HUP1000069A2 - New salts for the preparation of pharmaceutical composition - Google Patents

New salts for the preparation of pharmaceutical composition

Info

Publication number
HUP1000069A2
HUP1000069A2 HU1000069A HUP1000069A HUP1000069A2 HU P1000069 A2 HUP1000069 A2 HU P1000069A2 HU 1000069 A HU1000069 A HU 1000069A HU P1000069 A HUP1000069 A HU P1000069A HU P1000069 A2 HUP1000069 A2 HU P1000069A2
Authority
HU
Hungary
Prior art keywords
preparation
pharmaceutical composition
new salts
salts
new
Prior art date
Application number
HU1000069A
Other languages
Hungarian (hu)
Inventor
Imre Kiraly
Puter Trinka
Tibor Szabo
Balazs Dr Volk
Laszlo Dr Pongo
Jozsef Dr Barkoczy
Gyorgy Ruzsics
Laszlo Szlavik
Gyula Dr Lukacs
Puter Dr Slugel
Magdolna Obreczan
Andras Boza
Andras Dr Dancso
Vari Monika Mez
Original Assignee
Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag
Priority to HU1000069A priority Critical patent/HUP1000069A2/en
Publication of HU1000069D0 publication Critical patent/HU1000069D0/en
Priority to CN2011800153251A priority patent/CN102858762A/en
Priority to PCT/HU2011/000014 priority patent/WO2011110876A1/en
Priority to EA201290726A priority patent/EA022496B1/en
Publication of HUP1000069A2 publication Critical patent/HUP1000069A2/en
Priority to ZA2012/06254A priority patent/ZA201206254B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU1000069A 2010-02-02 2010-02-02 New salts for the preparation of pharmaceutical composition HUP1000069A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HU1000069A HUP1000069A2 (en) 2010-02-02 2010-02-02 New salts for the preparation of pharmaceutical composition
CN2011800153251A CN102858762A (en) 2010-02-02 2011-02-02 Novel salts for the manufacture of pharmaceutical compositions
PCT/HU2011/000014 WO2011110876A1 (en) 2010-02-02 2011-02-02 Novel salts for the manufacture of pharmaceutical compositions
EA201290726A EA022496B1 (en) 2010-02-02 2011-02-02 Polymorphous form of dabigatran etexilate hydrochloride
ZA2012/06254A ZA201206254B (en) 2010-02-02 2012-08-20 Novel salts for the manufacture of pharmaceutical compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1000069A HUP1000069A2 (en) 2010-02-02 2010-02-02 New salts for the preparation of pharmaceutical composition

Publications (2)

Publication Number Publication Date
HU1000069D0 HU1000069D0 (en) 2010-04-28
HUP1000069A2 true HUP1000069A2 (en) 2012-05-02

Family

ID=89989543

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1000069A HUP1000069A2 (en) 2010-02-02 2010-02-02 New salts for the preparation of pharmaceutical composition

Country Status (5)

