PT1720972E - Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial - Google Patents
Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial Download PDFInfo
- Publication number
- PT1720972E PT1720972E PT57157877T PT05715787T PT1720972E PT 1720972 E PT1720972 E PT 1720972E PT 57157877 T PT57157877 T PT 57157877T PT 05715787 T PT05715787 T PT 05715787T PT 1720972 E PT1720972 E PT 1720972E
- Authority
- PT
- Portugal
- Prior art keywords
- tangential flow
- cell culturing
- continuous perfusion
- alternating tangential
- alternating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/06—Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Water Supply & Treatment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075702 | 2004-03-05 | ||
| EP04075703 | 2004-03-05 | ||
| EP04077657 | 2004-09-27 | ||
| EP04077656 | 2004-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1720972E true PT1720972E (pt) | 2014-04-07 |
Family
ID=34961830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT57157877T PT1720972E (pt) | 2004-03-05 | 2005-03-04 | Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8206981B2 (enExample) |
| EP (3) | EP2540815A1 (enExample) |
| JP (6) | JP2007525984A (enExample) |
| KR (1) | KR101050585B1 (enExample) |
| CN (3) | CN104388324A (enExample) |
| AU (1) | AU2005229359C1 (enExample) |
| CA (1) | CA2557046A1 (enExample) |
| DK (1) | DK1720972T3 (enExample) |
| ES (1) | ES2456015T3 (enExample) |
| IL (2) | IL177724A (enExample) |
| PL (1) | PL1720972T3 (enExample) |
| PT (1) | PT1720972E (enExample) |
| SI (1) | SI1720972T1 (enExample) |
| WO (1) | WO2005095578A1 (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104388324A (zh) | 2004-03-05 | 2015-03-04 | 帝斯曼知识产权资产管理有限公司 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| BRPI0707027B1 (pt) | 2006-02-24 | 2022-08-16 | Toray Industries, Inc | Método de fabricação de um produto químico e aparelho de fermentação contínua |
| EP1870450A1 (en) * | 2006-06-21 | 2007-12-26 | DSMIP Assets B.V. | Process for the culturing of E1-immortalized HER cells |
| AU2011211462C1 (en) * | 2006-07-14 | 2015-01-22 | Dpx Holdings B.V. | Improved process for the culturing of cells |
| DK2634242T3 (en) | 2006-07-14 | 2017-05-22 | Patheon Holdings I B V | IMPROVED PROCEDURE FOR CULTURING CELLS |
| EP2014760A1 (en) | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
| AU2008345231B2 (en) * | 2007-12-27 | 2014-09-11 | Takeda Pharmaceutical Company Limited | Cell culture processes |
| WO2010003759A2 (en) * | 2008-06-17 | 2010-01-14 | Dsm Ip Assets B.V. | Cell culturing method |
| MX2011002328A (es) * | 2008-09-02 | 2011-05-19 | Pluristem Ltd | Celulas adherentes del tejido de placenta y su uso en terapia. |
| WO2010060719A1 (en) * | 2008-11-03 | 2010-06-03 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
| PE20120571A1 (es) | 2009-07-16 | 2012-06-06 | Crucell Holland Bv | Produccion de titulos elevados de polivirus para la produccion de vacunas |
| CN102791852B (zh) | 2009-10-15 | 2014-05-07 | 克鲁塞尔荷兰公司 | 纯化腺病毒颗粒的方法 |
| KR101805938B1 (ko) | 2009-10-15 | 2018-01-10 | 얀센 백신스 앤드 프리벤션 비.브이. | 고밀도 세포 배양액에서 아데노바이러스의 정제 방법 |
| SMT201700529T1 (it) | 2009-11-17 | 2018-01-11 | Squibb & Sons Llc | Metodi per un'aumentata produzione di proteine |
| EP2536829B1 (en) * | 2010-02-15 | 2016-04-06 | Crucell Holland B.V. | Method for the production of Ad26 adenoviral vectors |
| US20120315696A1 (en) * | 2010-02-15 | 2012-12-13 | Alfred Luitjens | METHOD FOR THE PRODUCTION OF Ad26 ADENOVIRAL VECTORS |
| WO2011144561A1 (en) | 2010-05-18 | 2011-11-24 | Crucell Holland B.V. | Methods for welding ethylene vinyl acetate (eva) tubing, tubing obtained thereby and use of such tubing for sterile transfer of content into a bioreactor |
| EP2957628A1 (en) * | 2010-10-05 | 2015-12-23 | Novo Nordisk Health Care AG | Process for protein production |
| US9115381B2 (en) * | 2011-05-13 | 2015-08-25 | Octapharma Ag | Method of increasing the productivity of eucaryotic cells in the production of recombinant FVIII |
| CA2838695C (en) * | 2011-07-01 | 2017-02-14 | Amgen Inc. | Mammalian cell culture |
| CN104011073B (zh) | 2011-10-18 | 2017-08-25 | 科荣生生物科学公司 | 使用氨基酸稳定的依那西普制剂 |
| US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
| CN103305417A (zh) * | 2012-03-07 | 2013-09-18 | 无锡药明康德生物技术有限公司 | 进行蛋白生产的高产量反应器及其生产方法和应用 |
| GB201211256D0 (en) | 2012-06-25 | 2012-08-08 | Glaxosmithkline Biolog Sa | Fermentation process |
| EP2869816A4 (en) | 2012-07-09 | 2016-04-20 | Coherus Biosciences Inc | ETANERCEPT FORMULATIONS WITH CLEAR REDUCTION OF SUBVISIBLE PARTICLES |
| RS57013B1 (sr) | 2012-09-11 | 2018-05-31 | Coherus Biosciences Inc | Korektno savijeni etanercept sa visokom čistoćom i odličnim prinosom |
| JP6321661B2 (ja) * | 2012-09-27 | 2018-05-09 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | タンジェンシャルフロー灌流システム及び方法 |
| TWI637057B (zh) | 2012-11-09 | 2018-10-01 | 拜爾沙納有限公司 | 具交替生物反應器用途之不連續進料批次製程 |
| EP4008768A1 (en) * | 2013-03-15 | 2022-06-08 | Genzyme Corporation | High-density cell banking methods |
| DK2976418T3 (da) | 2013-03-19 | 2021-01-11 | Cmc Biologics As | Fremgangsmåde til fremstilling af et produkt (f.eks. polypeptid) i en kontinuerlig cellekulturfermenteringsproces |
| MX362922B (es) * | 2013-03-26 | 2019-02-25 | Coherus Biosciences Inc | Método de producción de proteínas. |
| US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
| KR102749545B1 (ko) * | 2013-09-16 | 2025-01-07 | 젠자임 코포레이션 | 세포 배양물을 가공하는 방법 및 시스템 |
| CN105579572B (zh) | 2013-09-30 | 2018-08-10 | 扬森疫苗与预防公司 | 用于净化高密度粗细胞培养收获物的方法 |
| CN103525756B (zh) * | 2013-10-23 | 2015-04-08 | 南京农业大学 | 一种原代鸡肝细胞的分离培养方法 |
| US20160289633A1 (en) * | 2013-12-20 | 2016-10-06 | Biogen Ma Inc. | Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality |
| KR102410393B1 (ko) * | 2014-01-29 | 2022-06-16 | 암젠 인크 | 재조합 단백질의 글리코실화를 조절하기 위한 n-글리코실화 경로 조절자의 과발현 |
| US20170009269A1 (en) * | 2014-02-17 | 2017-01-12 | Advantech Bioscience Farmacêutica Ltda | Enhancement of recombinant protein expression using a membrane-based cell retention system |
| CN106687575B (zh) | 2014-06-04 | 2021-04-30 | 美国安进公司 | 用于收获哺乳动物细胞培养物的方法 |
| EP3172317B1 (en) | 2014-07-24 | 2019-05-01 | Janssen Vaccines & Prevention B.V. | Process for the purification of poliovirus from cell cultures |
| JP6530171B2 (ja) * | 2014-09-09 | 2019-06-12 | 旭化成メディカル株式会社 | 培養産生物の回収方法 |
| MX383858B (es) * | 2014-09-18 | 2025-03-14 | Genzyme Corp | Métodos de establecimiento de bancos de células de densidad ultra-alta. |
| CN107109339B (zh) | 2014-10-29 | 2021-07-02 | 康宁股份有限公司 | 灌注生物反应器平台 |
| EP3212761A1 (en) | 2014-10-29 | 2017-09-06 | Corning Incorporated | Microwell design and fabrication for generation of cell culture aggregates |
| SG11201703493SA (en) | 2014-10-29 | 2017-05-30 | Corning Inc | Cell culture insert |
| WO2016073858A1 (en) | 2014-11-07 | 2016-05-12 | Genesis Technologies, Llc | Linear reciprocating actuator |
| MX383857B (es) | 2014-12-22 | 2025-03-14 | Genzyme Corp | Métodos de cultivo de una célula de mamífero. |
| EP3256565A1 (en) * | 2015-02-09 | 2017-12-20 | Univercells NV | System, apparatus and method for the production of cells and/or cell products |
| CA3018264A1 (en) | 2016-04-12 | 2017-10-19 | Artemis Biosystems, Inc. | Perfusion filtration systems |
| ES3054035T3 (en) | 2016-04-14 | 2026-01-28 | Ferring Ventures Ltd | Fixed-bed bioreactor with constant-flow pump/tubing system |
| EP3722436B1 (en) | 2016-04-14 | 2025-09-24 | Ferring Ventures Ltd | Fixed-bed bioreactor with constant-flow pump/tubing system |
| US12157877B2 (en) | 2016-04-15 | 2024-12-03 | Boehringer Ingelheim International Gmbh | Cell retention device and method |
| EP3480293A4 (en) * | 2016-06-30 | 2019-07-03 | FUJIFILM Corporation | Cell suspension membrane separation device and cell culture device |
| IL291373B2 (en) * | 2016-07-11 | 2023-10-01 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Methods and systems for growing cells in culture |
| JP7195302B2 (ja) | 2017-07-14 | 2022-12-23 | コーニング インコーポレイテッド | 3d培養のための細胞培養容器及び3d細胞の培養方法 |
| US11767499B2 (en) | 2017-07-14 | 2023-09-26 | Corning Incorporated | Cell culture vessel |
| PL3652290T3 (pl) | 2017-07-14 | 2022-08-22 | Corning Incorporated | Naczynia do hodowli komórkowej 3d do ręcznej lub automatycznej zmiany pożywek |
| US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
| CN111051496B (zh) * | 2017-09-06 | 2024-03-08 | 富士胶片株式会社 | 产物的制造方法 |
| WO2019055796A1 (en) * | 2017-09-15 | 2019-03-21 | Bristol-Myers Squibb Company | ONLINE BIOMASS CAPACITY MONITORING DURING LARGE SCALE PRODUCTION OF POLYPEPTIDES OF INTEREST |
| IL273549B2 (en) | 2017-10-06 | 2023-10-01 | Lonza Ag | Automated control of cell culture using Raman spectroscopy |
| TW202538049A (zh) | 2017-10-16 | 2025-10-01 | 美商再生元醫藥公司 | 灌注生物反應器及相關使用方法 |
| TWI827570B (zh) * | 2017-12-11 | 2024-01-01 | 美商安進公司 | 雙特異性抗體產品之連續製造製程 |
| AU2019231885B2 (en) * | 2018-03-08 | 2022-03-24 | Repligen Corporation | Tangential flow depth filtration systems and methods of filtration using same |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| EP3770266A4 (en) * | 2018-03-19 | 2021-06-09 | FUJIFILM Corporation | PRODUCT MANUFACTURING PROCESS |
| US11958018B2 (en) | 2018-05-25 | 2024-04-16 | Repligen Corporation | Tangential flow filtration systems and methods |
| CN108504562A (zh) * | 2018-06-21 | 2018-09-07 | 江苏澳创生物科技有限公司 | 一种发酵生产l-苏氨酸的系统及其应用 |
| CN111065725B (zh) | 2018-07-13 | 2024-03-29 | 康宁股份有限公司 | 包括具有互联的壁的微板的流体装置 |
| WO2020013845A1 (en) | 2018-07-13 | 2020-01-16 | Corning Incorporated | Cell culture vessels with stabilizer devices |
| US11912968B2 (en) | 2018-07-13 | 2024-02-27 | Corning Incorporated | Microcavity dishes with sidewall including liquid medium delivery surface |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| WO2020165873A1 (en) * | 2019-02-15 | 2020-08-20 | Oncosimis Biotech Private Limited | Method and system for enhanced continuous production, secretion and separation of recombinant polypeptides from bacteria |
| US20220243225A1 (en) * | 2019-04-29 | 2022-08-04 | Voyager Therapeutics, Inc. | SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS |
| EP3983520A1 (en) * | 2019-06-13 | 2022-04-20 | Amgen, Inc | Automated biomass-based perfusion control in the manufacturing of biologics |
| WO2021008571A1 (zh) * | 2019-07-16 | 2021-01-21 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| JP2023503849A (ja) * | 2019-11-15 | 2023-02-01 | ロンザ リミテッド | 接種物を生産するためのプロセスおよびシステム |
| CA3189533A1 (en) | 2020-07-28 | 2022-02-03 | Seagen Inc. | Methods and systems for producing polypeptides |
| JP2023546736A (ja) * | 2020-10-15 | 2023-11-07 | エージーシー バイオロジクス,インコーポレーテッド | 二重容器接線流濾過による連続的高細胞密度培養 |
| MX2023012193A (es) * | 2021-04-14 | 2023-10-25 | Genzyme Corp | Metodos de cultivo de perfusion de una celula de mamifero. |
| CA3266599A1 (en) | 2022-09-07 | 2024-11-07 | Quantitative Biosciences, Inc. | UNIQUE VARIABLE DOMAIN ANTIBODIES SPECIFIC TO FENTANYL AND USE IN A CONTINUOUS AGGLUTINATION TEST |
| CN116179464A (zh) * | 2022-12-06 | 2023-05-30 | 无锡药明生物技术股份有限公司 | 提高培养液细胞密度和高密度细胞培养的方法 |
| AU2024235963A1 (en) * | 2023-03-14 | 2025-08-07 | Sonnet BioTherapeutics, Inc. | Methods of making recombinant il-12 albumin binding domain fusion proteins |
| WO2024192116A1 (en) * | 2023-03-14 | 2024-09-19 | Repligen Corporation | High viable cell density transfection |
| EP4702164A1 (en) | 2023-04-24 | 2026-03-04 | Quantitative Biosciences, Inc. | Engineered biosensor strains of e. coli for continuous aerobic detection of analytes |
| CN121175432A (zh) * | 2023-05-31 | 2025-12-19 | 富士胶片株式会社 | 生产物的生产方法 |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
| EP4711442A1 (en) | 2024-09-15 | 2026-03-18 | Quantitative Biosciences, Inc. | Microfluidic chip for the parallel culture of microbial biosensor strains |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US54544A (en) * | 1866-05-08 | Improvement in low-water detecters | ||
| JPS61199788A (ja) | 1985-02-28 | 1986-09-04 | Mitsubishi Rayon Co Ltd | 醗酵生成物の分離濃縮方法及び連続醗酵方法 |
| US5286646A (en) | 1985-11-25 | 1994-02-15 | Boehringer Mannheim Gmbh | Method for mammalian cell culture |
| GB8617646D0 (en) | 1986-07-18 | 1986-08-28 | Manchester Inst Science Tech | Recovery of biological material |
| US4806484A (en) | 1987-08-07 | 1989-02-21 | Igb Products, Ltd. | Perfusion airlift bioreactor |
| JPH0797982B2 (ja) | 1987-09-24 | 1995-10-25 | 東洋紡績株式会社 | 細胞培養装置 |
| US4921792A (en) | 1987-11-27 | 1990-05-01 | Miles Inc. | Continuous cell dispersion, cultivation and substance recovery process |
| JPH01243985A (ja) | 1988-03-25 | 1989-09-28 | P C C Technol:Kk | 植物器官の培養法及びその培養槽 |
| US5595909A (en) * | 1988-05-23 | 1997-01-21 | Regents Of The University Of Minnesota | Filter device |
| DE68917642T2 (de) | 1988-05-25 | 1995-02-09 | Teijin Ltd | Verfahren zur kontinuierlichen Züchtung von haftenden tierischen Zellen. |
| JPH02113896A (ja) * | 1988-10-24 | 1990-04-26 | Snow Brand Milk Prod Co Ltd | ヒト抗リシンモノクローナル抗体およびそれを分泌するハイブリドーマ |
| US5019512A (en) * | 1989-03-17 | 1991-05-28 | Baxter International Inc. | Spin filter for removing substantially cell-free culture medium from suspension cell culture system |
| JPH0541984A (ja) * | 1990-09-07 | 1993-02-23 | Dow Chem Co:The | 攪拌容器における中空繊維においての細胞の増殖 |
| US5256294A (en) | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
| GB9118664D0 (en) | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| JPH05153973A (ja) | 1991-12-03 | 1993-06-22 | Hitachi Ltd | 細胞培養方法及び装置 |
| US6204000B1 (en) | 1995-04-28 | 2001-03-20 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1 |
| JP2752918B2 (ja) * | 1995-05-16 | 1998-05-18 | ユーエイチティー株式会社 | 動物細胞のマイクロキャリア培養法 |
| US6001585A (en) | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
| JP2997771B2 (ja) * | 1998-06-29 | 2000-01-11 | 金沢大学長 | 細胞の懸濁培養方法 |
| US8026096B1 (en) | 1998-10-08 | 2011-09-27 | Protein Sciences Corporation | In vivo active erythropoietin produced in insect cells |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| CA2252972C (en) | 1998-11-26 | 2012-09-18 | National Research Council Of Canada | Serum-free production of recombinant proteins and adenoviral vectors |
| WO2000044883A1 (en) * | 1999-01-26 | 2000-08-03 | Schering-Plough Ltd. | Propagation of bovine coronavirus in chinese hamster ovary cells |
| ES2237420T5 (es) * | 1999-04-15 | 2010-03-03 | Crucell Holland B.V. | Produccion de proteina recombinante en una celula humana. |
| US6855544B1 (en) * | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
| EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| JP2001149099A (ja) | 1999-11-26 | 2001-06-05 | Olympus Optical Co Ltd | 染色体異常解析のための有核細胞の標本作製方法 |
| US6544424B1 (en) | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| US6168941B1 (en) * | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
| JP4138209B2 (ja) | 2000-06-29 | 2008-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラバスタチン含有組成物 |
| JP2002113896A (ja) | 2000-10-05 | 2002-04-16 | Seiko Epson Corp | 画像形成装置 |
| ATE422216T1 (de) * | 2001-04-17 | 2009-02-15 | Seiren Kabushiki Kaisha | Mediumzusätze und medien für tierzellkulturen |
| DE10120835C2 (de) | 2001-04-27 | 2003-04-10 | Sifin Inst Fuer Immunpraeparat | Verfahren zur Herstellung von monoklonalen Antikörpern |
| CA2351156A1 (en) | 2001-07-04 | 2003-01-04 | Peter W. Zandstra | A bioprocess for the generation of pluripotent cell derived cells and tissues |
| KR100909316B1 (ko) * | 2001-08-31 | 2009-07-24 | 바이엘 헬스케어 아게 | 고세포밀도 발효를 수행하기 위한 유닛 및 방법 |
| MXPA04002099A (es) | 2001-09-05 | 2004-06-07 | Yamasa Corp | Composiciones medicinales para neuropatia diabetica. |
| WO2003025158A1 (en) | 2001-09-14 | 2003-03-27 | Medcell Biologics, Inc. | Oxygen enriched bioreactor and method of culturing cells |
| JP2003219873A (ja) | 2002-01-24 | 2003-08-05 | Japan Science & Technology Corp | サケ科キングサーモン由来の不死化細胞 |
| US20030186335A1 (en) | 2002-03-28 | 2003-10-02 | National Institute Of Advanced Industrial Science And Technology | Monoclonal antibodies, hybridomas, cell isolation method, isolated cells and immunological diagnostic method |
| DE10237082B4 (de) * | 2002-08-09 | 2014-12-31 | Sartorius Stedim Biotech Gmbh | Verfahren und Vorrichtung zur biotechnologischen Herstellung von Wertstoffen |
| CN100383238C (zh) | 2003-05-09 | 2008-04-23 | 克鲁塞尔荷兰公司 | E1-永生化的细胞培养物及培养所述细胞以提高从中获取的产物产量的方法 |
| JP2005041984A (ja) | 2003-07-22 | 2005-02-17 | Shin Kobe Electric Mach Co Ltd | 水架橋ポリオレフィン製シートの製造法 |
| CN104388324A (zh) | 2004-03-05 | 2015-03-04 | 帝斯曼知识产权资产管理有限公司 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| DK2634242T3 (en) * | 2006-07-14 | 2017-05-22 | Patheon Holdings I B V | IMPROVED PROCEDURE FOR CULTURING CELLS |
| JP2008308560A (ja) | 2007-06-13 | 2008-12-25 | Tohcello Co Ltd | 表面防汚性複合フィルムの製造方法 |
-
2005
- 2005-03-04 CN CN201410601800.9A patent/CN104388324A/zh active Pending
- 2005-03-04 CN CNA2005800071754A patent/CN1930281A/zh active Pending
- 2005-03-04 EP EP12186351A patent/EP2540815A1/en not_active Ceased
- 2005-03-04 JP JP2007501239A patent/JP2007525984A/ja active Pending
- 2005-03-04 PT PT57157877T patent/PT1720972E/pt unknown
- 2005-03-04 DK DK05715787.7T patent/DK1720972T3/da active
- 2005-03-04 CA CA002557046A patent/CA2557046A1/en not_active Withdrawn
- 2005-03-04 SI SI200531842T patent/SI1720972T1/sl unknown
- 2005-03-04 US US10/591,118 patent/US8206981B2/en active Active
- 2005-03-04 EP EP10183651A patent/EP2308958A3/en not_active Withdrawn
- 2005-03-04 CN CN201410471955.5A patent/CN104593277A/zh active Pending
- 2005-03-04 PL PL05715787T patent/PL1720972T3/pl unknown
- 2005-03-04 EP EP05715787.7A patent/EP1720972B1/en not_active Revoked
- 2005-03-04 AU AU2005229359A patent/AU2005229359C1/en not_active Ceased
- 2005-03-04 ES ES05715787.7T patent/ES2456015T3/es not_active Expired - Lifetime
- 2005-03-04 KR KR1020067018075A patent/KR101050585B1/ko not_active Ceased
- 2005-03-04 WO PCT/EP2005/002374 patent/WO2005095578A1/en not_active Ceased
-
2006
- 2006-08-28 IL IL177724A patent/IL177724A/en unknown
-
2010
- 2010-05-06 IL IL205606A patent/IL205606A/en unknown
-
2011
- 2011-02-22 JP JP2011036102A patent/JP2011125348A/ja active Pending
- 2011-11-28 JP JP2011259168A patent/JP2012090632A/ja active Pending
-
2012
- 2012-05-23 US US13/478,307 patent/US20130266985A1/en not_active Abandoned
-
2013
- 2013-10-14 US US14/052,878 patent/US9260695B2/en not_active Expired - Lifetime
-
2014
- 2014-01-31 JP JP2014016778A patent/JP5719947B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-26 JP JP2015209828A patent/JP2016039817A/ja active Pending
-
2017
- 2017-07-06 JP JP2017132997A patent/JP2017225443A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL177724A0 (en) | Process for cell culturing by continuous perfusion and alternating tangential flow | |
| EP1789528A4 (en) | BIOREACTOR FOR CULTIVATION OF CELLS UNDER PERFUSION | |
| GB2411178A8 (en) | Apparatus for culturing cells | |
| EP2089507A4 (en) | DEVICES AND METHODS PARTICULARLY EFFECTIVE IN CELL CULTURE | |
| PL2522717T3 (pl) | Pożywki do hodowli komórkowych wolne od oligopeptydów | |
| IL198486A0 (en) | Rationally designed media for cell culture | |
| EP1812141A4 (en) | PORTABLE MINI OXYGEN CONCENTRATOR | |
| IL196322A0 (en) | Improved process for the culturing of cells | |
| HU0402444D0 (en) | Process for enhancing the biogas production of thermophyl anagrobic fermenter | |
| IL184262A (en) | A method for culturing cells in culture | |
| EP1743025A4 (en) | METHOD OF MANUFACTURING REGULATOR T CELLS AND THEIR USE | |
| EP1820852A4 (en) | HUMAN SERUM FOR CELL CULTURE | |
| GB0420881D0 (en) | Bioreactor | |
| GB0514675D0 (en) | Flow cytometry method | |
| EP1753867A4 (en) | FERMENTATION PROCESSES | |
| EP1733781A4 (en) | APPARATUS FOR CONCENTRATING METHANE GAS | |
| ZA200802933B (en) | Method for culturing microorganisms | |
| ZA200706624B (en) | Reactive dyestuffs, method for the production thereof and use of the same | |
| HU0401841D0 (en) | Combined micropropagating process and bioreactor | |
| GB0419055D0 (en) | Cell culture medium | |
| HUP0700812A2 (en) | Fermenter, preferably for using in biogas technology | |
| PL115103U1 (en) | Inlet seal for sewage system well | |
| PL366679A1 (en) | Method for carrying research in water regions | |
| GB0423870D0 (en) | Fermentation process | |
| SE0402853D0 (sv) | Method for culturing mammalian cells |