CY1107358T1 - Μεθοδος για τη διαγνωση της ιδιοπαθους σκολιωσης εφηβων και σχετικων συνδρομων - Google Patents

Μεθοδος για τη διαγνωση της ιδιοπαθους σκολιωσης εφηβων και σχετικων συνδρομων

Info

Publication number
CY1107358T1
CY1107358T1 CY20081100337T CY081100337T CY1107358T1 CY 1107358 T1 CY1107358 T1 CY 1107358T1 CY 20081100337 T CY20081100337 T CY 20081100337T CY 081100337 T CY081100337 T CY 081100337T CY 1107358 T1 CY1107358 T1 CY 1107358T1
Authority
CY
Cyprus
Prior art keywords
cell sample
melatonin
signaling pathway
adolescents
diagnosis
Prior art date
Application number
CY20081100337T
Other languages
English (en)
Inventor
Alain Moreau
Original Assignee
Hopital Sainte-Justine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hopital Sainte-Justine filed Critical Hopital Sainte-Justine
Publication of CY1107358T1 publication Critical patent/CY1107358T1/el

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Testing Of Engines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Μέθοδος για τη διάγνωση υψηλού κινδύνου για πάθηση χαρακτηριζόμενη από δυσλειτουργική πορεία σηματοδότησης μελατονίνης σε ζώο, περιλαμβάνουσα την ανίχνευση της παρουσίας ή απουσίας τουλάχιστον μίας βλάβης στην πορεία σηματοδότησης μελατονίνης σε τουλάχιστον ένα από τα κύτταρα του ζώου, όπου η παρουσία τουλάχιστον μίας βλάβης στην πορεία σηματοδότησης μελατονίνης δείχνει ότι το ζώο εμφανίζει υψηλό κίνδυνο ανάπτυξης της εν λόγω πάθησης, και μέθοδος για την εξέταση ως προς ένωση χρήσιμη στην αντιμετώπιση παθήσεων χαρακτηριζόμενων από δυσλειτουργική πορεία σηματοδότησης μελατονίνης, η οποία μέθοδος περιλαμβάνει τα στάδια της επαφής μίας υποψήφιας ένωσης με τουλάχιστον ένα κύτταρο που εκφράζει τουλάχιστον μία βλάβη στην πορεία σηματοδότησης μελατονίνης, όπου η υποψήφια ένωση επιλέγεται εάν η εν λόγω βλάβη στην πορεία σηματοδότησης μελατονίνης περιορίζεται με την παρουσία της υποψήφιας ένωσης σε σύγκριση με τη βλάβη χωρίς την παρουσία αυτής.
CY20081100337T 2002-02-28 2008-03-24 Μεθοδος για τη διαγνωση της ιδιοπαθους σκολιωσης εφηβων και σχετικων συνδρομων CY1107358T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002373854A CA2373854A1 (en) 2002-02-28 2002-02-28 Methods of diagnosing and counteracting adolescent idiopathic scoliosis
EP03706157A EP1478928B1 (en) 2002-02-28 2003-02-28 Method of diagnosing adolescent idiopathic scoliosis and related syndromes

Publications (1)

Publication Number Publication Date
CY1107358T1 true CY1107358T1 (el) 2012-12-19

Family

ID=27762090

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100337T CY1107358T1 (el) 2002-02-28 2008-03-24 Μεθοδος για τη διαγνωση της ιδιοπαθους σκολιωσης εφηβων και σχετικων συνδρομων

Country Status (12)

