CY1107554T1 - Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης - Google Patents

Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης

Info

Publication number
CY1107554T1
CY1107554T1 CY20071100188T CY071100188T CY1107554T1 CY 1107554 T1 CY1107554 T1 CY 1107554T1 CY 20071100188 T CY20071100188 T CY 20071100188T CY 071100188 T CY071100188 T CY 071100188T CY 1107554 T1 CY1107554 T1 CY 1107554T1
Authority
CY
Cyprus
Prior art keywords
acid addition
addition salts
therapeutic agents
embolism
preventive
Prior art date
Application number
CY20071100188T
Other languages
English (en)
Inventor
Fumitoshi Asai
Taketoshi Ogawa
Hideo Naganuma
Naotoshi Yamamura
Teruhiko Inoue
Kazuyoshi Nakamura
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26595526&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1107554(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of CY1107554T1 publication Critical patent/CY1107554T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Άλατα προσθήκης οξέος της 2-ακετοξυ-5-(α-κυκλοπροπυλοκαρβονυλο-2-φθοροβενζυλο)-4,5,6,7-τετραϋδροθειενο[3,2-c]-πυριδίνης. Τα άλατα προσθήκης οξέος των παραγώγων τετραϋδροθειενοπυριδίνης της παρούσας εφεύρεσης εμφανίζουν εξαιρετική στοματική απορρόφηση, μεταβολισμό στη δραστική ένωση, και ανασταλτική συμπεριφορά έναντι συσσωμάτωσης αιμοπεταλίων, χαμηλή τοξικότητα, και εξαιρετική σταθερότητα φύλαξης και χειρισμού, και είναι χρήσιμα ως φάρμακα, κατά προτίμηση ως προληπτικά ή θεραπευτικά μέσα (ιδίως ως θεραπευτικά μέσα) για παθήσεις προκαλούμενες από θρόμβο ή έμβολο, κατά περαιτέρω προτίμηση ως προληπτικά ή θεραπευτικά μέσα (ιδίως ως θεραπευτικά μέσα) για θρόμβωση ή εμβολή.
CY20071100188T 2000-07-06 2007-02-12 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης CY1107554T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000205396 2000-07-06
JP2000266780 2000-09-04
PCT/JP2001/005764 WO2002004461A1 (fr) 2000-07-06 2001-07-03 Sels d'addition acides de dérivés hydropyridine

Publications (1)

Publication Number Publication Date
CY1107554T1 true CY1107554T1 (el) 2010-07-28

Family

ID=26595526

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20071100188T CY1107554T1 (el) 2000-07-06 2007-02-12 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης
CY20081100983T CY1110395T1 (el) 2000-07-06 2008-09-11 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης
CY2009011C CY2009011I1 (el) 2000-07-06 2009-08-03 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20081100983T CY1110395T1 (el) 2000-07-06 2008-09-11 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης
CY2009011C CY2009011I1 (el) 2000-07-06 2009-08-03 Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης

Country Status (24)

