CR20160599A - Diacuerpos Enlazados Covalentemente que tienen Inmunoreactividad con PD-1 y LAG-3, y Métodos de Uso de los Mismos - Google Patents

Diacuerpos Enlazados Covalentemente que tienen Inmunoreactividad con PD-1 y LAG-3, y Métodos de Uso de los Mismos

Info

Publication number
CR20160599A
CR20160599A CR20160599A CR20160599A CR20160599A CR 20160599 A CR20160599 A CR 20160599A CR 20160599 A CR20160599 A CR 20160599A CR 20160599 A CR20160599 A CR 20160599A CR 20160599 A CR20160599 A CR 20160599A
Authority
CR
Costa Rica
Prior art keywords
lag
immunoreactivity
diabodies
covalently linked
use methods
Prior art date
Application number
CR20160599A
Other languages
English (en)
Inventor
Ezio Bonvini
Kalpana Shah
Leslie S Johnson
Scott Koenig
Motte-Mohs Ross La
Paul A Moore
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of CR20160599A publication Critical patent/CR20160599A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La presente invención se dirige a un diacuerpo bi-específico que comprende dos o más cadenas de polipéptidos y que poseen al menos un Sitio de Unión de Epítopo que es inmunoespecífico para un epítopo de PD-1 y al menos un Sitio de Unión de Epítopo que es inmunoespecífico para un epítopo de LAG-3 (es decir, un ¿diacuerpo bi-específico de PD-1 x LAG-3¿).
CR20160599A 2014-06-26 2015-06-19 Diacuerpos Enlazados Covalentemente que tienen Inmunoreactividad con PD-1 y LAG-3, y Métodos de Uso de los Mismos CR20160599A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462017467P 2014-06-26 2014-06-26
PCT/US2015/036634 WO2015200119A1 (en) 2014-06-26 2015-06-19 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof

Publications (1)

Publication Number Publication Date
CR20160599A true CR20160599A (es) 2017-04-27

Family

ID=54938685

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160599A CR20160599A (es) 2014-06-26 2015-06-19 Diacuerpos Enlazados Covalentemente que tienen Inmunoreactividad con PD-1 y LAG-3, y Métodos de Uso de los Mismos

Country Status (34)

Country Link
US (3) US10160806B2 (es)
EP (1) EP3161004B1 (es)
JP (2) JP6890421B2 (es)
KR (1) KR102514330B1 (es)
CN (1) CN106715470B (es)
AR (1) AR101009A1 (es)
AU (1) AU2015280392B2 (es)
CA (1) CA2953818C (es)
CL (1) CL2016003335A1 (es)
CR (1) CR20160599A (es)
CY (1) CY1123917T1 (es)
DK (1) DK3161004T3 (es)
EA (1) EA036737B1 (es)
EC (1) ECSP16096342A (es)
ES (1) ES2843269T3 (es)
GE (1) GEP20197034B (es)
HR (1) HRP20210041T1 (es)
HU (1) HUE052615T2 (es)
IL (1) IL249764B (es)
LT (1) LT3161004T (es)
MX (1) MX369486B (es)
MY (1) MY177324A (es)
PE (1) PE20170767A1 (es)
PH (1) PH12016502590A1 (es)
PL (1) PL3161004T3 (es)
PT (1) PT3161004T (es)
RS (1) RS61284B1 (es)
SA (1) SA516380600B1 (es)
SG (1) SG11201610715SA (es)
SI (1) SI3161004T1 (es)
TW (1) TWI693232B (es)
UA (1) UA119673C2 (es)
WO (1) WO2015200119A1 (es)
ZA (1) ZA201608768B (es)

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