Country Link
US (7) US20050130250A1 (el)
EP (1) EP1478928B1 (el)
AT (1) ATE385574T1 (el)
AU (1) AU2003208204A1 (el)
CA (1) CA2373854A1 (el)
CY (1) CY1107358T1 (el)
DE (1) DE60318987T2 (el)
DK (1) DK1478928T3 (el)
ES (1) ES2298498T3 (el)
HK (1) HK1071601A1 (el)
PT (1) PT1478928E (el)
WO (1) WO2003073102A1 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2373854A1 (en) 2002-02-28 2003-08-28 Alain Moreau Methods of diagnosing and counteracting adolescent idiopathic scoliosis
US20090104620A1 (en) * 2007-07-03 2009-04-23 Axial Biotech, Inc. Simplified Method of Determining Predisposition to Scoliosis
US20090035769A1 (en) * 2007-12-31 2009-02-05 Nelson Lesa M Genetic Markers Associated with Scoliosis and Uses Thereof
US20090035772A1 (en) * 2007-07-03 2009-02-05 Axial Biotech, Inc. Genetic Markers Associated With Scoliosis And Uses Thereof
US7655403B2 (en) * 2006-12-02 2010-02-02 Texas Scottish Rite Hospital For Children CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis
US20100173296A1 (en) * 2007-03-19 2010-07-08 Chu Sainte-Justine Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same and kits using same
KR101436578B1 (ko) 2007-03-30 2014-09-01 슈 생-쥐스땡 척추 측만증의 발병 위험성을 측정하는 방법, 척추 측만증에 걸린 대상자를 계층화하는 방법, 척추 측만증에 걸린 대상자에 있어서 고정기의 효능을 평가하는 방법, 및 이를 위한 키트
TWI443337B (zh) * 2008-10-10 2014-07-01 Ct Hospitalier Universitaire Sainte Justine 用於脊柱側彎之分類及診斷的方法
WO2012045176A1 (en) 2010-10-04 2012-04-12 Chu Sainte-Justine Biomechanical-based methods of diagnosing scoliosis
AU2014284079B2 (en) 2013-06-17 2019-05-23 Chu Sainte-Justine A method of increasing GiPCR signalization in the cells of a scoliotic subject
EP3011332B1 (en) 2013-06-17 2019-09-18 CHU Sainte-Justine New markers for severe progression of idiopathic scoliosis and uses thereof to stratify scoliotic patients and predict the risk of developing scoliosis
US20160139146A1 (en) 2013-06-17 2016-05-19 Chu Sainte-Justine Gi protein phosphorylation as marker for scoliosis and scoliosis progression, methods of increasing gipcr signaling in scoliotic subjects
EP3044321B1 (en) * 2013-09-09 2019-07-31 Chu Sainte-Justine New marker for the classification, diagnosis and treatment of scoliosis
KR102397233B1 (ko) 2014-09-25 2022-05-12 프로제너티, 인크. 위치추정 능력을 갖는 전기기계 알약 장치
ES2734803T3 (es) * 2015-06-16 2019-12-12 Centro De Investig Biomedica En Red Ciber Método para el diagnóstico/pronóstico de la escoliosis idiopática del adolescente
JP7153633B2 (ja) * 2016-08-18 2022-10-14 ビオラ・セラピューティクス・インコーポレイテッド サンプリングシステム、ならびに関連する材料および方法
JP2019526423A (ja) 2016-09-09 2019-09-19 ミッチェル・ローレンス・ジョーンズＭｉｔｃｈｅｌｌ Ｌａｗｒｅｎｃｅ ＪＯＮＥＳ 分注可能物質の送達のための電気機械的摂取可能装置
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
JP7071995B2 (ja) 2017-03-31 2022-05-19 プロジェニティ， インコーポレイテッド 摂取可能装置
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
CN111575361A (zh) * 2020-04-20 2020-08-25 孙欣 一种褪黑素通路调控因子治疗ais患者的测试方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856124A (en) * 1994-06-17 1999-01-05 The General Hospital Corporation DNA encoding high-affinity melatonin receptors
US5889177A (en) * 1996-07-18 1999-03-30 The General Hospital Corporation Melatonin 1A receptor gene regulatory regions and uses thereof
JPH119282A (ja) * 1997-06-19 1999-01-19 Nippon Chem Res Kk メラトニン受容体発現細胞とその用途
WO2001009383A2 (en) * 1999-07-30 2001-02-08 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for prognostication, diagnosis, prevention, and treatment of bone-related disorders and other disorders
CA2373854A1 (en) 2002-02-28 2003-08-28 Alain Moreau Methods of diagnosing and counteracting adolescent idiopathic scoliosis

Also Published As

Publication number Publication date
US20110256582A1 (en) 2011-10-20
DE60318987T2 (de) 2009-01-29
US20120009600A1 (en) 2012-01-12
ES2298498T3 (es) 2008-05-16
DK1478928T3 (da) 2008-05-19
US20160258947A1 (en) 2016-09-08
DE60318987D1 (de) 2008-03-20
EP1478928A1 (en) 2004-11-24
PT1478928E (pt) 2008-04-09
HK1071601A1 (en) 2005-07-22
EP1478928B1 (en) 2008-02-06
US20130115615A1 (en) 2013-05-09
ATE385574T1 (de) 2008-02-15
US7989175B2 (en) 2011-08-02
US20140113313A1 (en) 2014-04-24
WO2003073102A1 (en) 2003-09-04
US8652791B2 (en) 2014-02-18
US20050130250A1 (en) 2005-06-16
AU2003208204A1 (en) 2003-09-09
US20090111110A1 (en) 2009-04-30
CA2373854A1 (en) 2003-08-28

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