Country Link
US (1) US6693115B2 (el)
EP (2) EP1298132B1 (el)
KR (6) KR20080021152A (el)
CN (1) CN1214031C (el)
AT (2) ATE398624T1 (el)
AU (2) AU2001267916B2 (el)
BR (1) BR0112168A (el)
CA (2) CA2415558C (el)
CY (3) CY1107554T1 (el)
CZ (1) CZ302990B6 (el)
DE (2) DE60134508D1 (el)
DK (2) DK1728794T3 (el)
ES (2) ES2308633T3 (el)
HK (2) HK1051362A1 (el)
HU (2) HU230762B1 (el)
IL (2) IL153546A0 (el)
MX (1) MXPA03000031A (el)
NO (1) NO328651B1 (el)
NZ (1) NZ523416A (el)
PL (1) PL208386B1 (el)
PT (2) PT1728794E (el)
RU (1) RU2238275C1 (el)
TW (1) TWI290927B (el)
WO (1) WO2002004461A1 (el)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400644A3 (en) 2000-12-25 2009-06-29 Ube Industries Pharmaceutical compositions containing aspirin
KR20050025604A (ko) * 2002-07-18 2005-03-14 상꾜 가부시키가이샤 동맥 경화증 치료를 위한 의약 조성물
US20060217351A1 (en) * 2003-05-05 2006-09-28 Brandt John T Method for treating cardiovascular diseases
US20060099262A1 (en) * 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
US20060099261A1 (en) * 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
US8586085B2 (en) * 2004-11-08 2013-11-19 Biokey, Inc. Methods and formulations for making pharmaceutical compositions containing bupropion
CN1318428C (zh) * 2005-02-23 2007-05-30 天津药物研究院 噻吩并吡啶取代的乙酰肼衍生物
TWI318571B (en) * 2005-06-10 2009-12-21 Lilly Co Eli Formulation of a thienopyridine platelet aggregation inhibitor
EA200800075A1 (ru) * 2005-06-17 2008-04-28 Эли Лилли Энд Компани Схема дозирования для празугреля
JP2009504737A (ja) * 2005-08-19 2009-02-05 イーライ リリー アンド カンパニー 脈管疾患の治療又は予防のためのｐａｒ−１／ｐａｒ−４阻害剤の使用
US8056072B2 (en) 2005-10-31 2011-11-08 Microsoft Corporation Rebootless display driver upgrades
WO2007115305A2 (en) 2006-04-04 2007-10-11 Cogentus Pharmaceuticals, Inc. Oral dosage forms including an antiplatelet agent and an acid inhibitor
TWI392681B (zh) * 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd 高純度普拉格雷及其酸加成鹽之製法
DE602007003024D1 (de) * 2006-06-27 2009-12-10 Sandoz Ag Neues verfahren zur salzherstellung
US20100062066A1 (en) * 2006-11-14 2010-03-11 Acusphere, Inc Formulations of Tetrahydropyridine Antiplatelet Agents for Parenteral or Oral Administration
BRPI0719393B8 (pt) * 2006-12-07 2021-05-25 Daiichi Sankyo Co Ltd composição farmacêutica
EP2100608A4 (en) * 2006-12-07 2009-12-09 Daiichi Sankyo Co Ltd METHOD FOR PRODUCING A SOLID PREPARATION
WO2008069262A1 (ja) * 2006-12-07 2008-06-12 Daiichi Sankyo Company, Limited 安定性が改善されたフィルムコーティング製剤
US20100004279A1 (en) * 2006-12-07 2010-01-07 Tomoyuki Watanabe Solid medicinal preparation containing mannitol or lactose
TWI488657B (zh) * 2006-12-07 2015-06-21 Daiichi Sankyo Co Ltd 貯藏安定性經改善之醫藥組成物及改善醫藥組成物之貯藏安定性的方法
SI2123656T1 (sl) * 2007-03-02 2014-09-30 Daiichi Sankyo Company, Limited Postopek izdelave hidroklorid prasugrela visoke ÄŤistosti
EP3766493B1 (en) 2007-04-27 2023-08-23 CyDex Pharmaceuticals, Inc. Method for improving the stability of clopidogrel using sulfoalkyl ether cyclodextrin
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
US20100261908A1 (en) * 2007-11-09 2010-10-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel , and its salts and polymorphs
