CN1886408A - 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 - Google Patents
利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 Download PDFInfo
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- CN1886408A CN1886408A CNA2004800030228A CN200480003022A CN1886408A CN 1886408 A CN1886408 A CN 1886408A CN A2004800030228 A CNA2004800030228 A CN A2004800030228A CN 200480003022 A CN200480003022 A CN 200480003022A CN 1886408 A CN1886408 A CN 1886408A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
Cmaxng/ml | Tmax小时 | AUC0-24ng·小时/ml | |
平均值 | 平均值 | 平均值 | |
多晶型物α | 2.632 | 9.5 | 13 |
多晶型物β | 1.096 | 4 | 11 |
多晶型物γ | 668.22 | 2.25 | 3908 |
Cmaxng/ml | Tmax小时 | AUC0-24ng·小时/ml | |
平均值 | 平均值 | 平均值 | |
多晶型物α | 2.632 | 9.5 | 13 |
多晶型物β | 1.096 | 4 | 11 |
多晶型物γ | 668.22 | 2.25 | 3908 |
时间(分钟) | 溶出的利福昔明(mg/cm2) | |
多晶型物β | 多晶型物γ | |
15 | 0.28 | 2.46 |
30 | 0.50 | 4.52 |
45 | 0.72 | 6.44 |
60 | 0.94 | 9.04 |
固有溶出速率(mg/分钟/cm2) | 0.0147 | 0.1444 |
Claims (20)
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ITMI2003A002144 | 2003-11-07 | ||
IT002144A ITMI20032144A1 (it) | 2003-11-07 | 2003-11-07 | Forme polimorfe di rifaximina, processi per ottenerle e |
PCT/EP2004/012490 WO2005044823A2 (en) | 2003-11-07 | 2004-11-04 | Polymorphous forms of rifaximin as antibiotics |
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CN2008100869308A Division CN101260114B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
CN2008100869327A Division CN101260115B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
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CN1886408A true CN1886408A (zh) | 2006-12-27 |
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CN2008100869308A Active CN101260114B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
CN2008100869327A Active CN101260115B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
CN2004800030228A Active CN1886408B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
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CN2008100869308A Active CN101260114B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
CN2008100869327A Active CN101260115B (zh) | 2003-11-07 | 2004-11-04 | 利福昔明的多晶型形式,它们的制备方法及其在药物制剂中的用途 |
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EP (6) | EP1557421B1 (zh) |
JP (5) | JP2005139161A (zh) |
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CN (4) | CN1613858A (zh) |
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AT (3) | ATE361927T1 (zh) |
AU (2) | AU2004200964A1 (zh) |
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UA (1) | UA86384C2 (zh) |
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UA101829C2 (uk) | 2008-02-25 | 2013-05-13 | Саликс Фармасьютикалз, Лтд. | ФОРМА η РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ В ТЕРАПЕВТИЧНІЙ ПРАКТИЦІ |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9034892B2 (en) | 2008-02-25 | 2015-05-19 | Salix Pharmaceuticals, Inc. | Forms of rifaximin and uses thereof |
US9181274B2 (en) | 2008-02-25 | 2015-11-10 | Karen S. Gushurst | Forms of rifaximin and uses thereof |
US9359357B2 (en) | 2008-02-25 | 2016-06-07 | Salix Pharmaceuticals, Ltd. | Forms of rifaximin and uses thereof |
US9546183B2 (en) | 2008-02-25 | 2017-01-17 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
US9700545B2 (en) | 2008-02-25 | 2017-07-11 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
CN102834398A (zh) * | 2010-02-19 | 2012-12-19 | 萨利克斯药品有限公司 | 利福昔明的晶型及其用途 |
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