HRP20030033B1 - Early diagnosis of conformational diseases - Google Patents

Early diagnosis of conformational diseases

Info

Publication number
HRP20030033B1
HRP20030033B1 HR20030033A HRP20030033A HRP20030033B1 HR P20030033 B1 HRP20030033 B1 HR P20030033B1 HR 20030033 A HR20030033 A HR 20030033A HR P20030033 A HRP20030033 A HR P20030033A HR P20030033 B1 HRP20030033 B1 HR P20030033B1
Authority
HR
Croatia
Prior art keywords
pathogenic conformer
pathogenic
conformational
conformer
disease
Prior art date
Application number
HR20030033A
Other languages
English (en)
Croatian (hr)
Inventor
Soto Jara Claudio
Saborio Gabriella
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of HRP20030033A2 publication Critical patent/HRP20030033A2/xx
Publication of HRP20030033B1 publication Critical patent/HRP20030033B1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20030033A 2000-07-07 2003-01-20 Early diagnosis of conformational diseases HRP20030033B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (2)

Publication Number Publication Date
HRP20030033A2 HRP20030033A2 (en) 2004-02-29
HRP20030033B1 true HRP20030033B1 (en) 2008-04-30

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030033A HRP20030033B1 (en) 2000-07-07 2003-01-20 Early diagnosis of conformational diseases

Country Status (31)

Country Link
US (1) US7351526B2 (el)
EP (2) EP1712920B1 (el)
JP (1) JP4790966B2 (el)
KR (1) KR100764981B1 (el)
CN (1) CN1221807C (el)
AR (1) AR029583A1 (el)
AT (2) ATE335204T1 (el)
AU (2) AU6408901A (el)
BG (1) BG66272B1 (el)
BR (1) BRPI0112262B8 (el)
CA (1) CA2413078C (el)
CY (1) CY1109106T1 (el)
CZ (1) CZ304365B6 (el)
DE (2) DE60138146D1 (el)
DK (2) DK1712920T3 (el)
EA (1) EA007391B1 (el)
EE (1) EE05675B1 (el)
ES (2) ES2264691T3 (el)
HK (1) HK1058065A1 (el)
HR (1) HRP20030033B1 (el)
HU (1) HU228813B1 (el)
IL (2) IL153824A0 (el)
MX (1) MXPA03000226A (el)
NO (1) NO331624B1 (el)
NZ (1) NZ523213A (el)
PL (1) PL211154B1 (el)
PT (2) PT1712920E (el)
RS (1) RS51523B (el)
SI (2) SI1712920T1 (el)
SK (1) SK287768B6 (el)
WO (1) WO2002004954A2 (el)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002073210A1 (de) * 2001-03-13 2002-09-19 Manfred Eigen Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
MXPA03011000A (es) 2001-05-31 2004-02-27 Arete Associates Metodo de sensor de proteinas deformadas.
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
AU2004248302B2 (en) 2003-06-19 2009-07-30 Merck Serono Sa Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
WO2005010533A2 (en) * 2003-07-31 2005-02-03 Hadasit Medical Research Services & Development Ltd. Methods and kits for the detection of prion diseases
AU2004264953B2 (en) 2003-08-13 2009-07-23 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒
EP1731911A1 (fr) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
JP5209477B2 (ja) 2005-09-09 2013-06-12 ノバルティス アーゲー プリオンに特異的なペプトイド試薬
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
US8673579B2 (en) 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
EP2074222A4 (en) * 2006-09-06 2010-03-03 Univ Texas METHODS AND COMPOSITIONS FOR DETECTION OF PROTEIN FOLDING DISORDERS
US8216788B2 (en) 2007-07-20 2012-07-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
US20110124843A1 (en) 2008-05-28 2011-05-26 Incorporated Administrative Agency National Agriculture And Food Research Organization Method for efficiently amplifying abnormal prion protein derived from bse
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
AU2010315133B2 (en) * 2009-11-04 2015-09-10 Novartis Ag Positively charged species as binding reagents in the separation of protein aggregates from monomers
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
EP2666020A1 (en) * 2011-01-18 2013-11-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
KR101483438B1 (ko) * 2014-04-17 2015-01-16 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
EP4292654A3 (en) 2014-09-11 2024-01-03 Board of Regents of the University of Texas System Detection of misfolded proteins
WO2016040903A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
EP3635393A4 (en) 2017-05-16 2021-03-10 Claudio Soto-Jara DETECTION OF MISFOLDED TAU PROTEIN
WO2019222554A2 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of brain injury or neurological disease using tau protein
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
DE934531T1 (de) 1996-10-15 2000-04-06 Imperial College Diagnose spongiformer encephalopathie
EP1210110A4 (en) * 1999-06-29 2003-03-19 Univ Mcgill PROTEINS BINDING TO PRION PROTEIN AND THEIR USE
EP1238290A1 (en) * 1999-12-10 2002-09-11 Misonix Incorporated Ultrasonic horn assembly
CN101218510A (zh) * 2005-04-20 2008-07-09 得克萨斯系统大学评议会 通过自动化的蛋白质错折叠循环扩增超灵敏检测朊病毒

Also Published As

Publication number Publication date
CZ200336A3 (cs) 2003-06-18
CY1109106T1 (el) 2014-07-02
CA2413078A1 (en) 2002-01-17
IL153824A (en) 2010-02-17
WO2002004954A3 (en) 2002-10-24
EE05675B1 (et) 2013-08-15
PL211154B1 (pl) 2012-04-30
SK287768B6 (sk) 2011-09-05
AU6408901A (en) 2002-01-21
BR0112262A (pt) 2003-05-20
AR029583A1 (es) 2003-07-02
MXPA03000226A (es) 2004-05-21
DE60121958D1 (de) 2006-09-14
SI1712920T1 (sl) 2009-10-31
EP1299729B1 (en) 2006-08-02
PT1712920E (pt) 2009-04-09
DE60138146D1 (de) 2009-05-07
HK1058065A1 (en) 2004-04-30
CN1449497A (zh) 2003-10-15
YU101202A (sh) 2006-01-16
NO20030059D0 (no) 2003-01-06
BG66272B1 (bg) 2012-11-30
HUP0301020A3 (en) 2010-03-29
NO331624B1 (no) 2012-02-06
NO20030059L (no) 2003-03-07
CN1221807C (zh) 2005-10-05
PL360397A1 (en) 2004-09-06
EA200300126A1 (ru) 2003-06-26
DE60121958T2 (de) 2007-02-01
KR20030036257A (ko) 2003-05-09
ES2322660T3 (es) 2009-06-24
US20050064505A1 (en) 2005-03-24
NZ523213A (en) 2005-01-28
AU2001264089B2 (en) 2006-03-30
CA2413078C (en) 2010-08-03
ATE335204T1 (de) 2006-08-15
RS51523B (sr) 2011-06-30
EP1712920B1 (en) 2009-03-25
EP1299729A2 (en) 2003-04-09
CZ304365B6 (cs) 2014-04-02
PT1299729E (pt) 2006-10-31
EP1712920A1 (en) 2006-10-18
HU228813B1 (en) 2013-05-28
DK1712920T3 (da) 2009-05-11
ES2264691T3 (es) 2007-01-16
JP2004503748A (ja) 2004-02-05
BRPI0112262B8 (pt) 2021-07-27
HRP20030033A2 (en) 2004-02-29
US7351526B2 (en) 2008-04-01
EE200300005A (et) 2004-08-16
SI1299729T1 (sl) 2006-10-31
BRPI0112262B1 (pt) 2016-08-09
WO2002004954A2 (en) 2002-01-17
DK1299729T3 (da) 2006-12-04
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
JP4790966B2 (ja) 2011-10-12
IL153824A0 (en) 2003-07-31
SK18582002A3 (sk) 2003-05-02
BG107498A (bg) 2003-11-28
KR100764981B1 (ko) 2007-10-09
ATE426816T1 (de) 2009-04-15

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: LABORATOIRES SERONO SA, CH

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SERONO S.A., CH

ODRP Renewal fee for the maintenance of a patent

Payment date: 20190506

Year of fee payment: 19

ODRP Renewal fee for the maintenance of a patent

Payment date: 20200522

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20210613