Country Link
CN (1) CN102858762A (en)
EA (1) EA022496B1 (en)
HU (1) HUP1000069A2 (en)
WO (1) WO2011110876A1 (en)
ZA (1) ZA201206254B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
WO2012027543A1 (en) * 2010-08-25 2012-03-01 Teva Pharmaceuticals Usa, Inc. Solid state forms of dabigatran etexilate, dabigatran etexilate mesylate and processes for preparation thereof
US9006448B2 (en) 2010-12-06 2015-04-14 Msn Laboratories Private Limited Process for the preparation of benzimidazole derivatives and its salts
CN102558153A (en) * 2012-02-08 2012-07-11 北京阜康仁生物制药科技有限公司 Novel pharmaceutical salt of dabigatran etexilate and preparation method thereof
EP2631234A1 (en) 2012-02-23 2013-08-28 Esteve Química, S.A. Solid forms of dabigatran etexilate mesylate and processes for their preparation
WO2013144971A1 (en) * 2012-03-27 2013-10-03 Cadila Healthcare Limited New solid forms of dabigatran etexilate bisulfate and mesylate and processes to prepare them
CN102633777B (en) * 2012-03-31 2014-04-16 天津药物研究院 Dabigatran etexilate 2-ketoglutarate as well as preparation method and application thereof
WO2013150545A2 (en) 2012-04-02 2013-10-10 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN103539779B (en) * 2012-07-13 2016-12-21 四川海思科制药有限公司 A kind of hydroxyl-substituted sulfonate of dabigatran etcxilate and its production and use
EP2872499A1 (en) * 2012-07-16 2015-05-20 Interquim, S.A. Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates
EP2900652A2 (en) 2012-09-28 2015-08-05 Ranbaxy Laboratories Limited Process for the preparation of dabigatran etexilate or pharmaceutically acceptable salt thereof
IN2015DN02616A (en) 2012-09-28 2015-09-18 Ranbaxy Lab Ltd
CN103864756B (en) * 2012-12-11 2018-06-15 四川海思科制药有限公司 Fourth disulfonic acid dabigatran etcxilate and its preparation method and application
WO2014178017A1 (en) 2013-04-30 2014-11-06 Ranbaxy Laboratories Limited Dabigatran etexilate impurity, process of its preparation, and its use as a reference standard
EP2835370A1 (en) 2013-08-08 2015-02-11 Medichem, S.A. New crystals of dabigatran etexilate mesylate
CN104418840A (en) * 2013-09-05 2015-03-18 天津汉瑞药业有限公司 Dabigatran etexilate mesylate anhydrous compound
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CN104892574A (en) * 2014-03-04 2015-09-09 浙江海正药业股份有限公司 Dabigatran etexilate mesylate crystal forms, preparation methods and uses thereof
CN108947966A (en) * 2014-04-04 2018-12-07 江苏天士力帝益药业有限公司 Dabigatran etcxilate mesylate novel crystal forms and preparation method thereof
EP3169677A1 (en) * 2014-07-18 2017-05-24 OLON S.p.A. Crystalline compounds of dabigatran etexilate
CN105348260A (en) * 2014-08-19 2016-02-24 天津药物研究院 Dabigatran etexilate hydrobromide, preparation method and applications thereof
CN106554370A (en) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 Dabigatran derivant containing phosphate ester and its production and use
CN116621815A (en) * 2023-07-21 2023-08-22 成都苑东生物制药股份有限公司 Industrial preparation method of dabigatran etexilate mesylate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE121699A1 (en) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma BICYCLE HETERO CYCLES DISSTITUTED AS INHIBITORS OF THROMBIN
DE10337697A1 (en) * 2003-08-16 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tablet containing 3 - [(2 - {[4- (hexyloxycarbonylamino-iminomethyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] - propionic acid ethyl ester or its salts
DE10339862A1 (en) * 2003-08-29 2005-03-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New crystalline forms of ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate used for post-operative prophylaxis of deep vein thrombosis
DE102005020002A1 (en) * 2005-04-27 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg New hexyloxycarbonylamino-imino-methyl-phenylamino-methyl-benzimidazole-pyridine-propionic acid-ethyl ester salts such as hydrochloride useful for the prophylaxis of vein thrombosis and stroke
DE102005025728A1 (en) 2005-06-04 2006-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl ester
DE102005061623A1 (en) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improved process for the preparation of 4- (benzimidazolylmethylamino) -benzamidines and their salts
BRPI0715492A2 (en) * 2006-07-17 2013-03-19 Boehringer Ingelheim Int use of direct thrombin inhibitors
US20100087488A1 (en) * 2006-10-10 2010-04-08 Boehringer Ingelheim International Gmgh Physiologically Acceptable Salts of 3-[(2--1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
DE102006054005A1 (en) 2006-11-16 2008-05-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg New polymorphs of 3 - [(2 - {[4- (hexyloxycarbonylamino-imino-methyl) -phenyl-amino] -methyl} -1-methyl-1H-benzimidazole-5-carbonyl) -pyridin-2-yl-amino] -propionic acid ethyl
CN100556642C (en) * 2007-06-06 2009-11-04 中国科学院化学研究所 The regulate and control method of aliphatic poly adipic acid fourth diester material degradation performance

Also Published As

Publication number Publication date
WO2011110876A8 (en) 2012-07-05
ZA201206254B (en) 2013-10-30
CN102858762A (en) 2013-01-02
WO2011110876A1 (en) 2011-09-15
EA022496B1 (en) 2016-01-29
HU1000069D0 (en) 2010-04-28
EA201290726A1 (en) 2013-07-30

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees