CN1930281A - 用于通过连续灌注和交互切向流来培养细胞的方法 - Google Patents
用于通过连续灌注和交互切向流来培养细胞的方法 Download PDFInfo
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- CN1930281A CN1930281A CNA2005800071754A CN200580007175A CN1930281A CN 1930281 A CN1930281 A CN 1930281A CN A2005800071754 A CNA2005800071754 A CN A2005800071754A CN 200580007175 A CN200580007175 A CN 200580007175A CN 1930281 A CN1930281 A CN 1930281A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Water Supply & Treatment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075703.1 | 2004-03-05 | ||
| EP04075702.3 | 2004-03-05 | ||
| EP04075702 | 2004-03-05 | ||
| EP04075703 | 2004-03-05 | ||
| EP04077656 | 2004-09-27 | ||
| EP04077656.9 | 2004-09-27 | ||
| EP04077657 | 2004-09-27 | ||
| EP04077657.7 | 2004-09-27 | ||
| PCT/EP2005/002374 WO2005095578A1 (en) | 2004-03-05 | 2005-03-04 | Process for cell culturing by continuous perfusion and alternating tangential flow |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410471955.5A Division CN104593277A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| CN201410601800.9A Division CN104388324A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1930281A true CN1930281A (zh) | 2007-03-14 |
Family
ID=34961830
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410601800.9A Pending CN104388324A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| CNA2005800071754A Pending CN1930281A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| CN201410471955.5A Pending CN104593277A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410601800.9A Pending CN104388324A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410471955.5A Pending CN104593277A (zh) | 2004-03-05 | 2005-03-04 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8206981B2 (enExample) |
| EP (3) | EP2540815A1 (enExample) |
| JP (6) | JP2007525984A (enExample) |
| KR (1) | KR101050585B1 (enExample) |
| CN (3) | CN104388324A (enExample) |
| AU (1) | AU2005229359C1 (enExample) |
| CA (1) | CA2557046A1 (enExample) |
| DK (1) | DK1720972T3 (enExample) |
| ES (1) | ES2456015T3 (enExample) |
| IL (2) | IL177724A (enExample) |
| PL (1) | PL1720972T3 (enExample) |
| PT (1) | PT1720972E (enExample) |
| SI (1) | SI1720972T1 (enExample) |
| WO (1) | WO2005095578A1 (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103305417A (zh) * | 2012-03-07 | 2013-09-18 | 无锡药明康德生物技术有限公司 | 进行蛋白生产的高产量反应器及其生产方法和应用 |
| CN103525756A (zh) * | 2013-10-23 | 2014-01-22 | 南京农业大学 | 一种原代鸡肝细胞的分离培养方法 |
| CN106414490A (zh) * | 2014-02-17 | 2017-02-15 | 爱德技术生物科学有限公司 | 使用基于膜的细胞截留系统增强重组蛋白的表达 |
| CN106687575A (zh) * | 2014-06-04 | 2017-05-17 | 美国安进公司 | 用于收获哺乳动物细胞培养物的方法 |
| CN107532132A (zh) * | 2015-02-09 | 2018-01-02 | 优尼沃赛尔斯公司 | 用于生产细胞和/或细胞产品的系统、装置和方法 |
| CN109714962A (zh) * | 2016-07-11 | 2019-05-03 | 耶路撒冷希伯来大学的益生研究开发有限公司 | 用于在体外培养细胞的系统和方法 |
| WO2021008571A1 (zh) * | 2019-07-16 | 2021-01-21 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| CN112410279A (zh) * | 2013-03-15 | 2021-02-26 | 建新公司 | 高密度细胞存储方法 |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1720972T3 (pl) | 2004-03-05 | 2014-06-30 | Dpx Holdings Bv | Proces hodowli komórek poprzez ciągłą perfuzję i zmienny przepływ styczny |
| BRPI0707027B1 (pt) | 2006-02-24 | 2022-08-16 | Toray Industries, Inc | Método de fabricação de um produto químico e aparelho de fermentação contínua |
| EP1870450A1 (en) * | 2006-06-21 | 2007-12-26 | DSMIP Assets B.V. | Process for the culturing of E1-immortalized HER cells |
| AU2011211462C1 (en) * | 2006-07-14 | 2015-01-22 | Dpx Holdings B.V. | Improved process for the culturing of cells |
| AU2007272054C1 (en) | 2006-07-14 | 2014-08-28 | Dpx Holdings B.V. | Improved process for the culturing of cells |
| EP2014760A1 (en) | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
| KR101798813B1 (ko) * | 2007-12-27 | 2017-11-16 | 박스알타 인코퍼레이티드 | 세포 배양 방법 |
| WO2010003759A2 (en) * | 2008-06-17 | 2010-01-14 | Dsm Ip Assets B.V. | Cell culturing method |
| SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
| NZ593235A (en) * | 2008-11-03 | 2013-02-22 | Crucell Holland Bv | Method for the production of recombinant adenovirus serotype 35 |
| KR101548790B1 (ko) | 2009-07-16 | 2015-08-31 | 크루셀 홀란드 비.브이. | 백신 제조를 위한 고역가 폴리오바이러스의 제조 |
| BR112012008516B1 (pt) | 2009-10-15 | 2021-10-19 | Janssen Vaccines & Prevention B.V. | Método para purificar partículas de adenovírus a partir de uma suspensão de célula |
| EA028875B1 (ru) | 2009-10-15 | 2018-01-31 | Янссен Вэксинс Энд Превеншн Б.В. | Способ очистки аденовирусных частиц из клеточной суспензии |
| PT2501822T (pt) | 2009-11-17 | 2017-10-18 | Squibb & Sons Llc | Métodos para produção de proteínas melhorada |
| EA023816B1 (ru) * | 2010-02-15 | 2016-07-29 | Круселл Холланд Б.В. | СПОСОБ ПРОДУЦИРОВАНИЯ ВИРУСНЫХ ЧАСТИЦ Ad26 |
| US20120315696A1 (en) * | 2010-02-15 | 2012-12-13 | Alfred Luitjens | METHOD FOR THE PRODUCTION OF Ad26 ADENOVIRAL VECTORS |
| WO2011144561A1 (en) | 2010-05-18 | 2011-11-24 | Crucell Holland B.V. | Methods for welding ethylene vinyl acetate (eva) tubing, tubing obtained thereby and use of such tubing for sterile transfer of content into a bioreactor |
| JP6282467B2 (ja) * | 2010-10-05 | 2018-02-21 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | タンパク質を生産するための方法 |
| EP3626737B1 (en) * | 2011-05-13 | 2023-11-29 | Octapharma AG | A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
| KR20230114317A (ko) * | 2011-07-01 | 2023-08-01 | 암젠 인크 | 포유동물 세포 배양 |
| US10485869B2 (en) | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
| KR20140079491A (ko) | 2011-10-18 | 2014-06-26 | 코히러스 바이오사이언시즈, 인코포레이티드 | 당과 폴리올과의 배합물로 안정화된 에타너셉트 제형 |
| GB201211256D0 (en) * | 2012-06-25 | 2012-08-08 | Glaxosmithkline Biolog Sa | Fermentation process |
| PE20150762A1 (es) | 2012-07-09 | 2015-06-20 | Coherus Biosciences Inc | Formulaciones de etanercept que muestran una marcada reduccion de la cantidad de particulas subvisibles |
| SG11201501460RA (en) | 2012-09-11 | 2015-04-29 | Coherus Biosciences Inc | Correctly folded etanercept in high purity and excellent yield |
| JP6321661B2 (ja) | 2012-09-27 | 2018-05-09 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | タンジェンシャルフロー灌流システム及び方法 |
| TWI637057B (zh) | 2012-11-09 | 2018-10-01 | 拜爾沙納有限公司 | 具交替生物反應器用途之不連續進料批次製程 |
| WO2014146933A1 (en) | 2013-03-19 | 2014-09-25 | Cmc Biologics A/S | A method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process. |
| MX362922B (es) * | 2013-03-26 | 2019-02-25 | Coherus Biosciences Inc | Método de producción de proteínas. |
| US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
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| AU2014326706A1 (en) | 2013-09-30 | 2016-03-10 | Janssen Vaccines & Prevention B.V. | Method for the clarification of high density crude cell culture harvest |
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| CN111051494B (zh) | 2017-07-14 | 2024-03-29 | 康宁股份有限公司 | 用于手动或自动培养基交换的3d细胞培养容器 |
| EP3663390A4 (en) | 2017-09-06 | 2020-08-05 | FUJIFILM Corporation | PROCESS FOR MANUFACTURING A PRODUCT |
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