MX362922B - Método de producción de proteínas. - Google Patents

Método de producción de proteínas.

Info

Publication number
MX362922B
MX362922B MX2015013668A MX2015013668A MX362922B MX 362922 B MX362922 B MX 362922B MX 2015013668 A MX2015013668 A MX 2015013668A MX 2015013668 A MX2015013668 A MX 2015013668A MX 362922 B MX362922 B MX 362922B
Authority
MX
Mexico
Prior art keywords
production method
protein production
folded protein
etanercept
titers
Prior art date
Application number
MX2015013668A
Other languages
English (en)
Other versions
MX2015013668A (es
Inventor
Ela Puchacz
James Russel Grove
Original Assignee
Coherus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coherus Biosciences Inc filed Critical Coherus Biosciences Inc
Publication of MX2015013668A publication Critical patent/MX2015013668A/es
Publication of MX362922B publication Critical patent/MX362922B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Wood Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)

Abstract

La presente invención se refiere a un método de perfusión para la manufactura de etanercept correctamente plegado, caracterizado porque comprende los siguientes pasos: (a) preparar una mezcla que comprende células capaces de expresar una proteína que comprende etanercept y un medio cultivo adecuado para llevar a cabo tal expresión; (b) en un recipiente de reacción adecuado que contiene la mezcla, causar que las células produzcan la proteína que comprende etanercept; y (c) remover periódica o continuamente medio de cultivo usado de, y agregar medio de cultivo fresco a, el recipiente de reacción, en donde la proteína que comprende etanercept producida en el método comprende al menos 40% en peso 50% en peso o 60% en peso de etanercept correctamente plegado, y en donde el medio de cultivo comprende un medio para célula de ovario de hámster Chino como un medio de alimento base y en donde el medio de cultivo comprende dexametasona, galactosa y N-acetilmanosamina (ManNac).
MX2015013668A 2013-03-26 2014-03-26 Método de producción de proteínas. MX362922B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361805215P 2013-03-26 2013-03-26
US201461933665P 2014-01-30 2014-01-30
PCT/US2014/031883 WO2014160790A1 (en) 2013-03-26 2014-03-26 Protein production method

Publications (2)

Publication Number Publication Date
MX2015013668A MX2015013668A (es) 2016-06-28
MX362922B true MX362922B (es) 2019-02-25

Family

ID=51621470

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015013668A MX362922B (es) 2013-03-26 2014-03-26 Método de producción de proteínas.
MX2019002183A MX2019002183A (es) 2013-03-26 2015-09-25 Metodo de produccion de proteinas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019002183A MX2019002183A (es) 2013-03-26 2015-09-25 Metodo de produccion de proteinas.

Country Status (12)

Country Link
US (2) US9765139B2 (es)
EP (2) EP2978498B1 (es)
JP (2) JP6689189B2 (es)
KR (1) KR20150133833A (es)
AU (2) AU2014241259B9 (es)
BR (1) BR112015024755A2 (es)
CA (1) CA2907771C (es)
HK (1) HK1218893A1 (es)
MX (2) MX362922B (es)
RS (1) RS59328B1 (es)
SG (2) SG11201507875RA (es)
WO (1) WO2014160790A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
CN107073051B (zh) 2014-10-21 2021-08-24 马萨诸塞大学 重组aav变体及其用途
KR101936049B1 (ko) 2015-10-15 2019-01-08 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 생산방법
KR20190075964A (ko) 2016-10-13 2019-07-01 유니버시티 오브 매사추세츠 Aav 캡시드 설계
US20200323958A1 (en) * 2017-11-13 2020-10-15 Amgen Inc. Methods for producing protein products
CN109971705A (zh) * 2019-04-16 2019-07-05 上海汉尼生物细胞技术有限公司 一种cho dg44细胞培养基添加物及其制备方法
EP4267717A1 (en) * 2020-12-22 2023-11-01 Amgen Inc. Cell culture method

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2817235A (en) 1954-03-22 1957-12-24 Phillips Petroleum Co Temperature measuring system for underground storage cavern
US2893211A (en) 1955-05-16 1959-07-07 Phillips Petroleum Co Underground storage system
US3064436A (en) 1955-10-27 1962-11-20 Robert L Loofbourow Sealing underground cavities
DE1126800B (de) 1958-03-17 1962-03-29 Stamicarbon Vorrichtung zum Hinaufbefoerdern grobkoernigen Gutes, wie Erz und Kohle, aus grosser Teufe, z.B. aus einer Zeche od. dgl., mittels einer Transportfluessigkeit
US3068654A (en) 1958-09-22 1962-12-18 Interstate Service Corp Underground storage cavern and method of making same
US3184922A (en) 1960-07-12 1965-05-25 Suburban Propane Gas Corp Method of and means for storing liquefied petroleum gases underground
US4011736A (en) 1975-11-12 1977-03-15 Halm Instrument Co., Inc. Cold storage tank
FR2372751A1 (fr) 1976-12-02 1978-06-30 Commissariat Energie Atomique Reservoir souterrain pour fluides sous pression
SE450509B (sv) 1981-08-07 1987-06-29 Karl Ivar Sagefors Metod att bygga en anleggning for lagring av flytande produkter i berg
EP0127612B1 (en) 1982-06-09 1987-04-01 CANEVALL, John Procedure for permanently storing radioactive material
US4488834A (en) 1982-11-17 1984-12-18 Empak, Inc. Method for using salt deposits for storage
FR2545067B1 (fr) 1983-04-26 1987-08-07 Geostock Procede et dispositif de stockage souterrain d'ammoniac et produits analogues
US5207530A (en) 1992-07-29 1993-05-04 Halliburton Company Underground compressed natural gas storage and service system
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
US6261805B1 (en) * 1999-07-15 2001-07-17 Boyce Thompson Institute For Plant Research, Inc. Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
US6826911B2 (en) 2001-03-12 2004-12-07 Pomfret Storage Company, Llc Storage of energy producing fluids and process thereof
ATE359358T1 (de) 2002-07-15 2007-05-15 Immunex Corp Verfahren und medien zur kontrolle der sialysierung von proteinen, die von säugetierzellen produziert werden
SI1720972T1 (sl) * 2004-03-05 2014-06-30 Dsm Ip Assets B.V. Postopek kultiviranja celic s kontinuiranim škropljenjem in spreminjanjem tangencialnega toka
US7300773B2 (en) 2004-08-27 2007-11-27 Wyeth Research Ireland Limited Production of TNFR-Ig
PL2267024T3 (pl) * 2005-06-03 2012-10-31 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
US7972810B2 (en) * 2005-12-08 2011-07-05 Amgen Inc. Production of glycoproteins using manganese
DK2115126T3 (en) 2007-03-02 2015-05-04 Wyeth Llc Use of copper and glutamate in cell culture for the preparation of polypeptides
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2014760A1 (en) * 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
EP2435577A4 (en) * 2009-05-26 2016-04-13 Momenta Pharmaceuticals Inc GLYCOPROTEIN PRODUCTION
US9540426B2 (en) * 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
GB201003701D0 (en) * 2010-03-05 2010-04-21 Cilian Ag System for the expression of a protein
WO2011116148A2 (en) 2010-03-16 2011-09-22 Dana Todd C Systems, apparatus and methods for extraction of hydrocarbons from organic materials
CN102382794B (zh) * 2010-09-01 2013-09-18 山东新时代药业有限公司 一种哺乳动物细胞的灌流培养方法
EP2702077A2 (en) * 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
KR20240005106A (ko) * 2011-07-01 2024-01-11 암젠 인크 포유동물 세포 배양
WO2013009526A1 (en) * 2011-07-08 2013-01-17 Merck Sharp & Dohme Corp. Method for purifying fc-fusion protein
CN103717729B (zh) * 2011-07-08 2017-11-21 动量制药公司 细胞培养方法

Also Published As

Publication number Publication date
SG11201507875RA (en) 2015-10-29
EP2978498A1 (en) 2016-02-03
US10975138B2 (en) 2021-04-13
SG10201802023RA (en) 2018-05-30
CA2907771A1 (en) 2014-10-02
RS59328B1 (sr) 2019-10-31
EP3391942A1 (en) 2018-10-24
EP2978498B1 (en) 2019-07-03
US9765139B2 (en) 2017-09-19
EP2978498A4 (en) 2016-10-05
MX2015013668A (es) 2016-06-28
JP6689189B2 (ja) 2020-04-28
JP2020073503A (ja) 2020-05-14
AU2014241259A1 (en) 2015-10-22
KR20150133833A (ko) 2015-11-30
AU2019201129A1 (en) 2019-03-07
JP2016514475A (ja) 2016-05-23
AU2014241259B9 (en) 2018-12-20
CA2907771C (en) 2023-01-10
WO2014160790A1 (en) 2014-10-02
BR112015024755A2 (pt) 2017-07-18
MX2019002183A (es) 2019-05-16
US20140296489A1 (en) 2014-10-02
US20160122427A1 (en) 2016-05-05
AU2014241259B2 (en) 2018-12-06
AU2019201129B2 (en) 2020-12-24
HK1218893A1 (zh) 2017-03-17

Similar Documents

Publication Publication Date Title
MX2019002183A (es) Metodo de produccion de proteinas.
EP3313863A4 (en) DEGRON FUSION CONSTRUCTS AND METHODS OF REGULATING PROTEIN PRODUCTION
ZA201802657B (en) Crystal forms of beta-nicotinamide mononucleotide
ZA201707233B (en) Gas fermentation for the production of protein or feed
EP3469932A4 (en) FLAVOR INHALER AND PRODUCTION METHOD
EP3030670A4 (en) Solid state fermentation systems and process for producing high-quality protein concentrate and lipids
MX368142B (es) Metodo de clonacion, expresion y purificacion novedoso para la preparacion de ranibizumab.
HK1249764A1 (zh) 產生l-亮氨酸的微生物以及使用其產生l-亮氨酸的方法
EP3385305A4 (en) PROCESS FOR PRODUCING A PROTEIN SOLUTION
EP3101120A4 (en) Method for controlling galactosylation of recombinant protein through optimization of culture medium
EP4353316A3 (en) Rsv-specific antibodies and functional parts thereof
PL2960326T3 (pl) Mikroorganizm zdolny do zwiększenia wytwarzania kwasu mlekowego i sposób wytwarzania kwasu mlekowego przy jego użyciu
MY180645A (en) Microbial production of fatty amines
EP3162892A4 (en) Method for culturing adhesive cells, culture vessel, and method for producing protein
EP3162895A4 (en) Improved fc-binding protein, method for producing said protein, antibody adsorbent using said protein, and method for separating antibody using said adsorbent
PL3141597T3 (pl) Mikroorganizm o ulepszonej produktywności l-lizyny i sposób wytwarzania l-lizyny z jego zastosowaniem
EP3318637A4 (en) Microorganism having l-lysine productivity and method for producing l-lysine by using same
MX2019002223A (es) Procedimiento mejorado para el cultivo de algas.
EP3048172A4 (en) Method for producing l-amino acid from seaweed-derived biomass
PL2987854T3 (pl) Mikroorganizmy o zdolności wytwarzania l-tryptofanu oraz sposób wytwarzania l-tryptofanu z ich zastosowaniem
EP3098313A4 (en) Method for producing rare fatty acid using novel enzyme, and novel rare fatty acid
MX2019002182A (es) Medios de perfusion.
EP3549946A4 (en) COMPOSITION OF PROTEIN, ITS PRODUCTION PROCESS AND PROCESS FOR IMPROVING THERMAL STABILITY
EP3305760A4 (en) METHOD FOR PRODUCING ALKYLAMINE DERIVATIVE AND INTERMEDIATE FOR PRODUCING ALKYLAMINE DERIVATIVE
EP3255150A4 (en) Microorganism capable of producing quinolinic acid, and method for producing quinolinic acid utilizing the microorganism

Legal Events

Date Code Title Description
FG Grant or registration