HU230261B1 (hu) * 2007-11-27 2015-11-30 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás gyógyszeripari intermedierek előállítására
CN101177430A (zh) * 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 氢化吡啶衍生物及其盐的制备方法
DE112009000268T5 (de) 2008-02-06 2011-06-01 Helm Ag Prasugrel-Salze mit verbesserten Eigenschaften
WO2009129983A1 (en) * 2008-04-21 2009-10-29 Ratiopharm Gmbh Acid addition salts of prasugrel and pharmaceutical compositions comprising the same
DE602008002820D1 (de) * 2008-04-25 2010-11-11 Sandoz Ag Hydrogensulfat von 2-Acetoxy-5-(a-cyclopropylcarbonyl-2-fluorbenzyl)-4,5,6,7-tetrahydrothienoÄ3,2-cÜpyridin und dessen Zubereitung
US20090281136A1 (en) * 2008-05-08 2009-11-12 Sandeep Mhetre Prasugrel pharmaceutical formulations
US9427448B2 (en) 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
US20130303477A1 (en) * 2008-05-13 2013-11-14 The Medicines Company Maintenance of Platelet Inhibition During Antiplatelet Therapy
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
US8759316B2 (en) * 2008-05-13 2014-06-24 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
KR20110045034A (ko) 2008-08-02 2011-05-03 루난 파마슈티컬 그룹 코퍼레이션 프라수그렐 황산수소염 및 이의 약제학적 조성물 및 용도
SI2398468T1 (sl) 2009-02-17 2017-03-31 Krka, D.D., Novo Mesto Farmacevtske sestave, ki obsegajo prasugrel ali njegove farmacevtsko sprejemljive kislinske adicijske soli in postopek za njihovo pripravo
WO2010111951A1 (zh) 2009-03-31 2010-10-07 上海医药工业研究院 普拉格雷氢溴酸盐的晶体
DE202010018378U1 (de) 2009-04-10 2016-04-07 Tufts Medical Center, Inc. PAR-1-Aktivierung durch Metalloproteinase-1 (MMP-1)
JP5808739B2 (ja) * 2009-05-13 2015-11-10 サイデックス・ファーマシューティカルズ・インコーポレイテッド プラスグレル及びシクロデキストリン誘導体を含む医薬組成物並びにその製造方法及び使用方法
EP2451816A4 (en) * 2009-07-06 2013-02-27 Glenmark Generics Ltd CRYSTALLINE FORM OF PRASUGREL HYDROBROMIDE AND PROCESS FOR PREPARING THE SAME
DE102009036646A1 (de) 2009-08-07 2011-02-10 Ratiopharm Gmbh Prasugrel in nicht-kristalliner Form und pharmazeutische Zusammensetzung davon
CN101993447A (zh) 2009-08-26 2011-03-30 浙江华海药业股份有限公司 一种人工合成普拉格雷的方法
WO2011036533A1 (en) 2009-09-23 2011-03-31 Glenmark Pharmaceuticals Limited Pharmaceutical composition comprising prasugrel and triflusal
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
ES2773040T3 (es) 2009-11-11 2020-07-09 Chiesi Farm Spa Métodos de tratamiento o prevención de trombosis de stent
CZ2009763A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a jeho nových farmaceuticky prijatelných solí.
CZ2009762A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Nové soli 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a zpusob jejich výroby
CZ2009828A3 (cs) 2009-12-09 2011-06-22 Zentiva, K.S. Zpusob prípravy hydrochloridu 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu hydrochloridu) v polymorfní forme B
HU229035B1 (en) * 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
WO2011092720A2 (en) * 2010-02-01 2011-08-04 Msn Laboratories Limited Pharmaceutical composition of prasugrel and its pharmaceutically acceptable salts
EP2360159A1 (de) 2010-02-11 2011-08-24 Ratiopharm GmbH Prasugrel in mikronisierter, kristalliner Form und pharmazeutische Zusammensetzung davon
