ECSP066542A - Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos - Google Patents

Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos

Info

Publication number
ECSP066542A
ECSP066542A EC2006006542A ECSP066542A ECSP066542A EC SP066542 A ECSP066542 A EC SP066542A EC 2006006542 A EC2006006542 A EC 2006006542A EC SP066542 A ECSP066542 A EC SP066542A EC SP066542 A ECSP066542 A EC SP066542A
Authority
EC
Ecuador
Prior art keywords
derivatives
sulphote
sulphoxide
disulfide
sulfide
Prior art date
Application number
EC2006006542A
Other languages
English (en)
Inventor
Moliner Jose Repolles
Coy Francisco Pubill
Original Assignee
Lacer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa filed Critical Lacer Sa
Publication of ECSP066542A publication Critical patent/ECSP066542A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

En la invención presente se revelan nuevos derivados de mononitrato de dianhydrohexitol correspondientes a la fórmula (I), tautómeros, sales farmacéuticamente aceptables, prodrogas y solvatos de los mismos: Así como composiciones farmacéuticas que comprenden estos compuestos y los usos de los mismos
EC2006006542A 2003-10-03 2006-05-03 Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos ECSP066542A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200302368A ES2258365B1 (es) 2003-10-03 2003-10-03 Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.

Publications (1)

Publication Number Publication Date
ECSP066542A true ECSP066542A (es) 2006-10-17

Family

ID=34451643

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2006006542A ECSP066542A (es) 2003-10-03 2006-05-03 Derivados de disulfuro, sulfuro, sulfóxido, y sulfota de azúcares cíclicos y sus usos

Country Status (35)

Country Link
US (3) US7521571B2 (es)
EP (1) EP1668017B1 (es)
JP (2) JP4809769B2 (es)
KR (1) KR101141683B1 (es)
CN (1) CN1863805B (es)
AP (1) AP1976A (es)
AR (1) AR045962A1 (es)
AT (1) ATE423781T1 (es)
AU (1) AU2004281916B2 (es)
BR (1) BRPI0415020A (es)
CA (1) CA2540500C (es)
DE (2) DE602004019666D1 (es)
DK (1) DK1668017T3 (es)
EA (1) EA008942B1 (es)
EC (1) ECSP066542A (es)
ES (2) ES2258365B1 (es)
GB (1) GB2421241B (es)
GE (1) GEP20084490B (es)
GT (1) GT200400200A (es)
HK (1) HK1092807A1 (es)
HR (1) HRP20090152T3 (es)
IL (1) IL174371A0 (es)
IS (1) IS8436A (es)
MX (1) MXPA06003610A (es)
NO (1) NO20061872L (es)
NZ (1) NZ546043A (es)
PA (1) PA8614201A1 (es)
PE (1) PE20050436A1 (es)
PL (1) PL1668017T3 (es)
PT (1) PT1668017E (es)
RS (1) RS20060241A (es)
SI (1) SI1668017T1 (es)
UY (1) UY28547A1 (es)
WO (1) WO2005037842A1 (es)
ZA (1) ZA200603475B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
CA2678319A1 (en) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Use of ranolazine for the treatment of coronary microvascular diseases
EP2117550A1 (en) * 2007-02-13 2009-11-18 CV Therapeutics Inc. Use of ranolazine for the treatment of non-coronary microvascular diseases
US20080214556A1 (en) * 2007-02-13 2008-09-04 Markus Jerling Use of ranolazine for the treatment of cardiovascular diseases
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
KR20100033490A (ko) * 2007-05-31 2010-03-30 질레드 팔로 알토 인코포레이티드 상승된 뇌-형 나트륨이뇨 펩티드에 대한 라놀라진
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
US8003811B2 (en) * 2008-02-07 2011-08-23 Nicox S.A. Nitric oxide donor compounds
EP2149577B1 (en) 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2177216A1 (en) 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) * 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
CA2822747A1 (en) * 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
FR2977252B1 (fr) * 2011-06-30 2013-08-02 Seppic Sa Nouveaux esters de derives n-acyles d'acides amines et d'isosorbide, procede pour leur preparation, et utilisation en cosmetique et comme medicament.
WO2013090138A1 (en) 2011-12-16 2013-06-20 3M Innovative Properties Company Mercapto-containing bisanhydrohexitol derivatives and uses thereof
KR20150123324A (ko) * 2013-03-05 2015-11-03 아처 다니엘 미드랜드 캄파니 이소헥시드 모노트리플레이트 및 이의 합성 방법

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AU465217B2 (en) * 1971-04-29 1975-09-18 American Home Products Corporation Mononitrte esters of 1,4:3, 6-dianhydro-d-glucitol
US3886186A (en) 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
DE3102947A1 (de) 1981-01-29 1982-09-02 Heinrich Mack Nachf., 7918 Illertissen Verfahren zur herstellung von isosorbid-5-nitrat
IT1204571B (it) * 1987-05-08 1989-03-10 Chiesi Farma Spa Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
FR2680173A1 (fr) * 1991-08-07 1993-02-12 Hoechst Lab Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires .
DE69321596T2 (de) * 1992-07-30 1999-04-22 Cal International Ltd Ester und kombinationen von einem organischen nitrat und einem salicyclat
DE4410997A1 (de) * 1994-03-30 1995-10-26 Isis Pharma Gmbh Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
ES2142773B1 (es) * 1998-10-07 2001-01-01 Lacer Sa Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
US20020013483A1 (en) 2000-07-13 2002-01-31 Consortium Fur Elektrochemische Industrie Gmbh Process for the preparation of dianhydrohexitol bisacylates
CA2678256A1 (en) * 2000-10-27 2002-05-02 Nitromed Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
UA63467A (en) 2003-04-22 2004-01-15 Pharmaceutical composition of organic nitrates, dosage form based on pharmaceutical composition of organic nitrates and method of manufacture
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.

Also Published As

Publication number Publication date
DE112004001860T5 (de) 2006-07-27
RS20060241A (en) 2008-06-05
US7777058B2 (en) 2010-08-17
KR20060066743A (ko) 2006-06-16
GB0605574D0 (en) 2006-04-26
US20060235052A1 (en) 2006-10-19
MXPA06003610A (es) 2006-06-05
US20090169560A1 (en) 2009-07-02
BRPI0415020A (pt) 2006-11-07
AP2006003605A0 (en) 2006-04-30
ES2258365B1 (es) 2007-12-01
AU2004281916B2 (en) 2010-10-21
JP2011012081A (ja) 2011-01-20
WO2005037842A1 (en) 2005-04-28
AP1976A (en) 2009-03-16
ZA200603475B (en) 2007-09-26
SI1668017T1 (sl) 2009-08-31
JP2007507451A (ja) 2007-03-29
ES2258365A1 (es) 2006-08-16
EP1668017B1 (en) 2009-02-25
GB2421241A (en) 2006-06-21
NO20061872L (no) 2006-06-30
EA008942B1 (ru) 2007-10-26
US8541607B2 (en) 2013-09-24
CN1863805B (zh) 2010-06-16
JP4809769B2 (ja) 2011-11-09
CA2540500C (en) 2012-08-28
DK1668017T3 (da) 2009-05-11
AU2004281916A1 (en) 2005-04-28
GEP20084490B (en) 2008-09-25
GT200400200A (es) 2005-05-23
CN1863805A (zh) 2006-11-15
US20100196387A1 (en) 2010-08-05
UY28547A1 (es) 2005-04-29
GB2421241B (en) 2008-04-16
AR045962A1 (es) 2005-11-16
PE20050436A1 (es) 2005-06-23
DE602004019666D1 (de) 2009-04-09
IL174371A0 (en) 2006-08-01
ATE423781T1 (de) 2009-03-15
KR101141683B1 (ko) 2012-05-07
IS8436A (is) 2006-05-03
NZ546043A (en) 2009-02-28
EP1668017A1 (en) 2006-06-14
PA8614201A1 (es) 2005-05-24
EA200600694A1 (ru) 2006-10-27
HRP20090152T3 (en) 2009-05-31
US7521571B2 (en) 2009-04-21
PL1668017T3 (pl) 2009-07-31
HK1092807A1 (en) 2007-02-16
CA2540500A1 (en) 2005-04-28
ES2322468T3 (es) 2009-06-22
PT1668017E (pt) 2009-03-09

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