ATE550331T1 - Glycosidasehemmer und verfahren zu dessen herstellung - Google Patents

Glycosidasehemmer und verfahren zu dessen herstellung

Info

Publication number
ATE550331T1
ATE550331T1 AT01901078T AT01901078T ATE550331T1 AT E550331 T1 ATE550331 T1 AT E550331T1 AT 01901078 T AT01901078 T AT 01901078T AT 01901078 T AT01901078 T AT 01901078T AT E550331 T1 ATE550331 T1 AT E550331T1
Authority
AT
Austria
Prior art keywords
group
production
glycosidase inhibitors
compounds
episulfides
Prior art date
Application number
AT01901078T
Other languages
English (en)
Inventor
Brian Pinto
Blair Johnston
Ahmad Ghavami
Original Assignee
Univ Fraser Simon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Fraser Simon filed Critical Univ Fraser Simon
Application granted granted Critical
Publication of ATE550331T1 publication Critical patent/ATE550331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/46—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings substituted on the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT01901078T 2000-01-07 2001-01-05 Glycosidasehemmer und verfahren zu dessen herstellung ATE550331T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17483700P 2000-01-07 2000-01-07
US09/627,434 US6455573B1 (en) 2000-01-07 2000-07-28 Glycosidase inhibitors and methods of synthesizing same
PCT/CA2001/000010 WO2001049674A2 (en) 2000-01-07 2001-01-05 Glycosidase inhibitors and preparation thereof

Publications (1)

Publication Number Publication Date
ATE550331T1 true ATE550331T1 (de) 2012-04-15

Family

ID=26870587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01901078T ATE550331T1 (de) 2000-01-07 2001-01-05 Glycosidasehemmer und verfahren zu dessen herstellung

Country Status (8)

Country Link
US (2) US6455573B1 (de)
EP (2) EP1248779B1 (de)
JP (1) JP5053494B2 (de)
CN (1) CN100341870C (de)
AT (1) ATE550331T1 (de)
AU (1) AU783127B2 (de)
CA (1) CA2396688C (de)
WO (1) WO2001049674A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389565B2 (en) * 2000-01-07 2013-03-05 Simon Fraser University Glycosidase inhibitors and methods of synthesizing same
JP4516282B2 (ja) * 2003-04-24 2010-08-04 森下仁丹株式会社 新規なα−グルコシダーゼ阻害活性を有する物質およびこれを含有する食品
JP4486792B2 (ja) * 2003-06-12 2010-06-23 学校法人近畿大学 環状オニウム化合物およびグルコシダーゼ阻害剤
EP1653945A2 (de) * 2003-06-25 2006-05-10 Simon Fraser University Glycosidasehemmer und methoden zu deren herstellung
US20060193845A1 (en) * 2004-09-14 2006-08-31 Elixir Pharmaceuticals, Inc. Combination therapy for controlled carbohydrate digestion
PT103385B (pt) * 2005-11-15 2011-06-27 Jorge Ruas Da Silva Ácido 2,3,4,5-tetrahidróxi-6-sulfooxi-hexanoico, seus sais farmaceuticamente aceitáveis e suas formas de equilíbrio, processo para a sua preparação, composições farmacêuticas contendo estes compostos e seu uso em medicina
EP2152265B1 (de) * 2007-05-22 2014-06-04 Amicus Therapeutics, Inc. Neues verfahren zur herstellung von isofagomin und seinen derivaten
US20090011060A1 (en) * 2007-07-06 2009-01-08 Peter Koepke Campsiandra angustifolia extract and methods of extracting and using such extract
US20090017140A1 (en) * 2007-07-09 2009-01-15 Peter Koepke Maytenus abenfolia extract and methods of extracting and using such extract
US20090035395A1 (en) * 2007-08-01 2009-02-05 Peter Koepke Spondias mombin l. extract and methods of extracting and using such extract
US7879369B2 (en) * 2007-09-18 2011-02-01 Selvamedica, Llc Combretum laurifolium Mart. extract and methods of extracting and using such extract
CN102413840A (zh) * 2009-04-22 2012-04-11 富士胶片株式会社 肠道细菌群落构成比例调节剂
WO2012105573A1 (ja) 2011-01-31 2012-08-09 学校法人近畿大学 環状スルホニウム塩、その製造方法およびそれを用いたα－グルコシダーゼ阻害剤
JP5635932B2 (ja) * 2011-03-30 2014-12-03 富士フイルム株式会社 プロセシンググルコシダーゼ阻害剤
WO2013133685A1 (en) 2012-03-09 2013-09-12 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
JP6268014B2 (ja) 2014-03-20 2018-01-24 富士フイルム株式会社 サラシノールの製造に有用な化合物およびそれらの製造法、サラシノールの製造法、ジオール基の保護方法および脱保護方法、並びにジオール基の保護剤
EP3316877B1 (de) 2015-07-02 2019-10-30 Horizon Orphan LLC Ado-resistente cysteamin-analoga und verwendungen davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0389723A1 (de) * 1989-03-29 1990-10-03 Merrell Dow Pharmaceuticals Inc. Alpha-glukosidase-Inhibitoren
US6121489A (en) * 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
GB9620884D0 (en) * 1996-10-07 1996-11-27 Mcdermott Sa J Ray Reel to reel transfer of pipe and large diameter tubing
JP3030008B2 (ja) 1997-07-07 2000-04-10 株式会社 タカマシステム α−グルコシダーゼの阻害作用を有する化合物

