CS235044B2 - Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production - Google Patents

Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production Download PDF

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Publication number
CS235044B2
CS235044B2 CS834404A CS440483A CS235044B2 CS 235044 B2 CS235044 B2 CS 235044B2 CS 834404 A CS834404 A CS 834404A CS 440483 A CS440483 A CS 440483A CS 235044 B2 CS235044 B2 CS 235044B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
compound
propoxymethyl
dihydroxy
group
Prior art date
Application number
CS834404A
Other languages
Czech (cs)
English (en)
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS235044(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of CS235044B2 publication Critical patent/CS235044B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS834404A 1981-05-21 1982-05-20 Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production CS235044B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (1)

Publication Number Publication Date
CS235044B2 true CS235044B2 (en) 1985-04-16

Family

ID=23017790

Family Applications (4)

Application Number Title Priority Date Filing Date
CS834404A CS235044B2 (en) 1981-05-21 1982-05-20 Method of n2 substitued derivatives 9-(1,3-dihydroxy-2-propoxymethyl)pguanin production
CS834402A CS235042B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3- dihydroxy-2-propomethyl ) p-guanin preparation
CS823735A CS235018B2 (en) 1981-05-21 1982-05-20 Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation
CS834403A CS235043B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3-dihydroxy-2-propoxymethyl)p-guanin preparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
CS834402A CS235042B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3- dihydroxy-2-propomethyl ) p-guanin preparation
CS823735A CS235018B2 (en) 1981-05-21 1982-05-20 Method of 9-/6 1,3-hydroxy-2-propoxymethyl/p-guanine preparation
CS834403A CS235043B2 (en) 1981-05-21 1982-05-20 Method of 9-(l1,3-dihydroxy-2-propoxymethyl)p-guanin preparation

Country Status (33)

Country Link
US (1) US4355032B2 (de)
EP (1) EP0066208B1 (de)
JP (2) JPS57203086A (de)
KR (1) KR890004663B1 (de)
AR (1) AR244227A1 (de)
AT (1) ATE15899T1 (de)
AU (1) AU572086B2 (de)
BR (1) BR8202931A (de)
CA (3) CA1305139C (de)
CS (4) CS235044B2 (de)
DD (2) DD203052A5 (de)
DE (1) DE3266644D1 (de)
DK (2) DK150304C (de)
ES (7) ES8404355A1 (de)
FI (1) FI73682C (de)
GR (1) GR76459B (de)
HK (1) HK67088A (de)
HU (2) HU188000B (de)
IE (1) IE53731B1 (de)
IL (1) IL65836A (de)
IN (1) IN156469B (de)
LU (1) LU88334I2 (de)
MY (1) MY8700793A (de)
NL (2) NL930022I1 (de)
NO (2) NO161740C (de)
NZ (1) NZ200691A (de)
PH (1) PH17975A (de)
PL (4) PL136579B1 (de)
PT (1) PT74934B (de)
RO (2) RO87387A (de)
SG (1) SG81687G (de)
SU (1) SU1176841A3 (de)
ZA (1) ZA823532B (de)

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KR910000198B1 (ko) * 1984-12-12 1991-01-23 신텍스(유.에스.에이.) 인코포레이티드 글리세롤의 알콕시메틸 에테르 및 알콕시메틸 에스테르의 제조방법
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
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US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
ES2132411T3 (es) * 1993-06-23 1999-08-16 Merrell Pharma Inc Derivados nucleosidicos carbo-aciclicos como agentes antivirasicos y antineoplasicos.
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
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Also Published As

Publication number Publication date
AU572086B2 (en) 1988-05-05
ES8601204A1 (es) 1985-11-16
RO84860B (ro) 1984-10-30
RO84860A (ro) 1984-09-29
ES8505681A1 (es) 1985-06-16
PL246770A1 (en) 1984-08-27
ES512414A0 (es) 1984-05-01
KR830010112A (ko) 1983-12-26
FI821794A0 (fi) 1982-05-20
JPH046195B2 (de) 1992-02-05
NO1994005I1 (no) 1994-07-29
DD213218A5 (de) 1984-09-05
PL236521A1 (en) 1984-01-02
ES529384A0 (es) 1987-01-01
CS235018B2 (en) 1985-04-16
ES529383A0 (es) 1986-05-16
AU8389282A (en) 1982-11-25
CA1305139C (en) 1992-07-14
PT74934A (en) 1982-06-01
GR76459B (de) 1984-08-10
IE821210L (en) 1982-11-21
NL930022I1 (nl) 1993-05-03
EP0066208A1 (de) 1982-12-08
CS235043B2 (en) 1985-04-16
DK227782A (da) 1982-11-22
PL136004B1 (en) 1986-01-31
DK504183A (da) 1983-11-03
NO821676L (no) 1982-11-22
DD203052A5 (de) 1983-10-12
HU188000B (en) 1986-03-28
ES8404355A1 (es) 1984-05-01
DK150304C (da) 1988-01-04
ES520849A0 (es) 1984-11-01
SU1176841A3 (ru) 1985-08-30
NL930139I1 (nl) 1993-11-01
PH17975A (en) 1985-02-22
ZA823532B (en) 1983-03-30
ES524899A0 (es) 1985-09-16
KR890004663B1 (ko) 1989-11-24
US4355032A (en) 1982-10-19
DK150304B (da) 1987-02-02
EP0066208B1 (de) 1985-10-02
RO87387B (ro) 1985-08-31
CA1305140C (en) 1992-07-14
NZ200691A (en) 1986-11-12
CA1305141C (en) 1992-07-14
FI73682C (fi) 1987-11-09
NO161740B (no) 1989-06-12
DK149001C (da) 1988-11-28
BR8202931A (pt) 1983-05-03
NL930139I2 (nl) 1997-07-01
DK504183D0 (da) 1983-11-03
HK67088A (en) 1988-09-02
ES8701496A1 (es) 1987-01-01
ES533821A0 (es) 1985-06-16
IN156469B (de) 1985-08-10
MY8700793A (en) 1987-12-31
LU88334I2 (fr) 1994-09-09
ES8500276A1 (es) 1984-11-01
ES524900A0 (es) 1985-11-16
PT74934B (en) 1984-05-08
PL136579B1 (en) 1986-02-28
PL242101A1 (en) 1984-07-16
AR244227A1 (es) 1993-10-29
PL242100A1 (en) 1984-04-24
PL136637B1 (en) 1986-03-31
HU186514B (en) 1985-08-28
IL65836A0 (en) 1982-08-31
PL136332B1 (en) 1986-02-28
IL65836A (en) 1991-04-15
IE53731B1 (en) 1989-02-01
NO161740C (no) 1989-09-20
ATE15899T1 (de) 1985-10-15
ES8606869A1 (es) 1986-05-16
US4355032B2 (en) 1990-10-30
SG81687G (en) 1989-07-07
DE3266644D1 (en) 1985-11-07
US4355032B1 (de) 1983-06-14
DK149001B (da) 1985-12-16
JPH04217983A (ja) 1992-08-07
JPH0529399B2 (de) 1993-04-30
FI73682B (fi) 1987-07-31
ES8507549A1 (es) 1985-09-16
JPS57203086A (en) 1982-12-13
CS235042B2 (en) 1985-04-16
RO87387A (ro) 1985-08-31

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