KR20060124656A - 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 - Google Patents
개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 Download PDFInfo
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- KR20060124656A KR20060124656A KR1020067012656A KR20067012656A KR20060124656A KR 20060124656 A KR20060124656 A KR 20060124656A KR 1020067012656 A KR1020067012656 A KR 1020067012656A KR 20067012656 A KR20067012656 A KR 20067012656A KR 20060124656 A KR20060124656 A KR 20060124656A
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- Prior art keywords
- epo
- fusion protein
- ser
- erythropoietin
- epo fusion
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019209078A1 (ko) * | 2018-04-26 | 2019-10-31 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
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| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| HUP0204475A2 (en) | 2000-02-11 | 2003-04-28 | Merck Patent Gmbh | Enhancing the circulating half-life of antibody-based fusion proteins |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| DE60239454D1 (de) | 2001-05-03 | 2011-04-28 | Merck Patent Gmbh | Rekombinanter, tumorspezifischer antikörper und dessen verwendung |
| EP1454138B1 (en) | 2001-12-04 | 2012-01-18 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| CN100467488C (zh) * | 2003-12-30 | 2009-03-11 | 默克专利有限公司 | Il-7融合蛋白 |
| RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| US7589179B2 (en) * | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
| US7566456B2 (en) * | 2005-06-23 | 2009-07-28 | Haiming Chen | Allergen vaccine proteins for the treatment and prevention of allergic diseases |
| US8470318B2 (en) | 2005-11-07 | 2013-06-25 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| ES2439641T3 (es) | 2005-12-20 | 2014-01-24 | Bristol-Myers Squibb Company | Composiciones y procedimientos de producción de una composición |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| ES2384055T3 (es) | 2005-12-30 | 2012-06-28 | Merck Patent Gmbh | Variantes de la interleucina-12p40 con estabilidad mejorada |
| ATE509954T1 (de) | 2005-12-30 | 2011-06-15 | Merck Patent Gmbh | Anti-cd19-antikörper mit reduzierter immunogenität |
| CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
| CN100475270C (zh) | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
| US7625564B2 (en) | 2006-01-27 | 2009-12-01 | Novagen Holding Corporation | Recombinant human EPO-Fc fusion proteins with prolonged half-life and enhanced erythropoietic activity in vivo |
| EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
| MX2008012843A (es) * | 2006-04-05 | 2009-01-19 | Univ Rockefeller | Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados. |
| US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
| CA2652570A1 (en) * | 2006-05-15 | 2007-11-22 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
| EP1873166B1 (en) * | 2006-06-30 | 2010-09-08 | CONARIS research institute AG | Improved sgp 130Fc dimers |
| AU2007317755A1 (en) * | 2006-10-27 | 2008-05-15 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| JP2010510794A (ja) | 2006-11-28 | 2010-04-08 | ハナル ファーマシューティカル カンパニー リミテッド | 修飾型エリスロポエチンポリペプチド及びこの治療用用途 |
| KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8Ｆｃ |
| KR101542752B1 (ko) | 2006-12-22 | 2015-08-10 | 체에스엘 베링 게엠베하 | 연장된 생체내 반감기를 갖는 변형된 응고 인자 |
| CN101219219B (zh) | 2007-01-10 | 2013-02-13 | 北京普罗吉生物科技发展有限公司 | 包含血管抑素或其片段的复合物、其制备方法及应用 |
| JP2010517529A (ja) | 2007-02-02 | 2010-05-27 | アムジエン・インコーポレーテツド | ヘプシジン及びヘプシジン抗体 |
| CA2678001C (en) | 2007-02-12 | 2017-07-11 | Stefan Schulte | Therapeutic application of kazal-type serine protease inhibitors |
| EP1961821B1 (en) | 2007-02-22 | 2009-06-10 | Polymun Scientific Immunbiologische Forschung GmbH | Erythropoietin fusion protein |
| WO2009006520A1 (en) * | 2007-07-03 | 2009-01-08 | Medimmune, Llc | Hinge domain engineering |
| US8067548B2 (en) | 2007-07-26 | 2011-11-29 | Novagen Holding Corporation | Fusion proteins having mutated immunoglobulin hinge region |
| ES2750254T3 (es) | 2007-09-27 | 2020-03-25 | Amgen Inc | Formulaciones farmacéuticas |
| EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| EP2574628B1 (en) | 2008-01-25 | 2015-05-20 | Amgen Inc. | Ferroportin antibodies and methods of use |
| EP2279410B1 (en) | 2008-04-22 | 2015-11-11 | The Rockefeller University | Methods of identifying anti-inflammatory compounds |
| CA2722600C (en) | 2008-05-01 | 2014-01-21 | Amgen Inc. | Anti-hepcidin antibodies and methods of use |
| RU2528855C2 (ru) | 2008-06-24 | 2014-09-20 | Цсл Беринг Гмбх | Модифицированный фактор виллебранда с удлиненным полупериодом существования in vivo, его применения и способы получения |
| EP2184070A1 (en) * | 2008-11-07 | 2010-05-12 | Hla-G Technologies | HLA-G proteins and pharmaceutical uses thereof |
| US8318167B2 (en) | 2008-11-13 | 2012-11-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
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| US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| US7589179B2 (en) * | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
| US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
| PL1966244T3 (pl) * | 2005-12-30 | 2012-08-31 | Merck Patent Gmbh | Przeciwciała anty-il-6 zapobiegające wiązaniu il-6 skompleksowanego z il-6ralpha do gp130 |
| ATE509954T1 (de) * | 2005-12-30 | 2011-06-15 | Merck Patent Gmbh | Anti-cd19-antikörper mit reduzierter immunogenität |
| ES2384055T3 (es) | 2005-12-30 | 2012-06-28 | Merck Patent Gmbh | Variantes de la interleucina-12p40 con estabilidad mejorada |
| EP1999154B1 (en) | 2006-03-24 | 2012-10-24 | Merck Patent GmbH | Engineered heterodimeric protein domains |
| CA2656700A1 (en) * | 2006-07-06 | 2008-01-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
-
2004
- 2004-12-22 RU RU2006127554/15A patent/RU2370276C2/ru not_active IP Right Cessation
- 2004-12-22 AU AU2004309063A patent/AU2004309063B2/en not_active Ceased
- 2004-12-22 JP JP2006546058A patent/JP2008504008A/ja active Pending
- 2004-12-22 ES ES04804204T patent/ES2387028T3/es not_active Expired - Lifetime
- 2004-12-22 KR KR1020067012656A patent/KR20060124656A/ko not_active Withdrawn
- 2004-12-22 WO PCT/EP2004/014608 patent/WO2005063808A1/en not_active Ceased
- 2004-12-22 CA CA2551916A patent/CA2551916C/en not_active Expired - Fee Related
- 2004-12-22 BR BRPI0417916-1A patent/BRPI0417916A/pt not_active IP Right Cessation
- 2004-12-22 EP EP04804204A patent/EP1699821B1/en not_active Expired - Lifetime
- 2004-12-22 DK DK04804204.8T patent/DK1699821T3/da active
- 2004-12-22 CN CNA2004800396709A patent/CN1902222A/zh active Pending
- 2004-12-22 PT PT04804204T patent/PT1699821E/pt unknown
- 2004-12-30 US US11/026,998 patent/US7465447B2/en not_active Expired - Fee Related
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2008
- 2008-09-26 US US12/238,840 patent/US20090092607A1/en not_active Abandoned
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- 2012-02-17 JP JP2012032557A patent/JP2012107042A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019209078A1 (ko) * | 2018-04-26 | 2019-10-31 | 주식회사 굳티셀 | 신규한 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008504008A (ja) | 2008-02-14 |
| CN1902222A (zh) | 2007-01-24 |
| US7465447B2 (en) | 2008-12-16 |
| AU2004309063A1 (en) | 2005-07-14 |
| RU2370276C2 (ru) | 2009-10-20 |
| RU2006127554A (ru) | 2008-02-10 |
| BRPI0417916A (pt) | 2007-04-10 |
| ES2387028T3 (es) | 2012-09-12 |
| PT1699821E (pt) | 2012-08-23 |
| DK1699821T3 (da) | 2012-07-16 |
| CA2551916C (en) | 2014-04-29 |
| EP1699821B1 (en) | 2012-06-20 |
| EP1699821A1 (en) | 2006-09-13 |
| JP2012107042A (ja) | 2012-06-07 |
| US20050192211A1 (en) | 2005-09-01 |
| AU2004309063B2 (en) | 2010-10-28 |
| US20090092607A1 (en) | 2009-04-09 |
| CA2551916A1 (en) | 2005-07-14 |
| WO2005063808A1 (en) | 2005-07-14 |
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