Also Published As

Publication number Publication date
CA2396688A1 (en) 2001-07-12
CA2396688C (en) 2013-05-21
US20030191104A1 (en) 2003-10-09
US6455573B1 (en) 2002-09-24
EP1248779B1 (de) 2012-03-21
EP1248779A2 (de) 2002-10-16
AU2659101A (en) 2001-07-16
EP2325179A1 (de) 2011-05-25
AU783127B2 (en) 2005-09-29
JP2003519220A (ja) 2003-06-17
JP5053494B2 (ja) 2012-10-17
CN100341870C (zh) 2007-10-10
CN1404476A (zh) 2003-03-19
WO2001049674A3 (en) 2001-11-29
WO2001049674A2 (en) 2001-07-12

Similar Documents

Publication Publication Date Title
ATE550331T1 (de) Glycosidasehemmer und verfahren zu dessen herstellung
DE60119894D1 (de) Piperidinverbindungen und diese enthaltenden medikamente
BRPI0211844B8 (pt) composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica
WO2000010965A3 (en) Quaternary ammonium salts and their use as anti-hiv agents
ATE287393T1 (de) Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
KR970704864A (ko) 세정제 조성물
ATE209645T1 (de) Neue verbindung, verfahren zu ihrer herstellung und antitumormittel
EA200100983A1 (ru) Производные 13-метилэритромицина
EA200501148A1 (ru) Пиридилоксиметильные и бензизоксазольные азабициклические производные
ATE453389T1 (de) Bestimmte pharmazeutisch wertvolle substituierte aminoalkyl-heterocyclen
ATE285410T1 (de) Naphthyridinderivate oder salze davon
KR910002774A (ko) 2-아미노펜탄 산 화합물 및 면역 억제제로 그들을 사용하는 방법
ATE241589T1 (de) Verfahren zur herstellung des neuraminidase- inhibitoren ro-64-0796
AP2000002008A0 (en) Tetrahydroquinoline derivatives as glycine antagonists.
ATE277887T1 (de) Verfahren zur herstellung von 1,4-bis((2- (dimethylamino)ethyl amino)-5,8- dihydroxyanthracene-9,10-dion
ATE376830T1 (de) Benzo(b(thiophenderivate und verfahren zu deren herstellung
DE60219950D1 (de) Verfahren zur überwachung/bekämpfung von thysanoptera
ATE302199T1 (de) Quinalozinon-derivate
PT1338596E (pt) Processos para a preparacao de agentes antibacterianos do tipo carbapenem
DE60001807D1 (de) VERFAHREN ZU HERSTELLUNG VON o-FLUORIERTEN TETRAHYDROTHIOPYRAN CARBAMATEN
BR0210512A (pt) Processo de decomposição papa o ácido (r)-(-)-2-hidroxi-2-(2-clorofenil) acético
EA200400756A1 (ru) Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
MY136065A (en) Prodrugs to nmda receptor ligands
ATE6500T1 (de) 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.
DE69430766T2 (de) Vasculäre Hypertrophicsuppressor