CN1845917A - 3-[(2-{[4-(已氧基羰基氨基-亚氨基-甲基)-苯氨基]-甲基}-1-甲基-1 h-苯并咪唑-5-羰基)-吡啶-2-基-氨基]-丙酸乙酯-甲磺酸酯及其作为药物的用途 - Google Patents
3-[(2-{[4-(已氧基羰基氨基-亚氨基-甲基)-苯氨基]-甲基}-1-甲基-1 h-苯并咪唑-5-羰基)-吡啶-2-基-氨基]-丙酸乙酯-甲磺酸酯及其作为药物的用途 Download PDFInfo
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- CN1845917A CN1845917A CNA2004800249521A CN200480024952A CN1845917A CN 1845917 A CN1845917 A CN 1845917A CN A2004800249521 A CNA2004800249521 A CN A2004800249521A CN 200480024952 A CN200480024952 A CN 200480024952A CN 1845917 A CN1845917 A CN 1845917A
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- XETBXHPXHHOLOE-UHFFFAOYSA-N dabigatran etexilate methanesulfonate Chemical compound CS(O)(=O)=O.C1=CC(C(\N)=N/C(=O)OCCCCCC)=CC=C1NCC1=NC2=CC(C(=O)N(CCC(=O)OCC)C=3N=CC=CC=3)=CC=C2N1C XETBXHPXHHOLOE-UHFFFAOYSA-N 0.000 title claims description 42
- 239000013078 crystal Substances 0.000 claims abstract description 32
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 45
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 22
- 239000003513 alkali Substances 0.000 claims description 21
- 229960000288 dabigatran etexilate Drugs 0.000 claims description 21
- KSGXQBZTULBEEQ-UHFFFAOYSA-N dabigatran etexilate Chemical compound C1=CC(C(N)=NC(=O)OCCCCCC)=CC=C1NCC1=NC2=CC(C(=O)N(CCC(=O)OCC)C=3N=CC=CC=3)=CC=C2N1C KSGXQBZTULBEEQ-UHFFFAOYSA-N 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 17
- GRCFSCSVLWPNGR-UHFFFAOYSA-N C(CCCCC)OC(=O)NC(C1=CC=C(C=C1)NCC1C(C(=O)O)(C=CC=C1C(=O)O)C)=N Chemical compound C(CCCCC)OC(=O)NC(C1=CC=C(C=C1)NCC1C(C(=O)O)(C=CC=C1C(=O)O)C)=N GRCFSCSVLWPNGR-UHFFFAOYSA-N 0.000 claims description 14
- QQVIHTHCMHWDBS-UHFFFAOYSA-N perisophthalic acid Natural products OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 claims description 14
- NFJCJDBKSWBKGU-UHFFFAOYSA-N CS(O)(=O)=O.CCOC(=O)CC Chemical class CS(O)(=O)=O.CCOC(=O)CC NFJCJDBKSWBKGU-UHFFFAOYSA-N 0.000 claims description 12
- 238000011081 inoculation Methods 0.000 claims description 11
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000001291 vacuum drying Methods 0.000 claims description 9
- 238000001556 precipitation Methods 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 206010051055 Deep vein thrombosis Diseases 0.000 claims description 2
- 206010047249 Venous thrombosis Diseases 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000002980 postoperative effect Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 3
- 239000012670 alkaline solution Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 10
- 230000004048 modification Effects 0.000 abstract description 8
- 238000012986 modification Methods 0.000 abstract description 8
- -1 compound 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridine-2-yl-amino]-propionic acid-ethyl ester methane sulphonate Chemical class 0.000 abstract description 5
- 239000013543 active substance Substances 0.000 description 14
- 150000001875 compounds Chemical class 0.000 description 13
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000013019 agitation Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000000634 powder X-ray diffraction Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000005280 amorphization Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Description
2θ[°] | dhkl值[] | 强度[%] |
4.4 | 20.1 | 100 |
8.94 | 9.90 | 5 |
9.23 | 9.57 | 4 |
9.55 | 9.26 | 4 |
10.55 | 8.38 | 2 |
10.95 | 8.08 | 11 |
12.73 | 6.95 | 1 |
13.46 | 6.57 | 7 |
13.95 | 6.34 | 3 |
14.26 | 6.21 | 2 |
15.17 | 5.84 | 1 |
15.93 | 5.56 | 1 |
16.46 | 5.38 | 1 |
17.66 | 5.02 | 8 |
18.07 | 4.91 | 13 |
18.60 | 4.77 | 2 |
19.89 | 4.46 | 6 |
20.28 | 4.38 | 2 |
20.54 | 4.32 | 2 |
21.12 | 4.20 | 4 |
22.06 | 4.03 | 8 |
22.85 | 3.89 | 6 |
24.12 | 3.69 | 1 |
25.10 | 3.54 | 3 |
25.99 | 3.43 | 1 |
26.52 | 3.36 | 2 |
26.83 | 3.32 | 2 |
27.16 | 3.28 | 1 |
27.64 | 3.22 | 2 |
28.09 | 3.17 | 2 |
29.08 | 3.07 | 1 |
29.26 | 3.05 | 1 |
29.94 | 2.98 | 1 |
31.88 | 2.80 | 1 |
34.37 | 2.61 | 1 |
36.21 | 2.48 | 1 |
38.26 | 2.35 | 1 |
39.47 | 2.28 | 1 |
39.98 | 2.25 | 1 |
2θ[°] | dhkl值[] | 强度[%] |
4.3 | 20.4 | 100 |
8.72 | 10.1 | 3 |
9.68 | 9.13 | 1 |
11.15 | 7.93 | 1 |
12.42 | 7.12 | 2 |
13.59 | 6.51 | 1 |
13.95 | 6.34 | 1 |
15.11 | 5.86 | 1 |
15.97 | 5.55 | 1 |
16.52 | 5.36 | 1 |
17.45 | 5.08 | 1 |
17.86 | 4.96 | 2 |
18.45 | 4.81 | 1 |
19.22 | 4.61 | 2 |
19.89 | 4.46 | 2 |
21.46 | 4.14 | 2 |
21.98 | 4.04 | 1 |
22.48 | 3.95 | 1 |
23.75 | 3.74 | 1 |
25.29 | 3.52 | 1 |
28.17 | 3.17 | 1 |
28.59 | 3.12 | 1 |
2θ[°] | dhkl值[] | 强度[%] |
3,9 | 22,8 | 100 |
4,4 | 20,1 | 10 |
5,64 | 15,7 | 2 |
7,57 | 11,8 | 16 |
8,25 | 10,7 | 17 |
8,77 | 10,1 | 12 |
9,34 | 9,46 | 7 |
10,69 | 8,27 | 13 |
11,33 | 7,80 | 3 |
11,66 | 7,58 | 1 |
11,96 | 7,39 | 1 |
13,04 | 6,78 | 3 |
14,54 | 6,09 | 11 |
15,16 | 5,84 | 1 |
16,56 | 5,35 | 13 |
17,27 | 5,13 | 6 |
17,78 | 4,98 | 12 |
18,75 | 4,73 | 1 |
19,41 | 4,57 | 3 |
19,95 | 4,45 | 24 |
20,38 | 4,35 | 4 |
20.84 | 4.26 | 4 |
21.21 | 4.19 | 12 |
22.22 | 4.00 | 6 |
22.46 | 3.96 | 5 |
23.05 | 3.85 | 3 |
23.40 | 3.80 | 4 |
23.85 | 3.73 | 12 |
24.44 | 3.64 | 7 |
25.30 | 3.52 | 1 |
25.63 | 3.47 | 1 |
26.22 | 3.40 | 2 |
26.52 | 3.36 | 3 |
27.06 | 3.29 | 1 |
27.45 | 3.25 | 2 |
29.27 | 3.05 | 3 |
30.78 | 2.90 | 2 |
32.32 | 2.77 | 2 |
32.59 | 2.75 | 2 |
34.31 | 2.61 | 1 |
34.91 | 2.57 | 1 |
36.04 | 2.49 | 1 |
37.00 | 2.43 | 1 |
37.84 | 2.38 | 1 |
38.13 | 2.36 | 1 |
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10339862A DE10339862A1 (de) | 2003-08-29 | 2003-08-29 | 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel |
DE10339862.7 | 2003-08-29 | ||
PCT/EP2004/009432 WO2005028468A1 (de) | 2003-08-29 | 2004-08-24 | 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1h-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester -methansulfonat und dessen verwendung als arzneimittel |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011100536316A Division CN102167695B (zh) | 2003-08-29 | 2004-08-24 | 苯并咪唑羰基吡啶氨基丙酸乙酯半水合物及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1845917A true CN1845917A (zh) | 2006-10-11 |
CN1845917B CN1845917B (zh) | 2011-05-11 |
Family
ID=34202202
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800249521A Expired - Lifetime CN1845917B (zh) | 2003-08-29 | 2004-08-24 | 3-[(2-{[4-(己氧基羰基氨基-亚氨基-甲基)-苯氨基]-甲基}-1-甲基-1h-苯并咪唑-5-羰基)-吡啶-2-基-氨基]-丙酸乙酯-甲磺酸盐及其作为药物的用途 |
CN2011100536316A Expired - Lifetime CN102167695B (zh) | 2003-08-29 | 2004-08-24 | 苯并咪唑羰基吡啶氨基丙酸乙酯半水合物及其用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011100536316A Expired - Lifetime CN102167695B (zh) | 2003-08-29 | 2004-08-24 | 苯并咪唑羰基吡啶氨基丙酸乙酯半水合物及其用途 |
Country Status (36)
Country | Link |
---|---|
US (2) | US20050234104A1 (zh) |
EP (2) | EP2060569B1 (zh) |
JP (2) | JP5348842B2 (zh) |
KR (1) | KR101331039B1 (zh) |
CN (2) | CN1845917B (zh) |
AR (2) | AR045520A1 (zh) |
AT (2) | ATE529420T1 (zh) |
AU (2) | AU2004274139B2 (zh) |
BR (1) | BRPI0413849A (zh) |
CA (2) | CA2749579C (zh) |
CO (1) | CO5660265A2 (zh) |
CY (2) | CY1109299T1 (zh) |
DE (2) | DE10339862A1 (zh) |
DK (2) | DK1660482T3 (zh) |
EA (1) | EA009736B1 (zh) |
EC (2) | ECSP066399A (zh) |
ES (2) | ES2326654T3 (zh) |
HK (2) | HK1096682A1 (zh) |
HR (2) | HRP20090311T1 (zh) |
IL (1) | IL173885A (zh) |
ME (1) | ME00340B (zh) |
MX (1) | MXPA06001959A (zh) |
MY (2) | MY145632A (zh) |
NO (2) | NO334115B1 (zh) |
NZ (2) | NZ578586A (zh) |
PE (1) | PE20050348A1 (zh) |
PL (2) | PL1660482T3 (zh) |
PT (2) | PT2060569E (zh) |
RS (2) | RS20060136A (zh) |
SG (1) | SG145734A1 (zh) |
SI (2) | SI2060569T1 (zh) |
TW (2) | TWI375674B (zh) |
UA (1) | UA85686C2 (zh) |
UY (2) | UY28493A1 (zh) |
WO (1) | WO2005028468A1 (zh) |
ZA (1) | ZA200600518B (zh) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103664882A (zh) * | 2012-09-20 | 2014-03-26 | 天津药物研究院 | 结晶变体形态的达比加群酯及其制备方法和用途 |
CN103864756A (zh) * | 2012-12-11 | 2014-06-18 | 四川海思科制药有限公司 | 丁二磺酸达比加群酯及其制备方法和用途 |
US8859540B2 (en) | 2002-10-10 | 2014-10-14 | Boehringer Ingelheim Vetmedica Gmbh | Use of dihydroimidazolones for the treatment of dogs |
CN104418840A (zh) * | 2013-09-05 | 2015-03-18 | 天津汉瑞药业有限公司 | 甲磺酸达比加群酯无水化合物 |
CN104725360A (zh) * | 2015-04-09 | 2015-06-24 | 重庆东得医药科技有限公司 | 一种甲磺酸达比加群酯ⅰ晶型的制备方法 |
WO2015149638A1 (zh) * | 2014-04-04 | 2015-10-08 | 江苏天士力帝益药业有限公司 | 达比加群酯甲磺酸盐晶型、其制备方法以及药物组合物 |
CN105461686A (zh) * | 2014-08-25 | 2016-04-06 | 江苏豪森药业股份有限公司 | 制备高纯度甲磺酸达比加群酯晶型的方法 |
US9820988B2 (en) | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
CN114380793A (zh) * | 2020-10-20 | 2022-04-22 | 北京澳合药物研究院有限公司 | 一种甲磺酸达比加群酯晶型i的制备方法及其应用 |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030181488A1 (en) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof |
DE10337697A1 (de) * | 2003-08-16 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tablette enthaltend 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenyl-amino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester oder dessen Salze |
DE102005020002A1 (de) * | 2005-04-27 | 2006-11-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
DE102005025728A1 (de) * | 2005-06-04 | 2006-12-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-Propionsäure-ethylester |
DE102006054005A1 (de) * | 2006-11-16 | 2008-05-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Polymorphe von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester |
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