EP2545059A1 (en) 2010-03-09 2013-01-16 Synthon BV A process for making prasugrel
KR101184915B1 (ko) 2010-03-11 2012-09-21 한미사이언스 주식회사 고순도 프라수그렐의 제조방법
EP2528924A1 (en) 2010-03-23 2012-12-05 Alembic Pharmaceuticals Limited A process for the preparation of prasugrel hcl salt
EP2377520A1 (de) 2010-03-24 2011-10-19 Ratiopharm GmbH Pharmazeutische Zusammensetzung des Prasugrels
CN102212068A (zh) * 2010-04-06 2011-10-12 刘桂坤 噻吩衍生物及其制备方法和在药物上的应用
ES2533681T3 (es) 2010-04-08 2015-04-14 Teva Pharmaceutical Industries Ltd. Formas cristalinas de sales de Prasugrel
CN102212071B (zh) * 2010-04-08 2014-03-26 上海医药工业研究院 普拉格雷盐酸盐乙酸溶剂合物及其结晶和制备方法
WO2011132201A1 (en) 2010-04-19 2011-10-27 Cadila Healthcare Limited A pharmaceutical composition comprising antiplatelet agents and an erythropoiesis stimulating agent
WO2012001486A1 (en) * 2010-06-28 2012-01-05 Mayuka Labs Pvt. Ltd. An improved process for the preparation of prasugrel hydrochloride and its intermediates
EP2409685A3 (en) 2010-07-19 2012-02-01 Sanovel Ilac Sanayi ve Ticaret A.S. Orally-disintegrating formulations of prasugrel
TR201006802A1 (tr) * 2010-08-17 2012-03-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Prasugrelin oral yolla dağılan formülasyonları.
TR201007926A1 (tr) 2010-07-19 2012-02-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Prasugrel tablet formülasyonları.
TR201005900A1 (tr) 2010-07-19 2012-02-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Geliştirilmiş stabiliteye sahip prasugrel granülleri.
WO2012023145A2 (en) * 2010-08-18 2012-02-23 Hetero Research Foundation Prasugrel hydrochloride crystalline particles
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN101985450B (zh) * 2010-11-02 2012-07-11 北京赛科药业有限责任公司 普拉格雷盐及其制备方法
CN102532157A (zh) * 2010-12-16 2012-07-04 瑞阳制药有限公司 普拉格雷的可药用酸加成盐化合物及其制备方法
CZ305314B6 (cs) * 2010-12-30 2015-07-29 Zentiva, K.S. Nový hydrobromid formy C 5-[2-cyklopropyl-1-(2-fluorofenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráněným názvem prasugrel a způsob jeho výroby
CN102199163A (zh) * 2011-04-01 2011-09-28 中国药科大学 2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN102746318A (zh) * 2011-04-20 2012-10-24 上海信谊药厂有限公司 用于制备普拉格雷盐酸盐的方法
JP2014515352A (ja) 2011-05-17 2014-06-30 ベリコ メディカル インコーポレイティッド シアリダーゼ阻害剤を用いた血小板の保存の改善法
US9609861B2 (en) 2011-05-17 2017-04-04 Velico Medical Inc. Platelet additive solution having a β-galactosidase inhibitor
US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
CN102838618A (zh) 2011-06-22 2012-12-26 广东东阳光药业有限公司 一种制备普拉格雷的方法及普拉格雷盐酸盐新晶型
EP2985023A1 (en) 2011-07-28 2016-02-17 Laboratorios Lesvi, S.L. Process for preparing prasugrel
CN103102355A (zh) * 2011-11-09 2013-05-15 丁克 具有旋光性的四氢噻吩并吡啶化合物
CZ2011872A3 (cs) 2011-12-22 2013-07-03 Zentiva, K.S. Farmaceutická formulace prasugrelu hydrobromidu
US8603537B2 (en) 2012-04-02 2013-12-10 Egis Pharmaceuticals Plc Prasugrel containing quickly released stable oral pharmaceutical compositions
EP2722037A1 (en) 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Prasugrel formulations
EP2722036A1 (en) 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral formulations of prasugrel
PL402028A1 (pl) 2012-12-12 2014-06-23 Instytut Farmaceutyczny Sposób wytwarzania postaci polimorficznej B chlorowodorku prasugrelu o czystości farmaceutycznej
HU230649B1 (hu) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására
WO2014120886A1 (en) 2013-01-30 2014-08-07 Velico Medical, Inc. Platelet additive solution having a self-assembling hydrogel-forming peptide
KR102235732B1 (ko) 2013-12-26 2021-04-02 에스케이플래닛 주식회사 쿠폰 관리 시스템 및 방법, 그리고 이를 위한 장치 및 컴퓨터 프로그램이 기록된 기록매체
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
EP2979693A1 (en) 2014-08-01 2016-02-03 Zaklady Farmaceutyczne Polpharma SA Pharmaceutical composition comprising prasugrel or pharmaceutically acceptable salt thereof and process for its preparation
CN104479502A (zh) * 2014-12-31 2015-04-01 江阴市天邦涂料股份有限公司 一种水性防腐涂料
WO2016122421A1 (en) 2015-01-29 2016-08-04 Pharmactive Ilaç Sanayi Ve Ticaret A.Ş. Stable pharmaceutical compositions containing prasugrel base
WO2016203018A1 (en) 2015-06-19 2016-12-22 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical compositions of prasugrel hydrobromide
EP3156049A1 (en) 2015-10-15 2017-04-19 Alembic Pharmaceuticals Limited Pharmaceutical composition of prasugrel
EP3158993A1 (en) 2015-10-22 2017-04-26 Zaklady Farmaceutyczne Polpharma SA Process for preparing a tablet comprising prasugrel or pharmaceutically acceptable salt thereof
HU231079B1 (hu) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával
EP3528790A1 (en) 2016-10-21 2019-08-28 Laboratorios Lesvi S.L. Pharmaceutical formulations of prasugrel and processes for the preparation thereof
CN106632391A (zh) * 2016-12-23 2017-05-10 山东鲁抗医药股份有限公司 一种盐酸普拉格雷化合物及其制备方法和含有盐酸普拉格雷的药物组合物
CA3060345A1 (en) 2017-06-23 2018-12-27 Chiesi Farmaceutici S.P.A. Method of preventing of systemic-to-pulmonary-artery shunt thrombosis
KR102063862B1 (ko) 2018-08-09 2020-01-08 한국기술교육대학교 산학협력단 Qr코드 기반의 공유시점관리 시스템
KR102491932B1 (ko) 2020-11-18 2023-01-27 현대엠시스템즈 주식회사 통신 방식 가변형 원격 모니터링 제어 시스템 및 방법
KR102485021B1 (ko) 2020-11-18 2023-01-05 효성중공업 주식회사 델타구조 반도체변압기 기반 에너지 저장장치의 SoC 균등제어 장치 및 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141894A (en) * 1976-11-02 1979-02-27 Eli Lilly And Company Trans-5a-aryl-decahydrobenzazepines
FR2576901B1 (fr) 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
JP2506376B2 (ja) * 1987-07-16 1996-06-12 三菱化学株式会社 ２−（４−メチルアミノブトキシ）ジフェニルメタン・塩酸塩の製造方法
FI101150B (fi) 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
US5342851A (en) * 1992-10-07 1994-08-30 Mcneil-Ppc, Inc. Substituted thiazole derivatives useful as platelet aggregation inhibitors
JPH07188168A (ja) * 1993-12-28 1995-07-25 Fujisawa Pharmaceut Co Ltd ジヒドロピリジン化合物およびその製造方法
HUP0400644A3 (en) * 2000-12-25 2009-06-29 Ube Industries Pharmaceutical compositions containing aspirin
CZ2009762A3 (cs) 2009-11-16 2011-05-25 Zentiva, K. S. Nové soli 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráneným názvem prasugrel a zpusob jejich výroby
CZ305314B6 (cs) 2010-12-30 2015-07-29 Zentiva, K.S. Nový hydrobromid formy C 5-[2-cyklopropyl-1-(2-fluorofenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu známého pod nechráněným názvem prasugrel a způsob jeho výroby

Also Published As

Publication number Publication date
PT1728794E (pt) 2008-07-15
AU6791601A (en) 2002-01-21
HK1096684A1 (en) 2007-07-20
HU227746B1 (en) 2012-02-28
CZ302990B6 (cs) 2012-02-08
CN1214031C (zh) 2005-08-10
KR20090033917A (ko) 2009-04-06
NO20030022L (no) 2003-03-05
US20030134872A1 (en) 2003-07-17
PL208386B1 (pl) 2011-04-29
ES2308633T3 (es) 2008-12-01
IL153546A (en) 2007-03-08
US6693115B2 (en) 2004-02-17
KR20120062906A (ko) 2012-06-14
PT1298132E (pt) 2007-01-31
ATE346071T1 (de) 2006-12-15
ATE398624T1 (de) 2008-07-15
MXPA03000031A (es) 2003-10-15
TWI290927B (en) 2007-12-11
EP1728794B1 (en) 2008-06-18
ES2276801T3 (es) 2007-07-01
DK1728794T3 (da) 2008-09-22
CY2009011I2 (el) 2010-07-28
KR20080021152A (ko) 2008-03-06
HUP1100350A2 (en) 2003-09-29
CA2703697C (en) 2012-09-04
EP1298132A1 (en) 2003-04-02
NO20030022D0 (no) 2003-01-03
CA2703697A1 (en) 2002-01-17
EP1728794A1 (en) 2006-12-06
HUP0301645A3 (en) 2006-05-29
HU230762B1 (hu) 2018-03-28
HK1051362A1 (en) 2003-08-01
EP1298132A4 (en) 2004-03-10
KR20030014294A (ko) 2003-02-15
CA2415558A1 (en) 2002-01-17
HUP0301645A2 (hu) 2003-09-29
DE60134508D1 (de) 2008-07-31
DE60124712D1 (de) 2007-01-04
EP1298132B1 (en) 2006-11-22
PL359393A1 (en) 2004-08-23
IL153546A0 (en) 2003-07-06
NZ523416A (en) 2004-10-29
AU2001267916B2 (en) 2004-09-09
DE60124712T2 (de) 2007-09-13
CY1110395T1 (el) 2015-04-29
DK1298132T3 (da) 2007-03-12
BR0112168A (pt) 2003-09-02
KR20130118395A (ko) 2013-10-29
CA2415558C (en) 2010-09-14
CN1452624A (zh) 2003-10-29
RU2238275C1 (ru) 2004-10-20
WO2002004461A1 (fr) 2002-01-17
KR20100105763A (ko) 2010-09-29
CY2009011I1 (el) 2010-07-28
NO328651B1 (no) 2010-04-19
CZ200318A3 (cs) 2003-05-14

Similar Documents

Publication Publication Date Title
CY1107554T1 (el) Αλατα προσθηκης οξεος παραγωγων υδροπυριδινης
DK0539204T3 (da) Antivirale 4-substituerede-deoxy-2,3-didehydroderivater af alfa-D-neuraminsyre
IS7552A (is) Bensótengdar heteróarýl amíð afleiður af þíenópýridíni, gagnlegar sem meðferðarmiðlar, lyfjasamsetningar sem innihalda þær og aðferðir við notkun þeirra
NO20034148L (no) Triazaspiro[5.5]undekanderivater og legemidler inneholdende disse som den aktive bestanddel
ATE407675T1 (de) Aspirin enthaltende medizinische zusammensetzungen
EA200601418A1 (ru) ПРОИЗВОДНЫЕ 1Н-ТИЕНО [2,3-с] ПИРАЗОЛА, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ИСПОЛЬЗОВАНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ
ATE331525T1 (de) Salzformarme polyallylamine
NO20070837L (no) Pyrido-pyrido pyrimidinderivater, fremstilling derav samt terapeutisk anvendelse for behandling av cancer.
ATE153337T1 (de) Thienopyridinderivate und diese enthaltende pharmazeutische zubereitungen
DK0992509T3 (da) Nye makrolid-derivater
ATE440838T1 (de) Pharmazeutisch aktive sulfonylaminosäurederivate
ATE161531T1 (de) Acridine-1,8-dionderivate als therapeutisches mittel
JP2003246735A5 (el)
IL140468A0 (en) Benzoxazole derivatives and pharmaceutical compositions containing the same
HUP0600084A2 (en) Pharmaceutical compositions containing ascorbic acid derivatives, methods of production of the active ingredient
NO20021337D0 (no) 4-benzylaminoquinolinkonjugater med gallesyre og deres heteroanaloger, fremgangsmåte for deres fremstilling, legemidlersom inneholder disse forbindelser og deres anvendelse
SE0301698D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
DK0952157T3 (da) 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin