg) 2007-10-31
NO322666B1 (no) 2006-11-13
BR0016952A (pt) 2002-10-08
PT1246816E (pt) 2004-08-31
KR20020063287A (ko) 2002-08-01
ES2213634T3 (es) 2004-09-01
UA72948C2 (uk) 2005-05-16
IL150241A (en) 2008-12-29
HUP0203722A3 (en) 2005-03-29
WO2001049678A1 (en) 2001-07-12
TR200201683T2 (tr) 2002-12-23
PL355539A1 (en) 2004-05-04
IL150241A0 (en) 2002-12-01

Similar Documents

Publication Publication Date Title
NO20015156L (no) 5-pyridyl-1,3-azolforbindelser, deres fremstilling og anvendelse
NO20014603D0 (no) Tienopyrimidinforbindelser, deres fremstilling og anvendelse
NO20021449L (no) Substituerte 2-tio-3,5-dicyano-4-aryl-6-aminopyridiner og deres anvendelse
NO20015113D0 (no) Nye forbindelser, deres fremstilling og anvendelse
NO20012567D0 (no) Azepinoindolderivater, fremstilling og anvendelse derav
NO20011956L (no) Substituerte fenylderivater, deres fremstilling og anvendelse
NO20024742D0 (no) Heterocykliske forbindelser, deres fremstilling og anvendelse
NO20006029D0 (no) Pyrazolinderivater, deres fremstilling og anvendelse som legemidler
DK1161434T3 (da) Pyridopyranoazepinderivater, deres fremstilling og terapeutiske anvendelse
NO20005146D0 (no) Tienylazolylalkoksyetanaminer, deres fremstilling og deres anvendelse som medikamenter
DK1073672T3 (da) Antipicornavirale forbindelser, deres fremstilling og anvendelse
NO20023146L (no) Substituerte fenyl-piperazinderivater, deres fremstilling og anvendelse
NO20031838D0 (no) Benzokazinonderivater, deres fremstilling og anvendelse
DK1043307T3 (da) 3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
NO20032234D0 (no) Nye imidazolderivater, deres fremstilling og anvendelse
NO20024107L (no) Tienopyridin derivater, deres fremstilling og anvendelse
NO20006479D0 (no) Tienopyridinforbindelser, deres fremstilling og anvendelse
NO20025209L (no) Cyklipostiner, deres fremstilling og anvendelse
NO20001782L (no) 3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
NO20012802L (no) Benzofuranderivater, deres fremstilling og anvendelse
NO20000066D0 (no) 6-pyrrolidin-2-ylpyrindin-derivater, deres fremstilling og deres farmasoeytiske anvendelse
NO996156L (no) Substituerte cykloheptener, deres fremstilling og anvendelse
NO20023188D0 (no) Nye heteroarylderivater, deres fremstilling og anvendelse
NO20020404D0 (no) Streptograminderivater, deres produksjon og forbindelser derav
DK1235809T3 (da) Substituerede 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazociner og deres anvendelse som lægemidler

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees