CN1902222A - 具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质 - Google Patents

具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质 Download PDF

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Publication number
CN1902222A
CN1902222A CNA2004800396709A CN200480039670A CN1902222A CN 1902222 A CN1902222 A CN 1902222A CN A2004800396709 A CNA2004800396709 A CN A2004800396709A CN 200480039670 A CN200480039670 A CN 200480039670A CN 1902222 A CN1902222 A CN 1902222A
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CN
China
Prior art keywords
epo
fused protein
erythropoietin
protein
cells
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Pending
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CNA2004800396709A
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English (en)
Chinese (zh)
Inventor
S·D·吉利斯
S·劳德
D·克雷斯
H-C·马勒
R·米勒
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNA2004800396709A 2003-12-31 2004-12-22 具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质 Pending CN1902222A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53385803P 2003-12-31 2003-12-31
US60/533,858 2003-12-31

Publications (1)

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CN1902222A true CN1902222A (zh) 2007-01-24

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CNA2004800396709A Pending CN1902222A (zh) 2003-12-31 2004-12-22 具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质

Country Status (13)

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US (2) US7465447B2 (enExample)
EP (1) EP1699821B1 (enExample)
JP (2) JP2008504008A (enExample)
KR (1) KR20060124656A (enExample)
CN (1) CN1902222A (enExample)
AU (1) AU2004309063B2 (enExample)
BR (1) BRPI0417916A (enExample)
CA (1) CA2551916C (enExample)
DK (1) DK1699821T3 (enExample)
ES (1) ES2387028T3 (enExample)
PT (1) PT1699821E (enExample)
RU (1) RU2370276C2 (enExample)
WO (1) WO2005063808A1 (enExample)

Cited By (10)

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CN102690354A (zh) * 2012-05-14 2012-09-26 安源生物科技(上海)有限公司 重组二聚化抗凝血酶III-Fc融合蛋白及其哺乳动物细胞高效表达系统
CN102712688A (zh) * 2009-09-23 2012-10-03 百奥杰诺瑞克斯股份有限公司 重组人红细胞生成素（epo）的纯化方法、由此纯化的epo以及包含纯化的epo的药物组合物
CN105884906A (zh) * 2016-05-27 2016-08-24 东莞太力生物工程有限公司 一种长效人促红细胞生成素融合蛋白的纯化方法
CN106573978A (zh) * 2014-08-01 2017-04-19 法国血液分割暨生化制品实验室 用于产生具有唾液酸化改善的Fc的变体的方法
CN107427554A (zh) * 2015-01-09 2017-12-01 格纳西尼有限公司 使用长效epo配制物治疗贫血的方法
CN107937425A (zh) * 2017-12-27 2018-04-20 北京四环生物制药有限公司 长效重组人促红素的生产方法
CN108137665A (zh) * 2015-10-07 2018-06-08 株式会社绿十字 包含长效红细胞生成素的组成物
CN111499764A (zh) * 2020-04-02 2020-08-07 北京翼方生物科技有限责任公司 一种具有促红细胞生成素活性的长效融合蛋白
CN114340653A (zh) * 2019-09-05 2022-04-12 分子免疫中心 人重组低唾液酸化红细胞生成素、其纯化方法及治疗用途
WO2023222040A1 (zh) * 2022-05-17 2023-11-23 广州汉腾生物科技有限公司 重组促红细胞生成素及其应用

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CN102690354B (zh) * 2012-05-14 2015-03-25 安源生物科技(上海)有限公司 重组二聚化抗凝血酶III-Fc融合蛋白及其哺乳动物细胞高效表达系统
CN102690354A (zh) * 2012-05-14 2012-09-26 安源生物科技(上海)有限公司 重组二聚化抗凝血酶III-Fc融合蛋白及其哺乳动物细胞高效表达系统
CN106573978A (zh) * 2014-08-01 2017-04-19 法国血液分割暨生化制品实验室 用于产生具有唾液酸化改善的Fc的变体的方法
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CN108137665A (zh) * 2015-10-07 2018-06-08 株式会社绿十字 包含长效红细胞生成素的组成物
CN105884906A (zh) * 2016-05-27 2016-08-24 东莞太力生物工程有限公司 一种长效人促红细胞生成素融合蛋白的纯化方法
CN107937425A (zh) * 2017-12-27 2018-04-20 北京四环生物制药有限公司 长效重组人促红素的生产方法
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CN111499764B (zh) * 2020-04-02 2022-02-08 北京翼方生物科技有限责任公司 一种具有促红细胞生成素活性的长效融合蛋白
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PT1699821E (pt) 2012-08-23
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AU2004309063B2 (en) 2010-10-28
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