SA516380600B1 - أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1 - Google Patents
أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1Info
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- SA516380600B1 SA516380600B1 SA516380600A SA516380600A SA516380600B1 SA 516380600 B1 SA516380600 B1 SA 516380600B1 SA 516380600 A SA516380600 A SA 516380600A SA 516380600 A SA516380600 A SA 516380600A SA 516380600 B1 SA516380600 B1 SA 516380600B1
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- lag
- diabodies
- epitope
- specific
- immunoreactivity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
يتعلق الاختراع الحالي بأجسام مضادة ثنائية التكافؤ مزدوجة النوعية bi-specific Fc diabody تشتمل على اثنين أو أكثر من سلاسل بولي ببتيد polypeptide chains وتتمتع بموقع ربط قمة لاصقة epitope واحد على الأقل يكون نوعي مناعي لقمة لاصقة من PD-1 وبموقع ربط قمة لاصقة واحد على الأقل يكون نوعي مناعي لقمة لاصقة من LAG-3 (أي، "PD-1 x LAG-3 جسم مضاد ثنائي التكافؤ مزدوج النوعية"). بصورة مفضلة، يتم توجيه الاختراع الحالي إلى أجسام مضادة ثنائية التكافؤ مزدوجة النوعية تشتمل على أربع سلاسل بولي ببتيد وتتمتع بموقعي ربط قمة لاصقة يكونان نوعيين مناعيين لقمة لاصقة واحدة (أو اثنتين) من PD-1 و موقعي ربط قمة لاصقة يكونان نوعيين مناعيين لقمة لاصقة واحدة (أو اثنتين) من LAG-3 (أي، "PD-1 x LAG-3 جسم مضاد ثنائي التكافؤ مزدوج النوعية، رباعي التكافؤ"). كما تم توجيه الاختراع الحالي إلى الأجسام الثنائية المذكورة التي تشتمل بالإضافة إلى ذلك على نطاق Fc لجلوبيولين مناعي immunoglobulin (أجسام ثنائية Fc مزدوجة النوعية وأجسام Fc مزدوجة النوعية رباعية التكافؤ"). الأجسام الثنائية للاختراع الحالي تكون قادرة على الارتباط المتزامن
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201462017467P | 2014-06-26 | 2014-06-26 | |
PCT/US2015/036634 WO2015200119A1 (en) | 2014-06-26 | 2015-06-19 | Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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SA516380600B1 true SA516380600B1 (ar) | 2022-02-08 |
Family
ID=54938685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SA516380600A SA516380600B1 (ar) | 2014-06-26 | 2016-12-25 | أجسام مضادة ثنائية التكافؤ مرتبطة تساهميا لها نشاط تفاعلي مناعي مع وطرق استخدامها lag-3 و pd-1 |
Country Status (35)
Country | Link |
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US (3) | US10160806B2 (ar) |
EP (1) | EP3161004B1 (ar) |
JP (2) | JP6890421B2 (ar) |
KR (1) | KR102514330B1 (ar) |
CN (1) | CN106715470B (ar) |
AR (1) | AR101009A1 (ar) |
AU (1) | AU2015280392B2 (ar) |
CA (1) | CA2953818C (ar) |
CL (1) | CL2016003335A1 (ar) |
CR (1) | CR20160599A (ar) |
CY (1) | CY1123917T1 (ar) |
DK (1) | DK3161004T3 (ar) |
EA (1) | EA036737B1 (ar) |
EC (1) | ECSP16096342A (ar) |
ES (1) | ES2843269T3 (ar) |
GE (1) | GEP20197034B (ar) |
HR (1) | HRP20210041T1 (ar) |
HU (1) | HUE052615T2 (ar) |
IL (1) | IL249764B (ar) |
LT (1) | LT3161004T (ar) |
MX (1) | MX369486B (ar) |
MY (1) | MY177324A (ar) |
NZ (1) | NZ727772A (ar) |
PE (1) | PE20170767A1 (ar) |
PH (1) | PH12016502590A1 (ar) |
PL (1) | PL3161004T3 (ar) |
PT (1) | PT3161004T (ar) |
RS (1) | RS61284B1 (ar) |
SA (1) | SA516380600B1 (ar) |
SG (1) | SG11201610715SA (ar) |
SI (1) | SI3161004T1 (ar) |
TW (1) | TWI693232B (ar) |
UA (1) | UA119673C2 (ar) |
WO (1) | WO2015200119A1 (ar) |
ZA (1) | ZA201608768B (ar) |
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