CS217961B2 - Method of preparation of the 7-substituted-3-cefem-4-carboxyl acids - Google Patents

Method of preparation of the 7-substituted-3-cefem-4-carboxyl acids Download PDF

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Publication number
CS217961B2
CS217961B2 CS781614A CS161478A CS217961B2 CS 217961 B2 CS217961 B2 CS 217961B2 CS 781614 A CS781614 A CS 781614A CS 161478 A CS161478 A CS 161478A CS 217961 B2 CS217961 B2 CS 217961B2
Authority
CS
Czechoslovakia
Prior art keywords
group
solution
carbon atoms
compound
cephem
Prior art date
Application number
CS781614A
Other languages
Czech (cs)
English (en)
Inventor
Takao Takaya
Hisashi Takasugi
Kiyoshi Tsuji
Toshiyuku Chiba
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB10699/77A external-priority patent/GB1600735A/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Priority claimed from KR7802782A external-priority patent/KR820001285B1/ko
Priority to CS796537A priority Critical patent/CS217960B2/cs
Priority to CS796536A priority patent/CS217959B2/cs
Priority claimed from KR1019820000231A external-priority patent/KR830000455B1/ko
Publication of CS217961B2 publication Critical patent/CS217961B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS781614A 1977-03-14 1978-03-14 Method of preparation of the 7-substituted-3-cefem-4-carboxyl acids CS217961B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CS796537A CS217960B2 (cs) 1977-10-11 1979-09-27 Způsob přípravy 7-substituovaných-3-cefem-4-karboxyIových kyselin
CS796536A CS217959B2 (cs) 1977-03-14 1979-09-27 Způsob přípravy syn isomeru 7-substituovaných-3-cefem nebo cefam-4-karboxylových kyselin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB10699/77A GB1600735A (en) 1977-03-14 1977-03-14 Cephem and cephem compounds and processes for preparation thereof
GB2924577 1977-07-12
GB4231577 1977-10-11
GB7578 1978-01-03
KR7802782A KR820001285B1 (ko) 1977-03-14 1978-09-13 세펨화합물의 제조방법
KR1019820000231A KR830000455B1 (ko) 1977-03-14 1982-01-18 세펨화합물의 제조방법

Publications (1)

Publication Number Publication Date
CS217961B2 true CS217961B2 (en) 1983-02-25

Family

ID=27546433

Family Applications (1)

Application Number Title Priority Date Filing Date
CS781614A CS217961B2 (en) 1977-03-14 1978-03-14 Method of preparation of the 7-substituted-3-cefem-4-carboxyl acids

Country Status (21)

Country Link
US (7) US4425341A (en, 2012)
JP (7) JPS53137988A (en, 2012)
AR (2) AR230452A1 (en, 2012)
AT (1) AT364456B (en, 2012)
BE (1) BE864810A (en, 2012)
CA (1) CA1321580C (en, 2012)
CH (1) CH637138A5 (en, 2012)
CS (1) CS217961B2 (en, 2012)
DD (2) DD144772A5 (en, 2012)
DE (1) DE2810922C2 (en, 2012)
DK (1) DK163832C (en, 2012)
ES (8) ES467828A1 (en, 2012)
FI (1) FI65779C (en, 2012)
FR (1) FR2383951A1 (en, 2012)
GR (1) GR63619B (en, 2012)
NL (2) NL182401C (en, 2012)
NZ (2) NZ186679A (en, 2012)
PH (2) PH17188A (en, 2012)
PT (1) PT67773A (en, 2012)
SE (3) SE438677B (en, 2012)
YU (3) YU41586B (en, 2012)

Families Citing this family (78)

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BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4464369A (en) * 1977-03-14 1984-08-07 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
FR2399418A1 (fr) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques
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DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
FR2410655A1 (fr) 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4284631A (en) 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
US4379922A (en) * 1978-09-12 1983-04-12 Fujisawa Pharmaceutical Co., Ltd. Cepham compounds
JPS5543011A (en) * 1978-09-20 1980-03-26 Shionogi & Co Ltd 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
FR2448543A1 (fr) 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2461713A1 (fr) * 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS56125392A (en) * 1980-03-06 1981-10-01 Fujisawa Pharmaceut Co Ltd Cepham and cephem compound and preparation thereof
JPS6238569A (ja) * 1985-08-13 1987-02-19 Nec Corp 磁気デイスク制御装置
US5059611A (en) * 1988-11-18 1991-10-22 Allergan, Inc. Anti-inflammatory 5-hydroxy-2-furanones

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ES8203865A1 (es) 1982-04-01
ES491183A0 (es) 1981-03-16
NZ199860A (en) 1984-07-31
DK114878A (da) 1978-09-15
DK163832B (da) 1992-04-06
ES487736A0 (es) 1980-11-01
SE7802933L (sv) 1978-09-15
JPH03115256A (ja) 1991-05-16
JPS6134435B2 (en, 2012) 1986-08-07
SE8304671D0 (sv) 1983-08-29
JPH0639464B2 (ja) 1994-05-25
NL8501475A (nl) 1985-09-02
JPH052666B2 (en, 2012) 1993-01-13
NL182401B (nl) 1987-10-01
DK163832C (da) 1992-09-21
JPH03115288A (ja) 1991-05-16
NL7802792A (nl) 1978-09-18
ES491184A0 (es) 1981-03-16
JPH0517230B2 (en, 2012) 1993-03-08
ES8100665A1 (es) 1980-11-01
AT364456B (de) 1981-10-27
ES491182A0 (es) 1981-03-16
FI780801A7 (fi) 1978-09-15
FR2383951A1 (fr) 1978-10-13
CA1321580C (en) 1993-08-24
US4822888A (en) 1989-04-18
ES487737A0 (es) 1980-12-01
US4425341A (en) 1984-01-10
JPS53137988A (en) 1978-12-01
YU42061B (en) 1988-04-30
US4460583A (en) 1984-07-17
NL182401C (nl) 1988-03-01
YU41586B (en) 1987-10-31
DE2810922A1 (de) 1978-09-21
JPH03135971A (ja) 1991-06-10
BE864810A (fr) 1978-09-13
SE8304670D0 (sv) 1983-08-29
FI65779C (fi) 1984-07-10
YU274582A (en) 1983-06-30
GR63619B (en) 1979-11-27
ES8103753A1 (es) 1981-03-16
ATA181378A (de) 1981-03-15
DE2810922C2 (de) 1985-08-29
US4563522A (en) 1986-01-07
ES480598A1 (es) 1980-07-01
YU274682A (en) 1983-10-31
US4294960A (en) 1981-10-13
DD144772A5 (de) 1980-11-05
ES497084A0 (es) 1982-04-01
ES467828A1 (es) 1979-09-01
US4447430A (en) 1984-05-08
SE438677B (sv) 1985-04-29
FR2383951B1 (en, 2012) 1983-02-11
ES8101077A1 (es) 1980-12-01
PH17188A (en) 1984-06-14
SE8304670L (sv) 1983-08-29
AR226423A1 (es) 1982-07-15
PH17064A (en) 1984-05-24
AR230452A1 (es) 1984-04-30
SE456909B (sv) 1988-11-14
DD136839A5 (de) 1979-08-01
YU60878A (en) 1983-04-30
JPH03135973A (ja) 1991-06-10
US4604456A (en) 1986-08-05
JPS6434974A (en) 1989-02-06
JPH0720947B2 (ja) 1995-03-08
FI65779B (fi) 1984-03-30
CH637138A5 (de) 1983-07-15
ES8103751A1 (es) 1981-03-16
NZ186679A (en) 1982-12-21
PT67773A (en) 1978-04-01
JPH03135972A (ja) 1991-06-10
ES8103752A1 (es) 1981-03-16

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