CO5700719A2 - Derivados de alcanos azaespiro como inhibidores de las metaloproteasas - Google Patents
Derivados de alcanos azaespiro como inhibidores de las metaloproteasasInfo
- Publication number
- CO5700719A2 CO5700719A2 CO05106414A CO05106414A CO5700719A2 CO 5700719 A2 CO5700719 A2 CO 5700719A2 CO 05106414 A CO05106414 A CO 05106414A CO 05106414 A CO05106414 A CO 05106414A CO 5700719 A2 CO5700719 A2 CO 5700719A2
- Authority
- CO
- Colombia
- Prior art keywords
- crdrf
- nrbc
- nrb
- nrbs
- substituted
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 125000004450 alkenylene group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- -1 hydantoinyl Chemical group 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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Abstract
1.- Un compuesto de Fórmula I o II: o un enantiómero, diaestereoisómero, prodroga, solvato, metabolito o sal farmacéuticamente aceptable del mismo, donde:A es CWOH, CWNHOH, CWNHOR5, N(OH)CHO, N(OH)CWR6, SH, SR7 o hidantoinilo;B es (CH2)n, (CH2)nC=W, (CRdRf)nNR8, NR8(CRdRf)n, (CRdRf)nO(CRdRf)r, (CRdRf)nS(CRdRf)r, O(C=W)NR8, O, N, NR8, S(O)m, S, C(O)NR8(CRdRf)n, C(O)(CRdRf)n o combinaciones de los mismos;G es (CH2)n, (CH2)nC=W, (CRdRf)nNR8, NR8(CRdRf)n, (CRdRf)nO(CRdRf)r, (CRdRf)nS(CRdRf)r, O(C=W)NR8, O, N, NR8, S(O)m, S, C(O)NR8(CRdRf)n, C(O)(CRdRf)n, o combinaciones de los mismos;D es oxígeno o azufre;X está ausente o es (CH2)j, alquileno C1-10 sustituido con 0 a 3 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRb, S(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)mNRb, (CRdRf)jNRb, NRb(CRdRf)j o combinaciones de los mismos;Y está ausente o es (CH2)j, alquileno C1-10 sustituido con 0 a 3 Ra, alquenileno C2-10 sustituido, con 0 a 2 Ra, N, O, NRb, S(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)mNRb, (CRdRf)jNRb, NRb(CRdRf)j o combinaciones de los mismos;M es CO o S(O)¡;U está ausente o es alquileno C1-10 sustituido con 0 a 5 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRb, NRbC(O), NRbC(O)O, NRbC(O)NRb, NRbS(O)m, NRbS(O)NRb o combinaciones de los mismos;V está ausente o es H, carbociclilo C3-13 sustituido con 0-5 Re o heterociclilo sustituido con 0-5 Re;U' está ausente o es alquileno C1-10 sustituido con 0 a 5 Ra, alquenileno C2-10 sustituido con 0 a 2 Ra, N, O, NRbS(O)m, C=O, NRbC(O), NRbC(O)O, NRbC(O)NRb, C(O)O, OC(O), S(O)mNRb, NRbS(O)m, NRbS(O)NRb o combinaciones de los mismos; ...
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