CO5660265A2 - Metanosulfonato del ester etilico del acido 3-[(2-{[4-(hexiloxi-carbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-benci-midazol-5-carbonil)-piridin-2-il-amino]-propionico y su utilizacion como medicamento - Google Patents

Metanosulfonato del ester etilico del acido 3-[(2-{[4-(hexiloxi-carbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-benci-midazol-5-carbonil)-piridin-2-il-amino]-propionico y su utilizacion como medicamento

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Publication number
CO5660265A2
CO5660265A2 CO06019918A CO06019918A CO5660265A2 CO 5660265 A2 CO5660265 A2 CO 5660265A2 CO 06019918 A CO06019918 A CO 06019918A CO 06019918 A CO06019918 A CO 06019918A CO 5660265 A2 CO5660265 A2 CO 5660265A2
Authority
CO
Colombia
Prior art keywords
methyl
imino
amino
propionic
ethyl ester
Prior art date
Application number
CO06019918A
Other languages
English (en)
Inventor
Rainer Sobotta
Peter Sieger
Rolf Schmid
Original Assignee
Boehringer Ingelheim Int
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34202202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5660265(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CO5660265A2 publication Critical patent/CO5660265A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

1.- Metanosulfonato del éster etílico del ácido 3-[(2- {[4-(hexiloxicarbonilamino-imino-metil)-fenilamino ]-metil}-1-metil--1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico en forma cristalina, caracterizado por un punto de fusión de Tp.f. = 180 + 3°C (forma I), (determinado por DSC; evaluación por pico máximo; tasa de calentamiento: 10°C/min). 2.- Metanosulfonato del éster etílico del ácido 3-[(2- {[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]-metil}-1-metil--1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico en forma cristalina, caracterizado por un punto de fusión de Tp.f. = 190 + 3°C (forma II), (determinado por DSC; eva- Iuación por pico máximo; tasa de calentamiento: 10°C/min).3.- Metanosulfonato del éster etílico del ácido 3-[(2- {[4-(hexiloxicarbonilamino-imino-metil)-fenilamino ]-metil}-1-metil--1H-bencimidazol-5-carbonil)-piridin-2-il-amino]-propiónico en forma cristalina, caracterizado por un punto de fusión de T.p.f. = 120 + 5°C (semihidrato), (determinado por DSC; evaluación por pico máximo; tasa de calentamiento: 10°C/min).4.- Medicamento que contiene la sal metanosulfonato del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino-imino- -metil)-fenilamino ]-metil}-1-metil-1H-bencimidazol-5-carbonil)- -piridin-2-il-amino]-propiónico conforme a una de las reivindicaciones 1 a 3, eventualmente junto a una o varias sustancias de soporte y/o diluyentes inertes.5.- Utilización del metanosulfonato del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino-imino-metil)-fenilamino]--metil}-1-metil-1H-bencimidazol-5-carbonil)-piridin-2-il-amino]propiónico conforme a una de las reivindicaciones 1 a 3 para la preparación de un medicamento, el cual es adecuado para la profilaxis posoperativa de trombosis venosas profundas y para la profilaxis de ataques de apoplejía.
CO06019918A 2003-08-29 2006-02-28 Metanosulfonato del ester etilico del acido 3-[(2-{[4-(hexiloxi-carbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-benci-midazol-5-carbonil)-piridin-2-il-amino]-propionico y su utilizacion como medicamento CO5660265A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10339862A DE10339862A1 (de) 2003-08-29 2003-08-29 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)- phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester-Methansulfonat und dessen Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CO5660265A2 true CO5660265A2 (es) 2006-07-31

Family

ID=34202202

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06019918A CO5660265A2 (es) 2003-08-29 2006-02-28 Metanosulfonato del ester etilico del acido 3-[(2-{[4-(hexiloxi-carbonilamino-imino-metil)-fenilamino]-metil}-1-metil-1h-benci-midazol-5-carbonil)-piridin-2-il-amino]-propionico y su utilizacion como medicamento

Country Status (36)

Country Link
US (2) US20050234104A1 (es)
EP (2) EP1660482B1 (es)
JP (2) JP5348842B2 (es)
KR (1) KR101331039B1 (es)
CN (2) CN1845917B (es)
AR (2) AR045520A1 (es)
AT (2) ATE430145T1 (es)
AU (2) AU2004274139B2 (es)
BR (1) BRPI0413849A (es)
CA (2) CA2749579C (es)
CO (1) CO5660265A2 (es)
CY (2) CY1109299T1 (es)
DE (2) DE10339862A1 (es)
DK (2) DK2060569T3 (es)
EA (1) EA009736B1 (es)
EC (2) ECSP066399A (es)
ES (2) ES2326654T3 (es)
HK (2) HK1157760A1 (es)
HR (2) HRP20090311T1 (es)
IL (1) IL173885A (es)
ME (1) ME00340B (es)
MX (1) MXPA06001959A (es)
MY (2) MY145632A (es)
NO (2) NO334115B1 (es)
NZ (2) NZ545984A (es)
PE (1) PE20050348A1 (es)
PL (2) PL1660482T3 (es)
PT (2) PT1660482E (es)
RS (2) RS20060136A (es)
SG (1) SG145734A1 (es)
SI (2) SI1660482T1 (es)
TW (2) TWI375674B (es)
UA (1) UA85686C2 (es)
UY (2) UY28493A1 (es)
WO (1) WO2005028468A1 (es)
ZA (1) ZA200600518B (es)

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EP1609784A1 (de) 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
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